Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-16T11:49:35.777Z Has data issue: false hasContentIssue false

Present Status of YU-AMS System

Published online by Cambridge University Press:  09 February 2016

Fuyuki Tokanai*
Affiliation:
Faculty of Science, Yamagata University, Yamagata 990-8560, Japan
Kazuhiro Kato
Affiliation:
Faculty of Science, Yamagata University, Yamagata 990-8560, Japan
Minoru Anshita
Affiliation:
Faculty of Science, Yamagata University, Yamagata 990-8560, Japan
Hirohisa Sakurai
Affiliation:
Faculty of Science, Yamagata University, Yamagata 990-8560, Japan
Akihiro Izumi
Affiliation:
Faculty of Science, Yamagata University, Yamagata 990-8560, Japan
Teiko Toyoguchi
Affiliation:
Division of Pharmacy, Yamagata University Hospital, Yamagata 990-9585, Japan
Takeshi Kobayashi
Affiliation:
Division of Pharmacy, Yamagata University Hospital, Yamagata 990-9585, Japan
Hiroko Miyahara
Affiliation:
Institute for Cosmic Ray Research, The University of Tokyo, Chiba 277-8582, Japan
Motonari Ohyama
Affiliation:
The Center for Academic Resources and Archives Botanical Gardens, Tohoku University, Miyagi 980-8576, Japan
Yasuharu Hoshino
Affiliation:
National Institutes for Cultural Heritage, Nara National Research Institute for Cultural Properties, Nara 630-8577, Japan
*
2Corresponding author. Email: tokanai@sci.kj.yamagata-u.ac.jp.

Abstract

A new compact accelerator mass spectrometry (AMS) system has been installed in the Kaminoyama Research Institute at Yamagata University (YU). The AMS system is based on a 0.5MV Pelletron accelerator developed by the National Electrostatics Corporation. An automated acid-alkali-acid (AAA) treatment system and an automated graphitization line were also installed in the same facility for sample preparation. Performance tests of the YU-AMS system were carried out by measuring the C-series standard samples (C1–C8) and HOxII provided by IAEA and NIST, respectively. We evaluated the YU-AMS system by comparing the radiocarbon ages of Japanese tree rings with dendrochronologically determined calendar ages with calibration data. We also carried out some performance tests using a control serum and a 14C-labeled drug (oxaliplatin).

