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Asperger syndrome and high-functioning autism

Published online by Cambridge University Press:  02 January 2018

Christopher Gillberg*
Affiliation:
Department of Child and Adolescent Psychiatry, Annedals Clinics, S-413 45 Göteburg, Sweden, Fax: +46 31 415545

Extract

This paper reviews the history of Asperger syndrome (AS) and high-functioning autism (HFA), current diagnostic concepts and criteria, some controversial diagnostic issues, epidemiology, background factors, outcome, and intervention guidelines.

Type
Review Articles
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

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References

Ahlsén, G., Rosengren, L., Belfrage, M., et al (1993) Glial fibrillary acidic protein in the cerebrospinal fluid of children with autism and other neuropsychiatric disorders. Biological Psychiatry, 33, 734743.Google Scholar
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn. Revised) (DSM–III–R). Washington. DC: APA.Google Scholar
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). Washington. DC: APA.Google Scholar
Annerén, G., Dahl, N. & Uddenfelt, U. (1995) Asperger syndrome in a boy with a balanced de novo translocation: t(17: 19) (p13.3; p11). American Journal of Medical Genetics, 56. 18.CrossRefGoogle Scholar
Asperger, H. (1944) Die autistischen Psychopathen im Kindesalter. Archiv für Psychiatrie und Nervenkrankheiten, 117, 76136.Google Scholar
Asperger, H. (1950) Bild and soziale Wertigkeit der autistischen Psychopathen. In Proceedings of the Second International Congress on Orthopedagogics. Keesing. Amsterdam: Publ. Systemen.Google Scholar
Asperger, H. (1952) Heilpädagogik, Berlin: Springer.CrossRefGoogle Scholar
Asperger, H. (1961) Heilpaedogogik (3rd edn). Vienna: Springer.CrossRefGoogle Scholar
Asperger, H. (1979) Problems of infantile autism. Communication, 13, 4552.Google Scholar
Baron-Cohen, S. (1995) Mind Blindness. An Essay on Autism and Theory of Mind. Cambridge, MA: MIT Press.Google Scholar
Baron-Cohen, , Leslie, A. M. & Frith, U. (1985) Does the autistic child have a theory of mind? Cognition, 21, 3746.Google Scholar
Beier, H. (1993) Autistiska syndrom. En angelägenhet även inom vuxenpsykiatrin. Läkartidningen, 90. 45604564.Google Scholar
Berthier, M. L., Santamaria, J., Encabo, H., et al (1992) Case study: Recurrent hypersomnia in two adolescent males with Asperger's syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 31. 735738.CrossRefGoogle ScholarPubMed
Berthier, M. L., Bayes, A. A. Tolosa, E. S. (1993) Magnetic resonance imaging in patients with concurrent Tourette's disorder and Asperger's syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 633639.CrossRefGoogle ScholarPubMed
Bishop, D. V. M. (1989) Autism, Asperger's syndrome and semantic – pragmatic disorders. Where are the boundaries? British Journal of Disorders of Communication, 24, 107121.Google Scholar
Bolton, P. & Rutter, M. (1990) Genetic influences in autism. International Review of Psychiatry, 2, 6780.CrossRefGoogle Scholar
Bolton, P., Macdoncald, H., Pickles, A., et al (1994) A case control family history study of autism. Journal of Child Psychology and Psychiatry, 35, 877900.CrossRefGoogle ScholarPubMed
Bowler, D. M. (1992) ‘Theory of mind’ in Asperger's Syndrome. Journal of Child Psychology and Psychiatry, 33, 877893.Google Scholar
Bolton, P. & Worley, K. (1994) Susceptibility to social influence in adults with Asperger's syndrome: a research note. Journal of Child Psychology and Psychiatry, 35, 689697.Google Scholar
Bowman, E. P. (1988) Asperger's syndrome and autism: the case for a connection. British Journal of Psychiatry, 152. 377382.CrossRefGoogle ScholarPubMed
