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Trends and Challenges in Experimental Macromolecular Crystallography

Abstract

Macromolecular X-ray crystallography underpins the vigorous field of structural molecular biology having yielded many protein, nucleic acid and virus structures in fine detail. The understanding of the recognition by these macromolecules, as receptors, of their cognate ligands involves the detailed study of the structural chemistry of their molecular interactions. Also these structural details underpin the rational design of novel inhibitors in modern drug discovery in the pharmaceutical industry. Moreover, from such structures the functional details can be inferred, such as the biological chemistry of enzyme reactivity. There is then a vast number and range of types of biological macromolecules that potentially could be studied. The completion of the protein primary sequencing of the yeast genome, and the human genome sequencing project comprising some 105 proteins that is underway, raises expectations for equivalent three dimensional structural databases.

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C. Abergel , M. P. Nesa & J. C. Fontecilla-Camps (1991). The effect of protein contaminants on the crystallisation of turkey egg white lysozyme. J. Cryst. Growth 110, 1119.

N. M. Allinson (1994). Development of non-intensified charge-coupled device area X-ray detectors. J. Synchrotron Rad. 1, 5462.

M. Ataka (1993). Protein crystal growth: an approach based on phase diagram determination. Phase Transitions 45, 205219.

M. Ataka & M. Asai (1988). Systematic studies on the crystallisation of lysozyme. Determination and use of phase diagrams. J. Cryst. Growth 90, 8693.

M. Ataka & S. Tanaka (1986). The growth of large single crystals of lysozyme. Biopolymers 25, 337350.

J. Berriman & N. Unwin (1994). Analysis of transient structures by cryo-microscopy combined with rapid measuring of spray droplets. Ultramicroscopy 56, 241252.

D. H. Bilderback , D. J. Thiel , R. Pahl & K. E. Brister (1994). X-ray applications with glass capillary optics. J. Synchrotron Rad. 1, 3742.

D. M. Blow , N. E. Chayen , L. F. Lloyd & E. Saridakis (1994). Control of nucleation of protein crystals. Protein Science 3, 16381643.

J. M. Bolduc , D. H. Dyer , W. G. Scott , P. Singer , R. M. Sweet , D. E. Koshland & B. L. Stoddard (1995). Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase. Science 268, 13121318.

R. Bosch , P. Lautenschlager , L. Potthast & J. Stapelmann (1992). Experimental equipment for protein crystallisation in microgravity facilities. J. Cryst. Growth 122, 310316.

D. Bourgeois , T. Ursby , M. Wulff , C. Pradervand , A. Legrand , W. Schildkamp , S. Labouré , V. Srajer , T. Y. Teng , M. Roth & K. Moffat (1996). Feasibility and realisation of single-pulse Laue diffraction on macromolecular crystals at ESRF. J. Synchrotron Rad. 3, 6574.

J. H. Burning , D. R. Herriot , J. E. Gallagher , D. P. Rosenfeld , A. D. White & D. J. Brangaccio (1974). Digital wavefront measuring interferometer for testing optical surfaces and lenses. Appl. Opt. 13, 2693.

J. W. Campbell , A. Deacon , J. Habash , J. R. Helliwell , S. McSweeney , Q. Hao , J. Raftery & E. Snell (1994). Electron density maps of lysozyme calculated using synchrotron Laue data comprising singles and deconvoluted multiples. Bull, of Mater. Sci. 17, 118.

C. W. Carter Jr. (1990). Efficient factorial designs and the analysis of macromolecular crystal growth conditions. Methods: a companion to Methods in Enzymology. 1, 1224.

G. A. Casay & W. W. Wilson (1992). Laser scattering in a hanging drop vapour diffusion apparatus for protein crystal growth in a microgravity environment. J. Cryst. Growth 122, 95101.

A. Cassetta , A. Deacon , C. Emmerich , J. Habash , J. R. Helliwell , S. McSweeney , E. H. Snell , A. W. Thompson & S. Weisgerber (1993). The emergence of the synchrotron Laue method for rapid data collection from protein crystals. Proc. Roy. Soc. Lond. 442, 177192.

