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The Biochemistry of Affective Disorders

  • Alec Coppen (a1)


The title of this review would be regarded by some psychiatrists as provocative; they would relegate the biochemical concomitants of depression and mania to a secondary position and deny that biochemical changes have any place in the aetiology of these conditions. However, in my view, the weight of evidence, although it is by no means conclusive, suggests that biochemical changes are most important in the aetiology of affective disorders. A biochemical aetiology implies that there are certain biochemical changes in the brain which need to be restored to normal before the patient's clinical condition will improve. This does not deny that psychological and environmental events may precipitate and maintain the biochemical events which in turn lead to the affective disorder. The study of these biochemical events is clearly at too early a stage for speculations about the interrelationship between environmental and endogenous elements to be fruitful; this study must wait until the biochemical aetiology is clearer than at present.



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1. Abood, L. G., Kimizuka, H., Rogeness, G., and Biel, J. M. (1963). “Anti-depressants and their mechanism of action on membranes.” Ann. NY. Acad. Sci., 107, 1139.
2. Achor, R. W. P., Hanson, N. O., and Gifford, R. W. (1955). “Hypertension treated with Rauwolfia Serpentina (whole root) and with reserpine.” J. Amer. med. Ass, 159, 841.
3. Allers, R. (1914). “Ergebnisse stoffwechselpathologischer Untersuchungen bei Psychosen: III. das manisch-depressive Irresein.” Z. ges. Neurol. Psychiat., 9, 585.
4. Altschule, M. D., and Tillotson, K. J. (1949). “Effect of electroconvulsive therapy on water metabolism in psychotic patients.” Amer. J. Psychiat., 105, 829.
5. Anderson, W. McC., and Dawson, J. (1962). “The clinical manifestations of depressive illness with abnormal acetyl methyl carbinol metabolism.” J. ment. Sci., 108, 80.
6. Anderson, W. McC., and Dawson, J. (1963). “Verbally retarded depression and sodium metabolism.” Brit. J. Psychiat., 109, 225.
7. Anderson, W. McC., and Dawson, J. (1965). “The variability of plasma 17-OHCS levels in affective illness and schizophrenia.” J. psychosom. Res., 9, 237.
8. Ashcroft, G. W., Eccleston, D., Knight, F., McDougall, E. J., and Waddell, J. L. (1965). “Changes in amine metabolism produced by anti-depressive drugs.” J. psychosom. Res., 9, 129.
9. Ashcroft, G. W., and Sharman, D. F. (1960). “5-hydroxyindoles in human cerebrospinal fluids.” Nature (Lond., 186, 1050.
10. Asher, R. (1949). “Myxoedematous madness.” Brit. med. J., ii, 555.
11. Axelrod, J., and Inscoe, J. K. (1963). “The uptake and binding of circulating serotonin and the effect of drugs.” J. Pharmacol. exp. Therap., 141, 161.
12. Baastrup, P. C., and Schou, M. (1967). “Lithium as a prophylactic agent against recurrent depressions and manic-depressive psychosis.” To be published.
13. Beckett, A. H., Rowland, M., and Turner, P. 1965). “Influence of urinary pH on excretion of amphetamine.” Lancet, i, 303.
14. Bellak, L. (1952). Manic-Depressive Psychosis and Allied Conditions. New York.
15. Bergsman, A. (1959). “The urinary excretion of adrenaline and noradrenaline in some mental diseases.” Acta psychiat. neurol. Scand., 33, suppl. 133.
16. Blackwell, B. (1963). “Hypertensive crises due to monoamine-oxidase inhibitors.” Lancet, ii, 849.
17. Bleuler, M. (1954). Endokrinologische Psychiatric. Stuttgart.
18. Bliss, E. L., Migeon, C. J., Branch, C. H. H., and Samuels, L. T. (1956). “Reaction of the adrenal cortex to emotional stress.” Psychosom. Med., 18, 56.
19. Board, F., Wadeson, R., and Persky, H. (1957). “Depressive affect and endocrine function.” Arch. Neurol. Psychiat. (Chic.), 78, 612.
20. Bowman, K. M., Miller, E. R., Dailey, M. E., Simon, A., and Mayer, B. F. (1950). “Thyroid function in mental disease.” J. nerv. ment. Dis., 112, 404.
