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Changes in distributed neural circuitry function in patients with first-episode schizophrenia

  • A. Mendrek (a1), K. R. Laurens (a1), K. A. Kiehl (a1), E. T. C. Ngan (a1), E. Stip (a1) and P. F. Liddle (a1)...
Extract
Background

A number of functional brain abnormalities have been reported in schizophrenia, but it remains to be determined which of them represent trait and state markers of the illness.

Aims

To delineate regional brain dysfunctions that remain stable and those that fluctuate during the course of schizophrenia.

Method

A cohort of patients with first-episode schizophrenia and a matched group of control participants underwent functional magnetic resonance imaging on two occasions 6–8 weeks apart during performance of a working memory task. The patients' disease was in partial remission at the second scan.

Results

Relative to control participants, the function of the left dorsolateral prefrontal cortex, left thalamus and right cerebellum remained disturbed in the people with schizophrenia, whereas the dysfunction of the right dorsolateral prefrontal cortex, right thalamus, left cerebellum and cingulate gyrus normalised, with significant reduction in symptoms.

Conclusions

These results suggest that dysfunction of the left fronto-thalamo-cerebellar circuitry is a relatively stable characteristic of schizophrenia, whereas disturbance of the right circuitry and cingulate gyrus is predominantly a state-related phenomenon.

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Copyright
Corresponding author
Dr Adrianna Mendrek, Department of Psychiatry, University of Montreal, Centre de recherche Fernand-Seguin, 7331 Hochelaga, Montreal, Québec HIN 3V2, Canada. Tel: + 1 514 251 4015 ext. 3528; fax: + 1 514 251 2617; e-mail: amendrek@crfs.umontreal.ca
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Declaration of interest

None. Funding detailed in Acknowledgements.

Footnotes
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  • ISSN: 0007-1250
  • EISSN: 1472-1465
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Changes in distributed neural circuitry function in patients with first-episode schizophrenia

  • A. Mendrek (a1), K. R. Laurens (a1), K. A. Kiehl (a1), E. T. C. Ngan (a1), E. Stip (a1) and P. F. Liddle (a1)...
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