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Caldani, Simona Amado, Isabelle Bendjemaa, Narjes Vialatte, François Mam-Lam-Fook, Célia Gaillard, Raphael Krebs, Marie-Odile and Pia Bucci, Maria 2017. Oculomotricity and Neurological Soft Signs: Can we refine the endophenotype? A study in subjects belonging to the spectrum of schizophrenia. Psychiatry Research, Vol. 256, p. 490.
Sugranyes, Gisela de la Serna, Elena Borras, Roger Sanchez-Gistau, Vanessa Pariente, Jose C Romero, Soledad Baeza, Inmaculada Díaz-Caneja, Covadonga M Rodriguez-Toscano, Elisa Moreno, Carmen Bernardo, Miguel Moreno, Dolores Vieta, Eduard and Castro-Fornieles, Josefina 2017. Clinical, Cognitive, and Neuroimaging Evidence of a Neurodevelopmental Continuum in Offspring of Probands With Schizophrenia and Bipolar Disorder. Schizophrenia Bulletin, Vol. 43, Issue. 6, p. 1208.
Kariuki, Maina Raudino, Alessandra Green, Melissa J Laurens, Kristin R Dean, Kimberlie Brinkman, Sally A Lenroot, Rhoshel K Liu, Enwu Harris, Felicity Luo, Luming and Carr, Vaughan J 2016. Hospital admission for infection during early childhood influences developmental vulnerabilities at age 5 years. Journal of Paediatrics and Child Health, Vol. 52, Issue. 9, p. 882.
Hirjak, Dusan Wolf, Robert C. Kubera, Katharina M. Stieltjes, Bram and Thomann, Philipp A. 2016. Multiparametric mapping of neurological soft signs in healthy adults. Brain Structure and Function, Vol. 221, Issue. 3, p. 1209.
Burton, Birgitte Klee Hjorthøj, Carsten Jepsen, Jens Richardt Thorup, Anne Nordentoft, Merete and Plessen, Kerstin J. 2016. Research Review: Do motor deficits during development represent an endophenotype for schizophrenia? A meta-analysis. Journal of Child Psychology and Psychiatry, Vol. 57, Issue. 4, p. 446.
Huber, Maria Pletzer, Belinda Giourgas, Alexandros Nickisch, Andreas Kunze, Silke and Illg, Angelika 2015. Schooling Relates to Mental Health Problems in Adolescents with Cochlear Implants—Mediation by Hearing and Family Variables. Frontiers in Psychology, Vol. 6,
Thomann, Philipp A. Hirjak, Dusan Kubera, Katharina M. Stieltjes, Bram and Wolf, Robert C. 2015. Neural network activity and neurological soft signs in healthy adults. Behavioural Brain Research, Vol. 278, p. 514.
Cox, David Chan, Man K. and Bahn, Sabine 2015. The Potential of Immune Biomarkers to Advance Personalized Medicine Approaches for Schizophrenia. The Journal of Nervous and Mental Disease, Vol. 203, Issue. 5, p. 393.
Chin-Lun Hung, Galen Hahn, Jill Alamiri, Bibi Buka, Stephen L Goldstein, Jill M Laird, Nan Nelson, Charles A Smoller, Jordan W and Gilman, Stephen E 2015. Socioeconomic disadvantage and neural development from infancy through early childhood. International Journal of Epidemiology, Vol. 44, Issue. 6, p. 1889.
Laurens, Kristin R. Luo, Luming Matheson, Sandra L. Carr, Vaughan J. Raudino, Alessandra Harris, Felicity and Green, Melissa J. 2015. Common or distinct pathways to psychosis? A systematic review of evidence from prospective studies for developmental risk factors and antecedents of the schizophrenia spectrum disorders and affective psychoses. BMC Psychiatry, Vol. 15, Issue. 1,
Schiffman, Jason Mittal, Vijay Kline, Emily Mortensen, Erik L. Michelsen, Niels Ekstrøm, Morten Millman, Zachary B. Mednick, Sarnoff A. and Sørensen, Holger J. 2015. Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder. Development and Psychopathology, Vol. 27, Issue. 4pt1, p. 1323.
Ibi, Daisuke and Yamada, Kiyofumi 2015. Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation. International Journal of Molecular Sciences, Vol. 16, Issue. 12, p. 28218.
Debnath, Monojit Venkatasubramanian, Ganesan and Berk, Michael 2015. Fetal programming of schizophrenia: Select mechanisms. Neuroscience & Biobehavioral Reviews, Vol. 49, p. 90.
Mufaddel, Amir Omer, Abdelaziz A. and Salem, Mohamed Omar 2014. Psychiatric Aspects of Infectious Diseases. Open Journal of Psychiatry, Vol. 04, Issue. 03, p. 202.
Madsen, Gitte Falcher Bilenberg, Niels Cantio, Cathriona and Oranje, Bob 2014. Increased Prepulse Inhibition and Sensitization of the Startle Reflex in Autistic Children. Autism Research, Vol. 7, Issue. 1, p. 94.
