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Pulsatile gonadotrophin-releasing hormone (GnRH) treatment in hypogonadotrophic amenorrhoea

Published online by Cambridge University Press:  02 March 2009

Didi DM Braat*
Affiliation:
Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
*
Didi DM Braat, Academic Hospital Vrije Universiteit, Department of Obstetrics and Gynaecology, PO Box 7057, 1007 MB Amsterdam, The Netherlands.

Extract

Following the isolation, and subsequent synthesis of the decapeptide gonadotrophin-releasing hormone (GnRH) in the laboratories of Schally and Guillemin in 1971, a more physiological treatment for hypogonadotrophic women became available. It was not, however, until 1980 that a successful, pulsatile mode of administration was established.

Type
Articles
Copyright
Copyright © Cambridge University Press 1993

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References

1Matsuo, H, Arimura, A, Nair, RMG, Schally, AV. Synthesis of the porcine LH- and FSH-releasing hormone by the solid phase method. Biochem Biophys Res Commun 1971; 45: 822–27.CrossRefGoogle ScholarPubMed
2Matsuo, H, Baba, Y, Nair, RMG, Arimura, A, Schally, AV. Structure of the porcine LH- and FSH-releasing amino acid sequence. Biochem Biophys Res Commun 1971; 43: 1334–39.CrossRefGoogle ScholarPubMed
3Burgus, R, Butcher, M, Ling, N et al. Structure moleculaire du facteur hypothalamique (LRF) d'origine ovine controlant la sécrétion de l'hormone gonadotrope hypofysaire de luteinisation. C R Acad Sci III 1971; 273: 1611–13.Google Scholar
4Dierschke, DJ, Bhattacharya, AN, Atkinson, LE, Knobil, E. Circhoral oscillations of plasma LH levels in the ovariectomized rhesus monkey. Endocrinology 1970; 87:850–53.CrossRefGoogle ScholarPubMed
5Carmel, PW, Araki, S, Ferin, M. Pituitary stalk portal blood collection in rhesus monkeys: evidence for pulsatile release of gonadotropin-releasing hormone (GnRH). Endocrinology 1976; 99: 243–48.CrossRefGoogle ScholarPubMed
6Eskay, RL, Mical, RS, Porter, JC. Relationship between luteinizing hormone-releasing hormone concentration in hypophysial portal blood and luteinizing hormone release in intact, castrated and electrochemically-stimulated rats. Endocrinology 1977; 100: 263–70.CrossRefGoogle ScholarPubMed
7Clarke, IJ, Cummins, JT. The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology 1982; 111: 1737–93.CrossRefGoogle ScholarPubMed
8Levine, JE, Pau, KF, Ramirez, VD. Simultaneous measurement of luteinizing hormone-releasing hormone and luteinizing hormone release in unanesthetized, ovariectomized sheep. Endocrinology 1982; 111: 1449–55.CrossRefGoogle ScholarPubMed
9Knobil, E. The neuroendocrine control of the menstrual cycle. Recent Prog Horm Res 1980; 36: 5388.Google ScholarPubMed
10Kastin, AJ, Zarate, A, Midgley, AR, Canales, ES, Schally, AV. Ovulation confirmed by pregnancy after infusion of porcine LH-RH. J Clin Endocrinol Metab 1971; 33:980–82.CrossRefGoogle ScholarPubMed
11Keller, PJ. Treatment of anovulation with synthetic luteinizing hormone-releasing hormone. Am J Obstet Gynecol 1973; 116: 698705.CrossRefGoogle ScholarPubMed
12Mortimer, CH, McNeilly, AS, Besser, GM. Gonadotrophin releasing hormone therapy. Ann Biol anim Bioch Biophys 1976; 16: 235–43.CrossRefGoogle Scholar
