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Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders

  • Tatiana Oviedo-Salcedo (a1), Lot de Witte (a2), Tania Kümpfel (a3), René S. Kahn (a2), Peter Falkai (a4), Peter Eichhorn (a5), Jurjen Luykx (a6) and Alkomiet Hasan (a4)...

Antibody-mediated encephalitis has been discussed as one possible cause for isolated psychotic syndromes. Mostly based on serum samples, findings have been controversial. We present the results of a retrospective study of 124 clinically diagnosed psychotic patients without documented relevant neurological symptoms. All were tested for different antineuronal antibodies in cerebrospinal fluid (CSF) while 81 received serum testing. Antineuronal antibodies in CSF were negative across the sample. 3.7% showed low positive serum antibodies. Our findings highlight the importance of a deeper discussion about the relevance of low positive serum antibodies without concurrent findings in CSF or clinical signs for autoimmune encephalitis.

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Correspondence: Tatiana Oviedo-Salcedo, Department of Psychiatry and Psychotherapy, Klinikum der Universität München, Ludwig Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany. Email:
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders

  • Tatiana Oviedo-Salcedo (a1), Lot de Witte (a2), Tania Kümpfel (a3), René S. Kahn (a2), Peter Falkai (a4), Peter Eichhorn (a5), Jurjen Luykx (a6) and Alkomiet Hasan (a4)...
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