Van Winkel, R, Stefanis, NC, Myin-Germeys, I. Psychosocial stress and psychosis. A review of the
neurobiological mechanisms and the evidence for gene-stress
interaction. Schizophr Bull
2008; 34: 1095–105.
Bendall, S, Jackson, HJ, Hulbert, CA, McGorry, PD. Childhood trauma and psychotic disorders: a
systematic, critical review of the evidence.
2008; 34: 568–79.
Bebbington, PE, Bhugra, D, Brugha, T, Singleton, N, Farrell, M, Jenkins, R, et al. Psychosis, victimisation and childhood
disadvantage. Evidence from the second British National Survey of
Psychiatric Morbidity. Br J Psychiatry
2004; 185: 220–6.
Kelleher, I, Harley, M, Lynch, F, Arseneault, L, Fitzpatrick, C, Cannon, M. Associations between childhood trauma, bullying and
psychotic symptoms among a school-based adolescent
sample. Br J Psychiatry
2008; 193: 378–82.
Spauwen, J, Krabbendam, L, Lieb, R, Wittchen, HU, van Os, J. Impact of psychological trauma on the development of
psychotic symptoms: relationship with psychosis
proneness. Br J Psychiatry
2006; 188: 527–33.
Janssen, I, Krabbendam, L, Bak, M, Hanssen, M, Vollebergh, W, de Graaf, R, et al. Childhood abuse as a risk factor for
psychotic experiences. Acta Psychiatr
Chen, ZY, Jing, D, Bath, KG, Ieraci, A, Khan, T, Siao, CJ, et al. Genetic variant BDNF (Val66Met) polymorphism
alters anxiety-related behavior. Science
2006; 314: 140–3.
Aguilera, M, Arias, B, Wichers, M, Barrantes-Vidal, N, Moya, J, Villa, H, et al. Early adversity and 5-HTT/BDNF genes: new
evidence of gene-environment interactions on depressive symptoms in a
general population. Psychol Med
2009; 39: 1425–32.
Buckley, PF, Mahadik, S, Pillai, A, Terry, A Jr. Neurotrophins and schizophrenia.
van Os, JS, Sham, P. Gene-environment interactions. In
The Epidemiology of Schizophrenia (eds Murray, RJ, Jones, PB, Susser, E, van Os, J, Cannon, M): 235–53. Cambridge University
Simons, CJ, Wichers, M, Derom, C, Thiery, E, Myin-Germeys, I, Krabbendam, L, et al. Subtle gene-environment interactions driving
paranoia in daily life. Genes Brain
Freedman, ML, Reich, D, Penney, KL, McDonald, GJ, Mignault, AA, Patterson, N, et al. Assessing the impact of population
stratification on genetic association studies.
2004; 36: 388–93.
Stefanis, NC, Hanssen, M, Smirnis, NK, Avramopoulos, DA, Evdokimidis, IK, Stefanis, CN, et al. Evidence that three dimensions of psychosis
have a distribution in the general population.
2002; 32: 347–58.
Bernstein, DPFL. Childhood Trauma Questionnaire: A Retrospective
Self-report. The Psychological
Bernstein, DP, Stein, JA, Newcomb, MD, Walker, E, Pogge, D, Ahluvalia, T, et al. Development and validation of a brief
screening version of the Childhood Trauma Questionnaire.
Child Abuse Negl
2003; 27: 169–90.
Barkus, E, Lewis, S. Schizotypy and psychosis-like experiences from
recreational cannabis in a non-clinical sample.
2008; 38: 1267–76.
Freeman, D, McManus, S, Brugha, T, Meltzer, H, Jenkins, R, Bebbington, P. Concomitants of paranoia in the general
population. Psychol Med
Barrantes-Vidal, N, Lewandowski, KE, Kwapil, TR. Psychopathology, social adjustment and personality
correlates of schizotypy clusters in a large nonclinical
sample. Schizophr Res
2010; 122: 219–25.