21. Brambilla, F., and Nuremberg, T. (1963). “Adrenal cortex function of cyclothymic patients in depressive phase.” Dis. nerv. Syst., 24, 727.
22. Brodie, B. B., Corner, M. S., Costa, E., and Dlabac, A. (1966). “The role of brain serotonin in the mechanism of the central action of reserpine.” J. Pharmacol. exper. Therap., 152, 340.
23. Brodie, B. B., and Costa, E. (1962). “Some current views on brain monoamines.” Psychopharmacology Service Centre Bulletin, 1, 1.
24. Brodie, B. B., and Shore, P. A. (1957). “A concept for a role of serotonin and norepinephrine as chemical mediators in the brain.” Ann. New York Acad. Sci., 66, 631.
25. Brody, E. B., and Man, E. B. (1950). “Thyroid function measured by serum precipitable iodine determinations in schizophrenic patients.” Amer. J. Psychiat., 107, 356.
26. Brooksbank, B. W. L., and Coppen, A. (1967). “Plasma 11-hydroxycorticosteroids in affective disorders.” Brit. J. Psychiat., 113, 395.
27. Brooksbank, B. W. L., and Pryse-Philips, W. (1964). “Urinary Δ16 androsten-3α-ol, 17-oxosteroids and mental illness.” Brit. med. J., i, 1602.
28. Browning, T. B., Atkins, R. W., and Weiner, H. (1954). “Cerebral metabolic disturbances in hypothyroidism.” Arch. int. Med., 93, 938.
29. Bruce, J., and Russell, G. F. M. (1962). “Weight changes and balance of water, sodium and potassium in women with premenstrual tension symptoms.” Lancet, ii, 267.
30. Bunney, W. E., and Davis, J. M. (1965). “Norepinephrine in depressive reaction.” Arch. gen. Psychiat. (Chic.), 13, 483.
31. Bunney, W. E., Mason, J. W., and Hamburg, D. (1965). “Correlations between behavioural variables and urinary 17-hydroxycorticosteroids in depressed patients.” Psychosom. Med., 27, 299.
32. Bursten, B. (1961). “Psychosis associated with thyrotoxicosis.” Arch. gen. Psychiat. (Chic.), 4, 267.
33. Büssow, H. (1950). “Uber die Wirkung des Wasser-toncphin-vcrsuches auf manisch-depressive Zustandsbilder.” Arch. Psychiat. Nervenkr., 184, 357.
34. Cade, J. F. L. (1964). “A significant elevation of plasma magnesium levels in schizophrenia and depressive states.” Med. J. Australia, 1, 195.
35. Campbell, H. J., and Eayrs, J. T. (1965). “Influence of hormones on the central nervous system.” Brit. med. Bull., 21, 81.
36. Carlsson, A., Lindqvist, M., Magnusson, T. (1957). 3, 4-dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists.” Nature, 180, 1200.
37. Carney, M. W. P., Roth, M., and Garside, R. F. (1965). “The diagnosis of depressive syndromes and the prediction of E.C.T. response.” Brit. J. Psychiat., 111, 659.
38. Christensen, H. N. (1960). “Reactive sites and biological transport.” Advanc. Protein Chem., 15, 239.
39. Christensen, H. N., Inui, Y., Wheeler, K. P., and Eavenson, E. (1966). “Amino acid transport and the sodium ion.” Fed. Proc., 25, 592.
40. Cleghorn, R. A. (1952). CibaColloq. Endocrin., 3, 141.
41. Conn, J. W. (1965). “Hypertension, the potassium ion and impaired carbohydrate tolerance.” New Eng. J. Med., 273, 1135.
42. Cope, C. L. (1965). Adrenal Steroids and Disease. London.
43. Coppen, A. (1960). “Abnormality of the blood-cerebrospinal-fluid barrier of patients suffering from a depressive illness.” J. Neurol. Neurosurg. Psychiat., 23, 156.
44. Coppen, A. (1965a). “Mineral metabolism in affective disorders.” Brit. J. Psychiat., 111, 1133.
45. Coppen, A. (1965b). “The prevalence of menstrual disorders in psychiatric patients.” Ibid., 111, 155.
46. Coppen, A., Fry, D., Julian, T., and Marks, V. (1967). “Body build and urinary steroid excretion in mental illness.” Ibid., 113, 269276.
