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Childhood maltreatment and characteristics of adult depression: Meta-analysis

  • Janna Nelson (a1), Anne Klumparendt (a1), Philipp Doebler (a2) and Thomas Ehring (a3)
Abstract
Background

Childhood maltreatment has been discussed as a risk factor for the development and maintenance of depression.

Aims

To examine the relationship between childhood maltreatment and adult depression with regard to depression incidence, severity, age at onset, course of illness and treatment response.

Method

We conducted meta-analyses of original articles reporting an association between childhood maltreatment and depression outcomes in adult populations.

Results

In total, 184 studies met inclusion criteria. Nearly half of patients with depression reported a history of childhood maltreatment. Maltreated individuals were 2.66 (95% CI 2.38–2.98) to 3.73 (95% CI 2.88–4.83) times more likely to develop depression in adulthood, had an earlier depression onset and were twice as likely to develop chronic or treatment-resistant depression. Depression severity was most prominently linked to childhood emotional maltreatment.

Conclusions

Childhood maltreatment, especially emotional abuse and neglect, represents a risk factor for severe, early-onset, treatment-resistant depression with a chronic course.

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Copyright
Corresponding author
Thomas Ehring, PhD, LMU Munich, Leopoldstr. 13, 80802 Munich, Germany. Email: thomas.ehring@lmu.de
Footnotes
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Declaration of interest

None.

