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Cancer mortality in patients with schizophrenia: systematic review and meta-analysis

  • Chuanjun Zhuo (a1), Ran Tao (a2), Ronghuan Jiang (a3), Xiaodong Lin (a4) and Mingjing Shao (a5)...
Abstract
Background

Previous studies have reported conflicting results on the association between schizophrenia and cancer mortality.

Aims

To summarise available evidence and quantify the association between schizophrenia and cancer mortality using meta-analysis.

Method

We systematically searched literature in the PubMed and Embase databases. Risk estimates and 95% confidence intervals reported in individual studies were pooled using the DerSimonian–Laird random-effects model.

Results

We included 19 studies in the meta-analysis. Among them, 15 studies reported standardised mortality ratios (SMRs) comparing patients with schizophrenia with the general population, and the pooled SMR was 1.40 (95% CI 1.29–1.52, P<0.001). The other four studies reported hazard ratios (HRs) comparing individuals with schizophrenia with those without schizophrenia; the pooled HR was 1.51 (95% CI 1.13–2.03, P = 0.006).

Conclusions

Patients with schizophrenia are at a significantly increased risk of cancer mortality compared with the general population or individuals without schizophrenia.

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Copyright
Corresponding author
Chuanjun Zhuo, Department of Psychiatry, Wenzhou Seventh People's Hospital, 522 Xishan East Road, Wenzhou, Zhejiang 325005, China. Email: chuanjunzhuotjmh@163.com
Footnotes
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This work was supported by Found of Tianjin Health Bureau (2014KR02 to C.Z.), Chinese Postdoctoral Science Foundation (2012M0585 to C.Z.), Jiangsu Haosen pharmaceutical Limited by Share Ltd (2016-Young scholar support project to C.Z.), Hainan Liou pharmaceutical Limited by Share Ltd (2016-Young scholar support project to C.Z.), Xuzhou Enhua pharmaceutical Limited by Share Ltd (2016-Young scholar support project to C.Z.), Shanghai Zhongxi pharmaceutical Limited by Share Ltd (2016-Young scholar support project to C.Z.).

Declaration of interest

None.

Footnotes
References
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Cancer mortality in patients with schizophrenia: systematic review and meta-analysis

  • Chuanjun Zhuo (a1), Ran Tao (a2), Ronghuan Jiang (a3), Xiaodong Lin (a4) and Mingjing Shao (a5)...
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