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Cortical thickness in obsessive–compulsive disorder: Multisite mega-analysis of 780 brain scans from six centres

  • Jean-Paul Fouche (a1), Stefan du Plessis (a2), Coenie Hattingh (a1), Annerine Roos (a3), Christine Lochner (a3), Carles Soriano-Mas (a4), Joao R. Sato (a5), Takashi Nakamae (a6), Seiji Nishida (a6), Jun Soo Kwon (a7), Wi Hoon Jung (a8), David Mataix-Cols (a9), Marcelo Q. Hoexter (a10), Pino Alonso (a11), OCD Brain Imaging Consortium, Stella J. de Wit (a12), Dick J. Veltman (a12), Dan J. Stein (a13) and Odile A. van den Heuvel (a14)...
Abstract
Background

There is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive–compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness.

Aims

To investigate alterations in cortical thickness and subcortical volume in OCD.

Method

In total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Between-group analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken.

Results

Significantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group x age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls.

Conclusions

Our findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. The group x age interaction effects may be the result of altered neuroplasticity.

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Copyright
Corresponding author
Jean-Paul Fouche, Department of Psychiatry and Mental Health, University of Cape Town, Faculty of Health Sciences, Anzio Road, Observatory, 7935, South Africa. Email: FCHJEA002@myuct.ac.za
Footnotes
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*

See online supplement DS1 for details of the members of the Consortium.

Declaration of interest

None.

