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Preventing falls and fractures in long-term care

  • Stephen J Wallis (a1) and Gordon A Campbell (a1)
Summary

The prevalence of falls and associated injuries increases with age and dependency. The highest occurs among individuals living in long-term care institutions. Preventing falls results in reduced physical and psychological morbidity as well as having cost-saving implications. This review explores both uni- and multifactorial approaches to reducing fall rates and risk in individuals in long-term care, as well as highlighting the differences in this group from community-dwelling individuals.

Copyright
Corresponding author
Address for correspondence: Stephen Wallis, Department of Medicine for the Elderly, Box 135, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ. Email: drstephenwallis@gmail.com
References
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1Prudham, D, Evans, JG. Factors associated with falls in the elderly: a community study. Age Ageing 1981; 10: 141–46.
2Blake, AJ, Morgan, K, Bendall, MJ, Dallosso, H, Ebrahim, SB, Arie, TH, Fentem, PH, Bassey, EJ. Falls by elderly people at home: prevalence and associated factors. Age Ageing 1988; 17: 365–72.
3Rubenstein, LZ. Falls in older people: epidemiology, risk factors and strategies for prevention. Age Ageing 2006; 35 S2: ii3741.
4Gibson, RE, Harden, M, Byles, J, Ward, J. Incidence of falls and fall-related outcomes among people in aged-care facilities in the Lower Hunter region, NSW. NSW Public Health Bull 2008; 19: 166–69.
5Rubenstein, LZ, Josephson, KR, Osterweil, LD. Falls and fall prevention in the nursing home. Clin Geriatr Med 1996; 12: 881902.
6Rubenstein, LZ, Josephson, KR, Robbins, AS. Falls in the nursing home. Ann Intern Med 1994; 121: 442–51.
7Sugarman, JR, Connell, FA, Hansen, A, Helgerson, SD, Jessup, MC, Lee, H. Hip fracture incidence in nursing home residents and community dwelling older people, Washington State, 1993–1995. J Am Geriatr Soc 2005; 50: 1638–43.
8Butler, M, Norton, R, Lee-Joe, T, Cheng, A, Campbell, AJ. The risks of hip fracture in older people from private homes and institutions. Age Ageing 1996; 25: 381–85.
9Bradley, C, Pointer, S. Hospitalisations due to falls by older people, Australia 2005–06. Injury research and statistics series number 50. Cat. no. INJCAT 122. Adelaide: AIHW; 2008.
10Peel, NM, Kassulke, DJ, McClure, RJ. Population based study of hospitalised fall related injuries in older people. Inj Prev 2002; 8: 280–83.
11Delbaere, K, Close, JCT, Brodaty, H, Sachdev, P, Lord, SR. Determinants of disparities between perceived and physiological risk of falling among elderly people: cohort study. BMJ 2010; 341: c4165.
12Cumming, RG, Salkeld, G, Thomas, M, Szonyi, G. Prospective study of the impact of fear of falling on activities of daily living, SF-36 scores, and nursing home admission. J Gerontol A Biol Sci Med Sci 2000; 55: 299305.
13Chung, MC, Mc Kee, KJ, Austin, D et al. Post-traumatic stress disorder in older people after a fall. Int J Geriatr Psychiatry 2009; 24: 955–64.
14Dowswell, T. Towner, E, Cryer, C, Jarvis, S, Edwards, P, Lowe, P. Accidental Falls: Fatalities and Injuries: an examination of the data sources and review of the literature in preventative strategies. University of Newcastle upon Tyne (1999).
15Carroll, NV, Delafuente, JC, Cox, FM, Narayan, S. Fall-related hospitalization and facility costs among residents of institutions providing long term care. Gerontologist. 2008; 48: 213–22.
16Torgerson, DJ, Iglesias, CP, Reid, DM. ‘The economics of fracture prevention’. In The Effective Management of Osteoporosis. London: Aesculapius Medical Press, 2001; pp. 111–21.
