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49, XXXYY Chromosome Anomaly in a Mentally Retarded Man

Published online by Cambridge University Press:  29 January 2018

Valerie A. Cowie ,
K. Rameshwari Singh  and
Richard Wheater
Valerie A. Cowie*
Affiliation:
University of Wales College of Medicine, Ely Hospital, Cardiff
K. Rameshwari Singh
Affiliation:
South Glamorgan Health Authority, Ely Hospital, Cardiff
Richard Wheater
Affiliation:
Regional Genetics Service and Cytogenetics Unit, University Hospital of Wales, Heath Park, Cardiff
*
∗ Correspondence
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Abstract

A case of 49, XXXYY chromosome anomaly in an adult male is reported. Features of Klinefelter's syndrome are predominant among the clinical findings. Characteristics suggestive of acromegaly have been associated with this chromosomal anomaly. Despite prognathism and an overhanging brow, acromegaly was not present in this case. Psychological traits sometimes reported in males with the XXY and XYY karyotypes were seen in this patient, but the variability of expression of these characteristics calls into question the validity of their correlation with the presence of supernumerary sex chromosomes.

Information

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 148 , Issue 2 , February 1986 , pp. 210 - 212
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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References

Bray, P. & Josephine, A. (1963) An XXXYY sex chromosome anomaly. Report of a mentally deficient male. Journal of American Medical Association, 184, 179–182.Google Scholar
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Slater, E. & Cowie, V. (1971) The Genetics of Mental Disorder. Oxford: Oxford University Press.Google Scholar
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