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Clozapine and D1/D2 Antagonism in Extrapyramidal Functions

Published online by Cambridge University Press:  06 August 2018

Jes Gerlach  and
Lars Hansen
Jes Gerlach*
Affiliation:
St Hans Hospital, Department P, DK-4000 Roskilde, Denmark
Lars Hansen
Affiliation:
St Hans Hospital, Department P, DK-4000 Roskilde, Denmark
*
Correspondence
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Abstract

One of the main advantages of clozapine is that it rarely produces extrapyramidal syndromes and tardive dyskinesia. This advantage is linked to the atypical biochemical profile of clozapine, especially its combined and low blockade of D1 and D2 receptors. The level of D2 receptor blockade is too low to induce extrapyramidal side-effects, and D1 antagonists have a lower extrapyramidal side-effect potential than traditional D2 neuroleptics, especially with respect to dystonia. The combined and balanced D1/D2 receptor blockade may prevent the development of a dysbalance between D1/D2 receptor function (in favour of D1) which otherwise might lead to tardive dyskinesia.

Information

Type
Research Article
Information
The British Journal of Psychiatry , Volume 160 , Issue S17: Clozapine - The Atypical Antipsychotic , May 1992 , pp. 34 - 37
Copyright
Copyright © The Royal College of Psychiatrists 

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