47. Coppen, A., and Kessel, N. (1963). “Menstruation and personality.” Ibid., 109, 711.
48. Coppen, A., Malleson, A., and Shaw, D. M. (1965). “Effect of lithium carbonate on electrolyte distribution in man.” Lancet, i, 682.
49. Coppen, A., and Mezey, A. G. (1960a). “The effects of sodium amytal on the respiratory abnormalities of anxious patients.” J. psychosom. Res., 5, 52.
50. Coppen, A., and Mezey, A. G. (1960b). “Metabolic effect of venepuncture in man.” Ibid., 5, 56.
51. Coppen, A., and Shaw, D. M. (1963). “Mineral metabolism in melancholia.” Brit. med. J., ii, 1439.
52. Coppen, A., and Shaw, D. M. (1967a). “Factors affecting the distribution of electrolytes in man.” To be published.
53. Coppen, A., and Shaw, D. M. (1967b). “Further observations on 5-hydroxytryptophan metabolism in patients suffering from depression.” To be published.
54. Coppen, A., Shaw, D. M., and Farrell, J. P. (1963). “Potentiation of the antidepressive effect of a monoamine oxidase inhibitor by tryptophan.” Lancet, i, 79.
55. Coppen, A., and Malleson, A. (1965). “Changes in 5-hydroxytryptophan metabolism in depression.” Brit. J. Psychiat., 111, 105.
56. Coppen, A., and Costain, R. (1966). “Mineral metabolism in mania.” Brit. med. J., i, 71.
57. Coppen, A., Eccleston, E., and Gundy, G. (1965). “Tryptamine metabolism in depression.” Brit. J. Psychiat., 111, 993.
58. Coppen, A., and Mangoni, A. (1962). “Total exchangeable sodium in depressive illness.” Brit. med. J., ii, 295.
59. Crammer, J. L. (1959). “Water and sodium in two psychotics.” Lancet, i, 1122.
60. Crossland, J. (1963). “The role of the monoamines in excitation and depression of the central nervous system.” In: The Clinical Chemistry of Monoamines (ed. Varley, H. and Gowenlock, A. H.). Amsterdam.
61. Curtis, G. C., Cleghorn, R. A., and Sourkes, T. L. (1960). “The relationship between affect and the excretion of adrenaline, norepinephrine and 17-hydroxycorticosteroids.” J. psychosom. Res., 4, 176.
62. Davis, V. E. (1963). “Effect of Cortisol and thyroxine on aromatic amino acid decarboxylation.” Endocrinology, 72, 33.
63. Dawson, J., Hullin, R. P., and Crocket, B. M. (1956). “Metabolic variations in manic depressive psychosis.” J. ment. Sci., 102, 168.
64. Degkwitz, R., Frowein, R., Kulenkampff, C., and Mohs, V. (1960). “The influence of reserpine, chlorpromazine, iproniazid and vitamin B6 on the effects of L-Dopa in men.” Klin. Wchnschr., 38, 120.
65. Dewhurst, W. G. (1965). “On the chemical basis of mood.” J. psychosom. Res., 9, 115.
66. Doe, R. P., Vennes, J. A., and Ulstrom, R. A. (1960). “Diurnal variation of 17-OHCS, sodium, potassium, magnesium and creatinine in normal subjects and in cases of treated adrenal insufficiency and Cushing's syndrome.” J. clin. Endocrin. Metab., 20, 253.
67. Doe, R. P., Zinneman, H. H., Flink, E. B., and Ulstrom, R. A. (1960). “Significance of the concentration of non-protein-bound plasma Cortisol in normal subjects, Cushing's syndrome, pregnancy and during oestrogen therapy.” J. clin. Endocrin., 20, 1484.
68. Dongier, M., Wittkower, E. D., Stephens-Newsham, L., and Hoffman, M. M. (1956). “Psychophysiological studies in thyroid function.” Psychosom. Med., 18, 310.
69. Driver, M. V., and Eilenberg, M. D. (1960). Photoconvulsive threshold in depressive illness and the effect of E.C.T.” J. ment. Sci., 106, 611.