17Heinrich, S, Rapp, K, Rissmann, U, Bercker, C, Konig, . Cost of falls in old age: a systematic review. Osteoporos Int 2010; 21: 891902.
18Oliver, D, Masud, T. Preventing fall and injuries in care homes. Age Ageing 2004; 33: 532–35.
19Oliver, D. Preventing falls and falls-injuries in hospitals and long-term facilities. Rev Clin Gerontol 2007; 17: 7591.
20Lamb, SE, Jorstad-Stein, EC, Hauer, K, Becker, C. Prevention of Falls Network Europe and Outcomes Consensus Group. Development of a common outcome data set for fall injury prevention trials: the Prevention of Falls Network Europe consensus. JAMA 2005; 53: 1618–22.
21Tinetti, ME, Williams, CS. Falls, injuries due to falls, and the risk of admission to a nursing home. N Engl J Med 1997; 337: 1279–84.
22Prevention of Falls in Older Persons. 2010 AGS/BGS Clinical Practice Guideline. Available at: http://www.medcats.com/FALLS/frameset.htm (accessed 12 February 2011).
23Chen, JS, Sambrook, PN, Simpson, JM, Cameron, ID, Cumming, RG, Seibel, MJ, Lord, SR, March, LM. Risk factors for hip fracture among institutionalised older people. Age Ageing 2009; 38: 429–34.
24Lord, SR, March, LM, Cameron, ID, Cumming, RG, Schwarz, J, Zochling, J, Chen, JS, Makaroff, J, Sitoh, YY, Lau, TC, Brnabic, A, Sambrook, PN. Differing risk factors of falls in nursing home and intermediate care residents who can and cannot stand unaided. JAGS 2003; 51: 1645–50.
25Delbaere, K, Close, JC, Menz, HB, Cumming, RG, Cameron, ID, Sambrook, PN, March, LM, Lord, SR. Development and validation of falls risk screening tools for use in residential aged care facilities. Med J Aust 2008; 189: 193–96.
26Podsiadlo, D, Richardson, S. The timed ‘Up & Go’: a test of basic functional mobility for frail elderly persons. JAMA 1991; 39: 142–48.
27Nordin, E, Lindelöf, N, Rosendahl, E, Jensen, J, Lundin-Olsson, L. Prognostic validity of the Timed Up-and-Go test, a modified Get-Up-and-Go test, staff's global judgement and falls history in evaluating falls risk in residential care facilities. Age Ageing 2008; 37: 442–48.
28Meyer, G, Kopke, S, Haastert, B, Muhlhauser, I. Comparison of a fall risk assessment tool with nurses’ judgement alone: a cluster-randomised controlled trial Age Ageing 2009; 38: 417–23.
29Barker, AL, Nitz, JC, Low Choy, NL, Haines, T. Measuring fall risk and predicting who will fall: Clinimetric properties of four fall risk assessment tools for residential aged care. J Gerontol A Biol Sci Med Sci 2009; 8: 916–24.
30Perell, KL, Nelson, A, Goldman, RL, Luther, SL, Prieto-Lewis, N, Rubenstein, LZ. Fall risk assessment measures: an analytic review. J Gerontol A Biol Sci Med Sci 2001; 56: M76166.
31Tinetti, ME, Williams, TF, Mayewski, R. Fall risk index for elderly patients based on number of chronic disabilities. Am J Med 1986; 80: 429–34.
32Berg, K. Balance and its measure in the elderly: a review. Physiother Can 1989; 41: 240–46.
33Close, JCT. Falls in older oeople: risk factors, assessment and intervention. IBMS BoneKEy 2009; 6: 368–84.
34Gillespie, LD, Robertson, MC, Gillespie, WJ, Lamb, SE, Gates, S, Cumming, RG, Rowe, BH. Interventions for preventing falls in older people living in the community (Review). Cochrane Database Syst Rev 2009; issue 2.
