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Effects of exercise on depressive symptoms in older adults with poorly responsive depressive disorder: Randomised controlled trial

  • Anne S. Mather (a1), Cesar Rodriguez (a1), Moyra F. Guthrie (a1), Anne M. McHarg (a1), Ian C. Reid (a2) and Marion E. T. McMurdo (a1)...

Abstract

Background

Depression is common in later life.

Aims

To determine whether exercise is effective as an adjunct to antidepressant therapy in reducing depressive symptoms in older people.

Method

Patients were randomised to attend either exercise classes or health education talks for 10 weeks. Assessments were made ‘blind’ at baseline, and at 10 and 34 weeks. The primary outcome was seen with the 17-item Hamilton Rating Scale for Depression (HRSD). Secondary outcomes were seen with the Geriatric Depression Scale, Clinical Global Impression and Patient Global Impression.

Results

At 10 weeks a significantly higher proportion of the exercise group (55% v. 33%) experienced a greater than 30% decline in depression according to HRSD (OR=2.51, P=0.05, 95% Cl 1.00–6.38).

Conclusions

Because exercise was associated with a modest improvement in depressive symptoms at 10 weeks, older people with poorly responsive depressive disorder should be encouraged to attend group exercise activities.

Copyright

Corresponding author

Professor Marion E. T. McMurdo, Section of Ageing and Health, Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. Tel: 01382 632436; fax: 01382 660675; e-mail: m.e.t.mcmurdo@dundee.ac.uk

Footnotes

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Declaration of interest

M. E. T. M. is co-director of DD Developments, a University of Dundee company providing exercise classes for older people and whose profits support research into ageing.

Footnotes

References

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Blumenthal, J. A. Babyak, M. A. Moore, K. A. et al (1999) Effects of exercise training on older patients with major depression. Archives of Internal Medicine, 159, 23492356.
Crowder, M. J. & Hand, D. J. (1990) Analysis of Repeated Measures. London: Chapman and Hall.
Dallosso, H. M. Morgan, K. Bassey, E. J. et al (1988) Levels of customary physical activity among the old and the very old living at home. Journal of Epidemiology and Community Health, 42, 121127.
Folstein, M. F. Folstein, S. E. & McHugh, P. R. (1975) ‘Mini-Mental State’: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.
Green, B. H. Copeland, J. R. Dewey, M. E. et al (1992) Risk factors for depression in elderly people: a prospective study. Acta Psychiatrica Scandinavica, 86, 213217.
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 5662.
Guy, W. (1976) ECDEU Assessment Manual for Psychopharmacology. Revised DHEW Pub. (ADM). Rockville, MD: National Institute for Mental Health.
Henderson, A. S. Jorm, A. F. Korten, A. E. et al (1998) Symptoms of depression and anxiety during adult life: evidence for a decline in prevalence with age. Psychological Medicine, 28, 13211328.
Lawlor, D. A. & Hopker, S. W. (2001) The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials. BMJ, 322, 763767.
Martinsen, E. W. Medhus, A. & Sandvik, L. (1985) Effects of aerobic exercise on depression: a controlled study. BMJ, 291, 109.
Martinsen, E. W. Hoffart, A. & Solberg, O. (1989) Comparing aerobic with nonaerobic forms of exercise in the treatment of clinical depression: a randomized trial. Comprehensive Psychiatry, 30, 324331.
McMurdo, M. E. Mole, P. A. & Paterson, C. R. (1997) Controlled trial of weight bearing exercise in older women in relation to bone density and falls. BMJ, 314, 569.
McNeil, J. K. LeBlanc, E. M. & Joyner, M. (1991) The effect of exercise on depressive symptoms in the moderately depressed elderly. Psychology and Ageing, 6, 487488.
Miller, C. A. Hooper, C. L. & Bakish, D. (1997) A comparison of placebo response with major depressive disorder in patients recruited through newspaper advertising versus consultation referrals. Psychopharmacology Bulletin, 33, 647651.
Mottram, P. Wilson, K. & Copeland, J. (2000) Validation of the Hamilton Depression Rating Scale and Montgomery and Åsberg Rating Scales in terms of AGECAT Depression Cases. International Journal of Geriatric Psychiatry, 15, 11131119.
Onega, L. L. & Abraham, I. L. (1997) Factor structure of the Hamilton Depression Rating Scale for depression in a cohort of community-dwelling elderly. International Journal of Geriatric Psychiatry, 12, 760766.
Paffenbarger, R. S. Jr. Lee, I. M. & Leung, R. (1994) Physical activity and personal characteristics associated with depression and suicide in American college men. Acta Psychiatrica Scandinavica Supplementum, 377, 1622.
Ruuskanen, J. M. & Ruoppila, I. (1995) Physical activity and psychological well-being among people aged 65 to 84 years. Age and Ageing, 24, 292296.
Schlernitzauer, M. Bierhals, A. J. Geary, M. D. et al (1998) Recruitment methods for intervention research in bereavement-related depression. Five years' experience. American Journal of Geriatric Psychiatry, 6, 6774.
Singh, N. A. Clements, K. M. & Fiatarone, M. A. (1997) A randomized controlled trial of progressive resistance training in depressed elders. Journal of Gerontology, 52, M27M35.
Stevens, T. Katona, C. Manela, M. et al (1999) Drug treatment of older people with affective disorders in the community: lessons from an attempted clinical trial. International Journal of Geriatric Psychiatry, 14, 467472.
World Health Organization (1992) Tenth Revision of the International Classification of Diseases and Related Health Problems (1CD–10). Geneva: WHO.
Yastrubetskaya, O. Chiu, E. & O'Connell, S. (1997) Is good clinical research practice for clinical trials good clinical practice? International Journal of Geriatric Psychiatry, 12, 227231.
Yesavage, J. A. (1988) Geriatric depression scale. Psychopharmacology Bulletin, 24, 709711.

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Effects of exercise on depressive symptoms in older adults with poorly responsive depressive disorder: Randomised controlled trial

  • Anne S. Mather (a1), Cesar Rodriguez (a1), Moyra F. Guthrie (a1), Anne M. McHarg (a1), Ian C. Reid (a2) and Marion E. T. McMurdo (a1)...
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