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Further Investigation of the Predictors of Outcome Following First Schizophrenic Episodes

Published online by Cambridge University Press:  02 January 2018

Eve C. Johnstone*
Northwick Park Hospital and Clinical Research Centre, Watford Road, Harrow, Middlesex, HA1 3UJ, University Department of Psychiatry, The Kennedy Tower, Royal Edinburgh Hospital, Edinburgh EH10 5HF
J. Fiona Macmillan
University of Birmingham (Northwick Park Hospital and Clinical Research Centre)
Christopher D. Frith
Northwick Park Hospital and Clinical Research Centre
Desmond K. Benn
Northwick Park Hospital and Clinical Research Centre, Northern Regional Health Authority
Timothy J. Crow
Northwick Park Hospital and Clinical Research Centre


The outcome at two years of patients who were eligible for a study of first schizophrenic episodes was assessed in terms of occupation (n = 237) and in terms of number of days spent as an in-patient from the time of first admission (n = 252), and was related to social, behavioural, mental state and neurological measures during the initial admission. Poor outcome was in general associated with more social withdrawal, inactivity and abnormal social presentation and with more ‘neurological soft signs'. Good occupational outcome in patients with a relatively short pre-treatment duration of illness was associated with the prescription of placebo medication during the follow-up period.

Copyright © Royal College of Psychiatrists, 1990 

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