35Leipzig, RM, Cumming, RG, Tinetti, ME. Drugs and falls in older people: A systematic review and meta-analysis: I. Psychotrophic drugs. J Am Geriatr Soc 1999; 47: 3039.
36Lawlor, DA, Patel, R, Ebrahim, S. Association between falls in elderly women and chronic diseases and drug use: cross sectional study. BMJ 2003; 327: 712.
37Woolcott, JC, Richardson, KJ, Wiens, MO, Patel, B, Marin, J, Khan, KM, Marra, CA. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med 2009; 169: 1952–60.
38Zermansky, AG, Alldred, DP, Petty, DR, Raynor, DK, Freemantle, N, Eastaugh, J, Bowie, P. Clinical medication review by a pharmacist of elderly people living in care homes – randomised controlled trial. Age Ageing 2006; 35: 586–91.
39Campbell, AJ, Robertson, MC, Gardner, MM, Norton, RN, Buchner, M. Psychotropic medication withdrawal and a home-based exercise program to prevent falls: a randomised, controlled trial. J Am Geriatr Soc 1999; 47: 850–53.
40Ooi, WL, Hossain, M, Lipsitz, LA. The association between orthostatic hypotension and recurrent falls in nursing home residents. Am J Med 2000; 108: 106–11.
41Aronow, WS, Ahn, C. Postprandial hypotension in 499 elderly persons in a long-term health care facility. J Am Geriatr Soc 1994; 42: 930–32.
42Le Couteur, DG, Fisher, AA, Davis, MW, McLean, AJ. Postprandial systolic blood pressure responses of older people in residential care: association with risk of falling. Gerontology 2003; 49: 260–64.
43Working Group of the Australian and New Zealand Bone and Mineral Society, Endocrine Society of Australia and Osteoporosis Australia. Vitamin D and adult bone health in Australia and New Zealand: a position statement. MJA 2005; 182: 281–85.
44Hirani, V, Primatesta, P. Vitamin D concentrations among people aged 65 years and over living in private households and institutions in England: population survey. Age Ageing 2005; 34: 485–91.
45Heaney, RP. Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr 2003; 78: 912–19.
46Department of Health. Nutrition and Bone Health: with particular reference to calcium and vitamin D. Report on Health and Social Subjects 49. London: The Stationery Office, 1998.
47Flicker, L, Mead, K, MacInnis, RJ, Nowson, C, Scherer, S, Stein, MS, Thomasx, J, Hopper, JL, Wark, JD. Serum vitamin D and falls in older women in residential care in Australia. JAGS 2003; 51: 1533–38.
48Prabhala, A, Garg, R, Dandona, P. Severe myopathy associated with vitamin D deficiency in western New York. Arch Intern Med 2000; 160: 1199–203.
49Skaria, J, Katiyar, BC, Srivastava, TP, Dube, B. Myopathy and neuropathy associated with osteomalacia. Acta Neurol Scand 1975; 51: 3758.
50Pfeifer, M, Begerow, B, Minne, HW. Vitamin D and muscle function. Osteoporos Int 2002; 13: 187–94.
51Bischoff, HA, Stähelin, HB, Dick, W, Akos, R, Knecht, M, Salis, C, Nebiker, M, Theiler, R, Pfeifer, M, Begerow, B, Lew, RA, Conzelmann, M. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 2003; 18: 343–51.
52Pfeifer, M, Begerow, B, Minne, HW, Abrams, C, Nachtigall, D, Hansen, C. The effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidsm in elderly women. J Bone Miner Res 2000; 15: 1113–18.
53Broe, KE, Chen, TC, Weinberg, J, Bischoff-Ferrari, HA, Holick, MF, Kiel, DP. A higher dose vitamin D reduces the risk of falls in nursing home residents: A randomised, multiple-dose study. JAGS 2007; 55: 234–39.