Raine, AB, Benishay, D. A brief screening instrument for schizotypal
personality disorder. J Pers Disord
1995; 9: 346–55.
Spielberg, CG, Gorsuch, RL, Lushene, RE. STAI Manual for the State-Trait Anxiety Inventory.
Consulting Psychologists Press,
Egan, MF, Kojima, M, Callicott, JH, Goldberg, TE, Kolachana, BS, Bertolino, A, et al. The BDNF val66met polymorphism affects
activity-dependent secretion of BDNF and human memory and hippocampal
2003; 112: 257–69.
Johns, LC, van Os, J. The continuity of psychotic experiences in the
general population. Clin Psychol Rev
2001; 21: 1125–41.
Barrett, TE, Etheridge, JB. Verbal hallucinations in normals. I: People who hear
voices. Appl Cogn Psychol
1992; 6: 379–87.
Posey, TL, Losch, ME. Auditory hallucinations of hearing voices in 375
normal subjects. Imagination Cognition
Garety, PA, Kuipers, E, Fowler, D, Freeman, D, Bebbington, PE. A cognitive model of the positive symptoms of
psychosis. Psychol Med
2001; 31: 189–95.
Read, J, Perry, BD, Moskowitz, A, Connolly, J. The contribution of early traumatic events to
schizophrenia in some patients: a traumagenic neurodevelopmental
2001; 64: 319–45.
Heim, C, Newport, DJ, Heit, S, Graham, YP, Wilcox, M, Bonsall, R, et al. Pituitary-adrenal and autonomic responses to
stress in women after sexual and physical abuse in
2000; 284: 592–7.
Vogel, M, Spitzer, C, Kuwert, P, Moller, B, Freyberger, HJ, Grabe, HJ. Association of childhood neglect with adult
dissociation in schizophrenic inpatients.
2009; 42: 124–30.
Gil, A, Gama, CS, de Jesus, DR, Lobato, MI, Zimmer, M, Belmonte-de-Abreu, P. The association of child abuse and neglect with
adult disability in schizophrenia and the prominent role of physical
neglect. Child Abuse Negl
2009; 33: 618–24.
Fisher, HL, Jones, PB, Fearon, P, Craig, TK, Dazzan, P, Morgan, K, et al. The varying impact of type, timing and
frequency of exposure to childhood adversity on its association with
adult psychotic disorder. Psychol Med
Whitfield, CL, Dube, SR, Felitti, VJ, Anda, RF. Adverse childhood experiences and
hallucinations. Child Abuse Negl
Morgan, C, Fisher, H. Environment and schizophrenia: environmental factors
in schizophrenia: childhood trauma–a critical review.
Harris, T. Recent developments in the study of life events in
relation to psychiatric and physical disorders. In
Psychiatric Epidemiology: Progress and Prospects (ed
Cooper, B): 81–102. Croom
Hlastala, SA, McClellan, J. Phenomenology and diagnostic stability of youths
with atypical psychotic symptoms. J Child Adolesc
Rutter, M, Moffitt, TE, Caspi, A. Gene-environment interplay and psychopathology:
multiple varieties but real effects. J Child
2006; 47: 226–61.
Munafo, MR, Flint, J. Replication and heterogeneity in gene×environment
interaction studies. Int J
2009; 12: 727–9.
Chen, ZY, Patel, PD, Sant, G, Meng, CX, Teng, KK, Hempstead, BL, et al. Variant brain-derived neurotrophic factor
(BDNF) (Met66) alters the intracellular trafficking and
activity-dependent secretion of wild-type BDNF in neurosecretory cells
and cortical neurons. J Neurosci
2004; 24: 4401–11.
Arseneault, L, Cannon, M, Witton, J, Murray, RM. Causal association between cannabis and psychosis:
examination of the evidence. Br J
2004; 184: 110–7.
Freeman, D, Garety, PA. Connecting neurosis and psychosis: the direct
influence of emotion on delusions and hallucinations.
Behav Res Ther
2003; 41: 923–47.