Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 161
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Drmota Prebil, Sara Slapšak, Urška Pavšič, Miha Ilc, Gregor Puž, Vid de Almeida Ribeiro, Euripedes Anrather, Dorothea Hartl, Markus Backman, Lars Plavec, Janez Lenarčič, Brigita and Djinović-Carugo, Kristina 2016. Structure and calcium-binding studies of calmodulin-like domain of human non-muscle α-actinin-1. Scientific Reports, Vol. 6, p. 27383.

    Gaburjakova, Jana and Gaburjakova, Marta 2016. Cardiac ryanodine receptor: Selectivity for alkaline earth metal cations points to the EF-hand nature of luminal binding sites. Bioelectrochemistry, Vol. 109, p. 49.

    Halling, D. Brent Liebeskind, Benjamin J. Hall, Amelia W. and Aldrich, Richard W. 2016. Conserved properties of individual Ca2+-binding sites in calmodulin. Proceedings of the National Academy of Sciences, Vol. 113, Issue. 9, p. E1216.

    Li, Qian Yao, Li Xia, Wenwen and Lin, S.H. 2015. Calculation of anharmonic effects in the unimolecular dissociation of M2+(H2O)2(M = Be, Mg, and Ca). Molecular Physics, Vol. 113, Issue. 22, p. 3480.

    Pang, Chun-Li Yuan, Hong-Bo Cao, Tian-Guang Su, Ji-Guo Chen, Ya-Fei Liu, Hui Yu, Hui Zhang, Hai-Ling Zhan, Yong An, Hai-Long and Han, Yue-Bin 2015. Molecular simulation assisted identification of Ca2+ binding residues in TMEM16A. Journal of Computer-Aided Molecular Design, Vol. 29, Issue. 11, p. 1035.

    Saxena, Akansha and García, Angel E. 2015. Multisite Ion Model in Concentrated Solutions of Divalent Cations (MgCl2and CaCl2): Osmotic Pressure Calculations. The Journal of Physical Chemistry B, Vol. 119, Issue. 1, p. 219.

    Cooper, Dermot M. F. and Tabbasum, Valentina G. 2014. Adenylate cyclase-centred microdomains. Biochemical Journal, Vol. 462, Issue. 2, p. 199.

    Jamalian, Azadeh Sneekes, Evert-Jan Dekker, Lennard J. M. Ursem, Mario Luider, Theo M. and Burgers, Peter C. 2014. Dimerization of Peptides by Calcium Ions: Investigation of a Calcium-Binding Motif. International Journal of Proteomics, Vol. 2014, p. 1.

    Johnson, Christopher N Damo, Steven M and Chazin, Walter J 2014. eLS.

    Kahlen, Jens Salimi, Leila Sulpizi, Marialore Peter, Christine and Donadio, Davide 2014. Interaction of Charged Amino-Acid Side Chains with Ions: An Optimization Strategy for Classical Force Fields. The Journal of Physical Chemistry B, Vol. 118, Issue. 14, p. 3960.

    Newman, Rhonda A. Sorensen, Brenda R. Kilpatrick, Adina M. and Shea, Madeline A. 2014. Calcium-dependent energetics of calmodulin domain interactions with regulatory regions of the Ryanodine Receptor Type 1 (RyR1). Biophysical Chemistry, Vol. 193-194, p. 35.

    Xu, Zhiyang Li, Dechang and Baohua, Ji 2014. Quantification of the stiffness and strength of cadherin ectodomain binding with different ions. Theoretical and Applied Mechanics Letters, Vol. 4, Issue. 3, p. 034001.

    Asp, Michelle L. Martindale, Joshua J. Heinis, Frazer I. Wang, Wang and Metzger, Joseph M. 2013. Calcium mishandling in diastolic dysfunction: Mechanisms and potential therapies. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1833, Issue. 4, p. 895.

    Kamenarova, Kunka Corton, Marta García-Sandoval, Blanca Panchev, Valentin Chakarova, Christina Ayuso, Carmen and Bhattacharya, Shomi S. 2013. NovelGUCA1AMutations Suggesting Possible Mechanisms of Pathogenesis in Cone, Cone-Rod, and Macular Dystrophy Patients. BioMed Research International, Vol. 2013, p. 1.

    Mack, Korrie L. Moroz, Olesia V. Moroz, Yurii S. Olsen, Alissa B. McLaughlin, Jaclyn M. and Korendovych, Ivan V. 2013. Reprogramming EF-hands for design of catalytically amplified lanthanide sensors. JBIC Journal of Biological Inorganic Chemistry, Vol. 18, Issue. 4, p. 411.

    Saxena, Akansha and Sept, David 2013. Multisite Ion Models That Improve Coordination and Free Energy Calculations in Molecular Dynamics Simulations. Journal of Chemical Theory and Computation, Vol. 9, Issue. 8, p. 3538.