54Kalyani, RR, Stein, B, Valiyil, R, Manno, R, Maynard, JW, Crews, DC. Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis. JAGS 2010; 58: 1299–310.
55Bischoff-Ferrari, HA, Dawson-Hughes, B, Staehelin, HB, Orav, JE, Stuck, AE, Theiler, R, Wong, JB, Egli, A, Kiel, DP, Henschkowski, J. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 2009; 339: b3692.
56Flicker, L, MacInnis, RJ, Stein, MS. Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial. JAGS 2005; 53: 1881–88.
57Mayes, N, Walker, K, Bayly, JR. Evaluating and improving clinical standards in the management of fracture risk in older people in residential care settings. J Bone Miner Res 2009; 24 (suppl 1): SU0397.
58Hippisley-Cox, J, Bayly, J, Potter, J, Fenty, J, Parker, C. Evaluation of standards of care for osteoporosis and falls in primary care. 2007 QRESEARCH: Final Report to The Information Centre for health and social care. Available at: http://www.ic.nhs.uk/statistics-and-data-collections/primary-care/general-practice/evaluation-of-standards-of-care-for-osteoporosis-and-falls-in-primary-care (accessed 12 February 2011).
59Bolland, MJ, Avenell, A, Baron, JA, Grey, A, MacLennan, GS, Gamble, GD, Reid, IR. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010; 341: c3691.
60Hsia, J, Heiss, G, Ren, H, Allison, M, Dolan, NC, Greenland, P, Heckbert, SR, Johnson, KC, Manson, JE, Sidney, S, Trevisan, M; Women's Health Initiative Investigators. Calcium/vitamin D supplementation and cardiovascular events. Circulation 2007; 115: 846–54.
61Autier, P, Gandini, S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 2007; 167: 1730–37.
62Malcolm Law, M, Withers, H, Morris, J, Anderson, F. Vitamin D supplementation and the prevention of fractures and falls: results of a randomised trial in elderly people in residential accommodation. Age Ageing 2006; 35: 482–86.
63Sanders, KM, Stuart, AL, Williamson, EJ. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 2010; 303: 1815–22.
64Chiarelli, PE, Mackenzie, LA, Osmotherly, PG. Urinary incontinence is associated with an increase in falls: a systematic review. Aust J Physiother 2009; 55: 8995.
65Hasegawa, J, Kuzuya, M, Iquchi, A. Urinary incontinence and behavioural symptoms are independent risk factors for recurrent and injurious falls, respectively, among residents in long-term care facilities. Arch Gerontol Geriatr 2010; 50: 7781.
66Ivers, RQ, Cumming, RG, Mitchell, P, Attebo, K. Visual impairment and falls in older adults: the Blue Mountains Eye Study. JAGS 1998; 46: 5864.
67Harwood, RH, Foss, AJE, Osborn, F, Gregson, RM, Zaman, A, Masud, T. Falls and health status in elderly women following first eye cataract surgery: a randomised controlled trial. Br J Opthalmol 2005; 89: 5359.
68Elliott, AF, McGwin, G, Owsley, C. Vision-enhancing interventions in nursing home residents and their short-term effect on physical and cognitive function. JAGS 57: 202–8.
69Cumming, RG, Ivers, R, Clemson, L, Cullen, J, Hayes, MF, Tanzer, M, Mitchell, P. Improving vision to prevent falls in frail older people: A randomized trial. JAGS 2007; 55: 175–81.
70La Grow, SJ, Robertson, MC, Campbell, AJ, Clarke, GA, Kerse, NM. Reducing hazard related falls in people 75 years and older with significant visual impairment: how did a successful program work? Inj Prev 2006; 12: 296301.
71Healey, F, Oliver, D, Milne, A, Connelly, J. The effect of bedrails on falls and injury: a systematic review of clinical studies. Age Ageing 2008; 37: 368–78.