N. E. Chayen (1995). Microgravity protein crystallisation aboard the Photon satellite. J. Cryst. Growth 153, 175179.

N. E. Chayen , J. Akins , S. Campbell-Smith & D. M. Blow (1988). Solubility of glucose isomerase in ammonium sulphate solutions. J. Cryst. Growth 90, 112116.

N. E. Chayen , L. Lloyd , C. A. Collyer & D. M. Blow (1989). Trigonal glucose isomerase crystals require thymol for their growth and stability. J. Cryst. Growth 97, 367374.

N. E. Chayen , P. D. Shaw Stewart , D. L. Maeder & D. M. Blow (1990). An automated system for microbatch protein crystallisation and screening. J. Appl. Cryst. 23, 297302.

N. E. Chayen , P. D. Shaw Stewart & D. M. Blow (1992). Microbatch crys tallisation under oil – a new technique allowing many small-volume crystallisation trials. J. Cryst. Growth 122, 176180.

N. E. Chayen , J. Radcliffe & D. M. Blow (1993). Control of nucleation in the crystallisation of lysozyme. Protein Science 2, 113118.

M. J. Cox & P. C. Weber (1987). Experiments with automated protein crystallisation. J. Appl. Cryst. 20, 366373.

C. G. Darwin (1922). The reflection of X-rays from imperfect crystals. Phil. Mag. 43, 800829.

A. Deacon , J. Habash , S. J. Harrop , J. R. Helliwell , W. N. Hunter , G. A. Leonard , M. Peterson , A. Haedener , A. J. Kalb (Gilboa) , N. M. Allinson , C. Castelli , K. Moon , S. McSweeney , A. Gonzalez , A. W. Thompson , S. Ealick , D. M. Szebenyi & R. Walter (1995 a). SR instrumentation for optimised anomalous scattering and high resolution structure studies of proteins and nucleic acids. Rev. Sci. Instrum. 66(2), 12871292.

L. J. DeLucas , M. M. Long , K. M. Moore , W. M. Rosenblum , T. L. Bray , C. Smith , M. Carson , S. V. L. Narayana , M. D. Harrington , D. Carter , A. D. Clark Jr., R. G. Nanni , J. Ding , A. Jacobo-Molina , G. Kamer , S. H. Hughes , E. Arnold , H. M. Einspahr , L. L. Clancy , G. S. J. Rao , P. F. Cook , B. G. Harris , S. H. Munson , B. C. Finzel , A. McPherson , P. C. Weber , F. A. Lewandowski , T. L. Nagabhushan , P. P. Trotta , P. Reichert , M. A. Navia , K. P. Wilson , J. A. Thompson , R. N. Richards , K. D. Bowersox , C. J. Meade , E. S. Baker , S. P. Bishop , B. J. Dunbar , E. Trinh , J. Prahl , A. Sacco Jr., & C. E. Bugg (1994). Recent results and new hardware developments for protein crystal growth in microgravity. J. Cryst. Growth 135, 183192.

R. C. DeMattei & R. S. Feigelson (1991). The solubility dependence of canavalin on pH and temperature. J. Cryst. Growth, 110, 3440.

J. C. Dewan & R. F. Tilton (1987). Greatly reduced radiation damage in ribonuclease crystals mounted on glass fibres. J. Appl. Cryst. 20, 130132.

H. R. Drew , S. Samson & R. E. Dickerson (1982). Structure of a B-DNA dodecamer at 16 K. Proc. Natl. Acad. Sci. USA 79, 40404044.

S. Ealick & R. Walter (1993). Synchrotron beamlines for macromolecular crystallography. Current Opinion in Structural Biology 3, 725736.

C. Engel , R. Wierenga & P. A. Tucker (1996). A removable arc for mounting and recovering flash-cooled crystals. J. Appl Crystallogr. 29, 208210.

R. Fourme , A. Ducruix , M. Riess-Kautt & B. Capelle (1995). The perfection of protein crystals probed by direct recording of Bragg reflection profiles with a quasiplanar X-ray wave. J. Synchrotron Rad. 2, 136142.

T. J. Greenhough & J. R. Helliwell (1982). Oscillation camera data processing; Reflecting range and prediction of partiality I. Conventional X-ray sources. J. Appl. Cryst. 15, 338351.