70. Dunlap, H. F., and Moersch, F. B. (1935). “Psychic manifestations associated with hyperthyroidism.” Amer. J. Psychiat., 91, 1215.
71. Eichhorn, O. (1954). “Zur Frage der Elektrolyt-funktionen bei Geisteskrankheiten.” Nervenarzt., 25, 207.
72. Ekman, H., Håkansson, B., McCarthy, J. D., Lehmann, J., and Sjögren, B. (1961). “Plasma 17-hydroxycorticosteroids in Cushing's syndrome.” J. clin. Endocrin. Metab., 21, 684.
73. Elmadijan, F. (1962). “Aldosterone excretion in behavioural disorders.” Res. Publ. Ass. Res. nerv. ment. Dis., 40, 414.
74. Feldstein, A., Hoagland, H., Wong, K. K., Oktem, M. R., and Freeman, H. (1965). “MAO activity in relation to depression.” Amer. J. Psychiat., 120, 1192.
75. Ferguson, H. C., Bartram, A. C. G., Fowlie, H. C., Cathro, D. M., Birchall, K., and Mitchell, F. L. (1964). “A preliminary investigation of steroid excretion in depressed patients before and after electroconvulsive therapy.” Acta endocrin. Kbh., 47, 58.
76. Fishman, J., Hamburg, D., Handlon, J., Mason, J. W., and Sachar, E. (1962). “Emotional and adrenal cortical responses to a new experience.” Arch. gen. Psychiat. (Chic.), 6, 271.
77. Flach, F. F. (1964). “Calcium metabolism in states of depression.” Brit. J. Psychiat., 110, 588.
78. Flach, F. F. (1966). “Psychopharmacologic and metabolic studies on states of depression.” Excerpta Medica. International Congress Series No. 117. IV World Congress of Psychiatry. p. 184.
79. Fleminger, J. J. (1955). “Differential effect of ACTH and cortisone on mood.” J. ment. Sci., 101, 123.
80. Fotherby, K., Ashcroft, G. W., Affleck, J. W., and Forrest, A. D. (1962). “Studies on sodium transfer and 5-hydroxyindoles in depressive illness.” J. Neurol. Neurosurg. Psychiat., 26, 71.
81. Furger, R. (1961). “Psychiatric investigation in Cushing's syndrome.” Schweiz. Arch. Neurol. Psychiat., 88, 9.
82. Gershon, S., Holmberg, G., Mattsson, E., Mattsson, N., and Marshall, A. (1962). “Imipramine hydrochloride.” Arch. gen. Psychiat. (Chic.), 6, 96.
83. Gibbons, J. L. (1960). “Total body sodium and potassium in depressive illness.” Clin Sci., 19, 133.
84. Gibbons, J. L. (1963). “Electrolytes and depressive illness.” Postgrad. Med. J., 39, 19.
85. Gibbons, J. L. (1964). “Cortisol secretion rate in depressive illness.” Arch. gen. Psychiat. (Chic), 10, 572.
86. Gibbons, J. L. (1965). “Endocrine changes in depressive illness.” Proc. roy Soc. Med., 58, 519.
87. Gibbons, J. L., Gibson, J., Maxwell, H., and Willcox, D. (1960). “An endocrine study of depressive illness.” J. psychosom. Res., 5, 32.
88. Gibbons, J. L. and McHugh, P. (1962). “Plasma Cortisol in depressive illness.” J. psychiat. Res., 1, 162.
89. Gjessing, , (1932). “Beiträge zur Kenntnis der Pathophysiologic des katatonen Stupors.” Arch. Psychiat. Nervenkr., 96, 319.
90. Glaser, G. H. (1953). “Psychotic reactions induced by corticotrophin (ACTH) and cortisone.” Psychosom. Med., 15, 280.
91. Gour, K. N., and Chaudrey, H. M. (1957). “Study of calcium metabolism in electroconvulsive therapy in certain mental diseases.” J. ment. Sci., 103, 275.
92. Greene, R., and Dalton, K. (1953). “The premenstrual syndrome.” Brit. med. J., i, 1007.
93. Hartigan, G. P. (1963). “The use of lithium salts in affective disorder.” Brit. J. Psychiat., 109, 810.
94. Henneman, D. H., Altschule, M. D., and Goncz, R. M. (1954). “Carbohydrate metabolism in brain disease. II. Glucose metabolism in schizophrenic, manic-depressive and involutional psychoses.” Arch. int. Med., 94, 402.