72Vellas, B, Conceicao, J, Lafont, C, Fontan, B, Garry, PJ, Adoue, D, Albarede, JL. Malnutrition and falls. Lancet 1990; 336: 1447.
73Gray-Donald, K, Payette, H, Boutier, V. Randomized clinical trial of nutritional supplementation shows little effect on functional status among free-living frail elderly. J Nutr 1995; 125: 2965–71.
74Kenkmann, A, Price, GM, Bolton, J, Hooper, L. Health, wellbeing and nutritional status of older people living in UK care homes: an exploratory evaluation of changes in food and drink provision. BMC Geriatrics 2010; 10: 28.
75Drahota, A, Gal, D, Windsor, J. Flooring as an intervention to reduce injuries from falls in healthcare settings: an overview. Qual Ageing Policy Pract Res 2007; 8: 38.
76Skelton, D, Dinan, S, Campbell, M, Rutherford, O. Tailored group exercise (Falls Management Exercise – FaME) reduces falls in community-dwelling older frequent fallers (an RCT) [letter]. Age Ageing 2005; 34: 636–39.
77Robertson, MC, Devlin, N, Gardner, MM, Campbell, AJ. Effectiveness and economic evaluation of a nurse delivered home exercise programme to prevent falls. 1: Randomised controlled trial. BMJ 2001; 322: 697701.
78Gillespie, LD, Robertson, MC, Gillespie, WJ, Lamb, SE, Gates, S, Cumming, RG, Rowe, BH. Interventions for preventing falls in older people living in the community (Review). Cochrane Database Syst Rev 2009; issue 2.
79Cameron, ID, Murray, GR, Gillespie, LD et al. Interventions for preventing falls in older people in nursing care facilities and hospitals. Cochrane Database Syst Rev 2010; issue 1.
80Sherrington, C, Whitney, JC, Lord, R, Herbert, RD, Cumming, RG, Close, JC. Effective exercise for the prevention of falls JAGS 2008; 56: 2234–43.
81Cameron, ID, Murray, GR, Gillespie, LD, Robertson, MC, Hill, KD, Cumming, RG, Kerse, N. Interventions for preventing falls in older people living in the community (Review). Cochrane Database Syst Rev 2009; issue 2.
82Jenson, J, Lundin-Olsson, L, Nyberg, L, Gustafson, Y. Falls and injury prevention in older people living in residential care facilities. Ann Intern Med 2002; 136: 733–41.
83Ray, WA, Taylor, JA, Meador, KG. A randomized trial of a consultation service to reduce falls in nursing homes. JAMA 1997; 278: 557–62.
84Becker, C, Kron, M, Lindemann, U. Effectiveness of a multifaceted intervention on falls in nursing home residents. J Am Geriatr Soc 2003; 51: 306–13.
85Dyer, CAE, Taylor, GJ, Reed, M, Dyer, CA, Robertson, DR, Harrington, R. Falls prevention in residential care homes: a randomised controlled trial. Age Ageing 2004; 33: 596602.
86Kerse, N, Peri, K, Robinson, E, Wilkinson, T, von Randow, M, Kiata, L, Parsons, J, Latham, N, Parsons, M, Willingale, J, Brown, P, Arroll, B. Does a functional activity programme improve function, quality of life, and falls for residents in long term care? Cluster randomised controlled trial. BMJ 2008; 337: a1445.
87Cusimano, MD, Kwok, J, Spadafora, K. Effectiveness of multifaceted fall-prevention programs for the elderly in residential care. Inj Prev 2008; 14: 113–22.
88Jensen, J, Nyberg, L, Gustafson, Y, Lundin-Olsson, L. Fall and injury prevention in residential care – effects in residents with higher and lower levels of cognition. J Am Geriatr Soc 2003; 51: 627–35.
89Matthews, FE, Denning, T. Prevalence of dementia in institutional care. Lancet 2002; 360: 225–25.