13Casas, PRF, Miechi, H, Badano, A et al. Clinical and gonadotropic response of amenorrheic patients treated with clomiphene and repeated injections of luteinizing hormone-releasing hormone. Fertil Steril 1977; 28: 293–94.Google Scholar
14Nakano, R, Katayama, K, Mizuno, T, Tojo, S. Induction of ovulation with synthetic luteinizing hormone-releasing hormone. Fertil Steril 1974; 25: 471–77.CrossRefGoogle ScholarPubMed
15Nillius, SJ. Gonadotrophin-releasing hormone for induction of ovulation in women. In: Hafez, ESE ed. Human ovulation. Amsterdam: Noord Holland, 1979: 385404.Google Scholar
16Leyendecker, G. The pathophysiology of hypothalamic ovarian failure. Diagnostic and therapeutical considerations. Eur J Obstet Gynecol Reprod Biol 1979; 9: 175–86.Google ScholarPubMed
17Leyendecker, G, Struve, T, Plotz, EJ. Induction of ovulation with intermittent (pulsatile) administration of LH-RH in women with hypothalamic and hyperprolactinemic amenorrhea. Arch Gynecol Obstet 1980; 229: 177–90.Google ScholarPubMed
18Crowley, WF Jr, McArthur, JW. Stimulation of the normal menstrual cycle in Kallman's syndrome by pulsatile administration of luteinizing hormone-releasing hormone (LHRH). J Clin Endocrinol Metab 1980; 51: 173–75.CrossRefGoogle Scholar
19Leyendecker, G, Wildt, L, Hansmann, M. Pregnancies following chronic intermittent (pulsatile) administration of GnRH by means of a portable pump (‘Zyklomat’): a new approach to the treatment of infertility in hypothalamic amenorrhea. J Clin Endocrinol Metab 1980; 51: 1214–16.CrossRefGoogle Scholar
20Morris, DV, Abdulwahid, N, Armar, NA, Jacobs, HS. The response of patients with organic hypothalamic-pituitary disease to pulsatile gonadotropin-releasing hormone therapy. Fertil Steril 1987; 47: 5459.CrossRefGoogle ScholarPubMed
21Braat, DDM, Veersema, S, Assies, J, Schoemaker, J. Triplet pregnancy after pulsatile gonadotropin-releasing hormone treatment in an acromegalie woman. In: Braat DDM ed. Multiple pregnancies in pulsatile GnRH treatment [Thesis]. Utrecht: Elinkwijk BV, 1992.Google Scholar
22Thomas, AK, Mander, J, Hale, J, Walstab, J, Forrest, MS. Induction of ovulation with subcutaneous pulsatile gonadotropin-releasing hormone correlation with body weight and other parameters. Fertil Steril 1989; 51: 786–90.CrossRefGoogle ScholarPubMed
23Van der Spuy, ZM, Steer, PJ, McCuster, M, Steele, SJ, Jacobs, HS. Outcome of pregnancy in underweight women after spontaneous and induced ovulation. Br Med J 1988; 296: 962–65.CrossRefGoogle ScholarPubMed
24Mortimer, CH, Besser, GM, McNeilly, AS et al. Luteinizing hormone and follicle stimulating hormone releasing hormone test in patients with hypothalamic pituitary gonadal dysfunction. Br Med J 1973; 4: 7377.CrossRefGoogle ScholarPubMed
25Delemarre-van de Waal, HA. Delayed puberty in the male patient. In: Rolland, R, Heineman, MJ, Naaktgeboren, N, Schoemaker, J, Vemer, H, Willemsen, WNP eds. Neuro-endocrinology of reproduction. Amsterdam, New York, Oxford: Excerpta Medica, 1987: 9397.Google Scholar
26Garcia, J, Jones, GS, Wentz, AC. The use of clomiphene citrate. Fertil Steril 1977; 28: 707–17.CrossRefGoogle ScholarPubMed
27Zacur, HA. Ovulation induction with gonadotropin-releasing hormone. Fertil Steril 1985; 44: 435–48.Google ScholarPubMed