    Wang, Wang Barnabei, Matthew S Asp, Michelle L Heinis, Frazer I Arden, Erik Davis, Jennifer Braunlin, Elizabeth Li, Qi Davis, Jonathan P Potter, James D and Metzger, Joseph M 2013. Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance. Nature Medicine, Vol. 19, Issue. 3, p. 305.

    Yuan, Hongbo Gao, Chongsen Chen, Yafei Jia, Mengwen Geng, Jinpeng Zhang, Hailin Zhan, Yong Boland, Linda M. and An, Hailong 2013. Divalent Cations Modulate TMEM16A Calcium-Activated Chloride Channels by a Common Mechanism. The Journal of Membrane Biology, Vol. 246, Issue. 12, p. 893.

    Gonzales, Albert L. and Earley, Scott 2012. Endogenous cytosolic Ca2+ buffering is necessary for TRPM4 activity in cerebral artery smooth muscle cells. Cell Calcium, Vol. 51, Issue. 1, p. 82.

    Lanjun, Zhang Feiteng, Ji Lili, Wang Dongdong, Qi Yan, Zhu and Xin, Deng 2012. A Small C2-domain Protein from the Resurrection Plant <I>Boea hygrometrica</I> Promotes Plant Responses to Abscisic Acid. CHINESE BULLETIN OF BOTANY, Vol. 47, Issue. 1, p. 11.


Molecular Tuning of Ion Binding to Calcium Signaling Proteins

  • Joseph J. Falke, Steven K. Drake, Andrea L. Hazard and Olve B. Peersen (a1)
  • DOI:
  • Published online: 01 March 2009

Intracellular calcium plays an essential role in the transduction of most hormonal, neuronal, visual, and muscle stimuli. (Recent reviews include Putney, 1993; Berridge, 1993a,b; Tsunoda, 1993; Gnegy, 1993; Bachs et al. 1992; Hanson & Schulman, 1992; Villereal & Byron, 1992; Premack & Gardner, 1992; Means et al. 1991).

Corresponding author
*To whom correspondence should be addressed.
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

F. R. Ahmed , D. R. Rose , S. V. Evans , M. E. Pippy & R. To (1993). Refinement of recombinant oncomodulin at 1·30 Å resolution. J. Mol. Biol. 230, 12161224.

M. Akke , S. Forsén & W. J. Chazin (1991). Molecular basis for co-operativity in Ca2+ binding to calbindin D9k: 1H nuclear magnetic resonance studies of (Cd2+),-bovine calbindin D9k. J. Mol. Biol. 220, 173189.

M. Akke , T. Drakenberg & W. J. Chazin (1992). Three-dimensional solution structure of Ca2+ -loaded porcine calbindin D9k determined by nuclear magnetic resonance spectroscopy. Biochemistry 31, 10111020.

M. Akke , N. J. Skelton , J. Kördel , A. G. Palmer & W. J. Chazin (1993). Effects of ion binding on the backbone dynamics of calbindin D9k determined by 15N NMR relaxation. Biochemistry 32, 98329844.

M.-C. Almasio , F. Arnaud-Neu & M.-J. Schwing-Weill (1983). Macrocyclic complexes of lanthanides: Stability and electrochemical behaviour in methanol and propylene carbonate. Helv. Chim. Acta 66, 12961306.

F. Arnaud-Neu , B. Spiess & M.-J. Schwing-Weill (1977). Stability in aqueous solution of some complexes of heavy metals with diaza-polyoxamacrocyclic ligands. Helv. Chim. Acta 60, 26332643.

C. R. Artalejo , M. E. Adams & A. P. Fox (1994). Three types of Ca2+ channel trigger secretion with different efficacies in chromaffin cells. Nature 367, 7276.

Y. S. Babu , J. S. Sack , T. J. Greenhough , C. E. Bugg , A. R. Means & W. J. Cook (1985). Three-dimensional structure of calmodulin. Nature 315, 3742.

Y. S. Babu , C. E. Bugg & W. J. Cook (1988). Structure of calmodulin refined at 2·2 Å resolution. J. Mol. Biol. 204, 191204.

O. Bachs , N. Agell & E. Carafoli (1992). Calcium and calmodulin function in the cell nucleus. Biochim. Biophys. Acta 1113, 259270.

H. Bading , D. D. Ginty & M. E. Greenberg (1993). Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 260, 181186.

G. Barbato , M. Ikura , L. E. Kay , R. W. Pastor & A. Bax (1992). Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: The central helix is flexible. Biochemistry 31, 52695278.

A. J. Bennett & C. R. Bagshaw (1986). The kinetis of bivalent metal ion dissociation from myosin subfragments. Biochem. J. 233, 173177.

M. J. Berridge (1993a). Inositol trisphosphate and calcium signalling. Nature 361, 315325.

M. J. Berridge (1993b). A tale of two messengers. Nature 365, 388389.

Y. Blancuzzi , A. Padilla , J. Parello & A. Cave (1993). Symmetrical rearrangement of the cation-binding sites of parvalbumin upon Ca2+/Mg2+ exchange. A study by 1H 2D NMR. Biochemistry 32, 13021309.

