Skip to main content Accessibility help
×
Home

Default mode network subsystem alterations in obsessive–compulsive disorder

  • Jan C. Beucke (a1), Jorge Sepulcre (a2), Mark C. Eldaief (a3), Miriam Sebold (a4), Norbert Kathmann (a5) and Christian Kaufmann (a5)...

Abstract

Background

Although neurobiological models of obsessive–compulsive disorder (OCD) traditionally emphasise the central role of corticostriatal brain regions, studies of default mode network integrity have garnered increasing interest, but have produced conflicting results.

Aims

To resolve these discrepant findings by examining the integrity of default mode network subsystems in OCD.

Method

Comparison of seed-based resting-state functional connectivity of 11 default mode network components between 46 patients with OCD and 46 controls using functional magnetic resonance imaging.

Results

Significantly reduced connectivity within the dorsal medial prefrontal cortex self subsystem was identified in the OCD group, and remained significant after controlling for medication status and life-time history of affective disorders. Further, greater connectivity between the self subsystem and salience and attention networks was observed.

Conclusions

Results indicate that people with OCD show abnormalities in a neural system previously associated with self-referential processing in healthy individuals, and suggest the need for examination of dynamic interactions between this default mode network subsystem and other large-scale networks in this disorder.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Default mode network subsystem alterations in obsessive–compulsive disorder
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Default mode network subsystem alterations in obsessive–compulsive disorder
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Default mode network subsystem alterations in obsessive–compulsive disorder
      Available formats
      ×

Copyright

Corresponding author

Jan C. Beucke, MS, Department of Psychology, Humboldt-Universität zu Berlin, Rudower Chaussee 18, 12489 Berlin, Germany. Email: jan.beucke@hu-berlin.de

Footnotes

Hide All

Declaration of interest

None.