Type
Articles
Copyright
Copyright © 2013 by the Arizona Board of Regents on behalf of the University of Arizona 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aerts-Bijma, AT, Meijer, HAJ, van der Plicht, J. 1997. AMS sample handling in Groningen. Nuclear Instruments and Methods in Physics Research B 123(1–4):221–5.Google Scholar
Burr, GS, Jull, AJT. 2009. Accelerator mass spectrometry for radiocarbon research. In: Gross, ML, Caprioli, R, editors. The Encyclopedia of Mass Spectrometry. Volume 5. Amsterdam: Elsevier. p 656–9.Google Scholar
European Agency for the Evaluation of Medicinal Products (EMEA). 2003. Position Paper on Non-Clinical Safety Studies to Support Clinical Trials for a Single Microdose. CPMP/SWP/2599/02. EMEA.Google Scholar
Food and Drug Administration (FDA). 2006. Guidance for Industry, Investigators, and Reviewers: Exploratory IND Studies. Center for Drug Evaluation Research (CDER).Google Scholar
Kitagawa, H, Masuzawa, T, Nakamura, T, Matsumoto, E. 1993. A batch preparation method for graphite targets with low background for AMS 14C measurements. Radiocarbon 35(2):295–300.CrossRefGoogle Scholar
Kobayashi, K, Niu, E, Itoh, S, Yamagata, H, Lomtatidze, Z, Jorjoliani, I, Nakamura, K, Fujine, H. 2007. The compact 14C AMS facility of Paleo Labo Co., Ltd., Japan. Nuclear Instruments and Methods in Physics Research B 259(1):31–5.Google Scholar
Lappin, G, Garner, RC. 2005. The use of accelerator mass spectrometry to obtain early human ADME/PK data. Expert Opinion on Drug Metabolism & Toxicology 1(1):2331.CrossRefGoogle ScholarPubMed
Lappin, G, Stevens, L. 2008. Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics. Expert Opinion on Drug Metabolism & Toxicology 4(8):1021–33.CrossRefGoogle ScholarPubMed
Minamimoto, R, Hamabe, Y, Miyaoka, T, Hara, T, Yoshida, K, Oka, T, Inoue, T. 2008. Accelerator mass spectrometry analysis of background 14C-concentrations in human blood: aiming at reference data for further microdosing studies. Annals of Nuclear Medicine 22(10):883–9.Google Scholar
Miyaji, Y, Ishizuka, T, Kawai, K, Hamabe, Y, Miyaoka, T, Oh-hara, T, Ikeda, T, Kurihara, A. 2009. Use of an intravenous microdose of 14C-labeled drug and accelerator mass spectrometry to measure absolute oral bioavailability in dogs; cross-comparison of assay methods by accelerator mass spectrometry and liquid chromatography-tandem mass spectrometry. Drug Metabolism and Pharmacokinetics 24(2):130–8.Google Scholar
Ministry of Health, Labour and Welfare Guidance (MHLW). 2008. Microdose clinical studies. Tokyo: Ministry of Health, Labour and Welfare, Pharmaceutical and Medical Safety Bureau.Google Scholar
Nakamura, T, Niu, E, Oda, H, Ikeda, A, Minami, M, Ohta, T, Oda, T. 2004. High precision 14C measurements with the HVEE Tandetron AMS system at Nagoya University. Nuclear Instruments and Methods in Physics Research B 223–224:124–9.Google Scholar
Nakamura, T, Miyahara, H, Masuda, K, Menjo, H, Kuwana, K, Kimura, K, Okuno, M, Minami, M, Oda, H, Rakowski, A, Ohta, T, Ikeda, A, Niu, E. 2007. High precision 14C measurements and wiggle-match dating of tree rings at Nagoya University. Nuclear Instruments and Methods in Physics Research B 259(1):408–13.Google Scholar
Reimer, PJ, Baillie, MGL, Bard, E, Bayliss, A, Beck, JW, Blackwell, PG, Bronk Ramsey, C, Buck, CE, Burr, GS, Edwards, RL, Friedrich, M, Grootes, PM, Guilderson, TP, Hajdas, I, Heaton, TJ, Hogg, AG, Hughen, KA, Kaiser, KF, Kromer, B, McCormac, FG, Manning, SW, Reimer, RW, Richards, DA, Southon, JR, Talamo, S, Turney, CSM, van der Plicht, J, Weyhenmeyer, CE. 2009. IntCal09 and Marine09 radiocarbon age calibration curves, 0–50,000 years cal BP. Radiocarbon 51(4):1111–50.CrossRefGoogle Scholar
Sakamoto, M, Kodaira, A, Imamura, M. 2004. An automated AAA preparation system for AMS radiocarbon dating. Nuclear Instrument and Method in Physics Research B 223–224:298–301.Google Scholar
Tuniz, C, Bird, JR, Fink, D, Herzog, GF. 1998. Accelerator Mass Spectrometry: Ultrasensitive Analysis for Global Science. Boca Raton: CRC Press.Google Scholar
Wacker, L, Nemec, M, Bourquin, J. 2010. A revolutionary graphitisation system: fully automated, compact and simple. Nuclear Instruments and Methods in Physics Research B 268(7–8):931–44.Google Scholar
Yuan, S, Wu, X, Gao, S, Wang, J, Cai, L, Guo, Z, Lu, X. 2000. The CO2 preparation system for AMS dating at Peking University. Nuclear Instruments and Methods in Physics Research B 172(1–4):458–61.Google Scholar
Zoppi, U, Crye, J, Song, Q, Arjomand, A. 2007. Performance evaluation of the new AMS system at Accium BioSciences. Radiocarbon 49(1):173–82.Google Scholar