S. L. Blechner , G. A. Olah , N. C. J. Strynadka , R. S. Hodges & J. Trewhella (1992). 4Ca2+ troponin C forms dimers in solution at neutral pH that dissociate upon binding various peptides: Small-angle X-ray scattering studies of peptide-induced structural changes. Biochemistry 31, 1132611334.

P. J. Breen , K. A. Johnson & W. D. Horrocks (1985). Stopped-flow kinetic studies of metal ion dissociation or exchange in a tryptophan-containing parvalbumin. Biochemistry 24, 49975004.

H. G. Brittain , F. S. Richardson & R. B. Martin (1976). Terbium(III) emission as a probe of calcium(II) binding sites in proteins, J. Am. Chem. Soc. 98, 82558260.

H.-J. Buschmann (1986 a). The macrocyclic and cryptate effects. 7. Influence of structural changes on the complexation behaviour of aza crown ethers and cryptands in different solvents. Inorg. Chim. Ada 120, 125129.

H.-J. Buschmann (1986 b). The macrocyclic and cryptate effects. 5. Complexation of alkali ions by monocyclic and bicyclic ligands in methanol. Inorg. Chim. Ada 125, 3135.

G. Carlström & W. J. Chazin (1993). Two-dimensional 1H nuclear magnetic resonance studies of the half-saturated (Ca2+)1 state of calbindin D9k. Further implications for the molecular basis of cooperative Ca2+ binding. J. Mol. Biol. 231, 415430.

A. Cave , J. Parello , T. Drakenberg , E. Thulin & B. Lindman (1979). Mg2+ binding to parvalbumins studied by 25Mg and 113Cd NMR spectroscopy. FEBS Lett. 100, 148152.

P. Chakrabarti (1990). Interaction of metal ions with carboxylic and carboxamide groups in protein structures. Prot. Eng. 4, 4956.

R. Chattopadhyaya , W. E. Meador , A. R. Means & F. A. Quiocho (1992). Calmodulin structure refined at 1·7 Å resolution. J. Mol. Biol. 228, 11771192.

P. Cohen , A. Burchell , J. G. Foulkes & P. T. W. Cohen (1978). Identification of the Ca2+-dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase. FEBS Lett. 92, 287293.

D. C. Corson , T. C. Williams & B. D. Sykes (1983). Calcium binding proteins: Optical stopped-flow and proton nuclear magnetic resonance studies of the binding of the lanthanide series of metal ions to parvalbumin. Biochemistry 22, 58825889.

B. G. Cox , Garcia-Rosas, J. & H. Schneider (1981). Solvent dependence of the kinetics of formation and dissociation of cryptate complexes. J. Am. Chem. Soc. 103, 10541059.

B. G. Cox , N. van Truong & H. Schneider (1984). Alkaline earth cryptates: Dynamics and stabilities in different solvents. J. Am. Chem. Soc. 106, 12731280.

B. G. Cox , P. Firman , I. Schneider & H. Schneider (1988). Rates and equilibria of alkaline-earth-metal complexes with diaza crown ethers in methanol. Inorg. Chem. 27, 40184021.

D. J. Cram , T. Kaneda , R. C. Helgeson & G. M. Lein (1979). Spherands – Ligands whose binding of cations relieves enforced electron–electron repulsions. J. Am. Chem. Soc. 101, 6752–6254.

D. J. Cram & G. M. Lein (1985). Host-guest complexation. 36. Spherand and lithium and sodium ion complexation rates and equilibria. J. Am. Chem. Soc. 107, 36573668.

D. J. Cram (1988). The design of molecular hosts, guests, and their complexes. Science 240, 760767.

D. T. Cronce & W. D. Horrocks (1992). Probing the metal-binding sites of cod parvalbumin using europium(III) ion luminescence and diffusion-enhanced energy transfer. Biochemistry 31, 79637969.

P. M. G. Curmi , J. A. Barden & C. G. Dos Remedios (1982). Conformational studies of G-actin containing bound lanthanide. Eur. J. Biochem. 122, 239244.

D. C. Dalgarno , R. E. Klevit , B. A. Levine , G. M. M. Scott , R. J. P. Williams , J. Gergely , Z. Grabarek , P. C. Leavis , R. J. A. Grand & W. Drabikowski (1984). The nature of the trifluoperazine binding sites on calmodulin and troponin-C. Biochim. Biophys. Acta 791, 164172.

T. N. Davis , M. S. Urdea , F. R. Masiarz & J. Thorner (1986). Isolation of the yeast calmodulin gene: Calmodulin is an essential protein. Cell 47, 423431.

J.-P. Declercq , B. Tinant , J. Parello & J. Rambaud (1991). Ionic interactions with parvalbumins. Crystal structure determination of pike 4·10 parvalbumin in four different ionic environments. J. Mol. Biol. 220, 10171039.

