Mathers, CD, Loncar, D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med
2006; 3: e442.
Roger, VL, Go, AS, Lloyd-Jones, DM, Benjamin, EJ, Berry, JD, Borden, WB, et al. Heart disease and stroke statistics – 2012 update: a report from the American Heart Association. Circulation
2012; 125: e2–220.
Ford, ES, Ajani, UA, Croft, JB, Critchley, JA, Labarthe, DR, Kottke, TE, et al. Explaining the decrease in U.S. deaths from coronary disease, 1980–2000. N Engl J Med
2007; 356: 2388–98.
Unal, B, Critchley, JA, Capewell, S. Explaining the decline in coronary heart disease mortality in England and Wales between 1981 and 2000. Circulation
2004; 109: 1101–7.
Vartiainen, E, Laatikainen, T, Peltonen, M, Juolevi, A, Mannisto, S, Sundvall, J, et al. Thirty-five-year trends in cardiovascular risk factors in Finland. Int J Epidemiol
2010; 39: 504–18.
Yusuf, S, Hawken, S, Ounpuu, S, Dans, T, Avezum, A, Lanas, F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet
2004; 364: 937–52.
Roest, AM, Martens, EJ, de Jonge, P, Denollet, J. Anxiety and risk of incident coronary heart disease: a meta-analysis. J Am Coll Cardiol
2010; 56: 38–46.
Lamers, F, van Oppen, P, Comijs, HC, Smit, JH, Spinhoven, P, van Balkom, AJ, et al. Comorbidity patterns of anxiety and depressive disorders in a large cohort study: the Netherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry
2011; 72: 341–8.
Nicholson, A, Kuper, H, Hemingway, H. Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies. Eur Heart J
2006; 27: 2763–74.
Hill, BA. The environment and disease: association or causation?
Proc Roy Soc Med
1965; 58: 295–300.
Moher, D, Liberati, A, Tetzlaff, J, Altman, DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med
2009; 6: e1000097.
Hayden, JA, Cote, P, Bombardier, C. Evaluation of the quality of prognosis studies in reviews. Ann Intern Med
2006; 144: 427–37.
Higgins, JP, Thompson, SG, Deeks, JJ, Altman, DG. Measuring inconsistency in meta-analyses. BMJ
2003; 327: 557–60.
Egger, M, Smith, GD, Schneider, M, Minder, C. Bias in meta-analysis detected by a simple, graphical test. BMJ
1997; 315: 629–34.
Duval, S, Tweedie, R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics
2000; 56: 455–63.
Biostat, . Comprehensive Meta-Analysis, version 2.2.064. .
Chen, YH, Hu, CJ, Lee, HC, Lin, HC. An increased risk of stroke among panic disorder patients: a 3-year follow-up study. Can J Psychiatry
2010; 55: 43–9.
Boscarino, JA. Psychobiologic predictors of disease mortality after psychological trauma: implications for research and clinical surveillance. J Nerv Ment Dis
2008; 196: 100–7.
Shen, BJ, Avivi, YE, Todaro, JF, Spiro, A, Laurenceau, JP, Ward, KD, et al. Anxiety characteristics independently and prospectively predict myocardial infarction in men the unique contribution of anxiety among psychologic factors. J Am Coll Cardiol
2008; 51: 113–9.
Kubzansky, LD, Kawachi, I, Spiro, A, Weiss, ST, Vokonas, PS, Sparrow, D. Is worrying bad for your heart? A prospective study of worry and coronary heart disease in the Normative Aging Study. Circulation
1997; 95: 818–24.
Kawachi, I, Sparrow, D, Vokonas, PS, Weiss, ST. Symptoms of anxiety and risk of coronary heart disease. The Normative Aging Study. Circulation
1994; 90: 2225–9.
Haines, AP, Imeson, JD, Meade, TW. Phobic anxiety and ischaemic heart disease. BMJ
1987; 295: 297–9.
Haynes, SG, Feinleib, M, Kannel, WB. The relationship of psychosocial factors to coronary heart disease in the Framingham Study. III. Eight-year incidence of coronary heart disease. Am J Epidemiol
1980; 111: 37–58.