Footnotes
References
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1 Andrade, L, Caraveo-Anduaga, JJ, Berglund, P, Bijl, RV, De Graaf, R, Vollebergh, W, et al The epidemiology of major depressive episodes: results from the International Consortium of Psychiatric Epidemiology (ICPE) Surveys. Int J Methods Psychiatr Res 2003; 12: 321.
2 Murray, CJL, Vos, T, Lozano, R, Naghavi, M, Flaxman, AD, Michaud, C, et al Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2197–223.
3 Sharpley, CF, Bitsika, V. Validity, reliability and prevalence of four ‘clinical content’ subtypes of depression. Behav Brain Res 2014; 259: 915.
4 Harald, B, Gordon, P. Meta-review of depressive subtyping models. J Affect Disord 2012; 139: 126–40.
5 Heun, R, Kockler, M, Papassotiropoulos, A. Distinction of early- and late-onset depression in the elderly by their lifetime symptomatology. Int J Geriatr Psychiatry 2000; 15: 1138–42.
6 Carter, GC, Cantrell, RA, Zarotsky, V, Haynes, VS, Phillips, G, Alatorre, CI, et al Comprehensive review of factors implicated in the heterogeneity of response in depression. Depress Anxiety 2012; 29: 340–54.
7 Ghaemi, SN. Why antidepressants are not antidepressants: STEP-BD, STARD, and the return of neurotic depression. Bipolar Disord 2008; 10: 957–68.
8 Driscoll, HC, Basinski, J, Mulsant, BH, Butters, MA, Dew, MA, Houck, PR, et al Late-onset major depression: clinical and treatment-response variability. Int J Geriatr Psychiatry 2005; 20: 661–7.
9 Arata, CM, Langhinrichsen-Rohling, J, Bowers, D, O'Farrill-Swails, L. Single versus multi-type maltreatment: An examination of the long-term effects of child abuse. J Aggress Maltreat Trauma 2005; 11: 2952.
10 Bernet, CZ, Stein, MB. Relationship of childhood maltreatment to the onset and course of major depression in adulthood. Depress Anxiety 1999; 9: 169–74.
11 Comijs, HC, van Exel, E, van der Mast, RC, Paauw, A, Voshaar, RO, Stek, ML. Childhood abuse in late-life depression. J Affect Disord 2013; 147: 241–6.
12 Nanni, V, Uher, R, Danese, A. Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am J Psychiatry 2012; 169: 141–51.
13 Norman, RE, Byambaa, M, De, R, Butchart, A, Scott, J, Vos, T. The long-term health consequences of child physical abuse, emotional abuse, and neglect: a systematic review and meta-analysis. PLoS Med 2012; 9: 131.
14 Spertus, IL, Yehuda, R, Wong, CM, Halligan, S, Seremetis, SV. Childhood emotional abuse and neglect as predictors of psychological and physical symptoms in women presenting to a primary care practice. Child Abuse Negl 2003; 27: 1247–58.
15 Jumper, SA. A meta-analysis of the relationship of child sexual abuse to adult psychological adjustment. Child Abuse Negl 1995; 19: 715–28.
16 Neumann, DA, Houskamp, BM, Pollock, VE, Briere, J. The long-term sequelae of childhood sexual abuse in women: a meta-analytic review. Child Maltreat 1996; 1: 616.
17 Al-Modallal, H, Peden, A, Anderson, D. Impact of physical abuse on adulthood depressive symptoms among women. Issues Merit Health Nurs 2008; 29: 299314.
18 Beitchman, JH, Zucker, KJ, Hood, J E, daCosta, GA, Akman, D. A review of the short-term effects of child sexual abuse. Child Abuse Negl 1991; 15: 537–56.
19 Buist, A. Childhood abuse, postpartum depression and parenting difficulties: a literature review of associations. Aust NZ J Psychiatry 1998; 32: 370–8.
20 Kendall-Tackett, K. The health effects of childhood abuse: four pathways by which abuse can influence health. Child Abuse Negl 2002; 26: 715–29.
21 Martin, CMS, de Carvalho Tofoli, SM, Von Werne Baes, C, Juruena, M. Analysis of the occurrence of early life stress in adult psychiatric patients: a systematic review. Psychol Neurosci 2011; 4: 219–27.
22 Tipton, E. Small sample adjustments for robust variance estimation with meta-regression. Psychol Methods 2015; 20: 375–93.
23 Hedges, LV, Tipton, E, Johnson, MC. Robust variance estimation in meta-regression with dependent effect size estimates. Res Synth Methods 2010; 1: 3965.
24 Fisher, Z, Tipton, E. Robumeta: Robust Variance Meta-Regression. R package version 1.3. R-project.org, 2014 (http://CRAN.R-project.org/package=robumeta).
25 Higgins, JPT, Thompson, SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21: 1539–58.
26 Rothstein, HR, Sutton, AJ, Borenstein, M. Publication Bias in Meta-Analysis: Prevention, Assessment and Adjustments. John Wiley and Sons, 2005.
27 Egger, M, Davey Smith, G, Schneider, M, Minder, C. Bias in meta-analysis detected by a simple graphical test. BMJ 1997; 315: 629–34.
28 Sterne, JAC, Egger, M. Regression methods to detect publication and other bias in meta-analysis. In Publication bias in Meta-Analysis: Prevention, Assessment, and Adjustments (eds Rothstein, HR, Sutton, AJ, Borenstein, M): 99110. Wiley, 2005.
29 Duval, S, Tweedie, R. Trim and fill: a simple funnel plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000; 56: 455–63.
30 Peters, JL, Sutton, AJ, Jones, DR, Abrams, KR, Rushton, L. Comparison of two methods to detect publication bias in meta-analysis. JAMA 2006; 295: 676–80.
31 Holm, S. A simple sequentially rejective multiple test procedure. Scand J Statist 1979; 6: 6570.
32 Tipton, E, Pustejovsky, JE. Small-sample adjustments for tests of moderators and model fit using robust variance estimation in meta-regression. J Educ Behav Stat 2015; 40: 604–34.
33 Peyrot, WJ, Middeldorp, CM, Jansen, R, Smit, JH, de Geus, EJ, Hottenga, JJ, et al Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample. J Affect Disord 2013; 146: 91–9.
34 Cohen, J. Statistical Power Analysis for the Behavioral Sciences (2nd edn). Erlbaum, 1988.
35 Pinto, R, Correia, L, Maia, Â. Assessing the reliability of retrospective reports of adverse childhood experiences among adolescents with documented childhood maltreatment. J Fam Violence 2014; 29: 431–8.
36 Fergusson, DM, Horwood, U, Boden, JM. Structural equation modeling of repeated retrospective reports of childhood maltreatment. Int J Methods Psychiatr Res 2011; 20: 93104.
37 Scott, KM, McLaughlin, KA, Smith, DAR, Ellis, PM. Childhood maltreatment and DSM-IV adult mental disorders: Comparison of prospective and retrospective findings. Br J Psychiatry 2012; 200: 469–75.
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Childhood maltreatment and characteristics of adult depression: Meta-analysis

  • Janna Nelson (a1), Anne Klumparendt (a1), Philipp Doebler (a2) and Thomas Ehring (a3)
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