W. F. Degrado (1988). Design of peptides and proteins. Adv. Prot. Chem. 39, 51124.

H. Diebler , M. Eigen , G. Ilgenfritz , G. Maab & R. Winkler (1969). Kinetics and mechanism of reactions of main group metal ions with biological carriers. Pure & Appl. Chem. 20, 93115.

I. Durussel , J. A. Rhyner , E. E. Strehler & J. A. Cox (1993). Cation binding and conformation of human calmodulin-like protein. Biochemistry 32, 60896094.

I. R. Epstein (1991). Spiral waves in chemistry and biology. Science 252, 67.

C. H. Evans (1990). Biochemistry of the lanthanides. of the series Biochemistry of the elements. 8, New York: Plenum Press.

J. J. Falke , E. E. Snyder , K. C. Thatcher & C. S. Voertler (1991). Quantitating and engineering the ion specificity of an EF-hand-like Ca2+ binding site. Biochemistry 30, 86908697.

C. Fewtrell (1993). Ca2+ oscillations in non-excitable cells. Annu. Rev. Phys. 55, 427454.

S. Forsén , S. Linse , E. Thulin , B. Lindegård , S. R. Martin , P. M. Bayley , P. Brodin & T. Grundström (1988). Kinetics of calcium binding to calbindin mutants. Eur. J. Biochem. 177, 4752.

R. D. Gandour (1981). On the importance of orientation in general base catalysis by carboxylate. Bioorg. Chem. 10, 169176.

J. Gariepy & R. S. Hodges (1983). Localization of a trifluoperazine binding site on troponin C. Biochemistry 22, 15861594.

J. R. Geiser , D. van Tuinen , S. E. Brockerhoff , M. M. Neff & T. N. Davis (1991). Can calmodulin function without binding calcium? Cell 65, 949959.

J. T. Gerig , P. Singh , L. A. Levy & R. E. London (1987). Calcium complexation with a highly calcium selective chelator: Crystal structure of Ca(CaFBAPTA) 5H2O. J. Inorg. Biochem. 31, 113121.

P. I. Hanson & H. Schulman (1992). Neuronal Ca2+/calmodulin-dependent protein kinases. Annu. Rev. Biochem. 61, 559601

O. Herzberg & M. N. G. James (1988). Refined crystal structure of troponin C from turkey skeletal muscle at 2·0 Å resolution. J. Mol. Biol. 203, 761779.

H. D. Holtje & M. A. Mense (1989). A molecular modelling study on binding of drugs to calmodulin. J. Comput.-Aided Mol. Design 3, 101109.

W. D. Horrocks & M. Albin (1984). Lanthanide ion luminescence in coordination chemistry and biochemistry. Prog. Inorg. Chem., 31, 1104.

T.-T. Hou , J. D. Johnson & J. A. Rall (1992). Effect of temperature on relaxation rate and Ca2+, Mg2+ dissociation rates from parvalbumin of frog muscle fibres. J. Physiol. (Lond.) 449, 399410.

J. B. Hurley (1993). Sensing calcium in rod cells. Nature 361, 2021.

M. Ikura , G. M. Clore , A. M. Gronenborn , G. Zhu , C. B. Klee & A. Bax (1992). Solution structure of a calmodulin-target peptide complex by multidimensional NMR. Science 256, 632637.

M. Isac , I. Morano & J. C. Rüegg (1988). Alteration of calcium sensitivity of skinned frog skeletal muscle fibres by inositol triphosphate and calmodulin antagonists. Pflügers Arch. 412, 253257.

A. P. Jackson , M. P. Timmerman , C. R. Bagshaw & C. C. Ashley (1987). The kinetics of calcium binding to fura-2 and indo-1. FEBS Lett 216, 3539.

C. Johansson , P. Brodin , GrunströT. m , E. Thulin , S. Forsén and T. Drakenberg (1990). Biophysical studies of engineered mutant proteins based on calbindin D9k modified in the pseudo EF-hand. Eur. J. Biochem. 187, 455460.

S. P. Kasprzyk & R. G. Wilkins (1982). Kinetics of interaction of metal ions with two tetraaza tetraacetate macrocycles. Inorg. Chem. 21, 33493352.

M. Kataoka , J. F. Head , B. A. Seaton & D. M. Engelman (1989). Melittin binding causes a large calcium-dependent conformational change in calmodulin. Proc. Natl. Acad. Sci. USA 86, 69446948.

M. Kataoka , J. F. Head , T. Vorherr , J. Krebs & E. Carafoli (1991). Small-angle X-ray scattering study of calmodulin bound to two peptides corresponding to parts of the calmodulin-binding domain of the plasma membrane Ca2+ pump. Biochemistry 30, 62476251.

E. Kauffmann , J.-M. Lehn & J.-P. Sauvage (1976). Enthalpy and entropy of formation of alkali and alkaline-earth macrobicyclic cryptate complexes. Helv. Chim. Acta 59, 10991111.

