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Chromatin-remodeling and the initiation of transcription

  • Yahli Lorch (a1) and Roger D. Kornberg (a1)
Abstract

The nucleosome serves as a general gene repressor by the occlusion of regulatory and promoter DNA sequences. Repression is relieved by the SWI/SNF-RSC family of chromatin-remodeling complexes. Research reviewed here has revealed the essential features of the remodeling process.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
* Author for correspondence: Dr Y. Lorch, Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Tel.: 650-723-6988; Fax: 650-292-2255; E-mail: lorch@stanford.edu
References
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Quarterly Reviews of Biophysics
  • ISSN: 0033-5835
  • EISSN: 1469-8994
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