95. Hertting, G., Axelrod, J., and Whitby, L. G. (1961). “Effect of drugs on the uptake and metabolism of H3-norepinephrine.” J. Pharmacol. and exper. Therap., 134, 146.
96. Herzberg, B., Coppen, A., and Marks, V. (1968). “Glucose tolerance in depression.” Brit. J. Psychiat. (in press).
97. Hess, S. M., and Doepfner, W. (1961). “Behavioural effects and brain amine content in rats.” Arch. intern. Pharmacodyn., 134, 89.
98. Hetzel, B. S., de la Haba, D. S., and Hinkle, L. E. (1952). “Life stress and thyroid function in human subjects.” J. clin. Endocrin. Metab., 12, 941.
99. Himwich, H. E., and Himwich, W. A. (1964). Progress in Brain Research. Vol. VIII. Biogenic Amines. Amsterdam.
100. Hodges, J. R., Jones, M., Elithorn, A., and Bridges, P. (1964). “Effect of electroconvulsive therapy on plasma Cortisol levels.” Nature, 204, 754.
101. Holmberg, G. (1963). “Biological aspects of electroconvulsive therapy.” Internat. Rev. Neurobiol., 5, 389.
102. Howarth, E. (1961). “Possible synergistic effects of the new thymoleptics in connection with poisoning.” J. ment. Sci., 107, 100.
103. Hurxthal, L. M., and O'Sulltvan, J. B. (1959). Ann. intern. Med., 51, 1.
104. Hutter, O. F., and Kostial, K. (1954). “The effect of magnesium and calcium ions on the release of acetylcholine.” J. Physiol., 124, 234.
105. Iacobellis, M., Muntwyler, E., and Dodgen, C. L. (1956). “Free amino acid patterns of certain tissues from potassium and/or protein-deficient rats.” Amer. J. Physiol., 185, 275.
106. Jakobson, T., Stenbäck, A., Strandström, L., and Rimón, R. (1966). “The excretion of urinary 11-deoxy and 11-oxy-17-hydroxycorticosteroids in depressive patients during basal conditions and during the administration of methopyrapone.” J. psychosom. Res., 9, 363.
107. Jensen, K. (1959). “Depression in patients treated with reserpine for arterial hypertension.” Acta psychiat. neurol. Scand., 34, 195.
108. Karstens, P. (1951). “Über die Beeinflussung des psychischen Zustandes normaler durch Aufnahme und Retention unphysiologisch grosser Wassermengen.” Arch. Psychiat. Nervenkr., 186, 231.
109. Kernan, R. P. (1965). Cell K. London.
110. Kessel, N., and Coppen, A. (1963). “The prevalence of common menstrual symptoms.” Lancet, ii, 61.
111. Kety, S. S. (1963). “Aminoacids, amines and behaviour.” Ass. Res. Nerv. and Ment. Dis. Proc., 40, 311.
112. Kety, S. S. (1966). “Catecholamines in neuropsychiatric states.” Pharmacol. Rev., 18, 787.
113. Keynes, R. D., and Swan, R. C. (1959). “The permeability of frog muscle fibres to lithium ions.” J. Physiol., 147, 626.
114. Klein, R. (1950). “Clinical and biochemical investigations in a manic-depressive with short cycles.” J. ment. Sci., 96, 293.
115. Klein, L., and Carey, J. (1957). “Total exchangeable sodium in the menstrual cycle.” Amer. J. Obstet. Gynec., 74, 956.
116. Klein, R., and Nunn, R. F. (1945). “Clinical and biochemical analysis of a case of manic-depressive psychosis showing regular weekly cycles.” J. ment. Sci., 91, 79.
117. Kleinschmidt, H. J., Waxenberg, S. E., and Cuker, R. (1956). “Psychophysiology and psychiatric management of thyrotoxicosis: a two year follow-up study.” J. Mt. Sinai Hosp., 23, 131.
118. Klerman, G. L., Schildkraut, J. J., Hasenbush, L. L., Greenblatt, M., and Friend, D. G. (1963). “Clinical experience with dihydroxyphenylalanine (Dopa) in depression.” J. psychiat. Res., 1, 289.