S. Gruner & S. Ealick (1995). Charge coupled device X-ray detectors for macromolecular crystallography. Structure 3, 1315.

A. Hadfield & J. Hajdu (1993). A fast and portable microspectrophotometer for protein crystallography. J. Appl. Cryst. 26, 839842.

A. Hädener , P. K. Matzinger , V. N. Malashkevich , G. V. Louie , S. P. Wood , P. Oliver , P. R. Alefounder , A. R. Pitt , C. Abell & A. R. Battersby (1993). Purification, characterisation, crystallisation and X-ray analysis of selenomethioninelabelled hydroxymethylbilane synthase from Escherichia coli. Eur. J. Biochem. 211, 615624.

J. Hajdu & I. Andersson (1993). Fast X-ray crystallography and time-resolved structures. Annu. Rev. Biophys. Biomol. Struct. 22, 467498.

J. Hajdu , P. A. Machin , J. W. Campbell , T. J. Greenhough , I. J. Clifton , S. Zurek , S. Gover , L. N. Johnson & M. Elder (1987). Millisecond X-ray diffraction: first electron density map from Laue photographs of a protein crystal. Nature 329, 178181.

G. Hall (1995). Silicon pixel detectors for X-ray diffraction studies with synchrotron radiation. Quarterly Reviews of Biophysics 28(1), 1.

B. Hedman , K. O. Hodgson , J. R. Helliwell , R. Liddington & M. Z. Papiz (1985). Protein micro-crystal diffraction and the effects of radiation damage with ultra high flux synchrotron radiation. PNAS.USA 82, 76047607.

J. R. Helliwell (1982). The use of electronic area detectors for synchrotron X-radiation protein crystallography with particular reference to the Daresbury SRS. Nucl. Instrum. & Meths. 201, 153174.

J. R. Helliwell (1985). Protein Crystallography with Synchrotron Radiation. J. Molec. Struct. 130, 6391.

J. R. Helliwell (1988). Protein crystal perfection and the nature of radiation damage. J. Cryst. Growth 90, 259272.

J. R. Helliwell (1992 b). Synchrotron X-ray crystallography techniques: Timeresolved aspects of data collection. Phil. Trans. Roy. Soc. Lond. A 340, 221232.

J. R. Helliwell & M. Helliwell (1996). X-ray crystallography in structural chemistry and molecular biology. Feature Article, Chem. Comm., No. 14, 15951602.

J. R. Helliwell , T. J. Greenhough , P. Carr , S. A. Rule , P. R. Moore , A. W. Thompson & J. S. Worgan (1982). Central data collection facility for protein crystallography, small angle diffraction and scattering at the Daresbury SRS. J. Phys. E. 15. 13631372.

J. R. Helliwell , J. Habash , D. W. Cruickshank J., M. M. Harding , T. J. Greenhough , J. W. Campbell , I. J. Clifton , M. Elder , P. A. Machin , M. Z. Papiz & S. Zurek (1989). The recording and analysis of Laue diffraction photographs. J. Appl. Cryst. 22, 483497.

R. Henderson (1990). Cryo-protection of protein crystals against radiation damage in electron and X-ray diffraction. Proc. R. Soc. Lond. B 241, 68.

W. Hendrickson (1991). Determination of macromolecular structures from anomalous diffraction of synchrotron radiation. Science 254, 5158.

H. Hope (1988). Cryo-crystallography of biological macromolecules: a generally applicable method. Acta Cryst. B 44, 2226.

H. Hope (1990). Crystallography of biological macromolecules at ultra-low temperature. Annu. Rev. Biophys., Biophys. Chem. 19, 107126.

S. B. Howard , P. J. Twigg , K. Baird & E. J. Meehan (1988). The solubility of hen egg white lysozyme. J. Cryst. Growth, 90, 94104.

J. Jancarik & S. H. Kim (1991). Sparse matrix sampling: a screening method for crystallisation of proteins. J. Appl. Cryst. 24, 409411.

J. Karle (1967). Anomalous scattering in X-ray diffraction and use of several wavelengths. Appl. Opt. 6, 21322135.

R. L. Kingston , H. M. Baker & E. N. Baker (1994). Search designs for protein crystallisation based on orthogonal arrays. Acta Cryst. D 50, 429440.

