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RNA folding at elementary step resolution

  • CHRISTOPH FLAMM (a1), WALTER FONTANA (a2) (a3), IVO L. HOFACKER (a1) and PETER SCHUSTER (a1)
  • Published online: 01 March 2000
Abstract

We study the stochastic folding kinetics of RNA sequences into secondary structures with a new algorithm based on the formation, dissociation, and the shifting of individual base pairs. We discuss folding mechanisms and the correlation between the barrier structure of the conformational landscape and the folding kinetics for a number of examples based on artificial and natural sequences, including the influence of base modification in tRNAs.

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Corresponding author
Reprint requests to: Christoph Flamm, Institut für Theoretische Chemie und Molekulare Strukturbiologie, Währingerstrasse 17, A-1090 Wien, Austria; e-mail: xtof@tbi.univie.ac.at.
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RNA
  • ISSN: 1355-8382
  • EISSN: 1469-9001
  • URL: /core/journals/rna
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