28Burger, CW, Korsen, T, van Kessel, H, van Dop, PA, Caron, FJM, Schoemaker, J. Pulsatile luteinizing hormone patterns in the follicular phase of the menstrual cycle, polycystic ovary-like disease (PCOD) and non-PCOD secondary amenorrhea. J Clin Endocrinol Metab 1985; 61: 1126–32.CrossRefGoogle Scholar
29Kazer, RR, Kessel, B, Yen, SSC. Circulating luteinizing hormone pulse frequency in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1987; 65: 233–36.CrossRefGoogle ScholarPubMed
30Molloy, BG, Hancock, KW, Glass, MR. Ovulation induction in clomiphene nonresponsive patients: the place of pulsatile gonadotropin-releasing hormone in clinical practice. Fertil Steril 1985; 43: 2633.CrossRefGoogle Scholar
31Burger, CW, Korsen, TJM, Hompes, PGA, van Kessel, H, Schoemaker, J. Ovulation induction with pulsatile luteinizing hormone releasing hormone in women with clomiphene citrate-resistant polycystic ovary-like disease: clinical results. Fertil Steril 1986; 46:1045–54.CrossRefGoogle ScholarPubMed
32Ory, SJ, London, SN, Tyrey, L, Hammond, CB. Ovulation induction with pulsatile gonadotropin-releasing hormone administration in patients with polycystic ovarian syndrome. Fertil Steril 1985; 43: 2025.CrossRefGoogle ScholarPubMed
33Filicori, M, Campaniello, E, Michelacci, L et al. Gonadotropin-releasing hormone (GnRH) analog suppression renders polycystic ovarian disease patients more susceptible to ovulation induction with pulsatile GnRH. J Clin Endocrinol Metab 1988; 66: 327–33.CrossRefGoogle ScholarPubMed
34Filicori, M, Flamigni, C, Meriggiola, MC et al. Endocrine response determines the clinical outcome of pulsatile gonadotropin-releasing hormone ovulation induction in different ovula tory disorders. J Clin Endocrinol Metab 1991; 72: 965–72.CrossRefGoogle Scholar
35Sebeele, F, Hompes, PGA, Van der Meer, M, Schoute, E, Schoemaker, J. Pulsatile gonadotropin-releasing hormone stimulation after medium term pituitary suppression in polycystic ovary syndrome. Hum Reprod 1993 (in press).CrossRefGoogle Scholar
36Surrey, ES, de Ziegler, D, Lu, JKH, Chang, RJ, Judd, HL. Effects of pituitary gonadotropin-releasing hormone (GnRH) agonist on pituitary and ovarian responses to pulsatile GnRH therapy in polycystic ovarian disease. Fertil Steril 1989; 52: 547–52.CrossRefGoogle ScholarPubMed
37Homburg, R, Kilborn, J, West, C, Jacobs, HS. Treatment with pulsatile luteinizing hormone-releasing hormone modulates folliculogenesis in response to ovarian stimulation with exogenous gonadotropins in patients with polycystic ovaries. Fertil Steril 1990; 54: 737–93.CrossRefGoogle ScholarPubMed
38Liu, JH, Durfee, R, Muse, K, Yen, SSC. Induction of multiple ovulation by pulsatile administration of gonadotropin-releasing hormone. Fertil Steril 1983; 40: 1822.CrossRefGoogle ScholarPubMed
39Shaw, RW, Ndukwe, G, Imoedernhe, D, Burford, G, Chan, R. Stimulation of multiple follicular growth for in vitro fertilization by administration of pulsatile luteinizing hormone-releasing hormone during the midfollicular phase. Fertil Steril 1986; 46: 135–37.CrossRefGoogle ScholarPubMed
40Braat, DDM, Berkhout, GMJ, Ten Brug, CS, Schoemaker, J. Multiple follicular development in women with normal menstrual cycles treated with pulsatile gonadotropin-releasing hormone. Hum Reprod 1991; 6: 1379–83.CrossRefGoogle Scholar