P. Kebarle (1977). Ion thermochemistry and solvation from gas phase ion equilibria. Ann. Rev. Phys. Chem. 28, 445476.

M.-S. Kim , T. Morii , L.-X. Sun , K. Imoto & Y. Mori (1993). Structural determinants of ion selectivity in brain calcium channel. FEBS Lett. 318, 145148.

J. Kördel , N. J. Skelton , M. Akke , A. G. Palmer & W. J. Chazin (1992). Backbone dynamics of calcium-loaded calbindin D9k studied by two-dimensional proton-detected 15N NMR spectroscopy. Biochemistry 31, 48564866.

R. H. Kretsinger (1992). The linker of calmodulin – to helix or not to helix. Cell Calcium 13, 363376.

R. H. Kretsinger & S. Nakayama (1993). Evolution of EF-hand calcium-modulated proteins. IV. Exon shuffling did not determine the domain compositions of EF-hand proteins. J. Mol. Evol. 36, 477488.

G. A. Krudy , R. M. M. Brito , J. A. Putkey & P. R. Rosevear (1992). Conformational changes in the metal-binding sites of cardiac troponin C induced by calcium binding. Biochemistry 31, 15951602.

V. D. Kumar , L. Lee & B. F. P. Edwards (1990). Refined crystal structure of calcium-liganded carp parvalbumin 4·25 at 1·5-Å resolution. Biochemistry 29, 14041412.

N. Kurebayashi & Y. Ogawa (1988). Increase by trifluoperazine in calcium sensitivity of myofibrils in a skinned fibre from frog skeletal muscle. J. Physiol. 403, 407424.

P. C. Leavis & E. L. Kraft (1978). Calcium binding to cardiac troponin C. Arch. Biochem. Biophys. 186, 411415.

J. Lechleiter , S. Girard , D. Clapham & E. Peralta (1991). Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors. Nature 350, 505508.

J.-M. Lehn (1980). Dinuclear cryptates: Dimetallic macropolycyclic inclusion complexes. Pure & Appl. Chem. 52, 24412459.

J.-M. Lehn & J. P. Sauvage (1975). [2]-Cryptates: Stability and selectivity of alkali and alkaline-earth macrobicyclic complexes. J. Am. Chem. Soc. 97, 67006707.

J.-M. Lehn & F. Montavon (1978). Cryptates. XXV). Stability and selectivity of cation inclusion complexes of polyaza-macrobicyclic ligands. Selective complexation of toxic heavy metal cations. Helv. Chim. Acta 61, 6782.

S. Linse , P. Brodin , T. Drakenberg , E. Thulin , P. Sellers , K. Elmdén , T. Grundström & S. Forsén (1987). Structure-function relationships in EF-hand Ca2+-binding proteins. Protein engineering and biophysical studies of calbindin D9k. Biochemistry 26, 67236735.

S. Linse , P. Brodin , C. Johansson , E. Thulin , T. Grundström & S. Forsén (1988). The role of protein surface charges in ion binding. Nature 335, 651652.

S. Linse , O. Teleman & T. Drakenberg (1990). Ca2+ binding to calbindin D9k strongly affects backbone dynamics: Measurements of exchange rates of individual amide protons using 1H NMR. Biochemistry 29, 59255934.

S. Linse , C. Johansson , P. Brodin , T. Grundström , T. Drakenberg & S. Forsén (1991 a). Electrostatic contributions to the binding of Ca2+ in calbindin D9k. Biochemistry 30, 154162.

V. M. Loyola , R. Pizer & R. G. Wilkins (1977). The kinetics of complexing of the alkaline-earth ions with several cryptands. J. Am. Chem. Soc. 99, 71857188.

K. P. Lu & A. R. Means (1993). Regulation of the cell cycle by calcium and calmodulin. Endocr. Rev. 14, 4058.

C. Lugnier , A. Follenius , D. Gerard & J. C. Stoclet (1984). Bepridil and flunarizine as calmodulin inhibitors. Eur. J. Pharmacol. 98, 157158.

B. J. Marsden , R. S. Hodges & B. D. Sykes (1989). A 1H NMR determination of the solution conformation of a synthetic peptide analogue of calcium-binding site III of rabbit skeletal troponin C. Biochemistry 28, 88398847.

B. J. Marsden , G. S. Shaw & B. D. Sykes (1990). Calcium binding proteins. Elucidating the contributions to calcium affinity from an analysis of species variants and peptide fragments. Biochem. Cell. Biol. 68, 587601.

L. Marshall , K. Parris , J. Rebek , S. V. Luis & M. I. Burguete (1988). A new class of chelating agents. J. Am. Chem. Soc. 110, 51925193.

S. R. Martin , Andersson A. Teleman , P. M. Bayley , T. Drakenberg & S. Forsén (1985). Kinetics of calcium dissociation from calmodulin and its tryptic fragments. A stopped-flow fluorescence study using Quin 2 reveals a two-domain structure. Eur. J. Biochem. 151, 543550.