Hida, Hirotake Mouri, Akihiro Ando, Yu Mori, Kentaro Mamiya, Takayoshi Iwamoto, Kunihiro Ozaki, Norio Yamada, Kiyofumi Nabeshima, Toshitaka and Noda, Yukihiro 2014. Combination of neonatal PolyI:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice. Behavioural Brain Research, Vol. 258, p. 34.
Hirjak, Dusan Wolf, Robert Christian Koch, Sabine C. Mehl, Laura Kelbel, Janna K. Kubera, Katharina Maria Traeger, Tanja Fuchs, Thomas and Thomann, Philipp Arthur 2014. Neurological Abnormalities in Recent-Onset Schizophrenia and Asperger-Syndrome. Frontiers in Psychiatry, Vol. 5,
Nielsen, Philip R. Benros, Michael. E. and Mortensen, Preben B. 2014. Hospital Contacts With Infection and Risk of Schizophrenia: A Population-Based Cohort Study With Linkage of Danish National Registers. Schizophrenia Bulletin, Vol. 40, Issue. 6, p. 1526.
Mittal, V. A. Dean, D. J. Bernard, J. A. Orr, J. M. Pelletier-Baldelli, A. Carol, E. E. Gupta, T. Turner, J. Leopold, D. R. Robustelli, B. L. and Millman, Z. B. 2014. Neurological Soft Signs Predict Abnormal Cerebellar-Thalamic Tract Development and Negative Symptoms in Adolescents at High Risk for Psychosis: A Longitudinal Perspective. Schizophrenia Bulletin, Vol. 40, Issue. 6, p. 1204.
Tamagni, Corinne Studerus, Erich Gschwandtner, Ute Aston, Jacqueline Borgwardt, Stefan and Riecher-Rössler, Anita 2013. Are neurological soft signs pre-existing markers in individuals with an at-risk mental state for psychosis?. Psychiatry Research, Vol. 210, Issue. 2, p. 427.
Neurological soft signs preceding adult-onset schizophrenia suggest a neurodevelopmental origin and could reflect physical illness in childhood.
To investigate possible associations of adult-onset psychosis with neurological soft signs and common infectious illnesses in childhood.
Using data from the UK National Child Development Study, a longitudinal general population sample, odds ratios were calculated for clinical diagnoses of common childhood viral illnesses and later adult psychotic illness, childhood epilepsy and a range of neurological soft signs.
The number of illnesses per individual did not relate either to the number of soft signs, or to any particular adult outcome. Schizophrenia, affective psychosis and epilepsy were not associated with common childhood illness but were associated with neurological soft signs and an increased, but small, frequency of previous meningitis and tuberculosis.
Overall the data support the notion of neurological soft signs as markers of disordered neurodevelopment in schizophrenia (but the early neurological abnormalities are not caused by infectious illness) and an association between meningitis or tuberculosis in childhood and a small proportion of cases of epilepsy, affective psychosis and schizophrenia.
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Caldani, Simona Amado, Isabelle Bendjemaa, Narjes Vialatte, François Mam-Lam-Fook, Célia Gaillard, Raphael Krebs, Marie-Odile and Pia Bucci, Maria 2017. Oculomotricity and Neurological Soft Signs: Can we refine the endophenotype? A study in subjects belonging to the spectrum of schizophrenia. Psychiatry Research, Vol. 256, p. 490.
Sugranyes, Gisela de la Serna, Elena Borras, Roger Sanchez-Gistau, Vanessa Pariente, Jose C Romero, Soledad Baeza, Inmaculada Díaz-Caneja, Covadonga M Rodriguez-Toscano, Elisa Moreno, Carmen Bernardo, Miguel Moreno, Dolores Vieta, Eduard and Castro-Fornieles, Josefina 2017. Clinical, Cognitive, and Neuroimaging Evidence of a Neurodevelopmental Continuum in Offspring of Probands With Schizophrenia and Bipolar Disorder. Schizophrenia Bulletin, Vol. 43, Issue. 6, p. 1208.
Kariuki, Maina Raudino, Alessandra Green, Melissa J Laurens, Kristin R Dean, Kimberlie Brinkman, Sally A Lenroot, Rhoshel K Liu, Enwu Harris, Felicity Luo, Luming and Carr, Vaughan J 2016. Hospital admission for infection during early childhood influences developmental vulnerabilities at age 5 years. Journal of Paediatrics and Child Health, Vol. 52, Issue. 9, p. 882.
Hirjak, Dusan Wolf, Robert C. Kubera, Katharina M. Stieltjes, Bram and Thomann, Philipp A. 2016. Multiparametric mapping of neurological soft signs in healthy adults. Brain Structure and Function, Vol. 221, Issue. 3, p. 1209.
Burton, Birgitte Klee Hjorthøj, Carsten Jepsen, Jens Richardt Thorup, Anne Nordentoft, Merete and Plessen, Kerstin J. 2016. Research Review: Do motor deficits during development represent an endophenotype for schizophrenia? A meta-analysis. Journal of Child Psychology and Psychiatry, Vol. 57, Issue. 4, p. 446.