41Loucopoulos, A, Ferin, M. The treatment of luteal phase defects with pulsatile infusion of gonadotropin-releasing hormone. Fertil Steril 1987; 48: 933–36.CrossRefGoogle ScholarPubMed
42Keogh, EJ, Mallal, SA, Giles, PFH, Evans, DV. Ovulation induction with intermittent subcutaneous LHRH. Lancet 1981; i: 147.CrossRefGoogle Scholar
43Hurley, DM, Brian, RJ, Burger, HG. Ovulation induction with subcutaneous pulsatile gonadotropin-releasing hormone: singleton pregnancies in patients with previous multiple pregnancies after gonadotropin therapy. Fertil Steril 1983; 40: 575–79.CrossRefGoogle ScholarPubMed
44Blunt, SM, Butt, WR. Pulsatile GnRH therapy for the induction of ovulation in hypogonadotropic hypogonadism. Acta Endocrinol (Copenh) 1988; 288: 5865.Google ScholarPubMed
45McIntosh, RP, McIntosh, JEA. Influence of the characteristics of pulses of gonadotropin-releasing hormone on the dynamics of luteinizing hormone release from perifused sheep pituitary cells. J. Endocrinol 1983; 98: 411–21.CrossRefGoogle Scholar
46Handelsman, DJ, Jansen, RPS, Boylan, LM, Spaliviero, JA, Turtle, JR. Pharmacokinetics of gonadotropin-releasing hormone: comparison of subcutaneous and intravenous routes. J Clin Endocrinol Metab 1984; 59: 739–46.CrossRefGoogle ScholarPubMed
47Loucopoulos, A, Ferin, M, Vande Wiele, RL et al. Pulsatile administration of gonadotropin-releasing hormone for induction of ovulation. Am J Obstet Gynecol 1984; 148: 895900.CrossRefGoogle ScholarPubMed
48Menon, V, Butt, WR, Clayton, RN, Logan Edwards, R, Lynch, SS. Pulsatile administration of GnRH for the treatment of hypogonadotrophic hypogonadism. Clin Endocrinol (Oxf) 1984; 21: 223–32.CrossRefGoogle ScholarPubMed
49Reid, RL, Sauerbrei, E. Evaluation of techniques for induction of ovulation in outpatients employing pulsatile gonadotropin-releasing hormone. Am J Obstet Gynecol 1984; 148: 648–56.CrossRefGoogle ScholarPubMed
50Reid, RL, Leopold, GR, Yen, SSC. Induction of ovulation and pregnancy with pulsatile luteinizing hormone releasing factor: dosage and mode of delivery. Fertil Steril 1981; 36: 553–59.CrossRefGoogle ScholarPubMed
51Blunt, SM, Menon, BKV, Butt, WR. Pulsatile LHRH in hypogonadotrophic hypogonadism. In: Bloom, SR, Jacobs, HS eds. Therapeutic applications of LHRH. London: Royal Society of Medicine Services, 1986; 8998.Google Scholar
52Mason, P, Adams, J, Morris, DV et al. Induction of ovulation with pulsatile luteinizing hormone releasing hormone. Br Med J 1984; 288: 181–85.CrossRefGoogle Scholar
53Homburg, R, Eshel, A, Armar, NA et al. One hundred pregnancies after treatment with pulsatile luteinizing hormone-releasing hormone to induce ovulation. Br Med J 1989; 298: 809–12.CrossRefGoogle ScholarPubMed
54Seibel, MM, Kamrava, M, McArdle, C, Taymor, ML. Ovulation induction and conception using subcutaneous pulsatile luteinizing hormone-releasing hormone. Obstet Gynecol 1983; 61: 292–98.Google ScholarPubMed
55Hurley, DM, Brian, R, Outch, K et al. Induction of ovulation and fertility in amenorrheic women by pulsatile low-dose gonadotropin-releasing hormone. N Engl J Med 1984; 310:1069–74.CrossRefGoogle ScholarPubMed
56Soules, MR, Steiner, RA, Cohen, NL, Bremner, WJ, Clifton, DK. Nocturnal slowing of pulsatile luteinizing hormone secretion in women during the follicular phase of the menstrual cycle. J Clin Endocrinol Metab 1985; 61: 4349.CrossRefGoogle ScholarPubMed
57Rossmanith, WG, Yen, SSC. Sleep-associated decrease in luteinizing hormone pulse frequency during the early follicular phase of the menstrual cycle: evidence for an opiodergic mechanism. J Clin Endocrinol Metab 1987; 65: 715–18.CrossRefGoogle Scholar
58Midgley, AR, Jaffe, RB. Regulation of human gonadotropins. X: episodic fluctuations of LH during the menstrual cycle. J Clin Endocrinol Metab 1971; 33: 962–69.CrossRefGoogle ScholarPubMed
59Santen, RJ, Bardin, CW. Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanism. J Clin Invest 1973; 52: 2617–28.CrossRefGoogle Scholar
60Reame, N, Sauder, SE, Kelch, RP, Marshall, JC. Pulsatile gonadotropin secretion during the human menstrual cycle: evidence for altered frequency of gonadotropin-releasing hormone secretion. J Clin Endocrinol Metab 1984; 59: 328–37.CrossRefGoogle ScholarPubMed
61Filicori, M, Santoro, N, Merriam, GR, Crowley, WF. Characterization of the physiological pattern of episodic gonadotropin secretion throughout the human menstrual cycle. J Clin Endocrinol Metab 1986; 62: 1136–44.CrossRefGoogle ScholarPubMed
62Schoemaker, J, Simons, AHM, Van Osnabrugge, GJC, Lugtenburg, C, Van Kessel, H. Pregnancy after prolonged pulsatile administration of luteinizing hormone-releasing hormone in a patient with clomiphene-resistant secondary amenorrhea. J Clin Enodcrinol Metab 1981; 52: 882–85.CrossRefGoogle Scholar
63Hanker, JP, Nieschlag, L, Schneider, HPG. Pulsatile LH-RH substitution in hypothalamic amenorrhea. In: The 7th International Congress of Endocrinology, Exerpta Medica International Congress series 652. Amsterdam: Elsevier Science Publishers, 1984: abstract 972.Google Scholar
64Bringer, J, Hedon, B, Jaffiol, C et al. Influence of frequency of gonadotropin-releasing hormone (GnRH) administration on ovulatory responses in women with anovulation. Fertil Steril 1985; 44: 4248.CrossRefGoogle ScholarPubMed
65Filicori, M, Flamigni, C, Campaniello, E et al. Evidence for a specific role of GnRH pulse frequency in the control of the human menstrual cycle. Am J Physiol 1989; 257: E930–36.Google ScholarPubMed
66Leyendecker, G, Wildt, L. Induction of ovulation with chronic-intermittent (pulsatile) administration of GnRH in women with hypothalamic amenorrhea. J Reprod Fertil 1983; 69: 397409.CrossRefGoogle Scholar
67Braat, DDM, Ayalon, D, Blunt, SM et al. Pregnancy outcome in gonadotropin-releasing hormone induced cycles: a multicentre study. Gynecol Endocrinol 1989; 3:3544.CrossRefGoogle ScholarPubMed
68Santoro, N, Wierman, ME, Filicori, M, Waldstreicher, J, Crowley, WF Jr. Intravenous administration of pulsatile gonadotropin-releasing hormone in hypothalamic amenorrhea: effects of dosage. J Clin Endocrinol Metab 1986; 62: 109–16.CrossRefGoogle ScholarPubMed
69Miller, DS, Reid, RR, Cetel, NS, Rebar, RW, Yen, SSC. Pulsatile administration of low-dose gonadotropin-releasing hormone. Ovulation and pregnancy in women with hypothalamic amenorrhea. JAMA 1983; 250: 2937–41.CrossRefGoogle ScholarPubMed
70Oliva, A, Le Donne, M, Fattori, A, Dugo, C, Scarselli, G. Pregnancy following administration of GnRH by means of a portable pump: hormonal evaluation before and during therapy. Acta Eur Fertil 1989; 20: 7175.Google ScholarPubMed
71Braat, DDM, Schoemaker, J. Endocrinology of gonadotropin-releasing hormone induced cycles in hypothalamic amenorrhea: the role of the pulse dose. Fertil Steril 1991; 56: 1054–59.CrossRefGoogle ScholarPubMed