S. R. Martin , S. Linse , C. Johansson , P. M. Bayley & S. Forsén (1990). Protein surface charges and Ca2+ binding to individual sites in calbindin D9k: Stopped-flow studies. Biochemistry 29, 41884193.

L. Massom , H. Lee & H. W. Jarrett (1990). Trifluoperazine binding to porcine brain calmodulin and skeletal muscle troponin C. Biochemistry 29, 671681.

L. R. Massom , T. J. Lukas , A. Persechini , R. H. Kretsinger , D. M. Watterson & H. W. Jarrett (1991). Trifluoperazine binding to mutant calmodulins. Biochemistry 30, 663667.

F. Mathieu , B. Metz , D. Moras & R. Weiss (1978). Cavities in macrobicyclic ligands and complexation selectivity. Crystal structures of two cryptates, [Na+. 221].SCN and [K+.221].SCN. J. Am. Chem. Soc. 100, 44124416.

W. E. Meador , A. R. Means & F. A. Quiocho (1992). Target enzyme recognition by calmodulin: 2·4 Å structure of a calmodulin-peptide complex. Science 257, 12511255.

W. E. Meador , A. R. Means & F. A. Quiocho (1993). Modulation of calmodulin plasticity in molecular recognition on the basis of X-ray structure. Science 262, 17181721.

A. R. Means , M. F. A. VanBerkum , I. Bagchi , K. P. Lu & C. D. Rasmussen (1991). Regulatory functions of calmodulin. Pharmac. Ther. 50, 255270.

T. Meyer & L. Stryer (1991). Calcium spiking. Annu. Rev. Biophys. Biophys. Chem. 20, 153174.

C. Miller (1992). Ion channel structure and function. Science 258, 240241.

C. Miller (1993). Potassium selectivity in proteins: Oxygen cage or π in the face? Science 261, 16921693.

H. J. Moeschler , J.-J. Schaer & J. A. Cox (1980). A thermodynamic analysis of the binding of calcium and magnesium ions to parvalbumin. Eur.J. Biochem. 111, 7378.

N. D. Moncrief , R. H. Kretsinger & M. Goodman (1990). Evolution of EF-hand calcium-modulated proteins. I. Relationships based on amino acid sequences. J. Mol. Evol. 30, 522562.

O. D. Monera , G. S. Shaw , B.-Y. Zhu , B. D. Sykes , C. M. Kay & R. S. Hodges (1992). Role of interchain α-helical hydrophobic interactions in Ca2+ affinity, formation, and stability of a two-site domain in troponin C. Prot. Sci. 1, 945955.

S. Nakayama & R. H. Kretsinger (1993). Evolution of EF-hand calcium-modulated proteins. III. Exon sequences confirm most dendrograms based on protein sequences: Calmodulin dendrograms show significant lack of parallelism. J. Mol. Evol. 36, 458476.

S. Nakayama , N. D. Moncrief & R. H. Kretsinger (1992). Evolution of EF-hand calcium-modulated proteins. II. Domains of several subfamilies have diverse evolutionary histories. J. Mol. Evol. 34, 416448.

J. V. Needham , T. Y. Chen & J. J. Falke (1993). Novel ion specificity of a caboxylate cluster Mg(II) binding site: Strong charge selectivity and weak size selectivity. Biochemistry 32, 33633367.

K. T. O'Neil & W. F. DeGardo (1989). The interaction of calmodulin with fluorescent and photoreactive model peptides: Evidence for a short interdomain separation. Proteins 6, 284293.

K. T. O'Neil & W. F. DeGrado (1990). How calmodulin binds its targets: Sequence independent recognition of amphiphilic α-helices. Trends Biol. Sci. 15, 5964.

B. B. Olwin & D. R. Storm (1985). Calcium binding to complexes of calmodulin and calmodulin binding proteins. Biochemistry 24, 80818086.

M. Ovaska & J. Taskinen (1991). A model for human cardiac troponin C and for modulation of its Ca2+ affinity by drugs. Proteins 11, 7994.

A. Padilla , A. Cave & J. Parello (1988). Two-dimensional 1H nuclear magnetic resonance study of pike pl 5·0 parvalbumin (Esox lucius). Sequential resonance assignments and folding of the polypeptide chain. J. Mol. Biol. 204, 9951017.

J.-F. Pechère , J. Derancourt & J. Haiech (1977). The participation of parvalbumins in the activation-relaxation cycle of vertebrate fast skeletal-muscle. FEBS Lett. 75, 111114.

C. J. Pedersen (1967). Cyclic polyethers and their complexes with metal salts. J. Am. Chem. Soc. 89, 70177036.

J. W. Pflugrath & F. A. Quiocho (1985). Sulphate sequestered in the sulphate-binding protein of Salmonella typhimurium is bound soley by hydrogen bonds. Nature 314, 257260.

J. W. Putney (1993). Excitement about calcium signaling in inexcitable cells. Science 262, 676678.

S. T. Rao , S. Wu , K. A. Satyshur , K.-Y. Ling , C. Kung & M. Sundaralingam (1993). Structure of Paramecium Tetraurelia calmodulin at 1·8 Å resolution. Prot. Sci. 2, 436447.