119. Kline, N. S., and Sacks, W. (1963). “Relief of depression within one day using an MAO inhibitor with 5-HTP.” Amer. J. Psychiat., 120, 274.
120. Kline, N. S., and Simpson, G. M. (1964). “Further studies on one day treatment of depression with 5-HTP.” Amer. J. Psychiat., 121, 379.
121. Kopin, I. J. (1964). “Storage and metabolism of catecholamines: the role of monoamine oxidase.” Pharmacol. Rev., 16, 179.
122. Kuhn, R. (1958). “The treatment of depressive states with G22355 (imipramine hydrochloride).” Amer. J. Psychiat., 115, 459.
123. Kurland, H. D. (1964). “Steroid excretion in depressive disorders.” Arch. gen. Psychiat. (Chic.), 10, 554.
124. Lauer, J. W., Inskip, W. M., Bernsohn, J., and Zeller, E. A. (1958). “Observations in schizophrenic patients after iproniazid and tryptophan.” Arch. Neurol. Psychiat. (Chic.), 80, 122.
125. Lemieux, G., Davionon, H., and Genest, J. (1956). “Depressive states during Rauwolfia therapy for arterial hypertension.” Canad. med. Assoc. J., 74, 522.
126. Lidz, T., and Whitehorn, J. (1949). “Psychiatric problems in a thyroid clinic.” J. Amer. med. Ass., 139, 698.
127. Lingjaerde, O. (1963). “Tetrabcnazine (Nitoman) in the treatment of psychosis.” Acta psychiat. Scand. Suppl., 170.
128. Lingjaerde, P., Skaug, D. E., and Lingjaerde, O. (1960). “The determination of thyroid function with radio-iodine (I131) in mental patients.” Acta psychiat. neurol. Scand., 35, 498.
129. Loomer, H. P., Saunders, J. C., and Kline, N. S. (1957). “A clinical and pharmacodynamic evaluation of iproniazid as a psychic energizer.” In: Research in Affect (ed. Cleghorn, R. A.) Psychiatric Research Reports No. 8 of the American Psychiatric Association, p. 129.
130. Lubin, M., and Ennis, H. L. (1964). “On the role of intracellular potassium in protein synthesis.” Biochem. biophys. Acta, 81, 614.
131. Maggs, R. (1963). “Treatment of manic illness with lithium carbonate.” Brit. J. Psychiat., 109, 56.
132. Mandell, A. J., and Ruben, R. T. (1966). “ACTH-induced changes in tryptophan turnover along induceable pathways in man.” Life Sciences, 5, 1153.
133. Mason, J. W. (1959). “Psychological influences on the pituitary-adrenal cortical system.” Recent Prog. in Hormone Research, 15, 345.
134. Mason, J. W., Harwood, C. T., and Rosenthal, N. (1957). “Influence of some environmental factors on plasma and urinary 17-hydroxycortico-steroid levels in Rhesus monkeys.” Amer. J. Physiol., 190, 429.
135. Mayer-Gross, W., Slater, E., and Roth, M. (1960). Clinical Psychiatry. 2nd ed. London.
136. Mendel, J. (1965). “Electroconvulsive therapy and depression.” Brit. J. Psychiat., 111, 675.
137. Mezey, A. G., and Coppen, A. (1960). “The influence of isoprenaline and prednisone on the respiratory adaptation of normal subjects.” J. psychosom. Res., 5, 60.
138. Mezey, A. G., and Coppen, A. (1961). “Respiratory adaptation to exercise in anxious patients.” Clin. Sci., 20, 171.
139. Michael, R. P. (1965). “Oestrogens in the central nervous system.” Brit. med. Bull., 21, 87.
140. Michael, R. P. and Gibbons, J. L. (1963). “Interrelationships between the endocrine system and neuropsychiatry.” Internat. Rev. Neurobiol., 5, 243.
141. Morse, W. I., Clarke, A. F., MacLeod, S. C., Ernst, W. A., and Gosse, C. L. (1964). “Urine oestrogen responses to human chorionic gonadotrophin in young, old and hypogonadal men.” J. clin. Endocrin. Metab., 22, 678.