Burgoine, E. & Wing, L. (1983) Identical triplets with Asperger's syndrome. British Journal of Psychiatry, 143, 261265.Google Scholar
Caron, C. & Rutter, M. (1991) Comorbidity in child psychopathology: concepts, issues and research strategies. Journal of Child Psychology and Psychiatry, 32, 10631080.Google Scholar
Chiron, C., Leboyer, M., Leon, F., et al (1995) SPECT of the brain in childhood autism: evidence for a lack of normal hemispheric asymmetry. Developmental Medicine and Child Neurology, 37, 849860.CrossRefGoogle ScholarPubMed
Dauner, I. & Martin, M. (1978) Autismus Asperger oder Früschizophrenie? Zur nosologischen Abgrenzung beider Krankheitsbilder. Paeditrishe Paedologie, 13. 3138.Google Scholar
Davies, S., Bishop, D., Manstead, A. S., et al (1994) Face perception in children with autism and Asperger's syndrome. Journal of Child Psychology and Psychiatry, 35. 10331057.Google Scholar
De Long, G. R. & Dwyer, J. T. (1988) Correlation of family history with specific autistic subgroups: Asperger's syndrome and bipolar affective disease. Journal of Autism and Developmental Disorders, 18, 593600.Google Scholar
De Long, G. R. & Nohria, C. (1994) Psychiatric family history and neurological disease in autism spectrum disorders. Developmental Medicine and Child Neurology, 36. 441448.Google Scholar
DeMyer, M., Hingtgen, J. M. & Jackson, R. K. (1981) Infantile autism reviewed: A decade of research. Schizophrenic Bulletin, 7, 388451.Google Scholar
Eaves, L. C., Ho, H. H. & Eaves, D. M. (1994) Subtypes of autism by cluster analysis. Journal of Autism and Developmental Disorders, 24. 322.Google Scholar
Ehlers, S. & Gillberg, C. (1993) The epidemiology of Asperger syndrome. A total population study. Journal of Child Psychology and Psychiatry, 34, 13271350.CrossRefGoogle ScholarPubMed
Ehlers, S., Nydén, A., Gillberg, C, et al (1996) Asperger syndrome, autism and attention disorders: A comparative study of cognitive profile of 120 children. Journal of Child Psychology and Psychiatry, 38. 207217.CrossRefGoogle Scholar
Ellis, H. D., Ellis, D. M., Fraser, W., et al (1994) A preliminary study of right hemisphere cognitive deficits and impaired social judgements among young people with Asperger syndrome. European Child & Adolescent Psychiatry, 3, 255266.Google Scholar
Fine, J., Bartolucci, G., Ginsberg, G., et al (1991) The use of intonation to communicate in pervasive developmental disorders. Journal of Child Psychology and Psychiatry, 5, 771782.Google Scholar
Folstein, S. E. & Piven, J. (1991) Etiology of autism: genetic influences. Pediatrics, 87, 767773.Google Scholar
Frith, U. (1989) Autism and ‘theory of mind’. In Diagnosis and Treatment of Autism (ed. Gillberg, C.), pp. 3352. New York: Plenum Press.Google Scholar
Frith, U. (1991) Autism and Asperger Syndrome. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Ghaziuddin, M., Tasi, L. Y. & Ghaziuddin, N. (1992) Brief report: A reappraisal of clumsiness as a diagnostic feature of Asperger syndrome. Journal of Autism and Developmental Disorders, 22, 651656.Google Scholar
Ghaziuddin, N., Metler, L., Ghaziuddin, M., et al (1993) Three siblings with Asperger syndrome: a family case history. European Child & Adolescent Psychiatry, 2, 4449.Google Scholar
Gillberg, C. (1983) Psychotic behaviour in children and young adults in a mental handicap hostel. Acta Psychiatrica Scandinavica, 68, 351358.Google Scholar
Gillberg, C. (1985) Asperger's syndrome and recurrent psychosis –a case study. Journal of Autism and Developmental Disorders, 15, 389397.Google Scholar
Gillberg, C. (1988) Autism. Stockholm: Natur och Kultur. Gillberg, C. (1989) Asperger syndrome in 23 Swedish children. Developmental Medicine and Child Neurology, 31, 520531.Google Scholar