H. Komatsu , S. Miyashita & Y. Suzuki (1993). Interferometric observation of the interfacial concentration gradient layers around a lysozyme crystal, Jpn. J. Appl. Phys. 32 Pt.2, 18551857.

S. Koszelak , D. Martin , J. NG & A. McPherson (1991). Protein crystal growth rates determined by time lapse microphotography J. Cryst. Growth 110, 177181.

S. Koszelak , J. Day , C. Leja , R. Cudney & A. McPherson (1995). Protein and virus crystal growth on International Microgravity Laboratory-2. Biophys. J. 69, 1319.

Y. G. Kuznetsov , A. J. Malkin , A. Greenwood & A. McPherson (1995). Interferometric studies of growth kinetics and surface morphology in macromolecular crystal growth: Canavalin, thaumatin and turnip yellow mosaic virus. J. Structural Biology 114, 184196.

T. A. Land , A. J. Malkin , Y. G. Kuznetsov , A. McPherson & J. J. DeYoreo (1995). Mechanisms of protein crystal growth: An atomic force microscopy study of canavalin crystallization. Physical Review Letters Vol. 75, No. 14, 27742777.

R. A. Lewis (1994). Multiwire gas proportional counters: decrepit antiques or classic performers? J. Synchrotron Rad. 1, 4353.

B. Lorber , M. Skouri , J. P. Munch & R. Giegé (1993). The influence of impurities on protein crystallisation; the case of lysozyme. J. Cryst. Growth 128, 12031211.

B. Lorber , G. Jenner & R. Giegé (1996). Effect of high hydrostatic pressure on nucleation and growth of protein crystals. J. Cryst. Growth 158, 103117.

B. M. Low , C. C. Chen , J. E. Berger , L. Singmann & J. F. Pletcher (1966). Studies of insulin crystals at low temperatures: effects on mosaic character and radiation sensitivity. Proc. Natl. Acad. Sci. USA 56, 17461750.

A. J. Malkin , J. Cheung & A. McPherson (1993). Crystallisation of satellite tobacco mosaic virus 1. nucleation phenomena. J. Cryst. Growth 126, 544554.

A. J. Malkin , Y. G. Kuznetsov , T. A. Land , J. J. Deyoreo & A. McPherson (1995). Mechanisms of growth for protein and virus crystals. Nature Structural Biology 2, 956959.

A. McPherson (1992). Two approaches to the rapid screening of crystallisation conditons. J. Cryst. Growth 122, 161167.

A. McPherson (1993). Virus and protein crystal growth on earth and in microgravity. J. Phys. D. Appl. Phys. 26, B104B112.

A. McPherson (1995). Increasing the size of microcrystals by fine sampling of pH limits. J. Appl. Cryst. 28, 362365.

A. McPherson & P. Schlichta (1988). Heterogeneous and epitaxial nucleation of protein crystals on mineral surfaces. Science 239, 385387.

A. McPherson , A. J. Malkin & Y. G. Kuznetsov (1995). The science of macromolecular crystallisation. Structure 3, 759768.

V. Mikol & R. Giegé (1989). Phase diagram of a crystalline protein: determination of the solubility of concanavalin A by a microquantitation assay. J. Cryst. Growth 97, 324332.

V. Mikol , E. Hirsch & R. Giege (1989). Monitoring protein crystallisation by dynamic light scattering. FEBS Letters 258, 6366.

E. P. Mitchell & E. F. Garman (1994). Flash freezing of protein crystals: investigation of mosaic spread and diffraction limit with variation of cryoprotectant concentration, J. Appl. Cryst. 27, 10701074.

S. Miyashita , H. Komatsu , Y. Suzuki & T. Nakada (1994). Observation of the concentration distribution around a growing lysozyme crystal. J. Cryst. Growth 141, 419424.

K. Moffat & Henderson (1995). Freeze trapping of reaction intermediates. Current Opinion in Structural Biology 5, 656663.

K. Moffat , D. M. Szebenyi & D. Bilderback (1984). X-ray Laue diffraction from protein crystals. Science 223, 14231425.

A. C. Niemann , P. K. Matzinger & A. Haedener (1994). A kinetic analysis of the reaction catalysed by (Hydroxymethyl) bilane synthase. Helvetica Chimica Acta 77, 17911809.

