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Asperger syndrome and high-functioning autism

  • Christopher Gillberg (a1)

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This paper reviews the history of Asperger syndrome (AS) and high-functioning autism (HFA), current diagnostic concepts and criteria, some controversial diagnostic issues, epidemiology, background factors, outcome, and intervention guidelines.

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Ahlsén, G., Rosengren, L., Belfrage, M., et al (1993) Glial fibrillary acidic protein in the cerebrospinal fluid of children with autism and other neuropsychiatric disorders. Biological Psychiatry, 33, 734743.
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn. Revised) (DSM–III–R). Washington. DC: APA.
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). Washington. DC: APA.
Annerén, G., Dahl, N. & Uddenfelt, U. (1995) Asperger syndrome in a boy with a balanced de novo translocation: t(17: 19) (p13.3; p11). American Journal of Medical Genetics, 56. 18.
Asperger, H. (1944) Die autistischen Psychopathen im Kindesalter. Archiv für Psychiatrie und Nervenkrankheiten, 117, 76136.
Asperger, H. (1950) Bild and soziale Wertigkeit der autistischen Psychopathen. In Proceedings of the Second International Congress on Orthopedagogics. Keesing. Amsterdam: Publ. Systemen.
Asperger, H. (1952) Heilpädagogik, Berlin: Springer.
Asperger, H. (1961) Heilpaedogogik (3rd edn). Vienna: Springer.
Asperger, H. (1979) Problems of infantile autism. Communication, 13, 4552.
Baron-Cohen, S. (1995) Mind Blindness. An Essay on Autism and Theory of Mind. Cambridge, MA: MIT Press.
Baron-Cohen, , Leslie, A. M. & Frith, U. (1985) Does the autistic child have a theory of mind? Cognition, 21, 3746.
Beier, H. (1993) Autistiska syndrom. En angelägenhet även inom vuxenpsykiatrin. Läkartidningen, 90. 45604564.
Berthier, M. L., Santamaria, J., Encabo, H., et al (1992) Case study: Recurrent hypersomnia in two adolescent males with Asperger's syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 31. 735738.
Berthier, M. L., Bayes, A. A. Tolosa, E. S. (1993) Magnetic resonance imaging in patients with concurrent Tourette's disorder and Asperger's syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 633639.
Bishop, D. V. M. (1989) Autism, Asperger's syndrome and semantic – pragmatic disorders. Where are the boundaries? British Journal of Disorders of Communication, 24, 107121.
Bolton, P. & Rutter, M. (1990) Genetic influences in autism. International Review of Psychiatry, 2, 6780.
Bolton, P., Macdoncald, H., Pickles, A., et al (1994) A case control family history study of autism. Journal of Child Psychology and Psychiatry, 35, 877900.
Bowler, D. M. (1992) ‘Theory of mind’ in Asperger's Syndrome. Journal of Child Psychology and Psychiatry, 33, 877893.
Bolton, P. & Worley, K. (1994) Susceptibility to social influence in adults with Asperger's syndrome: a research note. Journal of Child Psychology and Psychiatry, 35, 689697.
Bowman, E. P. (1988) Asperger's syndrome and autism: the case for a connection. British Journal of Psychiatry, 152. 377382.
Burgoine, E. & Wing, L. (1983) Identical triplets with Asperger's syndrome. British Journal of Psychiatry, 143, 261265.
Caron, C. & Rutter, M. (1991) Comorbidity in child psychopathology: concepts, issues and research strategies. Journal of Child Psychology and Psychiatry, 32, 10631080.
Chiron, C., Leboyer, M., Leon, F., et al (1995) SPECT of the brain in childhood autism: evidence for a lack of normal hemispheric asymmetry. Developmental Medicine and Child Neurology, 37, 849860.
Dauner, I. & Martin, M. (1978) Autismus Asperger oder Früschizophrenie? Zur nosologischen Abgrenzung beider Krankheitsbilder. Paeditrishe Paedologie, 13. 3138.
Davies, S., Bishop, D., Manstead, A. S., et al (1994) Face perception in children with autism and Asperger's syndrome. Journal of Child Psychology and Psychiatry, 35. 10331057.
De Long, G. R. & Dwyer, J. T. (1988) Correlation of family history with specific autistic subgroups: Asperger's syndrome and bipolar affective disease. Journal of Autism and Developmental Disorders, 18, 593600.