90Neyens, JC, Dijcks, BP, Twisk, J, Schols, JM, van Haastregt, JC, Van Den Heuvel, WJ, de Witte, LP. A multifactorial intervention for the prevention of falls in psychogeriatric nursing home patients, a randomised controlled trial (RCT). Age Ageing 2009; 38: 194–99.
91Kannus, P, Parkkari, J, Niemi, S, Pasanen, M, Palvanen, M, Järvinen, M, Vuori, I. Prevention of hip fracture in elderly people with the use of a hip protector. N Eng J Med 2000; 343: 1506–13.
92O'Halloran, PD, Cran, GW, Beringer, TR, Kernohan, G, O'Neill, C, Orr, J, Dunlop, L, Murray, LJ. A cluster randomised controlled trial to evaluate a policy of making hip protectors available to residents of nursing homes. Age Ageing 2004; 33: 582–88.
93Parker, MJ, Gillespie, WJ, Gillespie, LD. Hip protectors for preventing hip fractures in older people. Cochrane Database Syst Rev 2005; issue 3.
94Sawka, AM, Boulos, P, Beattie, K, Thabane, L, Papaioannou, A, Gafni, A, Cranney, A, Zytaruk, N, Hanley, DA, Adachi, JD. Do hip protectors decrease the risk of hip fracture in institutional- and community-dwelling elderly? A systematic review and meta-analysis of randomized controlled trials. Osteoporos Int 2005; 16: 1461–74.
95Koike, T, Orito, Y, Toyoda, H. External hip protectors are effective for the elderly with higher-than average risk factors for hip fractures. Osteoporosis Int 2009; 20: 1613–20.
96Waldegger, L, Cranney, A, Man-Son-Hing, M, Coyle, D. Cost effectiveness of hip protectors in institutional dwelling elderly. Osteoporos Int 2003; 14: 243–50.
97Koike, T, Orito, Y, Toyoda, H. External hip protectors are effective for the elderly with higher-than average risk factors for hip fractures. Osteoporosis Int 2009; 20: 1613–20.
98Warnke, A, Meyer, G, Bender, R, Muhlhauser, I. Predictors of adherence to the use of hip protectors in nursing home residents. JAGS 2004; 52: 340–45.
99Final Appraisal Determination. Alendronate, etidronate, risedronate, raloxifene and strontium ranelate and parathyroid hormone for the primary prevention of osteoporotic fragility fractures in postmenopausal women. Technology Appraisal Guideline 161. National Institute for Health and Clinical Excellence. October 2008. Available at: http://guidance.nice.org.uk/TA161/Guidance/pdf/English (accessed 12 February 2011).
100Osteoporosis. Clinical Guideline for prevention and treatment. Executive Summary National Osteoporosis Guideline Group 2008. Available at: www.shef.ac.uk/NOGG/downloads.html (accessed 12 February 2011).
101Dawson-Hughes, B, Heaney, RP, Holick, MF, Lips, P, Meunier, PJ, Vieth, R. Estimates of optimal vitamin D status. Osteoporosis Int 2005; 16: 713–16.
102Chapuy, MC, Arlot, ME, Duboeuf, F, Brun, J, Crouzet, B, Arnaud, S, Delmas, PD, Meunier, PJ. Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 1992; 327: 1637–42.
103DIPART (vitamin D Individual Patient Analysis of Randomized Trials) Group. Patient level pooled analysis of 68,500 patients from seven major vitamin D fracture trials in US and Europe. BMJ 2010; 340: b5463.
104Bischoff-Ferrari, HA, Willett, WC, Wong, JB, Giovannucci, E, Dietrich, T, Dawson-Hughes, B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomised controlled trials. JAMA 2005; 293: 2257–64.
105Campbell, GA. Current thoughts on osteoporosis. CME Geriatric Medicine 2009; 11: 5472.
