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Biological vulnerability to depression: linked structural and functional brain network findings

  • N. L. Nixon (a1), P. F. Liddle (a1), E. Nixon (a1), G. Worwood (a1), M. Liotti (a2) and L. Palaniyappan (a3)...
Abstract
Background

Patients in recovery following episodes of major depressive disorder (MDD) remain highly vulnerable to future recurrence. Although psychological determinants of this risk are well established, little is known about associated biological mechanisms. Recent work has implicated the default mode network (DMN) in this vulnerability but specific hypotheses remain untested within the high risk, recovered state of MDD.

 Aims

To test the hypothesis that there is excessive DMN functional connectivity during task performance within recovered-state MDD and to test for connected DMN cortical gyrification abnormalities.

 Method

A multimodal structural and functional magnetic resonance imaging (fMRI) study, including task-based functional connectivity and cortical folding analysis, comparing 20 recovered-state patients with MDD with 20 matched healthy controls.

 Results

The MDD group showed significant task-based DMN hyperconnectivity, associated with hypogyrification of key DMN regions (bilateral precuneus).

 Conclusions

This is the first evidence of connected structural and functional DMN abnormalities in recovered-state MDD, supporting recent hypotheses on biological-level vulnerability.
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Copyright
COPYRIGHT: © Royal College of Psychiatrists, 2014 
Corresponding author
N. L. Nixon, Division of Psychiatry, Institute of Mental Health, University of Nottingham, Triumph Road, Nottingham NG7 2TU, UK. Email neil.nixon@nottingham.ac.uk
Footnotes
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Declaration of interest

N.L.N. received funding from the Institute of Mental Health, Nottingham, which enabled him to carry out this research project, and has received financial assistance to attend academic meetings from Janssen-Cilag, AstraZeneca, Servier and Shire. He has also taken part in advisory panels for Janssen-Cilag and Servier. P.F.L. has received honoraria for academic presentations from GlaxoSmithKline, AstraZeneca, Janssen-Cilag, Bristol-Myers Squibb, Eli Lilly and Johnson & Johnson Pharmaceuticals. He has also taken part in advisory panels for Eli Lilly, Pfizer and GlaxoSmithKline. G.W. has received honoraria for academic presentations from Janssen-Cilag. M.L. received a grant from the National Alliance for Research on Schizophrenia and Depression (NARSAD). L.P. has received a travel fellowship from the International Bipolar Disorder Society sponsored by Eli Lilly in 2010.

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  • Cited by 21
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    Figueroa, Caroline A Mocking, Roel J T van Wingen, Guido Martens, Suzanne Ruhé, Henricus G and Schene, Aart H 2017. Aberrant default-mode network-hippocampus connectivity after sad memory-recall in remitted-depression. Social Cognitive and Affective Neuroscience, Vol. 12, Issue. 11, p. 1803.

    Molent, Cinzia Maggioni, Eleonora Cecchetto, Filippo Garzitto, Marco Piccin, Sara Bonivento, Carolina Maieron, Marta D'Agostini, Serena Balestrieri, Matteo Perna, Giampaolo Altamura, A. Carlo and Brambilla, Paolo 2017. Reduced cortical thickness and increased gyrification in generalized anxiety disorder: a 3 T MRI study. Psychological Medicine, p. 1.

    Rus, O. G. Reess, T. J. Wagner, G. Zaudig, M. Zimmer, C. and Koch, K. 2017. Hypogyrification in obsessive-compulsive disorder. Psychological Medicine, Vol. 47, Issue. 06, p. 1053.

    Mel’nikov, M. E. Bezmaternykh, D. D. Petrovskii, E. D. Kozlova, L. I. Shtark, M. B. Savelov, A. A. Shubina, O. S. and Natarova, K. A. 2017. Peculiarities in Interaction of Independent Components of Resting-State fMRI Signal in Patients with Mild Depressions. Bulletin of Experimental Biology and Medicine, Vol. 163, Issue. 4, p. 497.

