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Effects of Amylobarbitone and Nitrazepam on the Electrodermogram and Other Features of Sleep

  • Ijaz Haider (a1) and Ian Oswald (a2)
Extract

The elctrical resistance of the palmar skin, and the naturally-occurring difference in electrical potential between the palm and the dorsal surface of the forearm show simultaneous changes in response to sudden or emotionally-laden sensory stimuli (the ‘galvanic skin response’ or GSR). Spontaneous GSRs occur during wakefulness, especially in anxiety states, but they are reduced by general relaxation and it might be supposed that they would be absent during sleep of uniform EEG appearance. However, Oswald et al. (1959) reported that this was not so and that in sleep with very high voltage slow waves (today generally called Stage 4 sleep) there could be present random spontaneous GSR activity, measured by the potential difference technique. Since these electrical phenomena cannot be related to any known stimulus, to call them galvanic skin responses is inappropriate, and they may better be termed electrodermogram (EDG) activity.

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Baekland, F. (1967). ‘Pentobarbital and dexamphetamine sulfate; effects on the sleep cycle in man.Psychopharmacologia (Berl.), 11, 388–96.
Haider, I. (1968). ‘A double-blind controlled trial of a non-barbiturate hypnotic: nitrazepam.Brit. J. Psychiat., 114, 337–43.
Hartmann, E. (1968a). ‘The effect of four drugs on sleep patterns in man.Psychopharmacologia (Berl.), 12, 346–53.
Hartmann, E. (1968b). ‘On the pharmacology of dreaming sleep (the D-state).J. nerv. ment. Dis., 146, 165–73.
Kales, A., Malmstrom, E. J., Scharf, M., and Rubin, R. T. (1969). ‘Psychophysiological and biochemical changes following use and withdrawal of hypnotics.’ in Sleep: Physiology and Pathology (ed. Kales, A.). Philadelphia.
Lanoir, J., and Killam, E. K. (1968). ‘Alteration in the sleep-wakefulness patterns by benzodiazepines in the cat.Electroenceph. clin. Neurophysiol., 25, 530–42.
Lehman, H. E., and Ban, T. A. (1968). “The effect of hypnotics on rapid eye movement (REM).” Int. J. clin. Pharmacol., 15, 424–7.
Lester, B. K., Burgh, N. R., and Dossett, R. C. (1967). ‘Nocturnal EEG-GSR profiles: the influence of presleep states.Psychophysiology, 3, 238–48.
Lester, B. K., Coulter, J. D., Cowden, L. C., and Williams, H. L. (1968). ‘Secobarbital and nocturnal physiological patterns.Psychopharmacologia (Berl.), 13, 275–86.
Lewis, S. A., and Oswald, I. (1969). ‘Overdose of tricyclic antidepressants and deductions concerning their cerebral action.Brit. J. Psychiat., 115, 1403–10.
Lob, H., Papy, J. J., and Gastaut, H. (1966). ‘Action du Ro-4–5360 (Mogadon) sur le sommeil nocturne.Rev. Neurol. (Paris), 115, 545–6.
Matthew, H., Proudfoot, A. T., Aitken, R. C. B., Raeburn, J. A., and Wright, N., (1969). ‘Nitrazepam—a safe hypnoticBrit. med. J., 3, 23–5.
Oswald, I. (1962). Sleeping and Waking: Physiology and Psychology. Amsterdam.
Oswald, I., Taylor, A. M., and Triesman, M. (1959). ‘Further studies of response to stimulation during sleep.Electroenceph. clin. Newrophysiol., 11, 840–1.
Oswald, I., Berger, R. J., Jaramillo, R. A., Keddie, K. M. G., Olley, P. C., and Plunkett, G. A. (1963). ‘Melancholia and barbiturates: a controlled EEG, body and eye movement study of sleep.Brit. J. Psychiat., 109, 6678.
Oswald, I., Berger, R. J., Jaramillo, R. A., Keddie, K. M. G., Olley, P. C., and Priest, R. G. (1965). ‘Five weeks to escape the sleeping pill habit.Brit. med. J., 2, 1093–99.
Rechtschaffen, A., and Kales, A. (eds.) (1968). A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Washington, D.C.
Tissot, R. (1965). ‘The effects of certain drugs on the sleep cycle in man.’ In Sleep Mechanisms (ed. Akert, K., Bally, C. and Schadé, J. P.). Amsterdam.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Effects of Amylobarbitone and Nitrazepam on the Electrodermogram and Other Features of Sleep

  • Ijaz Haider (a1) and Ian Oswald (a2)
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