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Morris, Gerwyn Berk, Michael and Puri, Basant K. 2017. A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?. Molecular Neurobiology,
Sarfati, David Evans, Vanessa C. Tam, Edwin M. Woo, Cindy Iverson, Grant L. Yatham, Lakshmi N. and Lam, Raymond W. 2017. The impact of fatigue and energy on work functioning and impairment in patients with major depressive disorder treated with desvenlafaxine. International Clinical Psychopharmacology, Vol. 32, Issue. 6, p. 343.
O'Shea, Deirdre M. De Wit, Liselotte Szymkowicz, Sarah M. McLaren, Molly E. Talty, Francis and Dotson, Vonetta M. 2016. Anxiety Modifies the Association between Fatigue and Verbal Fluency in Cognitively Normal Adults. Archives of Clinical Neuropsychology,
Morris, Gerwyn Berk, Michael Walder, Ken and Maes, Michael 2015. Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses. BMC Medicine, Vol. 13, Issue. 1,
Palmer, Susan M. Crewther, Sheila G. and Carey, Leeanne M. 2015. A Meta-Analysis of Changes in Brain Activity in Clinical Depression. Frontiers in Human Neuroscience, Vol. 8,
Hawkins, Misty A.W. Dolansky, Mary A. Schaefer, Julie T. Fulcher, Michael J. Gunstad, John Redle, Joseph D. Josephson, Richard and Hughes, Joel W. 2015. Cognitive Function in Heart Failure Is Associated With Nonsomatic Symptoms of Depression But Not Somatic Symptoms. The Journal of Cardiovascular Nursing, Vol. 30, Issue. 5, p. E9.
Richieri, Raphaëlle Boyer, Laurent Faget-Agius, Catherine Farisse, Jean Mundler, Olivier Lançon, Christophe and Guedj, Eric 2015. Determinants of brain SPECT perfusion and connectivity in treatment-resistant depression. Psychiatry Research: Neuroimaging, Vol. 231, Issue. 2, p. 134.
Medow, Marvin S. Sood, Shilpa Messer, Zachary Dzogbeta, Seli Terilli, Courtney and Stewart, Julian M. 2014. Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome. Journal of Applied Physiology, Vol. 117, Issue. 10, p. 1157.
Kim, S. E. and Chang, L. 2012. Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms?. Neurogastroenterology & Motility, Vol. 24, Issue. 10, p. 895.
Ocon, Anthony J. Messer, Zachary R. Medow, Marvin S. and Stewart, Julian M. 2012. Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome. Clinical Science, Vol. 122, Issue. 5, p. 227.
Stewart, Julian M. Medow, Marvin S. Messer, Zachary R. Baugham, Ila L. Terilli, Courtney and Ocon, Anthony J. 2012. Postural neurocognitive and neuronal activated cerebral blood flow deficits in young chronic fatigue syndrome patients with postural tachycardia syndrome. American Journal of Physiology-Heart and Circulatory Physiology, Vol. 302, Issue. 5, p. H1185.
Santamarina-Pérez, Pilar Eiroa-Orosa, Francisco José Sáez, Naia and Alegre, José 2011. Respuesta. Medicina Clínica, Vol. 137, Issue. 12, p. 572.
Flor-Henry, Pierre Lind, John C. and Koles, Zoltan J. 2010. EEG source analysis of chronic fatigue syndrome. Psychiatry Research: Neuroimaging, Vol. 181, Issue. 2, p. 155.
DeLuca, John Genova, Helen M. Capili, Emlyn J. and Wylie, Glenn R. 2009. Functional Neuroimaging of Fatigue. Physical Medicine and Rehabilitation Clinics of North America, Vol. 20, Issue. 2, p. 325.
Chen, J.-R. Wang, T.-J. Huang, H.-Y. Chen, L.-J. Huang, Y.-S. Wang, Y.-J. and Tseng, G.-F. 2009. Fatigue reversibly reduced cortical and hippocampal dendritic spines concurrent with compromise of motor endurance and spatial memory. Neuroscience, Vol. 161, Issue. 4, p. 1104.
Begré, Stefan Lütgert, Tobias Remonda, Luca Wiest, Roland Kiefer, Claus and Von Känel, Roland 2008. Relationship between Perceived Sleep Problems and Thalamic Size in Patients with Chronic Fatigue Syndrome Compared to Non-Fatigued Controls: A Preliminary Study. Clinical Medicine Insights: Psychiatry, Vol. 1, p. CMPsy.S704.
Erdman, Katherine M. 2008. How biological abnormalities separate CFS from depression. Journal of the American Academy of Physician Assistants, Vol. 21, Issue. 3, p. 19.
Patients with chronic fatigue syndrome (CFS) and depressive illness share many, but not all, features.
To test the hypothesis that patients with CFS have abnormal cerebral perfusion, that differs from that in patients with depressive illness.
We recruited 30 patients with CFS who were not depressed, 12 depressed patients and 15 healthy volunteers. Regional cerebral perfusion at rest was assessed using region of interest (ROI) and voxel-based statistical parametric mapping (SPM) techniques.