Gafarov, VV, Gromova, EA, Gagulin, IV, Gafarova, AV. Study of myocardial infarction risk factors within the framework of the WHO Monica–psychosocial program. Klin Med (Mosk)
2006; 84: 24–6.
Gafarov, VV, Pak, VA, Gagulin, IV, Gafarova, AV. Personal anxiety and ischaemic heart disease [in Russian]. Ter Arkh
2005; 77: 25–9.
Davidson, KW, Mostofsky, E, Whang, W. Don't worry, be happy: positive affect and reduced 10-year incident coronary heart disease: the Canadian Nova Scotia Health Survey. Eur Heart J
2010; 31: 1065–70.
Phillips, AC, Batty, GD, Gale, CR, Deary, IJ, Osborn, D, MacIntyre, K, et al. Generalized anxiety disorder, major depressive disorder, and their comorbidity as predictors of all-cause and cardiovascular mortality: the Vietnam experience study. Psychosom Med
2009; 71: 395–403.
Holt, RI, Phillips, DI, Jameson, KA, Cooper, C, Dennison, EM, Peveler, RC. The relationship between depression, anxiety and cardiovascular disease: findings from the Hertfordshire Cohort Study. J Affect Disord
2013; 150: 84–90.
Shirom, A, Toker, S, Jacobson, O, Balicer, RD. Feeling vigorous and the risks of all-cause mortality, ischemic heart disease, and diabetes: a 20-year follow-up of healthy employees. Psychosom Med
2010; 72: 727–33.
Nabi, H, Hall, M, Koskenvuo, M, Singh-Manoux, A, Oksanen, T, Suominen, S, et al. Psychological and somatic symptoms of anxiety and risk of coronary heart disease: the health and social support prospective cohort study. Biol Psychiatry
2010; 67: 378–85.
Eaker, ED, Sullivan, LM, Kelly-Hayes, M, D'Agostino, RB, Benjamin, EJ. Tension and anxiety and the prediction of the 10-year incidence of coronary heart disease, atrial fibrillation, and total mortality: the Framingham Offspring Study. Psychosom Med
2005; 67: 692–6.
Carriere, I, Ryan, J, Norton, J, Scali, J, Stewart, R, Ritchie, K, et al. Anxiety and mortality risk in community-dwelling elderly people. Br J Psychiatry
2013; 203: 303–9.
Brenes, GA, Kritchevsky, SB, Mehta, KM, Yaffe, K, Simonsick, EM, Ayonayon, HN, et al. Scared to death: results from the Health, Aging, and Body Composition study. Am J Geriatr Psychiatry
2007; 15: 262–5.
Bowlin, SJ, Medalie, JH, Flocke, SA, Zyzanski, SJ, Goldbourt, U. Epidemiology of intermittent claudication in middle-aged men. Am J Epidemiol
1994; 140: 418–30.
Gomez-Caminero, A, Blumentals, WA, Russo, LJ, Brown, RR, Castilla-Puentes, R. Does panic disorder increase the risk of coronary heart disease? A cohort study of a national managed care database. Psychosom Med
2005; 67: 688–91.
Cohen, HW, Gibson, G, Alderman, MH. Excess risk of myocardial infarction in patients treated with antidepressant medications: association with use of tricyclic agents. Am J Med
2000; 108: 2–8.
Hamer, M, David, BG, Seldenrijk, A, Kivimaki, M. Antidepressant medication use and future risk of cardiovascular disease: the Scottish Health Survey. Eur Heart J
2011; 32: 437–42.
Smoller, JW, Allison, M, Cochrane, BB, Curb, JD, Perlis, RH, Robinson, JG, et al. Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women's Health Initiative study. Arch Intern Med
2009; 169: 2128–39.
Lapane, KL, Zierler, S, Lasater, TM, Barbour, MM, Carleton, R, Hume, AL. Is the use of psychotropic drugs associated with increased risk of ischemic heart disease?
1995; 6: 376–81.
Albert, CM, Chae, CU, Rexrode, KM, Manson, JE, Kawachi, I. Phobic anxiety and risk of coronary heart disease and sudden cardiac death among women. Circulation
2005; 111: 480–7.