142. Mosher, L. R., Klerman, G. L., and Greanly, J. F. (1966). “A clinical trial of alpha-methyl dopa in elated states.” Amer. J. Psychiat., 122, 1185.
143. Muller, J. C., Pryor, W. W., Gibbons, J. E., and Orgain, E. S. (1955). “Depression and anxiety occurring during Rauwolfia therapy.”’ J. Amer. med. Ass., 159, 836.
144. Oates, J. A., and Sjoerdsma, A. (1960). “Neurological effects of tryptophan in patients receiving monoamine oxidase inhibitor.” Neurology, 10, 1076.
145. Pace, N., and Rathbun, E. N. (1945). “Studies on body composition III. The body water and chemically combined nitrogen content in relation to fat content.” J. biol. Chem., 158, 685.
146. Pare, C. M. B. (1965). “Some clinical aspects of antidepressant drugs.” In: The Scientific Basis of Drug Therapy in Psychiatry (ed. Marks, J. and Pare, C. M. B.). Oxford.
147. Persky, H., Grosz, H. J., Norton, J. A., and McMurty, M. (1959). “Effect of hypnotically induced anxiety on the plasma Cortisol of normal subjects.” J. clin. Endocrin. Metab., 19, 700.
148. Pitts, F. N., and Guze, S. B. (1961). “Psychiatric disorders and myxoedema.” Amer. J. Psychiat., 118, 142.
149. Pletscher, A. (1965). “Pharmacology of monoamine oxidase inhibitors.” In: The Scientific Basis of Drug Therapy (ed. Marks, J. and Pare, C. M. B.). Oxford.
150. Pollin, W., Cardon, P. V., and Kety, S. S. (1961). “Effects of amino acid feedings in schizophrenic patients treated with iproniazid.” Science, 133, 104.
151. Pollitt, J. D. (1965). “Suggestions for a physiological classification of depression.” Brit. J. Psychiat., 111, 489.
152. Pryce, I. G. (1958). “Melancholia, glucose tolerance and body weight.” J. ment. Sci., 104, 421
153. Pryce, I. G. (1964). “The relationship between 17-hydroxy-corticosteroid excretion and glucose utilization in depressions.” Brit. J. Psychiat., 110, 90.
154. Quarton, G. C., Clark, L. D., Cobb, S., and Bauer, W. (1955). “Mental disturbances associated with ACTH and cortisone: a review of explanatory hypotheses.” Medicine, 34, 13.
155. Rees, L. (1960). “Constitutional factors and abnormal behaviour.” In: Handbook of Abnormal Psychology (ed. Eysenck, H. J.). London.
156. Rey, J. H., and Coppen, A. (1959). “Distribution of androgyny in a psychiatric population.” Brit. med. J., ii, 1445.
157. Rodnight, R. (1961). “Body fluid indoles in mental illness.” Internat. Rev. Neurobiol., 3, 251.
158. Rosenblatt, S., and Chanley, J. D. (1965). “Differences in the metabolism of norepinephrine in depression.” Arch. gen, Psychiat. (Chic.), 13, 495.
159. Rosenblatt, S., Chanley, J. D., Sobotka, H., and Kaufman, M. R. (1960). “Interrelationships between electroshock and the blood-brain barrier and catecholamines.” J. Neurochem., 5, 172.
160. Russell, G. F. M. (1960). “Body weight and balance of water, sodium and potassium in depressed patients given electroconvulsive therapy.” Clin. Sci., 19, 327.
161. Schapiro, S., Yuwiler, A., and Geller, E. (1964). “Stress-activated inhibition of the Cortisol effect on hepatic transaminase.” Life Sciences, 3, 1221.
162. Scheckel, C. L., and Boff, E. (1964). “Behavioural effects of interacting imipramine and other drugs with d-amphetamine, cocaine and tetrabenazine.” Psychopharmacologia, 5, 198.
163. Schildkraut, J. J. (1965). “The catecholamine hypothesis of affective disorders: a review of the supporting evidence.” Amer. J. Psychiat., 122, 509.
164. Schottstaedt, W. W., Grace, W. J., and Wolff, H. G. (1956). “Life situations, behaviour, attitudes, emotions and renal excretion of fluid and electrolytes. I to V.” J. psychosom. Res., 1, 75, 147, 203, 287, 292.
