Mathew, CG. New links to the pathogenesis of Crohn disease
provided by genome-wide association scans. Nat
Zeggini, E, Scott, LJ, Saxena, R, Voight, BF, Marchini, JL, Hu, T, et al. Meta-analysis of genome-wide association data
and large-scale replication identifies additional susceptibility loci for
type 2 diabetes. Nat Genet
2008; 40: 638–45.
Wellcome Trust Case Control Consortium.
Genome-wide association study of 14,000 cases of seven
common diseases and 3,000 shared controls.
2007; 447: 661–78.
McCarthy, MI, Abecasis, GR, Cardon, LR, Goldstein, DB, Little, J, Ioannidis, JP, et al. Genome-wide association studies for complex
traits: consensus, uncertainty and challenges.
Nat Rev Genet
2008; 9: 356–69.
Craddock, N, O'Donovan, MC, Owen, MJ. Genome-wide association studies in psychiatry:
lessons from early studies of non-psychiatric and psychiatric
phenotypes. Mol Psychiatry
2008; 13: 649–53.
Angst, J. Psychiatric diagnoses: the weak component of modern
research. World Psychiatry
2007; 6: 94–5.
Craddock, N, Owen, MJ. Rethinking psychosis: the disadvantages of a
dichotomous classification now outweigh the advantages.
McGuffin, P, Farmer, A, Harvey, I. A polydiagnostic application of operational criteria
in studies of psychotic illness. Development and reliability of the
OPCRIT system. Arch Gen Psychiatry
1991; 48: 764–70.
Craddock, M, Asherson, P, Owen, MJ, Williams, J, McGuffin, P, Farmer, AE. Concurrent validity of the OPCRIT diagnostic system.
Comparison of OPCRIT diagnoses with consensus best-estimate lifetime
diagnoses. Br J Psychiatry
Spitzer, RL, Endicott, J, Robins, E. Research diagnostic criteria: rationale and
reliability. Arch Gen Psychiatry
1978; 35: 773–82.
American Psychiatric Association. Diagnostic and
Statistical Manual of Mental Disorder (4th edn) (DSM–IV).
World Health Organization. The ICD–10
Classification of Mental and Behavioural Disorders: Clinical Descriptions
and Diagnostic Guidelines. WHO,
Purcell, S, Neale, B, Todd-Brown, K, Thomas, L, Ferreira, MA, Bender, D, et al. PLINK: a tool set for whole-genome
association and population-based linkage analyses.
Am J Hum Genet
2007; 81: 559–75.
Devlin, B, Roeder, K. Genomic control for association
O'Donovan, MC, Craddock, N, Norton, N, Norton, N, Williams, H, Peirce, T, et al. Identification of loci associated with
schizophrenia by genome-wide association and follow-up.
2008; 40: 1053–5.
Robins, E, Guze, SB. Establishment of diagnostic validity in psychiatric
illness: its application to schizophrenia. Am J
1970; 126: 983–7.
Kendler, KS, Karkowski-Shuman, L, O'Neill, FA, Straub, RE, MacLean, CJ, Walsh, D. Resemblance of psychotic symptoms and syndromes in
affected sibling pairs from the Irish Study of High-Density Schizophrenia
Families: evidence for possible etiologic heterogeneity.
Am J Psychiatry
1997; 154: 191–8.
Kendler, KS, Karkowski, LM, Walsh, D. The structure of psychosis: latent class analysis of
probands from the Roscommon Family Study. Arch
1998; 55: 492–9.
McGrath, JA, Nestadt, G, Liang, KY, Lasseter, VK, Wolyniec, PS, Fallin, MD, et al. Five latent factors underlying schizophrenia:
analysis and relationship to illnesses in relatives.
2004; 30: 855–73.
Sham, PC, Castle, DJ, Wessely, S, Farmer, AE, Murray, RM. Further exploration of a latent class typology of
schizophrenia. Schizophr Res
1996; 20: 105–15.
