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Fronto-parietal activation in attention-deficit hyperactivity disorder, combined type: Functional magnetic resonance imaging study

  • T. Silk (a1), A. Vance (a2), N. Rinehart (a3), G. Egan (a4), M. O'Boyle (a5), J. L. Bradshaw (a6) and R. Cunnington (a7)...

Summary

Afunctional magnetic resonance imaging mental rotation paradigm was used to investigate the patterns of activation of fronto-parietal brain areas in male adolescents with attention-deficit hyperactivity disorder, combined type (ADHD–CT) compared with age-, gender-, handedness- and performance IQ-matched healthy controls. The ADHD-CT group had (a) decreased activation of the ‘action-atttentional’ system (including Brodmann's areas (BA) 46, 39, 40) and the superior parietal (BA7) and middle frontal (BA10) areas and (b) increased activation of the posterior midline attentional system. These different neuroactivation patterns indicate widespread frontal, striatal and parietal dysfunction in adolescents with ADHD-CT.

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Copyright

Corresponding author

Professor A. Vance, Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne, Parkville, 3052, Victoria, Australia. E-mail: avance@unimelb.edu.au

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Declaration of interest

None.

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References

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Fronto-parietal activation in attention-deficit hyperactivity disorder, combined type: Functional magnetic resonance imaging study

  • T. Silk (a1), A. Vance (a2), N. Rinehart (a3), G. Egan (a4), M. O'Boyle (a5), J. L. Bradshaw (a6) and R. Cunnington (a7)...

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Fronto-parietal activation in attention-deficit hyperactivity disorder, combined type: Functional magnetic resonance imaging study

  • T. Silk (a1), A. Vance (a2), N. Rinehart (a3), G. Egan (a4), M. O'Boyle (a5), J. L. Bradshaw (a6) and R. Cunnington (a7)...
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