N. Niimura , Y. Minezaki , M. Ataka & T. Katsura (1994). Small angle neutron scattering from lysozyme in unsaturated solutions, to characterise the precrystallisation process. J. Cryst. Growth 137, 671675.

N. Niimura , Y. Minezaki , M. Ataka & T. Katsura (1995). Aggregation in supersaturated lysozyme solution studied by time-resolved small angle neutron scattering. J. Cryst. Growth 154, 136144.

D. Normile (1995). Search for better crystals explores inner, outer space. Science 270, 19211992.

T. Odahara , M. Ataka & T. Katsura (1994). Phase diagram determination to elucidate the crystal growth of the photoreaction center from Rhodobacter sphaeroides. Acta Cryst. D 50, 639642.

Y. Okaya & R. Pepinsky (1956). Determination of crystal structures by, means of anomalously scattered X-rays. Phys. Rev. 103, 16451647.

T. J. Oldfield , T. A. Ceska & R. L. Brady (1991). A flexible approach to automated protein crystallisation. J. Appl. Cryst. 24, 255260.

K. Onuma , T. Tsukamoto & S. Nakadate (1993). Application of real time phase shift interferometer to the measurement of concentration field. J. Cryst. Growth 129, 706718.

S. Patel , B. Cudney & A. McPherson (1995). Polymeric precipitants for the crystallisation of macromolecules. Biochem. Biophys. Res. Commun. 207, 819828.

M. R. Peterson , S. J. Harrop , S. M. McSweeney , G. A. Leonard , A. W. Thompson , W. N. Hunter & J. R. Helliwell (1996). MAD phasing strategies explored with a brominated oligonucleotide crystal at 1·65 Å resolution. J. Synchrotron Rad. 3, 2434.

G. A. Petsko (1975). Protein crystallography at sub-zero temperatures: cryo-protective mother liquors for protein crystals. J. Mol. Biol. 96, 381392.

K. Provost & M. C. Robert (1995). Crystal growth of lysozymes in media contaminated by parent molecules: influence of gelled media. J. Cryst. Growth 156, 112120.

M. Pryzbylska (1989). A double cell for controlling nucleation and growth of protein crystals. J. Appl. Cryst. 22, 115118.

M. L. Pusey (1991). Estimation of the initial equlibrium constants in the formation of tetragonal lysozyme nuclei. J. Cryst. Growth, 110, 6065.

M. L. Pusey & K. Gernert (1988). A method for rapid liquid-solid phase solubility measurements using the protein lysozyme. J. Cryst. Growth 88, 419424.

M. L. Pusey & S. Munson (1991). Micro-apparatus for rapid determinations of protein solubilities. J. Cryst. Growth 113, 385389.

Z. Ren & K. Moffat (1994). Laue crystallography for studying rapid reactions. J. Synchrotron Rad. 1, 7882.

Z. Ren & K. Moffat (1995 a). Quantitative analysis of synchrotron Laue diffraction patterns in macromolecular crystallography. J. Appl. Cryst. 28, 461481.

Z. Ren & K. Moffat (1995 b). Deconvolution of energy overlaps in Laue diffraction. J. Appl. Cryst. 28, 482493.

M. C. Robert & F. Lefaucheux (1988). Crystal growth in gels: principles and applications. J. Cryst. Growth 90, 358367.

D. Rodgers (1994). Cryocrystallography. Structure, Vol 2. No. 12, 11351140.

F. Rosenberger , S. B. Howard , J. W. Sowers & T. A. Nyce (1993). Temperature dependence of protein solubility – determination and application to crystallisation in X-ray capillaries. J. Cryst. Growth 129, 112.

B. Rubin , J. Talatous & D. Larson (1991). Minimal intervention robotic protein crystallisation. J. Cryst. Growth 110, 156163.

N. Sadaoui , J. Janin & A. Lewit-Bently (1994). TAOS: an automatic system for protein crystallisation. J. Appl. Cryst. 27, 622626.