Gillberg, C. (1991) Clinical and neurobiological aspects of Asperger syndrome in six family studies. In Autism and Asperger Syndrome (ed. Frith, U.), pp. 122146. Cambridge: Cambridge University Press.Google Scholar
Gillberg, C. (1992) The Emanuel Miller Memorial Lecture 1991: Autism and autistic-like conditions: subclasses among disorders of empathy. Journal of Child Psychology and Psychiatry, 33, 813842.Google Scholar
Gillberg, C. (1995) The prevalence of autism and autism spectrum disorders. In The Epidemiology of Child and Adolescent Psychopathology (ed. Verhulst, F. C. & Koot, H. M.), pp. 227257. Oxford: Oxford University Press.Google Scholar
Gillberg, C. & Schau mann, H. (1982) Social class and infantile autism. Journal of Autism and Developmental Disorders, 12, 223228.CrossRefGoogle ScholarPubMed
Gillberg, C. & Forsell, C. (1984) Childhood psychosis and neurofibromatosis – more than a coincidence? Journal of Autism and Developmental Disorders, 14, 18.Google Scholar
Gillberg, C. & Coleman, M. (1992) The Biology of the Autistic Syndromes. Clinics in Developmental Medicine No 126. London: MacKeith Press.Google Scholar
Gillberg, C., Steffenburg, S. & Jakobsson, G. (1987) Neurobiological findings in 20 relatively gifted children with Kanner-type autism or Asperger syndrome. Developmental Medicine and Child Neurology, 29, 641649.CrossRefGoogle ScholarPubMed
Gillberg, C., Steffenburg, S. & Schaumann, H. (1991) Is autism more common now than 10 years ago? British Journal of Psychiatry, 158, 403409.CrossRefGoogle ScholarPubMed
Gillberg, I. C. & Gillberg, C. (1989) Asperger syndrome – some epidemiological considerations: a research note. Journal of Child Psychology and Psychiatry, 30, 631638.Google Scholar
Gillberg, I. C., Bjure, J., Uvebrant, P., et al (1993) SPECT (single photon emission computed tomography) in 31 children and adolescents with autism and autistic-like conditions. European Child & Adolescent Psychiatry, 2, 5059.Google Scholar
Gillberg, I. C., Råstam, M. & Gillberg, C. (1994a) Anorexia nervosa outcome: six year controlled longitudinal study of 51 cases including a population cohort. Journal of the American Academy of Child and Adolescent Psychiatry, 33, 729739.Google Scholar
Gillberg, I. C., Gillberg, C. & Ahlsén, G. (1994b) Autistic behaviour and attention deficits in tuberous sclerosis. A population-based study. Developmental Medicine and Child Neurology, 36, 5056.Google Scholar
Gordon, C. T., State, R. C., Nelson, J. E., et al (1993) A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. Archives of General Psychiatry, 50, 441447.Google Scholar
Gordon, C. T., Frazier, J. A., McKenna, K., et al (1994) Childhood onset schizophrenia: an NIMH study in progress. Schizophrenia Bulletin, 20, 697712.Google Scholar
Gray, C. (1996) The social story kit. Journal of Autism and Developmental Disorders, in press.Google Scholar
Hagerman, R. J. (1989) Chromosomes, genes and autism. In Diagnoses and Treatment of Autism (ed. Gillberg, C.), pp. 105132. New York: Plenum Press.Google Scholar
Happé, F. G. E. (1994) Current psychological theories of autism: the ‘theory of mind’ account and rival theories. Journal of Child Psychology and Psychiatry, 35, 215229.CrossRefGoogle ScholarPubMed
Happé, F. G. E., Ehlers, S., Frackowiak, R. S. J., et al (1996) ‘Theory of mind’ in the brain. Evidence from a PET scan study of Asperger syndrome. Neuroreport, 8, 197201.Google Scholar
Hart, H., Bax, M. & Jenkins, S. (1978) The value of a developmental history. Developmental Medicine and Child Neurology, 20, 442452.CrossRefGoogle ScholarPubMed
Hellgren, L., Gillberg, C. & Gillberg, I. C. (1994) Children with deficits in attention, motor control and perception (DAMP) almost grown up: the contribution of various background factors to outcome at age 16 years. European Child & Adolescent Psychiatry, 3, 115.Google Scholar