Footnotes

References

Hide All
1 Salkovskis, PM. Obsessional-compulsive problems: a cognitive-behavioural analysis. Behav Res Ther 1985; 23: 571–83.
2 Saxena, S Brody, AL Schwartz, JM Baxter, LR Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br J Psychiatry 1998; 173 (suppl 35): 2637.
3 Harrison, BJ Pujol, J Cardoner, N Deus, J Alonso, P, Lopez-Sola, M et al. Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder. Biol Psychiatry 2013; 73: 321–8.
4 Beucke, JC Sepulcre, J Talukdar, T Linnman, C Zschenderlein, K Endrass, T, et al. Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder. JAMA Psychiatry 2013; 70: 619–29.
5 Menzies, L Chamberlain, SR Laird, AR Thelen, SM Sahakian, BJ, Bullmore, ET Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev 2008; 32: 525–49.
6 Greicius, MD Krasnow, B Reiss, AL Menon, V Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A 2003; 100: 253–8.
7 Seeley, WW Menon, V Schatzberg, AF Keller, J Glover, GH Kenna, H, et al. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 2007; 27: 2349–56.
8 Fox, MD Corbetta, M Snyder, AZ Vincent, JL, Raichle, ME Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proc Natl Acad Sci U S A 2006; 103: 10046–51.
9 Sylvester, CM Corbetta, M Raichle, ME Rodebaugh, TL Schlaggar, BL Sheline, YI, et al. Functional network dysfunction in anxiety and anxiety disorders. Trends Neurosci 2012; 35: 527–35.
10 Menon, V. Large-scale brain networks and psychopathology: a unifying triple network model. Trends Cogn Sci 2011; 15: 483506.
11 Fitzgerald, KD Stern, ER Angstadt, M Nicholson-Muth, KC Maynor, MR Welsh, RC et al. Altered function and connectivity of the medial frontal cortex in pediatric obsessive-compulsive disorder. Biol Psychiatry 2010; 68:1039–47.
12 Cocchi, L Harrison, BJ Pujol, J Harding, IH Fornito, A Pantelis, C, et al. Functional alterations of large-scale brain networks related to cognitive control in obsessive-compulsive disorder. Hum Brain Mapp 2012; 33: 1089–106.
13 Jang, JH Kim, JH Jung, WH Choi, JS Jung, MH Lee, JM, et al. Functional connectivity in fronto-subcortical circuitry during the resting state in obsessive-compulsive disorder. Neurosci Lett 2010; 474: 158–62.
14 Stern, ER Fitzgerald, KD Welsh, RC Abelson, JL, Taylor, SF Resting-state functional connectivity between fronto-parietal and default mode networks in obsessive-compulsive disorder. PLoS One 2012; 7: e36356.
15 Li, P Li, S Dong, Z Luo, J Han, H Xiong, H, et al. Altered resting state functional connectivity patterns of the anterior prefrontal cortex in obsessive-compulsive disorder. Neuroreport 2012; 23: 681–6.
16 Fitzgerald, KD Welsh, RC Gehring, WJ Abelson, JL Himle, JA Liberzon, I, et al. Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder. Biol Psychiatry 2005; 57: 287–94.
17 Marsh, R Horga, G Parashar, N Wang, Z Peterson, BS, Simpson HB. Altered activation in fronto-striatal circuits during sequential processing of conflict in unmedicated adults with obsessive-compulsive disorder. Biol Psychiatry 2014; 75: 615–22.
18 Andrews-Hanna, JR Reidler, JS Sepulcre, J Poulin, R, Buckner, RL Functional-anatomic fractionation of the brain's default network. Neuron 2010; 65: 550–62.
19 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorder (4th edn) (DSM-IV). APA, 1994.
20 First, MB Spitzer, RL Gibbon, M Williams, JBW Structured Clinical Interview for DSM-IV Axis 1 Disorders. American Psychiatric Press, 1996.
21 Goodman, WK Price, LH Rasmussen, SA Mazure, C Fleischmann, RL Hill, CL, et al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 1989; 46: 1006–11.
22 Foa, EB Huppert, JD Leiberg, S Langner, R Kichic, R Hajcak, G, et al. The Obsessive-Compulsive Inventory: development and validation of a short version. Psychol Assess 2002; 14: 485–96.
23 Spielberger, CD Gorsuch, RL Lushene, RE Manual for the State-Trait Anxiety Inventory. Consulting Psychologists Press, 1970.
24 Beck, AT Ward, CH Mendelson, M Mock, J, Erbaugh, J An inventory for measuring depression. Arch Gen Psychiatry 1961; 4: 561–71.
25 Montgomery, SA Asberg, M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979; 134: 382–9.
26 Oldfield, RC. The assessment and analysis of h andedness: the Edinburgh Inventory. Neuropsychologia 1971; 9: 97113.
27 Schmidt, KH Metzler, P. Wortschatztest (WST) [Vocabulary Test]. Beltz, 1992.
28 Van Dijk, KR Sabuncu, MR Buckner, RL The influence of head motion on intrinsic functional connectivity MRI. NeuroImage 2012; 59: 431–8.
29 Posner, J Hellerstein, DJ Gat, I Mechling, A Klahr, K Wang, Z, et al. Antidepressants normalize the default mode network in patients with dysthymia. JAMA Psychiatry 2013; 70: 373–82.
30 Radua, J Mataix-Cols, D. Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder. Br J Psychiatry 2009; 195: 393402.
31 Gusnard, DA Akbudak, E Shulman, GL Raichle, ME Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci U S A 2001; 98: 4259–64.
32 Fossati, P Hevenor, SJ Graham, SJ Grady, C Keightley, ML Craik, F, et al. In search of the emotional self: an fMRI study using positive and negative emotional words. Am J Psychiatry 2003; 160: 1938–45.
D'Argembeau A, Jedidi H, Balteau E, Bahri M, Phillips C, Salmon E. Valuing one's self: medial prefrontal involvement in epistemic and emotive investments in self-views. Cereb Cortex 2012; 22: 659–67.
34 Purdon, C Clark, DA. Metacognition and obsessions. Clinical Psychol Psychother 1999; 6: 102–10.
35 Fox, MD Snyder, AZ Zacks, JM Raichle, ME Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses. Nat Neurosci 2006; 9: 23–5.
36 Greicius, MD Flores, BH Menon, V Glover, GH Solvason, HB Kenna, H, et al. Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol Psychiatry 2007; 62: 429–37.
37 Sheline, YI Barch, DM Price, JL Rundle, MM Vaishnavi, SN Snyder, AZ, et al. The default mode network and self-referential processes in depression. Proc Natl Acad Sci U S A 2009; 106: 1942–7.
38 Buckner, RL Andrews-Hanna, JR Schacter, DL The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci 2008; 1124: 138.
39 Muller, J Roberts, JE. Memory and attention in obsessive-compulsive disorder: a review. J Anxiety Disord 2005; 19: 128.
40 Ischebeck, M Endrass, T Simon, D Kathmann, N Auditory novelty processing is enhanced in obsessive-compulsive disorder. Depress Anxiety 2011; 28: 915–23.
Type Description Title
PDF
Supplementary materials

Beucke et al. supplementary material
Supplementary Material

 PDF (5.6 MB)
5.6 MB

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Default mode network subsystem alterations in obsessive–compulsive disorder

  • Jan C. Beucke (a1), Jorge Sepulcre (a2), Mark C. Eldaief (a3), Miriam Sebold (a4), Norbert Kathmann (a5) and Christian Kaufmann (a5)...
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *