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Role of cytokines in endometrium and at the fetomaternal interface

Published online by Cambridge University Press:  02 March 2009

S Tabibzadeh
S Tabibzadeh*
Affiliation:
University of South Florida Health Sciences Center and Moffitt Cancer Center, Tampa, Florida, USA
*
S Tabibzadeh, Department of Pathology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.
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Extract

Cytokines were first recognized as factors involved in the immune responses. However, emerging evidence suggests that cytokines serve as the unanimous language through which cells in organ systems as diverse as hypothalamus to endometrium communicate. Evidence for the participation of these factors in the normal function of the endometrium and uteroplacental unit and development of the embryo is being recognized. This review will highlight the significant insight gained over the past several years for the role of cytokines in the field of reproductive biology. Major emphasis will be placed on interleukins, tumour necrosis factor-α, transforming growth factors, colony stimulating factors and interferon-gamma.

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Reproductive Medicine Review , Volume 3 , Issue 1 , March 1994 , pp. 11 - 28
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Copyright © Cambridge University Press 1994

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