De Long, G. R. & Nohria, C. (1994) Psychiatric family history and neurological disease in autism spectrum disorders. Developmental Medicine and Child Neurology, 36. 441448.
DeMyer, M., Hingtgen, J. M. & Jackson, R. K. (1981) Infantile autism reviewed: A decade of research. Schizophrenic Bulletin, 7, 388451.
Eaves, L. C., Ho, H. H. & Eaves, D. M. (1994) Subtypes of autism by cluster analysis. Journal of Autism and Developmental Disorders, 24. 322.
Ehlers, S. & Gillberg, C. (1993) The epidemiology of Asperger syndrome. A total population study. Journal of Child Psychology and Psychiatry, 34, 13271350.
Ehlers, S., Nydén, A., Gillberg, C, et al (1996) Asperger syndrome, autism and attention disorders: A comparative study of cognitive profile of 120 children. Journal of Child Psychology and Psychiatry, 38. 207217.
Ellis, H. D., Ellis, D. M., Fraser, W., et al (1994) A preliminary study of right hemisphere cognitive deficits and impaired social judgements among young people with Asperger syndrome. European Child & Adolescent Psychiatry, 3, 255266.
Fine, J., Bartolucci, G., Ginsberg, G., et al (1991) The use of intonation to communicate in pervasive developmental disorders. Journal of Child Psychology and Psychiatry, 5, 771782.
Folstein, S. E. & Piven, J. (1991) Etiology of autism: genetic influences. Pediatrics, 87, 767773.
Frith, U. (1989) Autism and ‘theory of mind’. In Diagnosis and Treatment of Autism (ed. Gillberg, C.), pp. 3352. New York: Plenum Press.
Frith, U. (1991) Autism and Asperger Syndrome. Cambridge: Cambridge University Press.
Ghaziuddin, M., Tasi, L. Y. & Ghaziuddin, N. (1992) Brief report: A reappraisal of clumsiness as a diagnostic feature of Asperger syndrome. Journal of Autism and Developmental Disorders, 22, 651656.
Ghaziuddin, N., Metler, L., Ghaziuddin, M., et al (1993) Three siblings with Asperger syndrome: a family case history. European Child & Adolescent Psychiatry, 2, 4449.
Gillberg, C. (1983) Psychotic behaviour in children and young adults in a mental handicap hostel. Acta Psychiatrica Scandinavica, 68, 351358.
Gillberg, C. (1985) Asperger's syndrome and recurrent psychosis –a case study. Journal of Autism and Developmental Disorders, 15, 389397.
Gillberg, C. (1988) Autism. Stockholm: Natur och Kultur. Gillberg, C. (1989) Asperger syndrome in 23 Swedish children. Developmental Medicine and Child Neurology, 31, 520531.
Gillberg, C. (1991) Clinical and neurobiological aspects of Asperger syndrome in six family studies. In Autism and Asperger Syndrome (ed. Frith, U.), pp. 122146. Cambridge: Cambridge University Press.
Gillberg, C. (1992) The Emanuel Miller Memorial Lecture 1991: Autism and autistic-like conditions: subclasses among disorders of empathy. Journal of Child Psychology and Psychiatry, 33, 813842.
Gillberg, C. (1995) The prevalence of autism and autism spectrum disorders. In The Epidemiology of Child and Adolescent Psychopathology (ed. Verhulst, F. C. & Koot, H. M.), pp. 227257. Oxford: Oxford University Press.
Gillberg, C. & Schau mann, H. (1982) Social class and infantile autism. Journal of Autism and Developmental Disorders, 12, 223228.
Gillberg, C. & Forsell, C. (1984) Childhood psychosis and neurofibromatosis – more than a coincidence? Journal of Autism and Developmental Disorders, 14, 18.
Gillberg, C. & Coleman, M. (1992) The Biology of the Autistic Syndromes. Clinics in Developmental Medicine No 126. London: MacKeith Press.
Gillberg, C., Steffenburg, S. & Jakobsson, G. (1987) Neurobiological findings in 20 relatively gifted children with Kanner-type autism or Asperger syndrome. Developmental Medicine and Child Neurology, 29, 641649.
Gillberg, C., Steffenburg, S. & Schaumann, H. (1991) Is autism more common now than 10 years ago? British Journal of Psychiatry, 158, 403409.
