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Are neuropsychiatric symptoms modifiable risk factors for cognitive decline in Alzheimer's disease and vascular dementia?

  • George Savulich (a1), John T. O'Brien (a2) and Barbara J. Sahakian (a3)
Summary

Alzheimer's disease and vascular dementia are associated with overlapping symptoms of anxiety and depression. More accurate discrimination between emerging neuropsychiatric and cognitive symptoms would better assist illness detection. The potential for protection against cognitive decline and dementia following early identification and intervention of neuropsychiatric symptoms warrants investigation.

Declaration of interest

B.J.S. consults for Peak, Mundipharma and Cambridge Cognition. J.T.O. has acted as a consultant for TauRx, Axon, GE Healthcare and Lilly.

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Copyright
Corresponding author
Correspondence: Dr George Savulich, Department of Psychiatry, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0SZ, UK. Email: gjs46@medschl.cam.ac.uk
Footnotes
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See Becker et al.2

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References
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1Lyketsos, CG, Carrillo, MC, Ryan, MJ, Khachaturian, AS, Trzepacz, P, Amatniek, J, et al. Neuropsychiatric symptoms in Alzheimer's disease. Alzheimers Dement 2011; 7: 532–9.
2Becker, E, Rios, CLO, Lahmann, C, Rücker, G, Bauer, J, Bocker, M. Anxiety as a risk factor of Alzheimer's disease and vascular dementia: systematic review and meta-analysis. Br J Psychiatry 2018; 213: 654–60.
3Swainson, R, Hodges, JR, Galton, CJ, Semple, J, Michael, A, Dunn, BD, et al. Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks. Dement Geriatr Cogn Disord 2001; 12: 265–80.
4O'Brien, JT, Thomas, A. Vascular dementia. Lancet 2015; 386: 1698–706.
5Brodaty, H, Arasaratnam, C. Meta-analysis of nonpharmacological interventions for neuropsychiatric symptoms of dementia. Am J Psychiatry 2012; 169: 946–53.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Are neuropsychiatric symptoms modifiable risk factors for cognitive decline in Alzheimer's disease and vascular dementia?

  • George Savulich (a1), John T. O'Brien (a2) and Barbara J. Sahakian (a3)
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