Andreasen, NC, Rice, J, Endicott, J, Coryell, W, Grove, WM, Reich, T. Familial rates of affective disorder. A report from
the National Institute of Mental Health Collaborative
Study. Arch Gen Psychiatry
1987; 44: 461–9.
Bertelsen, A, Gottesman, II. Schizoaffective psychoses: genetical clues to
classification. Am J Med Genet
Farmer, AE, McGuffin, P, Gottesman, II. Twin concordance for DSM–III schizophrenia.
Scrutinizing the validity of the definition. Arch
1987; 44: 634–41.
Gershon, ES, Hamovit, J, Guroff, JJ, Dibble, E, Leckman, JF, Sceery, W, et al. A family study of schizoaffective, bipolar I,
bipolar II, unipolar, and normal control probands.
Arch Gen Psychiatry
1982; 39: 1157–67.
Maier, W, Lichtermann, D, Minges, J, Hallmayer, J, Heun, R, Benkert, O, et al. Continuity and discontinuity of affective
disorders and schizophrenia. Results of a controlled family
study. Arch Gen Psychiatry
1993; 50: 871–83.
Slater, E, Cowie, C. The Genetics of Mental Disorders.
Oxford University Press,
Cardno, AG, Rijsdijk, FV, Sham, PC, Murray, RM, McGuffin, P. A twin study of genetic relationships between
psychotic symptoms. Am J Psychiatry
2002; 159: 539–45.
Williams, NM, Preece, A, Spurlock, G, Norton, N, Williams, HJ, Zammit, S, et al. Support for genetic variation in neuregulin 1
and susceptibility to schizophrenia. Mol
2003; 8: 485–7.
Park, N, Juo, SH, Cheng, R, Liu, J, Loth, JE, Lilliston, B, et al. Linkage analysis of psychosis in bipolar
pedigrees suggests novel putative loci for bipolar disorder and shared
susceptibility with schizophrenia. Mol
2004; 9: 1091–9.
Potash, JB, Zandi, PP, Willour, VL, Lan, TH, Huo, Y, Avramopoulos, D, et al. Suggestive linkage to chromosomal regions
13q31 and 22q12 in families with psychotic bipolar
disorder. Am J Psychiatry
2003; 160: 680–6.
Maier, W. Do schizoaffective disorders exist at
Acta Psychiatr Scand
2006; 113: 369–71.
Vollmer-Larsen, A, Jacobsen, TB, Hemmingsen, R, Parnas, J. Schizoaffective disorder – the reliability of its
clinical diagnostic use. Acta Psychiatr
2006; 113: 402–7.
Lake, CR, Hurwitz, N. Schizoaffective disorder merges schizophrenia and
bipolar disorders as one disease – there is no schizoaffective
disorder. Curr Opin Psychiatry
2007; 20: 365–79.
Malhi, GS, Green, M, Fagiolini, A, Peselow, ED, Kumari, V. Schizoaffective disorder: diagnostic issues and
future recommendations. Bipolar Disord
2008; 10: 215–30.
Dudbridge, F, Gusnanto, A. Estimation of significance thresholds for genomewide
association scans. Genet Epidemiol
2008; 32: 227–34.
Craddock, N, Jones, L, Jones, IR, Kirov, G, Green, EK, Grozeva, D, et al. Strong genetic evidence for a selective
influence of GABAA receptors on a component of the bipolar
disorder phenotype. Mol Psychiatry
Martin, CL, Duvall, JA, Ilkin, Y, Simon, JS, Arreaza, MG, Wilkes, K, et al. Cytogenetic and molecular characterization of
A2BP1/FOX1 as a candidate gene for autism. Am J
Med Genet B Neuropsychiatr Genet
2007; 144B: 869–76.
Bhalla, K, Phillips, HA, Crawford, J, McKenzie, OL, Mulley, JC, Eyre, H, et al. The de novo chromosome 16 translocations of
two patients with abnormal phenotypes (mental retardation and epilepsy)
disrupt the A2BP1 gene. J Hum Genet
2004; 49: 308–11.