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Converging evidence for a cognitive anomaly in early psychopathology

Published online by Cambridge University Press:  14 November 2002

LEYAN O.L. FERNANDES
Affiliation:
Department of Psychology, University of Illinois at Urbana-Champaign, USA
JENNIFER KELLER
Affiliation:
Department of Psychology, University of Illinois at Urbana-Champaign, USA
JANINE E. GIESE-DAVIS
Affiliation:
Department of Psychiatry, Stanford University, Stanford, California, USA
BLAIR D. HICKS
Affiliation:
Department of Psychology, University of Illinois at Urbana-Champaign, USA
DANIEL N. KLEIN
Affiliation:
Department of Psychology, State University of New York at Stony Brook, USA
GREGORY A. MILLER
Affiliation:
Departments of Psychology and Psychiatry, University of Illinois at Urbana-Champaign, USA
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Abstract

Subcomponents of the N200 component of the event-related brain potential believed to be differentially sensitive to involuntary and voluntary cognitive processes were examined. Nonpatients (N = 131) identified initially by the Chapman and Depue research scales and classified later on the basis of diagnostic symptom clusters and family psychiatric history provided converging evidence for an intact mismatch negativity subcomponent. In contrast, the N2b subcomponent distinguished several groups of subjects. Results suggested abnormal voluntary cognitive processing, perhaps reflecting compensatory efforts in subjects at risk for or manifesting psychopathology, particularly those showing negative symptoms.

Type
Research Article
Copyright
© 1999 Society for Psychophysiological Research

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