A. A. Rashin & B. Honig (1985). Re-evaluation of the Born model of ion hydration. J. Phys. Chem. 89, 55885593.

R. E. Reid (1985). The functional nature of calcium binding units in calmodulin, troponin C and parvalbumin. J. Theor. Biol. 114, 353374.

M. Renner , M. A. Danielson & J. J. Falke (1993). Kinetic control of Ca(II) signaling: Tuning the ion dissociation rates of EF-hand Ca(II) binding sites. Proc. Natl. Acad. Sci., USA 90, 64936497.

S. P. Robertson , J. D. Johnson & J. D. Potter (1981). The time-course of Ca2+ exchange with calmodulin, troponin, parvalbumin, and myosin in response to transient increases in Ca2+. Biophys. J. 34, 559569.

F. Roquet , J.-P. Declercq , B. Tinant , J. Rambaud & J. Parello (1992). Crystal structure of the unique parvalbumin component from muscle of the leopard shark (Triakis semifasciata). The first X-ray study of an α-parvalbumin. J. Mol. Biol. 223, 705720.

W. S. Sandberg & T. C. Terwilliger (1991). Repacking protein interiors. Trends Biotechnol. 9, 5963.

C. K. Schauer & O. P. Anderson (1987). Calcium-selective ligands. 2. Structural and spectroscopic studies on calcium and cadmium complexes of EGTA4−. J. Am. Chem. Soc. 109, 36463656.

R. W. Schmid & C. N. Reilley (1957). New complexon for titration of calcium in the presence of magnesium. Anal. Chem. 29, 264268.

G. Schwarzenbach (1952). Der chelateffekt. Helv. Chim. Acta 35, 23442359.

Y. C. Sekharudu & M. Sundaralingam (1988). A structure-function relationship for the calcium affinities of regulatory proteins containing ‘EF-hand’ pairs. Prot. Eng. 2, 139146.

G. S. Shaw , R. S. Hodges & B. D. Sykes (1990). Calcium-induced peptide association to form an intact protein domain: 1H NMR structural evidence. Science 249, 280283.

G. S. Shaw , L. F. Golden , R. S. Hodges & B. D. Sykes (1991). Interactions between paired calcium-binding sites in proteins: NMR determination of the stoichiometry of calcium binding to a synthetic troponin-C peptide. J. Am. Chem. Soc. 113, 55575563.

P. J. Silver , P. B. Pinto & J. Dachiw (1986). Modulation of vascular and cardiac contractile protein regulatory mechanism by calmodulin inhibitors and related compounds. Biochem. Pharmacol. 35, 25452551.

N. J. Skelton , J. Kördel , M. Akke & W. J. Chazin (1992). Nuclear magnetic resonance studies of the internal dynamics in Apo, (Cd2+)1 and (Ca2+)2. calbindin D9k. The rates of amide proton exchange with solvent. J. Mol. Biol. 227, 11001117.

P. D. Smith , G. W. Liesegang , R. L. Berger , G. Czerlinski & R. J. Podolsky (1984). A stopped-flow investigation of calcium ion binding by ethylene glycol bis(β-aminoethyl ether)-N, N'-tetraacetic acid. Anal. Biochem. 143, 188195.

E. E. SNYDER , B. W. Buoscio & J. J. Falke (1990). Calcium(II) site specificity: Effect of size and charge on metal ion binding to an EF-hand-like site. Biochemistry 29, 39373943.

M. A. Starovasnik , D.-R. Su , K. Beckingham & R. E. Klevit (1992). A series of point mutations reveal interactions between the calcium-binding sites of calmodulin. Prot. Sci. 1, 245253.

A. M. Stock , Martinez-E. Hackert , B. F. Rasmussen , A. H. West , J. B. Stock , D. Ringe & G. A. Petsko (1993). Structure of the Mg2+-bound form of CheY and mechanism of phosphoryl transfer in bacterial chemotaxis. Biochemistry 32, 1337513380.

N. C. J. Strynadka & M. N. G. James (1988). Two trifluoperazine-binding sites on calmodulin predicted from comparative molecular modelling with troponin-C. Proteins 3, 117.

N. C. J. Strynadka & M. N. G. James (1989). Crystal structures of the helix-loop-helix calcium-binding proteins. Annu. Rev. Biochem. 58, 951998.

M. F. Summers (1988). 113Cd NMR spectroscopy of coordination compounds and proteins. Coord. Chem. Rev. 86, 43134.

F. Sussman & H. Weinstein (1989). On the ion selectivity in Ca-binding proteins: The cyclo(-L-Pro-Gly-)3 peptide as a model. Proc. Natl. Acad. Sci. U.S.A 86, 78807884.

L. A. Svensson , E. Thulin & S. Forsén (1992). Proline cis-trans isomers in calbindin D9k observed by X-ray crystallography. J. Mol. Biol. 223, 601606.

