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Costs of accuracy determined by a maximal growth rate constraint

  • Måns Ehrenberg (a1) and C. G. Kurland (a1)

Extract

The present study is best understood as an extension and critique of two schools of thought. The first is that of Malloe and his students, among whom we number ourselves. It is to Maaloe that we are indebted for the idea that logarithmically growing bacteria assemble and use tibosomes in amounts that are optimally adjusted to yield the maximal growth rates supported by different media. Her, we begin our analysis by applying this optimization priciple to all the components of a logarithmically growing system. Our objective is to use the growth optimization constraint as a tool to explore the physiological limits on the accuracy of gene expression. This brings us to our second source of inspiration, which is Orgel's (1963) conception of a problem that Ninio (1982) has referred to as the ‘great error loop’.

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Andersson, D. & Kurland, C. G. (1983) RAM ribosomes are defective proofreaders. Molec. & Gen. Genet. 191, 378381.
Andersson, S., Buckingham, R. & Kurland, C. G. (1984) Does codon-composition influence ribosome function? EMBO J. 1, 9194.
Andersson, D., Bohman, K., Isaksson, L. & Kurland, C. G. (1982) Translation rates and misreading characteristics of rpsD mutants in Escherichia coli. Molec. & Gen. Genet. 187, 467472.
Blomberg, C., Ehrenberg, M. & Kurland, C. G. (1980) Free energy dissipation constraints on the accuracy of enzymatic selections. Q. Rev. Biophys. 13, 231254.
Bouadloun, F., Donner, D. & Kurland, C. G. (1983) Codon-specific missense errors in vivo. EMBO J. 2, 13511356.
Chavancy, G. & Garel, J. (1981) Does quantitative tRNA adaptation to codon content in mRNA optimize the ribosomal translation efficiency? Proposal for a translation system model. Biochimie 63, 187195.
Churchward, G., Estiva, E. & Bremer, H. (1981) Growth rsate-dependent control of chromosome replication initiation in Escherichia Coli. J. Bacter. 145, 12321238.
Churchward, G., Bremer, H. & Young, R. (1982) Macros-molecular composition of bacteria. J. theor. Biol. 94, 651670.
Ehrenberg, M. & Blomberg, C. (1980) Thermodynamic constraints on kinetic proofreading in biosynthetic pathways. Biophys. J. 31, 333358.
Fersht, A. (1977) Enzyme Structure and Mechanism. San Francisco: W. H. Freeman.
Fiers, W., Contreras, R., De Wachter, R., Haegeman, G., Merregaert, J., Min Jou, W. & Vandenberghe, A. (1971) Recent progress in the sequence determination of bacteriophage MS2 RNA. Biochimie 53, 495506.
Galas, J. & Branscomb, W. (1976) Ribosome slowed by mutation to streptomycin resistance. Nature, Lond. 262, 617619.
Gallant, J. & Prothero, J. (1980) Testing models of error propagation. J. theor. Biol. 83, 561578.
Garel, J. (1974) Functional adaptation of tRNA population. J. theor. Biol. 43, 211225.
Goel, N. & Ycas, M. (1975) The error catastrophe hypothesis with reference to aging and the evolution of the protein synthesizing machinery. J. theor. Biol. 55, 245282.
Gorini, L. (1971) Ribosomal discrimination of tRNAs. Nature (New Biol.) 234, 261264.
Grantham, R. & Gautier, C. (1980) Genetic distances from mRNA sequences. Naturwissenschaften 67, 9394.
Grantham, R., Gautier, C., Gouy, M., Jacobzone, M. & Mercier, R. (1981) Codon catalog usage is a genome strategy modulated for gene expressivity. Nucl. Acids Res. 9, r43–r74.
Grosjean, H. & Fiers, W. (1982) Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes. Gene 18, 199209.
