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Efficacy and safety of sildenafil citrate in the treatment of men with mild to moderate erectile dysfunction

  • Ian Eardley (a1), Robert Morgan (a2), Wallace Dinsmore (a3), Paula Yates (a4) and Mitradev Boolell (a4)...
Abstract
Background

Erectile dysfunction is a common, multi-factorial disorder.

Aims

To evaluate the efficacy, tolerability and frequency of use of sildenafil citrate in men with mild to moderate erectile dysfunction of no established organic cause.

Method

This double-blind, randomised, placebo-controlled, flexible-dose, two-way crossover study was conducted at four centres in the UK in 44 men with mild to moderate erectile dysfunction of no clinically obvious organic cause. The study included two 28-day treatment periods, during which time sildenafil or placebo (25–75 mg, based on efficacy) was taken as required.

Results

Compared with placebo, sildenafil was associated with increases in frequency of use, erections adequate for sexual intercourse and level of sexual satisfaction (P < 0.0001). More patients receiving sildenafil stated they would use the treatment again compared with those receiving placebo (P < 0.0001). There were no discontinuations due to sildenafil treatment.

Conclusions

Sildenafil is effective and well tolerated in men with mild to moderate erectile dysfunction of no clinically identifiable organic cause.

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Copyright
Corresponding author
Ian Eardley, Department of Urology, Leeds General Infirmary, Leeds LS1 3EX. Tel: 01132 923561; Fax: 01132 926347
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Declaration of interest

Research supported by Pfizer Inc.

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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Efficacy and safety of sildenafil citrate in the treatment of men with mild to moderate erectile dysfunction

  • Ian Eardley (a1), Robert Morgan (a2), Wallace Dinsmore (a3), Paula Yates (a4) and Mitradev Boolell (a4)...
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