Footnotes
References
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1 Fontenelle, LF, Mendlowicz, MV, Versiani, M. The descriptive epidemiology of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30: 327–37.
2 Hollander, E, Stein, DJ, Fineberg, NA, Marteau, F, Legault, M. Quality of life outcomes in patients with obsessive-compulsive disorder: relationship to treatment response and symptom relapse. J Clin Psychiatry 2010; 71: 784–92.
3 Rotge, J-Y, Guehl, D, Dilharreguy, B, Tignol, J, Bioulac, B, Allard, M, et al Meta-analysis of brain volume changes in obsessive-compulsive disorder. Biol Psychiatry 2009; 65: 7583.
4 Rotge, J-Y, Langbour, N, Guehl, D, Bioulac, B, Jaafari, N, Allard, M, et al Gray matter alterations in obsessive-compulsive disorder: an anatomic likelihood estimation meta-analysis. Neuropsychopharmacology 2010; 35: 686–91.
5 de Wit, SJ, Alonso, P, Schweren, L, Mataix-Cols, D, Lochner, C, Menchón, JM, et al Multicenter voxel-based morphometry mega-analysis of structural brain scans in obsessive-compulsive disorder. Am J Psychiatry 2014; 171: 340–9.
6 Radua, J, Mataix-Cols, D. Voxel-wise meta-analysis of grey matter changes in obsessive–compulsive disorder. Br J Psychiatry 2009; 195: 393402.
7 Radua, J, van den Heuvel, OA, Surguladze, S, Mataix-Cols, D. Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs other anxiety disorders. Arch Gen Psychiatry 2010; 67: 701–11.
8 Tops, M, Boksem, MAS. A potential role of the inferior frontal gyrus and anterior insula in cognitive control, brain rhythms, and event-related potentials. Front Psychol 2011; 2: 330.
9 Dale, AM, Fischl, B, Sereno, MI. Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 1999; 9: 179–94.
10 Wonderlick, JS, Ziegler, DA, Hosseini-Varnamkhasti, P, Locascio, JJ, Bakkour, A, van der Kouwe, A, et al Reliability of MRI-derived cortical and subcortical morphometric measures: effects of pulse sequence, voxel geometry, and parallel imaging. Neuroimage 2009; 44: 1324–33.
11 Shin, Y-W, Yoo, SY, Lee, JK, Ha, TH, Lee, KJ, Lee, JM, et al Cortical thinning in obsessive compulsive disorder. Hum Brain Mapp 2007; 28: 1128–35.
12 Kühn, S, Kaufmann, C, Simon, D, Endrass, T, Gallinat, J, Kathmann, N. Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder. Cortex 2013; 49: 2178–85.
13 Venkatasubramanian, G, Zutshi, A, Jindal, S, Srikanth, SG, Kovoor, JME, Kumar, JK, et al Comprehensive evaluation of cortical structure abnormalities in drug-naïve, adult patients with obsessive-compulsive disorder: a surface-based morphometry study. J Psychiatr Res 2012; 46: 1161–8.
14 Fullana, MA, Cardoner, N, Alonso, P, Subirà, M, López-Solà, C, Pujol, J, et al Brain regions related to fear extinction in obsessive-compulsive disorder and its relation to exposure therapy outcome: a morphometric study. Psychol Med 2014; 44: 845–56.
15 Nakamae, T, Narumoto, J, Sakai, Y, Nishida, S, Yamada, K, Kubota, M, et al Reduced cortical thickness in non-medicated patients with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2012; 37: 90–5.
16 Narayan, VM, Narr, KL, Phillips, OR, Thompson, PM, Toga, AW, Szeszko, PR. Greater regional cortical gray matter thickness in obsessive-compulsive disorder. Neuroreport 2008; 19: 1551–5.
17 Fan, Q, Palaniyappan, L, Tan, L, Wang, J, Wang, X, Li, C, et al Surface anatomical profile of the cerebral cortex in obsessive-compulsive disorder: a study of cortical thickness, folding and surface area. Psychol Med 2013; 43: 1081–91.
18 Goodman, WK, Price, LH, Rasmussen, SA, Mazure, C, Fleischmann, RL, Hill, CL, et al The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 1989; 46: 1006–11.
19 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorder (4th edn) (DSM–IV). APA, 1994.
20 Fischl, B, Dale, AM. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci USA 2000; 97: 11050–5.
21 Mathalon, DH, Sullivan, EV, Rawles, JM, Pfefferbaum, A. Correction for head size in brain-imaging measurements. Psychiatry Res 1993; 50: 121–39.
22 van den Heuvel, OA, Remijnse, PL, Mataix-Cols, D, Vrenken, H, Groenewegen, HJ, Uylings, HBM, et al The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems. Brain 2009; 132: 853–68.
23 Pujol, J, Soriano-Mas, C, Alonso, P, Cardoner, N, Menchón, JM, Deus, J, et al Mapping structural brain alterations in obsessive-compulsive disorder. Arch Gen Psychiatry 2004; 61: 720–30.
24 Yoo, SY, Roh, M-S, Choi, J-S, Kang, D-H, Ha, TH, Lee, JM, et al Voxel-based morphometry study of gray matter abnormalities in obsessive-compulsive disorder. J Korean Med Sci 2008; 23: 2430.
25 Li, P, Li, S, Dong, Z, Luo, J, Han, H, Xiong, H, et al Altered resting state functional connectivity patterns of the anterior prefrontal cortex in obsessive-compulsive disorder. Neuroreport 2012; 23: 681–6.
26 Kim, S-G, Jung, WH, Kim, SN, Jang, JH, Kwon, JS. Disparity between dorsal and ventral networks in patients with obsessive-compulsive disorder: evidence revealed by graph theoretical analysis based on cortical thickness from MRI. Front Hum Neurosci 2013; 7: 302.
