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Nucleosomes structure and its dynamic transitions

Published online by Cambridge University Press:  17 March 2009

Andrei D. Mirzabekov
Andrei D. Mirzabekov
Affiliation:
Institute of Molecular Biology, Academy of Science, Moscow, USSR
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The discovery of nucleosomes as a basic repeating unit of the chromatin structure organizing the major part of eukaryotic DNA greatly catalyzes the expansion of our knowledge on chromatin. Several lines of experimental evidence have led to the formulation of the nucleosome conception: the observation of chains of globular particles in electron micrographs of chromatin (Olins & Olins, 1974); the demonstration that DNA is released as a set of discrete sizes upon digestion of chromatin with endogenous nucleases (Hewish & Burgoyne, 1973); the isolation of discrete nucleoprotein particles upon digestion of chromatin with micrococcal nuclease (Rill & Van Holde, 1973).

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Research Article
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Quarterly Reviews of Biophysics , Volume 13 , Issue 2 , May 1980 , pp. 255 - 295
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Copyright © Cambridge University Press 1980

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