Skip to main content

Human ribonuclease P: Subunits, function, and intranuclear localization

    • Published online: 11 January 2002

Catalytic complexes of nuclear ribonuclease P (RNase P) ribonucleoproteins are composed of several protein subunits that appear to have specific roles in enzyme function in tRNA processing. This review describes recent progress made in the characterization of human RNase P, its relationship with the ribosomal RNA processing ribonucleoprotein RNase MRP, and the unexpected evolutionary conservation of its subunits. A new model for the biosynthesis of human RNase P is presented, in which this process is dynamic, transcription-dependent, and implicates functionally distinct nuclear compartments in tRNA biogenesis.

Corresponding author
Reprint requests to: Nayef Jarrous, Department of Molecular Biology, The Hebrew University–Hadassah Medical School, Jerusalem 91120, Israel; e-mail:
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

  • ISSN: 1355-8382
  • EISSN: 1469-9001
  • URL: /core/journals/rna
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Full text views

Total number of HTML views: 0
Total number of PDF views: 2 *
Loading metrics...

Abstract views

Total abstract views: 124 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 18th January 2018. This data will be updated every 24 hours.