Huber, Maria Pletzer, Belinda Giourgas, Alexandros Nickisch, Andreas Kunze, Silke and Illg, Angelika 2015. Schooling Relates to Mental Health Problems in Adolescents with Cochlear Implants—Mediation by Hearing and Family Variables. Frontiers in Psychology, Vol. 6,
Thomann, Philipp A. Hirjak, Dusan Kubera, Katharina M. Stieltjes, Bram and Wolf, Robert C. 2015. Neural network activity and neurological soft signs in healthy adults. Behavioural Brain Research, Vol. 278, p. 514.
Cox, David Chan, Man K. and Bahn, Sabine 2015. The Potential of Immune Biomarkers to Advance Personalized Medicine Approaches for Schizophrenia. The Journal of Nervous and Mental Disease, Vol. 203, Issue. 5, p. 393.
Chin-Lun Hung, Galen Hahn, Jill Alamiri, Bibi Buka, Stephen L Goldstein, Jill M Laird, Nan Nelson, Charles A Smoller, Jordan W and Gilman, Stephen E 2015. Socioeconomic disadvantage and neural development from infancy through early childhood. International Journal of Epidemiology, Vol. 44, Issue. 6, p. 1889.
Laurens, Kristin R. Luo, Luming Matheson, Sandra L. Carr, Vaughan J. Raudino, Alessandra Harris, Felicity and Green, Melissa J. 2015. Common or distinct pathways to psychosis? A systematic review of evidence from prospective studies for developmental risk factors and antecedents of the schizophrenia spectrum disorders and affective psychoses. BMC Psychiatry, Vol. 15, Issue. 1,
Schiffman, Jason Mittal, Vijay Kline, Emily Mortensen, Erik L. Michelsen, Niels Ekstrøm, Morten Millman, Zachary B. Mednick, Sarnoff A. and Sørensen, Holger J. 2015. Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder. Development and Psychopathology, Vol. 27, Issue. 4pt1, p. 1323.
Ibi, Daisuke and Yamada, Kiyofumi 2015. Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation. International Journal of Molecular Sciences, Vol. 16, Issue. 12, p. 28218.
Debnath, Monojit Venkatasubramanian, Ganesan and Berk, Michael 2015. Fetal programming of schizophrenia: Select mechanisms. Neuroscience & Biobehavioral Reviews, Vol. 49, p. 90.
Mufaddel, Amir Omer, Abdelaziz A. and Salem, Mohamed Omar 2014. Psychiatric Aspects of Infectious Diseases. Open Journal of Psychiatry, Vol. 04, Issue. 03, p. 202.
Madsen, Gitte Falcher Bilenberg, Niels Cantio, Cathriona and Oranje, Bob 2014. Increased Prepulse Inhibition and Sensitization of the Startle Reflex in Autistic Children. Autism Research, Vol. 7, Issue. 1, p. 94.
Hida, Hirotake Mouri, Akihiro Ando, Yu Mori, Kentaro Mamiya, Takayoshi Iwamoto, Kunihiro Ozaki, Norio Yamada, Kiyofumi Nabeshima, Toshitaka and Noda, Yukihiro 2014. Combination of neonatal PolyI:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice. Behavioural Brain Research, Vol. 258, p. 34.
Hirjak, Dusan Wolf, Robert Christian Koch, Sabine C. Mehl, Laura Kelbel, Janna K. Kubera, Katharina Maria Traeger, Tanja Fuchs, Thomas and Thomann, Philipp Arthur 2014. Neurological Abnormalities in Recent-Onset Schizophrenia and Asperger-Syndrome. Frontiers in Psychiatry, Vol. 5,
Nielsen, Philip R. Benros, Michael. E. and Mortensen, Preben B. 2014. Hospital Contacts With Infection and Risk of Schizophrenia: A Population-Based Cohort Study With Linkage of Danish National Registers. Schizophrenia Bulletin, Vol. 40, Issue. 6, p. 1526.
Mittal, V. A. Dean, D. J. Bernard, J. A. Orr, J. M. Pelletier-Baldelli, A. Carol, E. E. Gupta, T. Turner, J. Leopold, D. R. Robustelli, B. L. and Millman, Z. B. 2014. Neurological Soft Signs Predict Abnormal Cerebellar-Thalamic Tract Development and Negative Symptoms in Adolescents at High Risk for Psychosis: A Longitudinal Perspective. Schizophrenia Bulletin, Vol. 40, Issue. 6, p. 1204.
Tamagni, Corinne Studerus, Erich Gschwandtner, Ute Aston, Jacqueline Borgwardt, Stefan and Riecher-Rössler, Anita 2013. Are neurological soft signs pre-existing markers in individuals with an at-risk mental state for psychosis?. Psychiatry Research, Vol. 210, Issue. 2, p. 427.
Adult psychosis, common childhood infections and neurological soft signs in a national birth cohort
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