72Hutchison, JS, Zeleznik, AJ. The rhesus monkey corpus luteum is dependent on pituitary gonadotropin secretion throughout the luteal phase of the menstrual cycle. Endocrinology 1984; 115: 1780–86.CrossRefGoogle ScholarPubMed
73Weinstein, FG, Seibel, MM, Taymor, ML. Ovulation induction with subcutaneous pulsatile gonadotropin-releasing hormone: the role of supplemental human chorionic gonadotropin in the luteal phase. Fertil Steril 1984; 41: 546–50.CrossRefGoogle ScholarPubMed
74Goerzen, J, Corenblum, B, Wiseman, DA, Taylor, PJ. Ovulation induction and pregnancy in hypothalamic amenhorrea using self-administered intravenous gonadotropin-releasing hormone. Fertil Steril 1984; 41: 319–21.CrossRefGoogle Scholar
75Sutherland, IA, Chambers, GR. The development and performance of pulsatile infusion pumps. In: Bloom, SR, Jacobs, HS eds. Therapeutic applications of LHRH. London: Royal Society of Medicine Services, 1986: 6775.Google Scholar
76Braat, DDM, Schoemaker, R, Schoemaker, J. Life table analysis of fecundity in intravenously gonadotropin-releasing hormone treated patients with normagonadotropic and hypogonadotropic amenorrhea. Fertil Steril 1991; 55: 266–71.CrossRefGoogle Scholar
77Jansen, RPS, Handelsman, DJ, Boylan, LM, Conway, A, Shearman, RP, Fraser, IS. Pulsatile intravenous gonadotropin-releasing hormone for ovulation-induction in infertile women. I: safety and effectiveness with outpatient therapy. Fertil Steril 1987; 48: 3338.CrossRefGoogle Scholar
78Skarin, G, Nillius, SJ, Wide, L. Pulsatile subcutaneous low-dose gonadotropin-releasing hormone treatment of anovulatory infertility. Fertil Steril 1983; 40: 454–60.CrossRefGoogle ScholarPubMed
79MacLeod, TL, Eisen, A, Sussman, GL. Anaphylactic reaction to synthetic luteinizing hormone-releasing hormone. Fertil Steril 1987; 48: 500502.CrossRefGoogle ScholarPubMed
80Claman, P, Elkind-Hirsch, K, Oskowitz, SP, Seibel, MM. Urticaria associated with anti-gonadotropin-releasing hormone antibody in a female Kallman's syndrome patient being treated with gonadotropin-releasing hormone. Obstet Gynecol 1987; 69: 503505.Google Scholar
81Meakin, JL, Keigh, EJ, Martin, CE. Human antiluteinizing hormone-releasing hormone antibodies in patients treated with gonadotropin-releasing hormone. Fertil Steril 1985; 43: 811–13.CrossRefGoogle Scholar
82Lindner, J, McNeil, LW, Marney, S et al. Characterization of human anti-luteinizing hormone-releasing hormone (LRH) antibodies in the serum of a patient with isolated gonadotrophin deficiency treated with synthetic LRH. J Clin Endocrinol Metab 1981; 52: 267–70.CrossRefGoogle Scholar
83Van Loon, GR, Brown, GM. Secondary drug failure occurring during chronic treatment with LHRH: appearance of an antibody. J Clin Endocrinol Metab 1975; 41: 640–43.CrossRefGoogle ScholarPubMed
84Skarin, G, Nillius, SJ, Wide, L. Pulsatile low-dose luteinizing hormone releasing hormone treatment for induction of follicular maturation and ovulation in women with amenorrhoea. Acta Endocrinol 1982; 101: 7886.Google ScholarPubMed
85Berg, D, Mickan, H, Michael, S et al. Ovulation and pregnancy after pulsatile administration of gonadotropin releasing hormone. Arch Gynecol 1983; 233: 205–10.CrossRefGoogle ScholarPubMed