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Association between body size, weight change and depression: systematic review and meta-analysis

  • Sun Jae Jung (a1), Hyung-taek Woo (a2), Sooyoung Cho (a2), Kyounghoon Park (a2), Seokhun Jeong (a2), Yu Jin Lee (a3), Daehee Kang (a4) and Aesun Shin (a5)...
Abstract
Background

The association between body size, weight change and depression has not been systematically summarised, especially for individuals who are underweight.

Aims

To conduct a systematic review and a meta-analysis to examine the association between indices of body size, weight change and depression.

Method

A total of 183 studies were selected. Fully adjusted hazard ratios (HRs) or odds ratios (ORs) were extracted. A total of 76 studies contributed to data synthesis with a random-effect model, and subgroup analyses were conducted to evaluate the effect of potential moderators.

Results

In cohort studies, underweight at baseline increased the risk of subsequent depression (OR = 1.16, 95% CI 1.08–1.24). Overweight (BMI 25–29.9 kg/m2) showed no statistically significant relationship with depression overall; however, the subgroup analyses found different results according to gender (men: OR = 0.84, 95% CI 0.72–0.97, women: OR = 1.16, 95% CI 1.07–1.25). In cross-sectional designs, obesity with BMI >40kg/m2 showed a greater pooled odds ratio than obesity with BMI >30kg/m2.

Conclusions

Both underweight and obesity increase the risk of depression. The association between overweight and depression differs by gender.

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Copyright
Corresponding author
Aesun Shin, MD, PhD, Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. Email: shinaesun@snu.ac.kr
Footnotes
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This study was supported by grant 23-2015-0010 from the SNUH Research Fund.

Declaration of interest

None.

Footnotes
References
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Association between body size, weight change and depression: systematic review and meta-analysis

  • Sun Jae Jung (a1), Hyung-taek Woo (a2), Sooyoung Cho (a2), Kyounghoon Park (a2), Seokhun Jeong (a2), Yu Jin Lee (a3), Daehee Kang (a4) and Aesun Shin (a5)...
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