Gillberg, I. C. & Gillberg, C. (1989) Asperger syndrome – some epidemiological considerations: a research note. Journal of Child Psychology and Psychiatry, 30, 631638.
Gillberg, I. C., Bjure, J., Uvebrant, P., et al (1993) SPECT (single photon emission computed tomography) in 31 children and adolescents with autism and autistic-like conditions. European Child & Adolescent Psychiatry, 2, 5059.
Gillberg, I. C., Råstam, M. & Gillberg, C. (1994a) Anorexia nervosa outcome: six year controlled longitudinal study of 51 cases including a population cohort. Journal of the American Academy of Child and Adolescent Psychiatry, 33, 729739.
Gillberg, I. C., Gillberg, C. & Ahlsén, G. (1994b) Autistic behaviour and attention deficits in tuberous sclerosis. A population-based study. Developmental Medicine and Child Neurology, 36, 5056.
Gordon, C. T., State, R. C., Nelson, J. E., et al (1993) A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. Archives of General Psychiatry, 50, 441447.
Gordon, C. T., Frazier, J. A., McKenna, K., et al (1994) Childhood onset schizophrenia: an NIMH study in progress. Schizophrenia Bulletin, 20, 697712.
Gray, C. (1996) The social story kit. Journal of Autism and Developmental Disorders, in press.
Hagerman, R. J. (1989) Chromosomes, genes and autism. In Diagnoses and Treatment of Autism (ed. Gillberg, C.), pp. 105132. New York: Plenum Press.
Happé, F. G. E. (1994) Current psychological theories of autism: the ‘theory of mind’ account and rival theories. Journal of Child Psychology and Psychiatry, 35, 215229.
Happé, F. G. E., Ehlers, S., Frackowiak, R. S. J., et al (1996) ‘Theory of mind’ in the brain. Evidence from a PET scan study of Asperger syndrome. Neuroreport, 8, 197201.
Hart, H., Bax, M. & Jenkins, S. (1978) The value of a developmental history. Developmental Medicine and Child Neurology, 20, 442452.
Hellgren, L., Gillberg, C. & Gillberg, I. C. (1994) Children with deficits in attention, motor control and perception (DAMP) almost grown up: the contribution of various background factors to outcome at age 16 years. European Child & Adolescent Psychiatry, 3, 115.
Hermelin, B. & O'Connor, N. (1970) Psychological Experiments with Autistic Children. Oxford: Pergamon Press.
Heroki, S., Frackowiak, R. S. J., Le Couteur, A., et al (1988) Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults. Psychological Medicine, 18, 823831.
Hewett, E., Newson, E. & Newson, J. (1970) The Family and the Handicapped Child. London: Allen & Unwin.
Horwitz, B., Rumsey, J. M., Grady, C. L., et al (1988) The cerebral metabolic landscape in autism. Intercorrelations of regional glucose utilization. Archives of Neurology, 45, 749755.
Hurlburt, R. T., Happé, F. & Frith, U. (1994) Sampling the form of inner experience in three adults with asperger syndrome. Psychological Medicine, 24, 385395.
Kanner, L. (1943) Autistic disturbances of affective contact. Nervous Child, 2, 217250.
Kanner, L. (1954) To what extent is early childhood autism determined by constitutional inadequacies? Proceedings of the Association for Research in Nervous and Mental Diseases, 33, 378385.
Klin, A. (1993) Listening preferences in regard to speech in four children with developmental disabilities. Journal of Child Psychology and Psychiatry, 33, 763769.
Kopp, S. & Gillberg, C. (1996) Selective mutism. A population-based study. Journal of Child Psychology and Psychiatry, 38, 257262.
Kracke, I. (1994) Developmental prosopagnosia in Asperger syndrome: presentation and discussion of an individual case. Developmental Medicine and Child Neurology, 36, 873886.
Kretschmer, E. (1924) Körperbau und Character . Translated into English (1925) as Physique and Character. London: Kegan Paul, Trench and Trubner.
Landa, R., Piven, J., Wzorek, M. M., et al (1992) Social language in parents of autistic individuals. Psychological Medicine, 22, 245254.
Lewis, V. & Boucher, J. (1995) Generativity in the play of young people with autism. Journal of Autism and Developmental Disorders, 25, 105121.
Lister-Brook, S. A. Bowler, D. M. (1992) Autism by another name? Semantic and pragmatic impairments in children. Journal of Autism Developmental Disorders, 22, 6181.