A. Teleman , T. Drakenberg & S. Forsén (1986). Kinetics of Ca2+ binding to calmodulin and its tryptic fragments studied by 43Ca-NMR. Biochim. Biophys. Acta 873. 204213.

J. Trewhella (1992). The solution structures of calmodulin and its complexes with synthetic peptides based on target enzyme binding domains. Cell Calcium 13, 377390.

G. Trigo-Gonzalez , G. Awang , K. Racher , K. Neden & T. Borgford (1993). Helix variants of troponin C with tailored calcium affinities. Biochemistry 32, 98269831.

M.-D. Tsai , T. Drakenberg , E. Thulin & S. Forsén (1987). Is the binding of magnesium(II) to calmodulin significant? An investigation by magnesium-25 nuclear magnetic resonance. Biochemistry 26, 36353643.

R. Y. Tsien (1980). New calcium indicators and buffers with high selectivity against magnesium and protons: Design, synthesis, and properties of prototype structures. Biochemistry 19, 23962404.

R. Y. Tsien (1989). Fluorescent probes of cell signaling. Ann. Rev. Neurosci. 12, 227253.

R. W. Tsien & R. Y. Tsien (1990). Calcium channels, stores, and oscillations. Annu. Rev. Cell Biol. 6, 715760.

Y. Tsunoda (1993). Receptor-operated Ca2+ signaling and crosstalk in stimulus secretion coupling. Biochim. Biophys. Acta 1154, 105156.

R. Ungaro , B. El Haj & J. Smid (1976). Substituent effects on the stability of cation complexes of 4'-substituted monobenzo crown ethers. J. Am. Chem. Soc. 98, 51985202.

J. P. van Eerd & K. Takahashi (1976). Determination of the complete amino acid sequence of bovine cardiac troponin C. Biochemistry 15, 11711180.

S. Vijay-Kumar & W. J. Cook (1992). Structure of a sarcoplasmic calcium-binding protein from Nereis diversicolor refined at 2·0 Å resolution. J. Mol. Biol. 224, 413426.

N. K. Vyas , M. N. Vyas & F. A. Quiocho (1987). A novel calcium binding site in the galactose-binding protein of bacterial transport and chemotaxis. Nature 327, 635638.

N. K. Vyas , M. N. Vyas & F. A. Quiocho (1988). Sugar and signal-transducer binding sites of the Escherichia coli galactose chemoreceptor protein. Science 242, 12901295.

Y. Waltersson , S. Linse , P. Brodin & T. Grundström (1993). Mutational effects on the cooperativity of Ca+2 binding in calmodulin. Biochemistry 32, 78667871.

C.-L. A. Wang (1985). A note on Ca2+ binding to calmodulin. Biochem. Biophs. Res. Comm. 130, 426430.

C.-L. A. Wang & P. C. Leavis (1990). Distance measurements in cardiac troponin C. Arch. Biochem. Biophys. 276, 236241.

C.-L. A. Wang , P. C. Leavis & J. Gergely (1984). Kinetic studies show that Ca2+ and Tb3+ have different binding preferences toward the four Ca2+-binding sites of calmodulin. Biochemistry 23, 64106415.

B. Wendt , T. Hofmann , S. R. Martin , P. Bayley , P. Brodin , T. Grundström , E. Thulin , S. Linse & S. Forsén (1988). Effect of amino acid substitutions and deletions on the thermal stability, the pH stability and unfolding by urea of bovine calbindin D9k. Eur. J. Biochem. 175, 439445.

H. D. White (1988). Kinetic mechanism of calcium binding to whiting parvalbumin. Biochemistry 27, 33573365.

T. C. Williams , D. C. Corson & B. D. Sykes (1984). Calcium-binding proteins: Calcium(II)-lanthanide(III) exchange in carp pravalbumin. J. Am. Chem. Soc. 106, 56985702.

K. Yagi , M. Yazawa , M. Ikura & K. Hikichi (1989). Interaction between calmodulin and target proteins. Adv. Exp. Med. Biol. 255, 147154.

J. Yang , P. T. Ellinor , W. A. Sather , J.-F. Zhang & R. W. Tsien (1993). Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels. Nature 366, 158161.

M. Yazawa , T. Vorherr , P. James , E. Carafoli & K. Yagi (1992). Binding of calcium by calmodulin: Influence of the calmodulin binding domain of the plasma membrane calcium pump. Biochemistry 31, 31713176.

E. L. Yee , O. A. Gansow & M. J. Weaver (1980). Electrochemical studies of europium and ytterbium cryptate formation in aqueous solution. Effects of varying the metal oxidation state upon cryptate thermodynamics and kinetics. J. Am. Chem. Soc. 102, 22782285.

G. Yellen (1993). Calcium channels. Structure and selectivity. Nature 366, 109110.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Quarterly Reviews of Biophysics
  • ISSN: 0033-5835
  • EISSN: 1469-8994
  • URL: /core/journals/quarterly-reviews-of-biophysics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *