Hostname: page-component-cb9f654ff-hn9fh Total loading time: 0 Render date: 2025-08-07T02:08:18.537Z Has data issue: false hasContentIssue false
  • English
  • Français

Induction of Mania with Selective Serotonin Re-uptake Inhibitors and Tricyclic Antidepressants

Published online by Cambridge University Press:  02 January 2018

Malcolm Peet
Malcolm Peet*
Affiliation:
Department of Psychiatry, Northern General Hospital, Herries Road, Sheffield S5 7AU
Get access Rights & Permissions [Opens in a new window]

Abstract

The rate of treatment-emergent switch into mania has been calculated from all available clinical trial data on the selective serotonin re-uptake inhibitors (SSRIs) fluoxetine, fluvoxamine, paroxetine, and sertraline, relative to comparative groups treated with tricyclic antidepressants (TCAs) or placebo. In predominantly unipolar depressives, the rate of manic switch is less than 1% and differences between drugs and placebo are statistically but not clinically significant. In bipolar depressives, manic switch occurs substantially more often with TCAs (11.2%) than with SSRIs (3.7%) or placebo (4.2%).

Information

Type
Short Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 4 , April 1994 , pp. 549 - 550
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Ball, J. R. B. & Kiloh, L. G. (1959) A controlled trial of imipramine in treatment of depressive states. British Medical Journal, ii, 1052–1055.Google Scholar
Bunney, W. E. (1978) Psychopharmacology of the switch process in affective illness. In Psychopharmacology: a Generation of Progress (eds Lipton, M. A. & Kellam, K. F.), pp. 1249–1259. New York: Raven Press.Google Scholar
Henry, E. W., Chandler, L. P. & Rasmussen, J. G. C. (1992) Assessment of manic reactions during treatment with the SSRI sertraline. Does this afford patient benefit? (Abstract). Clinical Neuropsychopharmacology, 15 (suppl. 1), 317B.Google Scholar
Hon, D. & Preskorn, S. H. (1989) Mania during fluoxetine treatment for recurrent depression. American Journal of Psychiatry, 146, 1638–1639.Google Scholar
Lebuegue, B. (1987) Mania precipitated by fluoxetine. American Journal of Psychiatry, 144, 1620.Google Scholar
Lewis, J. L. & Winokur, G. (1982) The induction of mania: a natural history study with controls. Archives of General Psychiatry, 39, 303–306.CrossRefGoogle Scholar
Nakra, B. R. S., Szwabo, P. & Grossberg, G. T. (1989) Mania induced by fluoxetine. American Journal of Psychiatry, 146, 1515–1516.Google Scholar
Settle, E. C. & Settle, G. P. (1984) A case of mania associated with fluoxetine. American Journal of Psychiatry, 141, 280–281.Google ScholarPubMed
Wehr, T. A. & Goodwin, F. K. (1979) Rapid cycling between mania and depression caused by maintenance tricyclics. Psychopharmacology Bulletin, 15, 17–19.Google Scholar
Wehr, T. A. & Goodwin, F. K. (1987) Can antidepressants cause mania and worsen the course of affective illness? American Journal of Psychiatry, 144, 1403–1411.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.