Batelaan, NM, ten Have, M, van Balkom, AJ, Tuithof, M, de Graaf, R. Anxiety disorders and onset of cardiovascular disease: the differential impact of panic, phobias and worry. J Anxiety Disord
2014; 28: 252–8.
Sareen, J, Cox, BJ, Clara, I, Asmundson, GJ. The relationship between anxiety disorders and physical disorders in the U.S. National Comorbidity Survey. Depress Anxiety
2005; 21: 193–202.
Roy-Byrne, PP, Davidson, KW, Kessler, RC, Asmundson, GJ, Goodwin, RD, Kubzansky, L, et al. Anxiety disorders and comorbid medical illness. Gen Hosp Psychiatry
2008; 30: 208–25.
Hasler, G, Gergen, PJ, Kleinbaum, DG, Ajdacic, V, Gamma, A, Eich, D, et al. Asthma and panic in young adults: a 20-year prospective community study. Am J Respir Crit Care Med
2005; 171: 1224–30.
Nicholl, BI, Halder, SL, Macfarlane, GJ, Thompson, DG, O'Brien, S, Musleh, M, et al. Psychosocial risk markers for new onset irritable bowel syndrome – results of a large prospective population-based study. Pain
2008; 137: 147–55.
Laan, W, Termorshuizen, F, Smeets, HM, Boks, MP, de Wit, NJ, Geerlings, MI. A comorbid anxiety disorder does not result in an excess risk of death among patients with a depressive disorder. J Affect Disord
2011; 135: 284–91.
Denollet, J, Maas, K, Knottnerus, A, Keyzer, JJ, Pop, VJ. Anxiety predicted premature all-cause and cardiovascular death in a 10-year follow-up of middle-aged women. J Clin Epidemiol
2009; 62: 452–6.
Van Hout, HP, Beekman, AT, de Beurs, E, Comijs, H, van Marwijk, H, de Haan, M, et al. Anxiety and the risk of death in older men and women. Br J Psychiatry
2004; 185: 399–404.
Mykletun, A, Bjerkeset, O, Dewey, M, Prince, M, Overland, S, Stewart, R. Anxiety, depression, and cause-specific mortality: the HUNT study. Psychosom Med
2007; 69: 323–31.
Holman, EA, Silver, RC, Poulin, M, Andersen, J, Gil-Rivas, V, McIntosh, DN. Terrorism, acute stress, and cardiovascular health: a 3-year national study following the September 11th attacks. Arch Gen Psychiatry
2008; 65: 73–80.
Ostir, GV, Goodwin, JS. High anxiety is associated with an increased risk of death in an older tri-ethnic population. J Clin Epidemiol
2006; 59: 534–40.
Ringback Weitoft, G, Rosen, M. Is perceived nervousness and anxiety a predictor of premature mortality and severe morbidity? A longitudinal follow up of the Swedish survey of living conditions. J Epidemiol Community Health
2005; 59: 794–8.
Smoller, JW, Pollack, MH, Wassertheil-Smoller, S, Jackson, RD, Oberman, A, Wong, ND, et al. Panic attacks and risk of incident cardiovascular events among postmenopausal women in the Women's Health Initiative Observational Study. Arch Gen Psychiatry
2007; 64: 1153–60.
Yasuda, N, Mino, Y, Koda, S, Ohara, H. The differential influence of distinct clusters of psychiatric symptoms, as assessed by the general health questionnaire, on cause of death in older persons living in a rural community of Japan. J Am Geriatr Soc
2002; 50: 313–20.
Janszky, I, Ahnve, S, Lundberg, I, Hemmingsson, T. Early-onset depression, anxiety, and risk of subsequent coronary heart disease: 37-year follow-up of 49,321 young Swedish men. J Am Coll Cardiol
2010; 56: 31–7.
Aberg, MA, Waern, M, Nyberg, J, Pedersen, NL, Bergh, Y, Aberg, ND, et al. Cardiovascular fitness in males at age 18 and risk of serious depression in adulthood: Swedish prospective population-based study. Br J Psychiatry
2012; 201: 352–9.
De Jonge, P, Roest, AM. Depression and cardiovascular disease: the end of simple models. Br J Psychiatry
2012; 201: 337–8.
Nicholson, A, Fuhrer, R, Marmot, M. Psychological distress as a predictor of CHD events in men: the effect of persistence and components of risk. Psychosom Med
2005; 67: 522–30.
Moylan, S, Jacka, FN, Pasco, JA, Berk, M. Cigarette smoking, nicotine dependence and anxiety disorders: a systematic review of population-based, epidemiological studies. BMC Med
2012; 10: 123.
Falk Dahl, CA, Dahl, AA. Lifestyle and social network in individuals with high level of social phobia/anxiety symptoms: a community-based study. Soc Psychiatry Psychiatr Epidemiol
2010; 45: 309–17.
Jacka, FN, Mykletun, A, Berk, M, Bjelland, I, Tell, GS. The association between habitual diet quality and the common mental disorders in community-dwelling adults: the Hordaland Health study. Psychosom Med
2011; 73: 483–90.
Papakostas, GI, Ongur, D, Iosifescu, DV, Mischoulon, D, Fava, M. Cholesterol in mood and anxiety disorders: review of the literature and new hypotheses. Eur Neuropsychopharmacol
2004; 14: 135–42.
Player, MS, Peterson, LE. Anxiety disorders, hypertension, and cardiovascular risk: a review. Int J Psychiatry Med
2011; 41: 365–77.
Pitsavos, C, Panagiotakos, DB, Papageorgiou, C, Tsetsekou, E, Soldatos, C, Stefanadis, C. Anxiety in relation to inflammation and coagulation markers, among healthy adults: the ATTICA study. Atherosclerosis
2006; 185: 320–6.
Von Kanel, R, Mills, PJ, Fainman, C, Dimsdale, JE. Effects of psychological stress and psychiatric disorders on blood coagulation and fibrinolysis: a biobehavioral pathway to coronary artery disease?
2011; 63: 531–44.
Young, EA, Abelson, JA, Liberzon, I. Stress hormones and anxiety disorders. In Handbook of Anxiety and Fear (eds Blanchard, DC, Griebel, G, Nutt, D): 455–473. Elsevier, 2008.
Vreeburg, SA, Zitman, FG, van Pelt, J, Derijk, RH, Verhagen, JC, van Dyck, R, et al. Salivary cortisol levels in persons with and without different anxiety disorders. Psychosom Med
2010; 72: 340–7.
Friedman, BH. An autonomic flexibility–neurovisceral integration model of anxiety and cardiac vagal tone. Biol Psychol
2007; 74: 185–99.
Licht, CM, Penninx, BW, de Geus, EJ. Effects of antidepressants, but not psychopathology, on cardiac sympathetic control: a longitudinal study. Neuropsychopharmacology
2012; 37: 2487–95.
Petticrew, M, Davey Smith, G. The monkey puzzle: a systematic review of studies of stress, social hierarchies, and heart disease in monkeys. PLoS One
2012; 7: e27939.
Watson, SL, Shively, CA, Kaplan, JR, Line, SW. Effects of chronic social separation on cardiovascular disease risk factors in female cynomolgus monkeys. Atherosclerosis
1998; 137: 259–66.
Dhabhar, FS, Saul, AN, Holmes, TH, Daugherty, C, Neri, E, Tillie, JM, et al. High-anxious individuals show increased chronic stress burden, decreased protective immunity, and increased cancer progression in a mouse model of squamous cell carcinoma. PLoS One
2012; 7: e33069.
Lenze, EJ, Mantella, RC, Shi, P, Goate, AM, Nowotny, P, Butters, MA, et al. Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram. Am J Geriatr Psychiatry
2011; 19: 482–90.
Rice, KM, Blanchard, EB, Purcell, M. Biofeedback treatments of generalized anxiety disorder: preliminary results. Biofeedback Self Regul
1993; 18: 93–105.
Middleton, HC, Ashby, M. Clinical recovery from panic disorder is associated with evidence of changes in cardiovascular regulation. Acta Psychiatr Scand
1995; 91: 108–13.