Hermelin, B. & O'Connor, N. (1970) Psychological Experiments with Autistic Children. Oxford: Pergamon Press.Google Scholar
Heroki, S., Frackowiak, R. S. J., Le Couteur, A., et al (1988) Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults. Psychological Medicine, 18, 823831.Google Scholar
Hewett, E., Newson, E. & Newson, J. (1970) The Family and the Handicapped Child. London: Allen & Unwin.Google Scholar
Horwitz, B., Rumsey, J. M., Grady, C. L., et al (1988) The cerebral metabolic landscape in autism. Intercorrelations of regional glucose utilization. Archives of Neurology, 45, 749755.CrossRefGoogle ScholarPubMed
Hurlburt, R. T., Happé, F. & Frith, U. (1994) Sampling the form of inner experience in three adults with asperger syndrome. Psychological Medicine, 24, 385395.CrossRefGoogle ScholarPubMed
Kanner, L. (1943) Autistic disturbances of affective contact. Nervous Child, 2, 217250.Google Scholar
Kanner, L. (1954) To what extent is early childhood autism determined by constitutional inadequacies? Proceedings of the Association for Research in Nervous and Mental Diseases, 33, 378385.Google Scholar
Klin, A. (1993) Listening preferences in regard to speech in four children with developmental disabilities. Journal of Child Psychology and Psychiatry, 33, 763769.Google Scholar
Kopp, S. & Gillberg, C. (1996) Selective mutism. A population-based study. Journal of Child Psychology and Psychiatry, 38, 257262.Google Scholar
Kracke, I. (1994) Developmental prosopagnosia in Asperger syndrome: presentation and discussion of an individual case. Developmental Medicine and Child Neurology, 36, 873886.Google Scholar
Kretschmer, E. (1924) Körperbau und Character . Translated into English (1925) as Physique and Character. London: Kegan Paul, Trench and Trubner.Google Scholar
Landa, R., Piven, J., Wzorek, M. M., et al (1992) Social language in parents of autistic individuals. Psychological Medicine, 22, 245254.Google Scholar
Lewis, V. & Boucher, J. (1995) Generativity in the play of young people with autism. Journal of Autism and Developmental Disorders, 25, 105121.Google Scholar
Lister-Brook, S. A. Bowler, D. M. (1992) Autism by another name? Semantic and pragmatic impairments in children. Journal of Autism Developmental Disorders, 22, 6181.Google Scholar
Lockyer, L. & Rutter, M. (1970) A five to fifteen year follow-up study of infantile psychosis. IV: Patterns of cognitive ability British Journal of Social and Cognitive Ability, 9, 152163.Google Scholar
ManJivlona, J. & Prior, M. (1995) Comparison of Asperger syndrome and high-functioning autistic children on a test of motor impairment. Journal of Autism and Developmental Disorders, 25, 2339.Google Scholar
Marriage, K. J., Gordon, V. & Brand, L. (1995) A social skills group for boys with Asperger's syndrome. Australian & New Zealand Journal of Psychiatry, 29, 5862.Google Scholar
McEvoy, R. E., Roger, S. J. & Pennington, B. F. (1993) Executive function and social communication deficits in young autistic children. Journal of Child Psychology and Psychiatry, 34, 563578.Google Scholar
Mesibov, G. (1984) Social skills training with verbal autistic adolescents and adults: A program model. Journal of Autism and Developmental Disorders, 14, 395404.Google Scholar
Miller, J. N. & Ozonoff, S. (1997) Did Asperger's cases have Asperger disorders? A research note. Journal of Child Psychology and Psychiatry, 38, 247251.Google Scholar
Ozonoff, S. & Miller, J. N. (1995) Teaching theory of mind: A new approach to social skills training for individuals with autism. Journal of Autism and Developmental Disorders, 25, 415433.Google Scholar
Ozonoff, S., Rogers, S. J. & Pennington, B. F. (1991) Asperger's syndrome: evidence of an empirical distinction from high-functioning autism. Journal of Child Psychology and Psychiatry, 32, 11071122.Google Scholar
Ozonoff, S., Farham, J. M., et al (1994) Can standard measures identify subclinical markers of autism? Journal of Autism and Developmental Disorders, 23, 429441.CrossRefGoogle Scholar
Piven, J., Nehme, E., Simon, J., et al (1992) Magnetic resonance imaging in autism: measurement of the cerebellum. Biological Psychiatry, 31, 491504.Google Scholar
Prior, M., Dahlstrom, B. & Squires, T.-L. (1990) Autistic children's knowledge of thinking and feeling states in other people. Journal of Child Psychology and Psychiatry, 31, 587601.Google Scholar
Ramberg, C., Ehlers, S., Nydén, A., et al (1996) Language and pragmatic functions in school-age children on the autism spectrum. European Journal of Disorders of Communication, 31, 387414.Google Scholar
Rickarby, G., Carruthers, A. & Mitchell, M. (1991) Brief report: Biological factors associated with Asperger syndrome. Journal of Autism and Developmental Disorders, 21, 341348.CrossRefGoogle ScholarPubMed
Rourke, B. P. (1988) The syndrome of non-verbal learning disabled children: Developmental manifestations of neurological disease. Clinical Neuropsychologist, 2, 293330.Google Scholar
Rumsey, J. M. (1985) Conceptual problem-solving in highly verbal, nonretarded, autistic men. Journal of Autism and Developmental Disorders, 15, 2336.Google Scholar
Rumsey, J. M. & Hamburger, S. D. (1988) Neuropsychological findings in high-functioning men with infantile autism, residual state. Journal of Clinical and Experimental Neuropsychology, 10, 201221.Google Scholar
Rumsey, J. M., Rapoport, J. L. & Sceery, W. R. (1985) Autistic children as adults: psychiatric and behavioral outcomes. Journal of The American Academy of Child Psychiatry, 24, 465473.Google Scholar
Rutter, M. (1985) The treatment of autistic children. Journal of Child Psychology and Psychiatry, 28, 193214.Google Scholar
Råstam, M., Gillberg, C. & Garton, M. (1989) Anorexia nervosa in a Swedish urban region. A population-based study. British Journal of Psychiatry, 155. 642646.Google Scholar
Sacks, O. (1995) An Anthropologist on Mars. New York: Knopf.Google Scholar
Schooler, E., Andrew, C. E. & Strupp, K. (1979) Do autistic children come from upper-class parents? Journal of Autism and Developmental Disorders, 9. 139152.Google Scholar
Schooler, E., Reichler, R. J. & Renner, B. R. (1988) The Children Autism Rating Scale (CARS). Los Angeles, CA: Western Psychological Services.Google Scholar
Scragg, P. & Shah, A. (1994) Prevalence of Asperger's syndrome in a secure hospital. British Journal of Psychiatry, 165, 679682.Google Scholar
Shea, V. & Mesibov, G. B. (1985) Brief report: The relationship of learning disabilities and higher-level autism. Journal of Autism and Developmental Disorders, 15, 425435.Google Scholar
Sparrow, S. S., Rescorla, L. A., Provence, S., et al (1986) Follow-up of “atypical” children–a brief report. Journal of the American Academy of Child and Adolescent Psychiatry, 25, 181185.Google Scholar
Ssucharewa, G. E. (1926) Die schizoiden Psychopathien im Kindesalter. Monatsschrift für Psychiatrie und Neurologie, 60, 235261.Google Scholar
Strayhorn, J. (1989) More on methylphenidate in autism (letter). Journal of the American Academy of Child and Adolescent Psychiatry, 28, 299.Google Scholar
Szatmari, P., Bartolucci, G. & Brenner, R. (1989) Asperger's syndrome and autism: comparisons on early history and outcome. Developmental Medicine and Child Neurology, 31, 709720.Google Scholar