    Han, Kyu-Man Won, Eunsoo Kang, June Kim, Aram Yoon, Ho-Kyoung Chang, Hun Soo Son, Kyu Ri Lee, Min-Soo Tae, Woo-Suk and Ham, Byung-Joo 2017. Local gyrification index in patients with major depressive disorder and its association with tryptophan hydroxylase-2 (TPH2 ) polymorphism. Human Brain Mapping, Vol. 38, Issue. 3, p. 1299.

    Solowij, N. Zalesky, A. Lorenzetti, V. and Yücel, M. 2017. Handbook of Cannabis and Related Pathologies. p. 391.

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    Schilbach, L. Hoffstaedter, F. Müller, V. Cieslik, E.C. Goya-Maldonado, R. Trost, S. Sorg, C. Riedl, V. Jardri, R. Sommer, I. Kogler, L. Derntl, B. Gruber, O. and Eickhoff, S.B. 2016. Transdiagnostic commonalities and differences in resting state functional connectivity of the default mode network in schizophrenia and major depression. NeuroImage: Clinical, Vol. 10, p. 326.

    Posner, Jonathan Cha, Jiook Wang, Zhishun Talati, Ardesheer Warner, Virginia Gerber, Andrew Peterson, Bradley S and Weissman, Myrna 2016. Increased Default Mode Network Connectivity in Individuals at High Familial Risk for Depression. Neuropsychopharmacology, Vol. 41, Issue. 7, p. 1759.

    Barnhofer, Thorsten Huntenburg, Julia M. Lifshitz, Michael Wild, Jennifer Antonova, Elena and Margulies, Daniel S. 2016. How Mindfulness Training May Help to Reduce Vulnerability for Recurrent Depression. Clinical Psychological Science, Vol. 4, Issue. 2, p. 328.

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    Peng, Daihui Liddle, Elizabeth B. Iwabuchi, Sarina J. Zhang, Chen Wu, Zhiguo Liu, Jun Jiang, Kaida Xu, Lin Liddle, Peter F Palaniyappan, Lena and Fang, Yiru 2015. Dissociated large-scale functional connectivity networks of the precuneus in medication-naïve first-episode depression. Psychiatry Research: Neuroimaging, Vol. 232, Issue. 3, p. 250.

    Kim, Byung-Hoon Namkoong, Kee Kim, Jae-Jin Lee, Seojung Yoon, Kang Joon Choi, Moonjong and Jung, Young-Chul 2015. Altered resting-state functional connectivity in women with chronic fatigue syndrome. Psychiatry Research: Neuroimaging, Vol. 234, Issue. 3, p. 292.

    Peng, Daihui Shi, Feng Li, Gang Fralick, Drew Shen, Ting Qiu, Meihui Liu, Jun Jiang, Kaida Shen, Dinggang Fang, Yiru and He, Yong 2015. Surface Vulnerability of Cerebral Cortex to Major Depressive Disorder. PLOS ONE, Vol. 10, Issue. 3, p. e0120704.

    Shi, Huqing Wang, Xiang Yi, Jinyao Zhu, Xiongzhao Zhang, Xiaocui Yang, Juan and Yao, Shuqiao 2015. Default mode network alterations during implicit emotional faces processing in first-episode, treatment-naive major depression patients. Frontiers in Psychology, Vol. 6,

    Irle, Eva Barke, Antonia Lange, Claudia and Ruhleder, Mirjana 2014. Parietal abnormalities are related to avoidance in social anxiety disorder: A study using voxel-based morphometry and manual volumetry. Psychiatry Research: Neuroimaging, Vol. 224, Issue. 3, p. 175.

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Biological vulnerability to depression: linked structural and functional brain network findings

  • N. L. Nixon (a1), P. F. Liddle (a1), E. Nixon (a1), G. Worwood (a1), M. Liotti (a2) and L. Palaniyappan (a3)...
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