Lockyer, L. & Rutter, M. (1970) A five to fifteen year follow-up study of infantile psychosis. IV: Patterns of cognitive ability British Journal of Social and Cognitive Ability, 9, 152163.
ManJivlona, J. & Prior, M. (1995) Comparison of Asperger syndrome and high-functioning autistic children on a test of motor impairment. Journal of Autism and Developmental Disorders, 25, 2339.
Marriage, K. J., Gordon, V. & Brand, L. (1995) A social skills group for boys with Asperger's syndrome. Australian & New Zealand Journal of Psychiatry, 29, 5862.
McEvoy, R. E., Roger, S. J. & Pennington, B. F. (1993) Executive function and social communication deficits in young autistic children. Journal of Child Psychology and Psychiatry, 34, 563578.
Mesibov, G. (1984) Social skills training with verbal autistic adolescents and adults: A program model. Journal of Autism and Developmental Disorders, 14, 395404.
Miller, J. N. & Ozonoff, S. (1997) Did Asperger's cases have Asperger disorders? A research note. Journal of Child Psychology and Psychiatry, 38, 247251.
Ozonoff, S. & Miller, J. N. (1995) Teaching theory of mind: A new approach to social skills training for individuals with autism. Journal of Autism and Developmental Disorders, 25, 415433.
Ozonoff, S., Rogers, S. J. & Pennington, B. F. (1991) Asperger's syndrome: evidence of an empirical distinction from high-functioning autism. Journal of Child Psychology and Psychiatry, 32, 11071122.
Ozonoff, S., Farham, J. M., et al (1994) Can standard measures identify subclinical markers of autism? Journal of Autism and Developmental Disorders, 23, 429441.
Piven, J., Nehme, E., Simon, J., et al (1992) Magnetic resonance imaging in autism: measurement of the cerebellum. Biological Psychiatry, 31, 491504.
Prior, M., Dahlstrom, B. & Squires, T.-L. (1990) Autistic children's knowledge of thinking and feeling states in other people. Journal of Child Psychology and Psychiatry, 31, 587601.
Ramberg, C., Ehlers, S., Nydén, A., et al (1996) Language and pragmatic functions in school-age children on the autism spectrum. European Journal of Disorders of Communication, 31, 387414.
Rickarby, G., Carruthers, A. & Mitchell, M. (1991) Brief report: Biological factors associated with Asperger syndrome. Journal of Autism and Developmental Disorders, 21, 341348.
Rourke, B. P. (1988) The syndrome of non-verbal learning disabled children: Developmental manifestations of neurological disease. Clinical Neuropsychologist, 2, 293330.
Rumsey, J. M. (1985) Conceptual problem-solving in highly verbal, nonretarded, autistic men. Journal of Autism and Developmental Disorders, 15, 2336.
Rumsey, J. M. & Hamburger, S. D. (1988) Neuropsychological findings in high-functioning men with infantile autism, residual state. Journal of Clinical and Experimental Neuropsychology, 10, 201221.
Rumsey, J. M., Rapoport, J. L. & Sceery, W. R. (1985) Autistic children as adults: psychiatric and behavioral outcomes. Journal of The American Academy of Child Psychiatry, 24, 465473.
Rutter, M. (1985) The treatment of autistic children. Journal of Child Psychology and Psychiatry, 28, 193214.
Råstam, M., Gillberg, C. & Garton, M. (1989) Anorexia nervosa in a Swedish urban region. A population-based study. British Journal of Psychiatry, 155. 642646.
Sacks, O. (1995) An Anthropologist on Mars. New York: Knopf.
Schooler, E., Andrew, C. E. & Strupp, K. (1979) Do autistic children come from upper-class parents? Journal of Autism and Developmental Disorders, 9. 139152.
Schooler, E., Reichler, R. J. & Renner, B. R. (1988) The Children Autism Rating Scale (CARS). Los Angeles, CA: Western Psychological Services.
Scragg, P. & Shah, A. (1994) Prevalence of Asperger's syndrome in a secure hospital. British Journal of Psychiatry, 165, 679682.
Shea, V. & Mesibov, G. B. (1985) Brief report: The relationship of learning disabilities and higher-level autism. Journal of Autism and Developmental Disorders, 15, 425435.
Sparrow, S. S., Rescorla, L. A., Provence, S., et al (1986) Follow-up of “atypical” children–a brief report. Journal of the American Academy of Child and Adolescent Psychiatry, 25, 181185.