Sullivan, GM, Kent, JM, Kleber, M, Martinez, JM, Yeragani, VK, Gorman, JM. Effects of hyperventilation on heart rate and QT variability in panic disorder pre- and post-treatment. Psychiatry Res
2004; 125: 29–39.
Licht, CM, de Geus, EJ, van Dyck, R, Penninx, BW. Association between anxiety disorders and heart rate variability in The Netherlands Study of Depression and Anxiety (NESDA). Psychosom Med
2009; 71: 508–18.
Thombs, BD, de Jonge, P, Coyne, JC, Whooley, MA, Frasure-Smith, N, Mitchell, AJ, et al. Depression screening and patient outcomes in cardiovascular care: a systematic review. JAMA
2008; 300: 2161–71.
De Jonge, P, Honig, A, van Melle, JP, Schene, AH, Kuyper, AM, Tulner, D, et al. Nonresponse to treatment for depression following myocardial infarction: association with subsequent cardiac events. Am J Psychiatry
2007; 164: 1371–8.
Carney, RM, Blumenthal, JA, Freedland, KE, Youngblood, M, Veith, RC, Burg, MM, et al. Depression and late mortality after myocardial infarction in the Enhancing Recovery in Coronary Heart Disease (ENRICHD) study. Psychosom Med
2004; 66: 466–74.
Chida, Y, Steptoe, A. The association of anger and hostility with future coronary heart disease: a meta-analytic review of prospective evidence. J Am Coll Cardiol
2009; 53: 936–46.
Bogers, RP, Bemelmans, WJ, Hoogenveen, RT, Boshuizen, HC, Woodward, M, Knekt, P, et al. Association of overweight with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels: a meta-analysis of 21 cohort studies including more than 300 000 persons. Arch Intern Med
2007; 167: 1720–8.
Gami, AS, Witt, BJ, Howard, DE, Erwin, PJ, Gami, LA, Somers, VK, et al. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol
2007; 49: 403–14.
Li, J, Siegrist, J. Physical activity and risk of cardiovascular disease – a meta-analysis of prospective cohort studies. Int J Environ Res Public Health
2012; 9: 391–407.
Kessler, RC, Chiu, WT, Demler, O, Merikangas, KR, Walters, EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry
2005; 62: 617–27.
Batelaan, N, Rhebergen, D, de Graaf, R, Spijker, J, Beekman, A, Penninx, B. Panic attacks as a dimension of psychopathology: evidence for their impact on onset and course of mental disorders and functioning. J Clin Psychiatry
2012; 73: 1195–202.
Kessler, RC, Chiu, WT, Jin, R, Ruscio, AM, Shear, K, Walters, EE. The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication. Arch Gen Psychiatry
2006; 63: 415–24.
Lewinsohn, PM, Shankman, SA, Gau, JM, Klein, DN. The prevalence and co-morbidity of subthreshold psychiatric conditions. Psychol Med
2004; 34: 613–22.
National Institute for Health and Clinical Excellence. Generalised Anxiety Disorder and Panic Disorder (With or Without Agoraphobia) in Adults: Management in Primary, Secondary and Community Care. Clinical Guideline 113. NICE, 2011.
Wang, PS, Lane, M, Olfson, M, Pincus, HA, Wells, KB, Kessler, RC. Twelve-month use of mental health services in the United States: results from the National Comorbidity Survey Replication. Arch Gen Psychiatry
2005; 62: 629–40.
Gustad, LT, Laugsand, LE, Janszky, I, Dalen, H, Bjerkeset, O. Symptoms of anxiety and depression and risk of acute myocardial infarction: the HUNT 2 study. Eur Heart J
2014; 35: 1394–403.
Vaccarino, V, Goldberg, J, Rooks, C, Shah, AJ, Veledar, E, Faber, TL, et al. Post-traumatic stress disorder and incidence of coronary heart disease: a twin study. J Am Coll Cardiol
2013; 62: 970.
Chou, PH, Lin, CH, Loh, E, Chan, CH, Lan, TH. Panic disorder and risk of stroke: a population-based study. Psychosomatics
2012; 53: 463–9.