N. Sakabe (1983). A focusing Weissenberg camera with multi-layer-line screens for macromolecular crystallography. J. Appl. Cryst. 16, 542547.

N. Sakabe , S. Ikemizu , K. Sakabe , T. Higashi , A. Nakagawa , N. Watanabe , S. Adachi & K. Sasaki (1995). Weissenberg camera for macromolecules with imaging plate data collection system at the Photon Factory: Present status and future plan. Rev. Sci. Instrum. 66, 12761281.

E. E. G. Saridakis , Shaw P. D. Stewart , L. F. Lloyd & D. M. Blow (1994). Phase diagram and dilution experiments in the crystallisation of carboxypeptidase G2. Acta Cryst. D 50, 293297.

R. Savino & R. Monti (1996). Buoyancy and surface-tension-driven convection in hanging drop protein crystallization. J. Cryst Growth 165, 308318.

G. Sazaki , S. Aoki , H. Ooshima & J. Kato (1994). Effect of self-degradation products on crystallisation of protease thermolysin. J. Cryst Growth 139, 95103.

A. J. Scheidig , A. Sanchez-Llorente , A. Lautwein , E. F. Pai , J. E. T. Corrie , G. P. Reid , A. Wittinghofer & R. S. Goody (1994). Crystallographic studies on p21 (H-Ras) using the synchrotron Laue method – Improvement of crystal quality and monitoring of the GTPase reaction at different time points. Acta Cryst. D 50. 512520.

P. J. Schlichta (1986). Feasibility of mapping solution properties during the growth of protein crystals. J. Cryst. Growth 76, 656662.

I. Schlichting , S. C. Almo , G. Rapp , K. S. Wilson , A. Petratos , A. Lentfer , A. Wittinghofer , W. Kabsch , E. F. Pai , G. A. Petsko & R. S. Goody (1990). Time-resolved X-ray crystallographic study of the conformational changes in Ha-Ras p21 protein on GTP hydrolysis. Nature 345, 309315.

L. Shapiro , A. M. Fannon , P. D. Kwong , A. W. Thompson , M. S. Lehmann , G. Grubel , Legrand, J–F., J. Als-Nielsen , D. R. Colman and W. A. Hendrickson (1995). Structural basis of cell-cell adhesion by cadherins. Nature 374, 327337.

P. D. Shaw Stewart & M. Kahmisa (1994). Predispensed gradient matrices – a new rapid method of finding crystallisation conditions. Acta Cryst. D 50, 441442.

G. Sheldrick , Z. Dauter , K. S. Wilson , H. Hope and L. Sieker (1994). The application of direct methods and Patterson interpretation to high resolution native protein data. Acta Cryst. D 49, 1823.

F. Sica , D. Demasi , L. Mazzarella , A. Zagari , S. Capasso , L. H. Pearl , D'S. Auria , C. A. Raia & M. Rossi (1994). Elimination of twinning in crystals of Sulfolobus solfataricus alcohol dehydrogenase holo-enzyme by growth in agarose gels. Acta Cryst. D 50, 508511.

P. T. Singer , A. Smalas , R. P. Carty , W. F. Mangel & R. M. Sweet (1993). The hydrolytic water molecule in trypsin, revealed by time-resolved Laue crystallography. Science 259, 669673.

E. H. Snell , S. Weisgerber , J. R. Helliwell , E. Weckert , K. Holzer & K. Schroer (1995). Improvements in lysozyme protein crystal perfection through microgravity growth. Acta Cryst. D 51, 10991102.

E. H. Snell , J. R. Helliwell , T. J. Boggon , P. Lautenschlager & L. Potthast , (1996). First ground trials of a Mach-Zehnder interferometer for implementation into a microgravity protein crystallization facility–the APCF. Acta Cryst. D 52, 529533.

R. S. Snyder , K. Fuhrmann and H. U. Walter (1991). Protein crystallisation facilities for microgravity experiments. J. Cryst. Growth 110, 333338.

T. M. Soriano & J. C. Fontecilla-Camps (1993). ASTEC: an automated system for sitting drop protein crystallisation. J. Appl. Cryst. 26, 558562.

B. L. Stoddard & G. K. Farber (1995). Direct measurement of reactivity in the protein crystal by steady-state kinetic-studies. Structure 3, 991996.