165. Schou, M. (1957). “Biology and pharmacology of the lithium ion.” Pharmacol. Rev., 9, 17.
166. Schou, M. (1963). “Normothymotics, ‘mood-normalizers’. Are lithium and the imipramine drugs specific for affective disorders?Brit. J. Psychiat., 109, 803.
167. Shagass, C., and Schwartz, M. (1962). In: Physiological Correlates of Psychological Disorder (ed. by Roessler, R. and Greenfield, N. S.). p. 45. Madison.
168. Shagass, C., and Schwartz, M. (1966). “Somatosensory cerebral evoked responses in psychotic depression.” Brit. J. Psychiat., 111, 799.
169. Shaw, D. M. (1966). “Hind-brain 5-hydroxytryptamine in people who have committed suicide.” Excerpta Medica. International Congress Series No. 117, p. 392.
170. Shaw, D. M. and Coppen, A. (1966). “Potassium and water distribution in depression.” Brit. J. Psychiat., 112, 269.
171. Sigg, E. B. (1959). “Pharmacological studies with Tofranil.” Canad. Psychiat. A. J. Suppl. 1, 4, 75.
172. Sjoerdsma, A., Engelman, K., Spector, S., and Udenfriend, S. (1965). “Inhibition of catecholamine synthesis in man with alpha-methyltyrosine, an inhibitor of tyrosine hydroxylase.” Lancet, ii, 1092.
173. Sloane, R. B., Saffron, M., and Cleghorn, R. A. (1958). “Autonomic and adrenal responsivity in psychiatric patients.” Arch. Neurol. Psychiat., 79, 549.
174. Smith, B., and Prockop, D. J. (1962). “Central nervous system effects of ingestion of L-tryptophan by normal subjects.” New England J. Med., 267, 1338.
175. Sourkes, T. L. (1962). Biochemistry of Mental Disease. New York,
176. Sperry, W. M. (1954). “The biochemistry of depressions.” In: Depression (ed. Hoch, P. H. and Zubin, J.). New York.
177. Stenbäck, A., Jakobson, T., and Rimón, R. (1966). “Depression and anxiety ratings in relation to the excretion of urinary total 17-OHCS in depressive subjects.” J. psychosom. Res., 9, 355.
178. Stoll, W. A. (1953). Die Psychiatrie des Morbus Addison. Stuttgart.
179. Ström-Olsen, R., and Weil-Malherbe, H. (1958). “Humoral changes in manic-depressive psychosis with particular reference to the excretion of catecholamines in urine.” J. ment. Sci., 104, 696.
180. Tedeschi, D. H., Tedeschi, R. E., and Fellows, E. J. (1959). “The effects of tryptamine on the central nervous system, including a pharmacological procedure for the evaluation of iproniazid-like drugs.” J. Pharmacol. and exp. Therap., 126, 223.
181. Trethowan, W. H., and Cobb, S. (1952). “Neuropsychiatric aspects of Cushing's syndrome.” Arch. Neurol. Psychiat., 67, 283.
182. Veall, N., and Vetter, H. (1958). Radio-isotope Techniques in Clinical Research and Diagnosis. London.
183. Vidaver, G. A. (1964). “Some tests of the hypothesis that the sodium ion furnishes the energy for glycine active transport by pigeon red cells.” Biochemistry, 3, 803.
184. Wasserman, M. J., Belton, N. R., and Millichap, J. G. (1965). “Effect of corticotrophin (ACTH) on experimental seizures.” Neurology, 15, 1136.
185. Weissbach, H., King, W., Sjoerdsma, A., and Udenfriend, S. (1959). “Formation of indole-3-acetic acid and tryptamine in animals.” J. biol. Chem., 234, 81.
186. Woodbury, D. M. (1958). “Relation between adrenal cortex and the central nervous system.” Pharmacol. Rev., 10, 275.
187. Woodbury, D. M., Timiras, P. S., and Vernadakis, A. (1957). “Influence of adrenocortical steroids on brain function and metabolism.” In: Hormones, Brain Function and Behaviour (ed. by Hoagland, H.). New York.

The Biochemistry of Affective Disorders

  • Alec Coppen (a1)


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