27 Bannon, S, Gonsalvez, CJ, Croft, RJ, Boyce, PM. Executive functions in obsessive-compulsive disorder: state or trait deficits? Aust NZ J Psychiatry 2006; 40: 1031–8.
28 Penadés, R, Catalán, R, Rubia, K, Andrés, S, Salamero, M, Gastó, C. Impaired response inhibition in obsessive compulsive disorder. Eur Psychiatry 2007; 22: 404–10.
29 van den Heuvel, OA, Veltman, DJ, Groenewegen, HJ, Cath, DC, van Balkom, AJLM, van Hartskamp, J, et al Frontal-striatal dysfunction during planning in obsessive-compulsive disorder. Arch Gen Psychiatry 2005; 62: 301–9.
30 Chamberlain, SR, Fineberg, NA, Blackwell, AD, Clark, L, Robbins, TW, Sahakian, BJ. A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania. Neuropsychologia 2007; 45: 654–62.
31 Menzies, L, Chamberlain, SR, Laird, AR, Thelen, SM, Sahakian, BJ, Bullmore, ET. Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev 2008; 32: 525–49.
32 Stern, ER, Fitzgerald, KD, Welsh, RC, Abelson, JL, Taylor, SF. Resting-state functional connectivity between fronto-parietal and default mode networks in obsessive-compulsive disorder. PLoS One 2012; 7: e36356.
33 Zhang, T, Wang, J, Yang, Y, Wu, Q, Li, B, Chen, L, et al Abnormal small-world architecture of top-down control networks in obsessive-compulsive disorder. J Psychiatry Neurosci 2011; 36: 2331.
34 Meunier, D, Ersche, KD, Craig, KJ, Fornito, A, Merlo-Pich, E, Fineberg, NA, et al Brain functional connectivity in stimulant drug dependence and obsessive-compulsive disorder. Neuroimage 2012; 59: 1461–8.
35 Fischl, B, Salat, DH, Busa, E, Albert, M, Dieterich, M, Haselgrove, C, et al Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 2002; 33: 341–55.
36 Zhou, Y, Zambelli, J, Heredia, G. SU-E-I-70: Comparison of brain volume quantification with NeuroQuant & FreeSurfer. Med Phys 2015; 42: 3258.
37 Sowell, ER, Thompson, PM, Toga, AW. Mapping changes in the human cortex throughout the span of life. Neuroscientist 2004; 10: 372–92.
38 Grieve, SM, Clark, CR, Williams, LM, Peduto, AI, Gordon, E. Preservation of limbic and paralimbic structures in aging. Hum Brain Mapp 2005; 25: 391401.
39 Clarkson, MJ, Cardoso, MJ, Ridgway, GR, Modat, M, Leung, KK, Rohrer, JD, et al A comparison of voxel and surface based cortical thickness estimation methods. Neuroimage 2011; 57: 856–65.
40 Palaniyappan, L, Liddle, PF. Differential effects of surface area, gyrification and cortical thickness on voxel based morphometric deficits in schizophrenia. Neuroimage 2012; 60: 693–9.
41 Ruscio, AM, Stein, DJ, Chiu, WT, Kessler, RC. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry 2010; 15: 5363.
42 van Tol, M-J, van Der Wee, NJA, van den Heuvel, OA, Nielen, MMA, Demenescu, LR, Aleman, A, et al Regional brain volume in depression and anxiety disorders. Arch Gen Psychiatry 2010; 67: 1002–11.
43 Cardoner, N, Soriano-Mas, C, Pujol, J, Alonso, P, Harrison, BJ, Deus, J, et al Brain structural correlates of depressive comorbidity in obsessive-compulsive disorder. Neuroimage 2007; 38: 413–21.
44 Hoexter, MQ, de Souza Duran, FL, D'Alcante, CC, Dougherty, DD, Shavitt, RG, Lopes, AC, et al Gray matter volumes in obsessive-compulsive disorder before and after fluoxetine or cognitive-behavior therapy: a randomized clinical trial. Neuropsychopharmacology 2012; 37: 734–45.
45 Togao, O, Yoshiura, T, Nakao, T, Nabeyama, M, Sanematsu, H, Nakagawa, A, et al Regional gray and white matter volume abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study. Psychiatry Res 2010; 184: 2937.
46 Kim, J-J, Lee, MC, Kim, J, Kim, IY, Kim, SI, Han, MH, et al Grey matter abnormalities in obsessive-compulsive disorder: statistical parametric mapping of segmented magnetic resonance images. Br J Psychiatry 2001; 179: 330–4.
47 Alvarenga, PG, do Rosário, MC, Batistuzzo, MC, Diniz, JB, Shavitt, RG, Duran, FLS, et al Obsessive-compulsive symptom dimensions correlate to specific gray matter volumes in treatment-naive patients. J Psychiatr Res 2012; 46: 1635–42.
48 Lochner, C, Hemmings, SMJ, Kinnear, CJ, Nel, D, Hemmings, SMJ, Seedat, S, et al Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes. Isr J Psychiatry Relat Sci 2008; 45: 164–76.
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Cortical thickness in obsessive–compulsive disorder: Multisite mega-analysis of 780 brain scans from six centres

  • Jean-Paul Fouche (a1), Stefan du Plessis (a2), Coenie Hattingh (a1), Annerine Roos (a3), Christine Lochner (a3), Carles Soriano-Mas (a4), Joao R. Sato (a5), Takashi Nakamae (a6), Seiji Nishida (a6), Jun Soo Kwon (a7), Wi Hoon Jung (a8), David Mataix-Cols (a9), Marcelo Q. Hoexter (a10), Pino Alonso (a11), OCD Brain Imaging Consortium, Stella J. de Wit (a12), Dick J. Veltman (a12), Dan J. Stein (a13) and Odile A. van den Heuvel (a14)...
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