Szatmari, P., Offord, D. R., Siegel, L. S., et al (1990) The clinical significance of neurocognitive impairments among children with psychiatric disorders: diagnosis and situational specificity. Journal of Child Psychology and Psychiatry, 33. 287299.Google Scholar
Tantam, D. (1991) Asperger's syndrome in adulthood. In Autism and Asperger syndrome (ed. Frith, U.), pp. 147183. Cambridge: Cambridge University Press.Google Scholar
Tantam, D., Evered, C. & Hersov, L. (1990) Asperger's syndrome and ligamentus laxity. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 892896.CrossRefGoogle Scholar
Tantam, D., Holmes, D. & Condess, C. (1993) Nonverbal expression in autism of Asperger type. Journal of Autism and Developmental Disorder, 23, 111133.Google Scholar
Twachtman, D. (1998) Social and communication needs in Asperger syndrome: variations on the theme of autism. Journal of Autism and Developmental Disorders, in press.Google Scholar
Van Kreveien, D. A. (1971) Early infantile autism and autistic psychopathy. Journal of Autism and Childhood Schizophrenia, 1, 8286.Google Scholar
Van Kreveien, D. A. & Kuipers, C. (1962) The psychopathology of autistic psychopathy. Acta Paedopsychiatrica, 29, 2231.Google Scholar
Williamson, D. A. & Bolton, P. (1995) Brief report: Atypical autism and tuberous sclerosis in a sibling pair. Journal of Autism and Developmental Disorders, 25, 435442.Google Scholar
Wing, L. (1980) Childhood autism and social class: A question of selection. British Journal of Psychiatry, 137, 410417.CrossRefGoogle ScholarPubMed
Wing, L. (1981a) Asperger's syndrome: a clinical account. Psychological Medicine, 11, 115129.Google Scholar
Wing, L. (1981b) Sex ratios in early childhood autism and related conditions. Psychiatry Research, 5, 129137.Google Scholar
Wing, L. (1993) The definition and prevalence of autism: A review. European Child & Adolescent Psychiatry, 2. 6174.Google Scholar
Wing, L. (1996) Autism spectrum disorders. British Medical Journal, 312, 327328.Google Scholar
Wing, L. A. Gould, J. (1979) Severe impairments of social interaction and associated abnormalities in children: epidemiology and classification. Journal of Autism and Developmental Disorders, 9, 1129.Google Scholar
Wolff, S. (1991a) ‘Schizoid’ personality in childhood and adult life. I: The vagaries of diagnostic labelling. British Journal of Psychiatry, 159, 615620.Google Scholar
Wolff, S. (1991b) ‘Schizoid’ personality in childhood and adult life. Ill: The childhood picture. British Journal of Psychiatry, 159, 629635.Google Scholar
Wolff, S. (1995) Loners London: Routledge.Google Scholar
Wolff, S. (1996) The first account of the syndrome Asperger described? European Child and Adolescent Psychiatry, 5, 119132.Google Scholar
Wolff, S. & Chick, J. (1980) Schizoid personality in childhood: A controlled follow-up study. Psychological Medicine, 10, 85100.Google Scholar
Wolff, S. 7 McGuire, R. J. (1995) Schizoid personality in girls: a follow-up study – what are the links with Asperger's syndrome? Journal of Child Psychology and Psychiatry, 36, 793817.CrossRefGoogle ScholarPubMed
Wolff, S., Townsend, R., McGuire, R. J., et al (1991) ‘Schizoid’ personality in childhood and adult life. II: Adult adjustment and the continuity with schizotypal personality disorder. British Journal of Psychiatry, 159, 620629.Google Scholar
World Health Organization (1992) The ICD-10 Classification of Mental and Behavioural Disorders. Clinical Descriptions and Guidelines. Geneva: WHO.Google Scholar
World Health Organization (1993) The ICD-10 Classification of Mental and Behavioural Disorders. Diagnostic Criteria for Research. Geneva: WHO.Google Scholar
Wurst, F. (1974) Lernstörungen aus der Sicht des Arztes – Learning disorders from the medical point of view. Padiatrie und Podologie, 9, 329335.Google Scholar
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