Hoffman, G. W. (1974) On the origin of the genetic code and the stability of the translation apparatus. J. molec. Biol. 86, 349362.
Hopfield, J. J. (1974) Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. Proc. natn. Acad. Sci. U.S.A. 71, 41354139.
Ikemura, T. (1981) Correlation between the abundance of Escherichia Coli transfer RNAs and the occurrence of the respective codons in its protein genes. J. molec. Biol. 146, 121.
Jelenc, P. & Kurland, C. G. (1984) Multiple effects of kanamycin on translational accuracy. Molec. & Gen. Genet. 194, 195199.
Kirkwood, T. & Holiday, R. (1975) The stability of the translation apparatus. J. molec. Biol. 97, 257265.
Kirkwood, T. (1977) Evolution of ageing. Nature, Lond. 270, 301303.
Kjeldgaard, N. O. & Kurland, C. G. (1963) The distribution of soluble and ribosomal RNA as a function of growth rate. J. molec. Biol. 6, 341348.
Kurland, C. G. (1978) The role of guanine nucleotides in protein biosynthesis. Biophys. J. 22, 373388.
Kurland, C. G. & Ehrenberg, M. (1983) Optimization of translational accuracy. Progr. Mol. Biol. and Nucl. Acids Res. (in the Press).
Kurland, C. G., Andersson, D., Andersson, S., Bohman, K., Bouad-Loun, F., Ehrenberg, M., Jelenc, P. & Ruusala, T. (1983) Translational accuracy and bacterial growth. In Gene Expression. Alfred Benzon Symposium 19. Copenhagen: Munksgaard.
Maaløe, O. (1979). Regulation of the protein-synthesizing machinery ribosomes, tRNA, factors and so on. In Biological Regulation and Development (ed. Goldberger, R. F.), pp. 487542. New York: Plenum.
Neidhardt, F., Block, P., Pedersen, S. & Reeh, S. (1977) Chemical measurement of steady-state levels of ten aminoacyl-transfer ribonu-cleic acid synthetases in Escherichia coli. J. Bact. 129, 378387.
Ninio, J. (1974) A semi-quantitative treatment of missense and nonsense suppression in the strA and RAM ribosomal mutants of Escherichia Coli. Evaluation of some molecular parameters of translation in vivo. J. molec. Biol. 84, 297313.
Ninio, J. (1975) Kinetic amplification of enzyme discrimination. Biochimise 57, 587595.
Ninio, J. (1982) Molecular Evolution. London: Pitman.
Orgel, L. E. (1963) The maintenance of the accuracy of protein synthesis and its relevance to ageing. Proc. natn. Acad. Sci. U.S.A. 49, 517521.
Orgel, L. E. (1970) The maintenance of the accuracy of protein synthesis and its relevance to ageing: A correction. Proc. natn. Acad. Sci. U.S.A. 67, 14761480.
Piepersberg, W., Noseda, V. & Böck, A. (1979). Bacterial ribosomes with two ambiguity mutations: Effects on translational fidelity on the response to aminoglycosides and on the rate of protein synthesis.
Ruusala, T., Ehrenberg, M. & Kurland, C. G. (1982) Is there proofreading during polypeptide synthesis? EMBO J. 1, 741745.
Thompson, R. & Karim, A. (1982) The accuracy of protein biosynthesis is limited by its speed: High fidelity selection by ribosomes of aminoacyl-tRNA ternary complexes containing GTP γS]. Proc. natn. Acad. Sci. U.S.A. 79, 49224926.
Wain-Hobson, S., Nusssinov, R., Brown, R. & Sussman, J. (1981) Preferential codon usage in genes. Gene. 13, 355364.
Von Heijne, G. (1979). The concentration dependence of the error frequencies and some related quantities in protein synthesis. J. theor. Biol. 78, 113120.
Zengel, J., Young, R., Dennis, P. & Nomura, M. (1977) Role of ribosomal protein S12 in peptide chain elongation: Analysis of pleiotropic, streptomycin-resistant mutants of Escherichia coli. J. Bact. 129, 13201329.

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