Chen, YH, Tsai, SY, Lee, HC, Lin, HC. Increased risk of acute myocardial infarction for patients with panic disorder: a nationwide population-based study. Psychosom Med
2009; 71: 798–804.
Jordan, HT, Miller-Archie, SA, Cone, JE, Morabia, A, Stellman, SD. Heart disease among adults exposed to the September 11, 2001 World Trade Center disaster: results from the World Trade Center Health Registry. Prev Med
2011; 53: 370–6.
Scherrer, JF, Chrusciel, T, Zeringue, A, Garfield, LD, Hauptman, PJ, Lustman, PJ, et al. Anxiety disorders increase risk for incident myocardial infarction in depressed and nondepressed Veterans Administration patients. Am Heart J
2010; 159: 772–9.
Kubzansky, LD, Koenen, KC, Jones, C, Eaton, WW. A prospective study of posttraumatic stress disorder symptoms and coronary heart disease in women. Health Psychol
2009; 28: 125–30.
Boscarino, JA. A prospective study of PTSD and early-age heart disease mortality among Vietnam veterans: implications for surveillance and prevention. Psychosom Med
2008; 70: 668–76.
Jakobsen, AH, Foldager, L, Parker, G, Munk-Jorgensen, P. Quantifying links between acute myocardial infarction and depression, anxiety and schizophrenia using case register databases. J Affect Disord
2008; 109: 177–81.
Walters, K, Rait, G, Petersen, I, Williams, R, Nazareth, I. Panic disorder and risk of new onset coronary heart disease, acute myocardial infarction, and cardiac mortality: cohort study using the general practice research database. Eur Heart J
2008; 29: 2981–8.
Gafarov, VV, Gromova, HA, Gagulin, IV, Ekimova, YC, Santrapinskiy, DK. Arterial hypertension, myocardial infarction and stroke: risk of development and psychosocial factors. Alaska Med
2007; 49: 117–9.
Boyle, SH, Michalek, JE, Suarez, EC. Covariation of psychological attributes and incident coronary heart disease in U.S. Air Force veterans of the Vietnam war. Psychosom Med
2006; 68: 844–50.
Kubzansky, LD, Cole, SR, Kawachi, I, Vokonas, P, Sparrow, D. Shared and unique contributions of anger, anxiety, and depression to coronary heart disease: a prospective study in the normative aging study. Ann Behav Med
2006; 31: 21–9.
Thurston, RC, Kubzansky, LD, Kawachi, I, Berkman, LF. Do depression and anxiety mediate the link between educational attainment and CHD?
2006; 68: 25–32.
Haines, A, Cooper, J, Meade, TW. Psychological characteristics and fatal ischaemic heart disease. Heart
2001; 85: 385–9.
Bowen, RC, Senthilselvan, A, Barale, A. Physical illness as an outcome of chronic anxiety disorders. Can J Psychiatry
2000; 45: 459–64.
Kawachi, I, Colditz, GA, Ascherio, A, Rimm, EB, Giovannucci, E, Stampfer, MJ, et al. Prospective study of phobic anxiety and risk of coronary heart disease in men. Circulation
1994; 89: 1992–7.
Vogt, T, Pope, C, Mullooly, J, Hollis, J. Mental health status as a predictor of morbidity and mortality: a 15-year follow-up of members of a health maintenance organization. Am J Public Health
1994; 84: 227–31.
Eaker, ED, Pinsky, J, Castelli, WP. Myocardial infarction and coronary death among women: psychosocial predictors from a 20-year follow-up of women in the Framingham Study. Am J Epidemiol
1992; 135: 854–64.
Rosengren, A, Tibblin, G, Wilhelmsen, L. Self-perceived psychological stress and incidence of coronary artery disease in middle-aged men. Am J Cardiol
1991; 68: 1171–5.
Pearson, TA, Blair, SN, Daniels, SR, Eckel, RH, Fair, JM, Fortmann, SP, et al. AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases. American Heart Association Science Advisory and Coordinating Committee. Circulation
2002; 106: 388–91.