On SPM analysis there was increased perfusion in the right thalamus, pallidum and putamen in patients with CFS and in those with depressive illness. CFS patients also had increased perfusion in the left thalamus. Depressed patients differed from those with CFS in having relatively less perfusion of the left prefrontal cortex. The results were similar on ROI analysis.
Abnormal cerebral perfusion patterns in CFS subjects who are not depressed are similar but not identical to those in patients with depressive illness. Thalamic overactivity may be a correlate of increased attention to activity in CFS and depression; reduced prefrontal perfusion in depression may be associated with the greater neuropsychological deficits in that disorder.
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Morris, Gerwyn Berk, Michael and Puri, Basant K. 2017. A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?. Molecular Neurobiology,
Sarfati, David Evans, Vanessa C. Tam, Edwin M. Woo, Cindy Iverson, Grant L. Yatham, Lakshmi N. and Lam, Raymond W. 2017. The impact of fatigue and energy on work functioning and impairment in patients with major depressive disorder treated with desvenlafaxine. International Clinical Psychopharmacology, Vol. 32, Issue. 6, p. 343.
O'Shea, Deirdre M. De Wit, Liselotte Szymkowicz, Sarah M. McLaren, Molly E. Talty, Francis and Dotson, Vonetta M. 2016. Anxiety Modifies the Association between Fatigue and Verbal Fluency in Cognitively Normal Adults. Archives of Clinical Neuropsychology,
Morris, Gerwyn Berk, Michael Walder, Ken and Maes, Michael 2015. Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses. BMC Medicine, Vol. 13, Issue. 1,
Palmer, Susan M. Crewther, Sheila G. and Carey, Leeanne M. 2015. A Meta-Analysis of Changes in Brain Activity in Clinical Depression. Frontiers in Human Neuroscience, Vol. 8,
Hawkins, Misty A.W. Dolansky, Mary A. Schaefer, Julie T. Fulcher, Michael J. Gunstad, John Redle, Joseph D. Josephson, Richard and Hughes, Joel W. 2015. Cognitive Function in Heart Failure Is Associated With Nonsomatic Symptoms of Depression But Not Somatic Symptoms. The Journal of Cardiovascular Nursing, Vol. 30, Issue. 5, p. E9.
Richieri, Raphaëlle Boyer, Laurent Faget-Agius, Catherine Farisse, Jean Mundler, Olivier Lançon, Christophe and Guedj, Eric 2015. Determinants of brain SPECT perfusion and connectivity in treatment-resistant depression. Psychiatry Research: Neuroimaging, Vol. 231, Issue. 2, p. 134.
Medow, Marvin S. Sood, Shilpa Messer, Zachary Dzogbeta, Seli Terilli, Courtney and Stewart, Julian M. 2014. Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome. Journal of Applied Physiology, Vol. 117, Issue. 10, p. 1157.
Kim, S. E. and Chang, L. 2012. Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms?. Neurogastroenterology & Motility, Vol. 24, Issue. 10, p. 895.
Ocon, Anthony J. Messer, Zachary R. Medow, Marvin S. and Stewart, Julian M. 2012. Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome. Clinical Science, Vol. 122, Issue. 5, p. 227.
Stewart, Julian M. Medow, Marvin S. Messer, Zachary R. Baugham, Ila L. Terilli, Courtney and Ocon, Anthony J. 2012. Postural neurocognitive and neuronal activated cerebral blood flow deficits in young chronic fatigue syndrome patients with postural tachycardia syndrome. American Journal of Physiology-Heart and Circulatory Physiology, Vol. 302, Issue. 5, p. H1185.
Santamarina-Pérez, Pilar Eiroa-Orosa, Francisco José Sáez, Naia and Alegre, José 2011. Respuesta. Medicina Clínica, Vol. 137, Issue. 12, p. 572.
Flor-Henry, Pierre Lind, John C. and Koles, Zoltan J. 2010. EEG source analysis of chronic fatigue syndrome. Psychiatry Research: Neuroimaging, Vol. 181, Issue. 2, p. 155.
DeLuca, John Genova, Helen M. Capili, Emlyn J. and Wylie, Glenn R. 2009. Functional Neuroimaging of Fatigue. Physical Medicine and Rehabilitation Clinics of North America, Vol. 20, Issue. 2, p. 325.
Chen, J.-R. Wang, T.-J. Huang, H.-Y. Chen, L.-J. Huang, Y.-S. Wang, Y.-J. and Tseng, G.-F. 2009. Fatigue reversibly reduced cortical and hippocampal dendritic spines concurrent with compromise of motor endurance and spatial memory. Neuroscience, Vol. 161, Issue. 4, p. 1104.
Begré, Stefan Lütgert, Tobias Remonda, Luca Wiest, Roland Kiefer, Claus and Von Känel, Roland 2008. Relationship between Perceived Sleep Problems and Thalamic Size in Patients with Chronic Fatigue Syndrome Compared to Non-Fatigued Controls: A Preliminary Study. Clinical Medicine Insights: Psychiatry, Vol. 1, p. CMPsy.S704.
Erdman, Katherine M. 2008. How biological abnormalities separate CFS from depression. Journal of the American Academy of Physician Assistants, Vol. 21, Issue. 3, p. 19.
Cerebral perfusion in chronic fatigue syndrome and depression
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