Ssucharewa, G. E. (1926) Die schizoiden Psychopathien im Kindesalter. Monatsschrift für Psychiatrie und Neurologie, 60, 235261.
Strayhorn, J. (1989) More on methylphenidate in autism (letter). Journal of the American Academy of Child and Adolescent Psychiatry, 28, 299.
Szatmari, P., Bartolucci, G. & Brenner, R. (1989) Asperger's syndrome and autism: comparisons on early history and outcome. Developmental Medicine and Child Neurology, 31, 709720.
Szatmari, P., Offord, D. R., Siegel, L. S., et al (1990) The clinical significance of neurocognitive impairments among children with psychiatric disorders: diagnosis and situational specificity. Journal of Child Psychology and Psychiatry, 33. 287299.
Tantam, D. (1991) Asperger's syndrome in adulthood. In Autism and Asperger syndrome (ed. Frith, U.), pp. 147183. Cambridge: Cambridge University Press.
Tantam, D., Evered, C. & Hersov, L. (1990) Asperger's syndrome and ligamentus laxity. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 892896.
Tantam, D., Holmes, D. & Condess, C. (1993) Nonverbal expression in autism of Asperger type. Journal of Autism and Developmental Disorder, 23, 111133.
Twachtman, D. (1998) Social and communication needs in Asperger syndrome: variations on the theme of autism. Journal of Autism and Developmental Disorders, in press.
Van Kreveien, D. A. (1971) Early infantile autism and autistic psychopathy. Journal of Autism and Childhood Schizophrenia, 1, 8286.
Van Kreveien, D. A. & Kuipers, C. (1962) The psychopathology of autistic psychopathy. Acta Paedopsychiatrica, 29, 2231.
Williamson, D. A. & Bolton, P. (1995) Brief report: Atypical autism and tuberous sclerosis in a sibling pair. Journal of Autism and Developmental Disorders, 25, 435442.
Wing, L. (1980) Childhood autism and social class: A question of selection. British Journal of Psychiatry, 137, 410417.
Wing, L. (1981a) Asperger's syndrome: a clinical account. Psychological Medicine, 11, 115129.
Wing, L. (1981b) Sex ratios in early childhood autism and related conditions. Psychiatry Research, 5, 129137.
Wing, L. (1993) The definition and prevalence of autism: A review. European Child & Adolescent Psychiatry, 2. 6174.
Wing, L. (1996) Autism spectrum disorders. British Medical Journal, 312, 327328.
Wing, L. A. Gould, J. (1979) Severe impairments of social interaction and associated abnormalities in children: epidemiology and classification. Journal of Autism and Developmental Disorders, 9, 1129.
Wolff, S. (1991a) ‘Schizoid’ personality in childhood and adult life. I: The vagaries of diagnostic labelling. British Journal of Psychiatry, 159, 615620.
Wolff, S. (1991b) ‘Schizoid’ personality in childhood and adult life. Ill: The childhood picture. British Journal of Psychiatry, 159, 629635.
Wolff, S. (1995) Loners London: Routledge.
Wolff, S. (1996) The first account of the syndrome Asperger described? European Child and Adolescent Psychiatry, 5, 119132.
Wolff, S. & Chick, J. (1980) Schizoid personality in childhood: A controlled follow-up study. Psychological Medicine, 10, 85100.
Wolff, S. 7 McGuire, R. J. (1995) Schizoid personality in girls: a follow-up study – what are the links with Asperger's syndrome? Journal of Child Psychology and Psychiatry, 36, 793817.
Wolff, S., Townsend, R., McGuire, R. J., et al (1991) ‘Schizoid’ personality in childhood and adult life. II: Adult adjustment and the continuity with schizotypal personality disorder. British Journal of Psychiatry, 159, 620629.
World Health Organization (1992) The ICD-10 Classification of Mental and Behavioural Disorders. Clinical Descriptions and Guidelines. Geneva: WHO.
World Health Organization (1993) The ICD-10 Classification of Mental and Behavioural Disorders. Diagnostic Criteria for Research. Geneva: WHO.
Wurst, F. (1974) Lernstörungen aus der Sicht des Arztes – Learning disorders from the medical point of view. Padiatrie und Podologie, 9, 329335.

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Asperger syndrome and high-functioning autism

  • Christopher Gillberg (a1)
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