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Associations between residual depressive symptoms, cognition, and functioning in patients with euthymic bipolar disorder: results from the FACE-BD cohort

  • Paul Roux (a1), Aurélie Raust (a2), Anne-Sophie Cannavo (a1), Valérie Aubin (a3), Bruno Aouizerate (a4), Jean-Michel Azorin (a5), Frank Bellivier (a6), Raoul Belzeaux (a5), Thierry Bougerol (a7), Iréna Cussac (a3), Philippe Courtet (a8), Bruno Etain (a9), Sébastien Gard (a4), Sophie Job (a10), Jean-Pierre Kahn (a11), Marion Leboyer (a12), Emilie Olié (a8), the Fonda Mental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators, Chantal Henry (a13) and Christine Passerieux (a1)...
Abstract
Background

The relationship between residual depressive symptoms, cognition and functioning in patients with euthymic bipolar disorder is a subject of debate.

Aims

To assess whether cognition mediates the association between residual depressive symptoms and functioning in patients with bipolar disorder who were euthymic.

Method

We included 241 adults with euthymic bipolar disorder in a multicentre cross-sectional study. We used a battery of tests to assess six cognition domains. A path analysis was then used to perform a mediation analysis of the relationship between residual depressive symptoms, cognitive components and functioning.

Results

Only verbal and working memory were significantly associated with better functioning. Residual depressive symptoms were associated with poorer functioning. No significant relationship was found between residual depressive symptoms and any cognitive component.

Conclusions

Cognition and residual depressive symptoms appear to be two independent sources of variation in the functioning of people with euthymic bipolar disorder.

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      Associations between residual depressive symptoms, cognition, and functioning in patients with euthymic bipolar disorder: results from the FACE-BD cohort
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Copyright
Corresponding author
Paul Roux, MD, PhD, Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France. Email: paul.roux@uvsq.fr
Footnotes
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*

See the Appendix for the list of collaborators.

Declaration of interest

None.

Footnotes
References
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Associations between residual depressive symptoms, cognition, and functioning in patients with euthymic bipolar disorder: results from the FACE-BD cohort

  • Paul Roux (a1), Aurélie Raust (a2), Anne-Sophie Cannavo (a1), Valérie Aubin (a3), Bruno Aouizerate (a4), Jean-Michel Azorin (a5), Frank Bellivier (a6), Raoul Belzeaux (a5), Thierry Bougerol (a7), Iréna Cussac (a3), Philippe Courtet (a8), Bruno Etain (a9), Sébastien Gard (a4), Sophie Job (a10), Jean-Pierre Kahn (a11), Marion Leboyer (a12), Emilie Olié (a8), the Fonda Mental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators, Chantal Henry (a13) and Christine Passerieux (a1)...
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