R. K. Strong , B. Stoddard , A. Arrott & G. K. Farber (1992). Long duration growth of protein crystals in microgravity aboard the MIR space station. J. Cryst. Growth 119, 200214.

E. A. Stura & I. A. Wilson (1990). Analytical and production seeding techniques. Methods: a companion to Methods in Enzymology. 1, 3849.

E. A. Stura , A. C. Satterthwait , J. C. Calvo , D. C. Kaslow and I. A. Wilson (1994). Reverse screening. Acta Cryst. D 50, 448455.

P. Suortti & C. Schulze (1995). Fixed exit monochromators for high energy synchrotron radiation. J. Synchrotron Rad. 2, 612.

Y. Suzuki , S. Miyashita , H. Komatsu , K. Sato & T. Yagi (1994). Crystal growth of hen egg white lysozyme under high pressure. Jpn. J. Appl. Phys. 33, L 1568L 1570.

M. M. Teeter & H. Hope (1986). The structure of the protein crambin from X-ray diffraction at 140 K. Ann NY Acad. Sci. 482, 163165.

T. Y. Teng (1990). Mounting of crystals for macromolecular crystallography in a freestanding thin film. J. Appl. Cryst. 23, 387391.

K. J. Thiessen (1994). The use of two novel methods to grow protein crystals by microdialysis and vapour diffusion in an agarose gel. Acta Cryst. D 50, 491492.

A. W. Thompson , J. Habash , S. J. Harrop , J. R. Helliwell , C. Nave , P. Atkinson , S. S. Hasnain , I. D. Glover , P. R. Moore , N. Harris , S. Kinder & S. Buffey (1992). A new macromolecular crystallography station (9.5) on the SRS Wiggler beam line for very rapid Laue and rapidly tunable monochromatic measurements: commissioning and first results. Rev. Sci. Instrum. 63(1), 10621064.

P. G. Vekilov , M. Ataka & T. Katsura (1995). Growth process of protein crystals revealed by laser Michelson interferometry investigation. Acta Cryst. D 51, 207219.

H. U. Walter , ED. (1987). Fluid Sciences and Materials Science in Space. Springer Verlag.

J. Walter , W. Steigemann , T. P. Singh , H. Bartunik , W. Bode & R. Huber (1982). On the disordered activation domain in trypsinogen: chemical labelling and low temperature crystallography. Acta Cryst. B 38, 14621472.

K. D. Watenpaugh (1991). Macromolecular crystallography at cryogenic temperatures. Curr. Opin. Strud. Biol. 1, 10121015.

P. C. Weber (1990). A protein crystallisation strategy using automated grid searches on successively finer grids. Methods: a companion to Methods in Enzymology. 1, 3137.

S. Weisgerber & J. R. Helliwell (1993). High resolution crystallographic studies of native concanavalin A using rapid Laue data collection methods and the introduction of a monochromatic large-angle oscillation technique (LOT). Faraday Transadions, 89 (15), 26672675.

C. Wilkinson & M. Lehmann (1991). Quasi-Laue neutron diffractometer. Nucl. Instrum. & Methods 310(1–2), 411415.

S. A. Wilson , N. Chayen , A. M. Hemmings , R. E. Drew & L. H. Pearl (1991). Crystallisation and preliminary X-ray data for the negative regulator (AmiC) of the amidase operon of Pseudomonas aeruginosa. J. Mol. Biol. 222, 869871.

N. H. Xuong , Cork, C, R. Hamlin , A. Howard , B. Katz , P. Kuttner & C. Nielsen (1981). Low temperature studies of elastase. Acta Cryst. Suppl. A 37, C-51.

A. Yonath , J. Mussing & H. G. Wittman (1982). Parameters for crystal growth of ribosomal subunits. J. Cell Biochem. 19, 145155.

A. Young M. C , J. C. Dewan , C. Nave & R. F. Tilton (1993). Comparison of radiation-induced decay and structure refinement from X-ray data collected from lysozyme crystals at low and ambient temperatures. J. Appl. Cryst. 26, 309319.

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Quarterly Reviews of Biophysics
  • ISSN: 0033-5835
  • EISSN: 1469-8994
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