106Parikh, S, Avorn, J, Solomon, DH. Pharmacological management of osteoporosis in nursing homes populations: a systematic review. JAGS 2009; 57: 327–34.
107Boonen, S, McClung, MR, Eastell, R, El-Hajj Fuleihan, G, Barton, IP, Delmas, P. Safety and efficacy of risedronate in reducing fracture risk in osteoporotic women aged 80 and older: Implications for the use of antiresorptive agents in the old and oldest old. JAGS 2004; 52: 1832–39.
108Seeman, E, Vellas, B, Benhamou, C, Aquino, JP, Semler, J, Kaufman, JM, Hoszowski, K, Varela, AR, Fiore, C, Brixen, K, Reginster, JY, Boonen, S. Strontium ranelate reduces the risk of vertebral and non-vertebral fractures in women eighty years of age and older. J Bone Miner Res 2006; 21: 1113–20.
109Greenspan, SL, Schneider, DL, McClung, MR, Miller, PD, Schnitzer, TJ, Bonin, R, Smith, ME, DeLucca, P, Gormley, GJ, Melton, ME. Alendronate improves bone mineral density in elderly women with osteoporosis residing in long-term care facilities: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 2002; 136: 742–46.
110Lyles, KW, Colón-Emeric, CS, Magaziner, JS, Adachi, JD, Pieper, CF, Mautalen, C, Hyldstrup, L, Recknor, C, Nordsletten, L, Moore, KA, Lavecchia, C, Zhang, J, Mesenbrink, P, Hodgson, PK, Abrams, K, Orloff, JJ, Horowitz, Z, Eriksen, EF, Boonen, S; HORIZON Recurrent Fracture Trial. Zolendronic acid and clinical fractures and mortality after hip fracture. N Eng J Med 2007; 357: 1799–809.
111Black, D, Reid, I, Lyles, K et al. Reduction in the risk of clinical fractures after a single dose of zoledronic acid 5 mg. ASBMR Annual Meeting 2010. Presentation 1028.
112Bebbington, A, Darton, R, Netten, A. In Care Homes for Older People: Volume 2: Admissions, Needs and Outcomes. The 1995/96 National Longitudinal Survey of Publicly-Funded Admissions. Personal Social Services Research Unit, University of Kent at Canterbury (ISBN 1–902671-25–2); 2001.
113Cummings, SR, San Martin, J, McClung, MR, Siris, ES, Eastell, R, Reid, IR, Delmas, P, Zoog, HB, Austin, M, Wang, A, Kutilek, S, Adami, S, Zanchetta, J, Libanati, C, Siddhanti, S, Christiansen, C; FREEDOM Trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009; 361: 756–65.
114Ringe, JD, Moller, G. Differences in persistence, safety and efficacy of generic and original branded once weekly bisphosphonates in patients with postmenopausal osteoporosis: 1-year results of a retrospective patient chart review analysis. Rheumatol Int 2009; 30: 213–21.
115Black, DM, Schwartz, AV, Ensrud, KE, Cauley, JA, Levis, S, Quandt, SA, Satterfield, S, Wallace, RB, Bauer, DC, Palermo, L, Wehren, LE, Lombardi, A, Santora, AC, Cummings, SR; FLEX Research Group. Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. JAMA 2006; 296: 2927–38.
116Corley, DA, Kubo, AI, Zhao, W, Quesenberry, C. Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients. Gastroenterology 2010; 139: 93101.
117Habib, ZA, Havstad, SL, Wells, K, Divine, G, Pladevall, M, Williams, LK. Thiazolidinedione use and the longitudinal risk of fractures in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 2010; 95: 592600.
118Care Quality Commission. Prevention and management of falls – older people. Available at: http://www.cqc.org.uk/_db/_documents/20081126_Clinical_Triggers_Falls_198–06_-_On_New_Template.doc (accessed 4 March 2011).
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