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PRIME Lab Sample Handling and Data Analysis for Accelerator-Based Biomedical Radiocarbon Analysis

  • Darren J Hillegonds (a1), Rae Record (a2), Frank A Rickey (a3), Steve Badylak (a2), George S Jackson (a3), Abby Simmons-Byrd (a2), David Elmore (a3) and Michael E Lipschutz (a1)...

Abstract

Processing and measurement of 200 biomedical samples has provided an opportunity to better understand the characteristics of accelerator mass spectrometry (AMS) analysis of such samples. We have utilized established procedures (Vogel 1992) and developed new methods for handling various biological samples. We have included secondary standards of known isotope ratio for all assays. A method of determining maximum precision for each unknown sample value is also reported. The presented data are an update of the ongoing radiocarbon AMS biomedical program at Purdue University.

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References

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Jackson, GS, Elmore, D, Rickey, FA, Musameh, SA, Sharma, P, Hillegonds, D, Coury, L, Kissinger, P. 2000. The PRIME Lab biomedical program. Nuclear Instruments and Methods in Physics Research B172:899903.
Jull, AJT, Donahue, DJ, Hatheway, AL, Linick, TW, Toolin, LJ. 1986. Production of graphite targets by deposition from CO/H2 for precision accelerator 14C measurements. Radiocarbon 28(2A):191–7.
Record, RD, Hillegonds, DJ, Simmons, C, Tullius, R, Rickey, FA, Elmore, D, Badylak, SF. 2001. In vivo degradation of 14C-labeled small intestinal submucosa (SIS) when used for urinary bladder repair. Biomaterials 22:2653–9.
Rickey, FA, Elmore, D, Hillegonds, D, Badylak, S, Record, R, Simmons-Byrd, A. 2000. Regeneration of tissue about an animal-based scaffold: AMS studies of the fate of the scaffold. Nuclear Instruments and Methods in Physics Research B172:904–9.
Turteltaub, KW, Vogel, JS. 1996. Applications of accelerator mass spectrometry in toxicology: a highly sensitive tool for low-level isotope measurements. In: Burlingame, AL, Carr, SA, editors. Mass Spectrometry in the Biological Sciences. New Jersey: Humana Press.
Vogel, JS, Turteltaub, KW. 1992. Biomolecular tracing through accelerator mass spectrometry. Trends in Analytical Chemistry 11(4):142–9.
Vogel, JS, Turteltaub, KW, Felton, JS, Gledhill, BL, Nelson, DE, Southon, JR, Proctor, ID, Davis, JC. 1990. Application of AMS to the biomedical sciences. Nuclear Instruments and Methods in Physics Research B52:524–30.
Vogel, JS. 1992. Rapid production of graphite without contamination for biomedical AMS. 1992. Radiocarbon 34(3):344–50.
Wilson, AT. 1992. A simple technique for converting CO2 to AMS graphite. 1992. Radiocarbon 34(3):318–20.
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Radiocarbon
  • ISSN: 0033-8222
  • EISSN: 1945-5755
  • URL: /core/journals/radiocarbon
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