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Grey-matter abnormalities in boys with Tourette syndrome: magnetic resonance imaging study using optimised voxel-based morphometry

  • Andrea G. Ludolph (a1), Freimut D. Juengling (a2), Gerhard Libal (a3), Albert C. Ludolph (a4), Jörg M. Fegert (a5) and Jan Kassubek (a6)...
Summary
Summary

The genesis of Tourette syndrome is still unknown, but a core role for the pathways of cortico-striatal-thalamic-cortical circuitry (CSTC) is supposed. Volume-rendering magnetic resonance imaging data-sets were analysed in 14 boys with Tourette syndrome and 15 age-matched controls using optimised voxel-based morphometry. Locally increased grey-matter volumes (corrected P < 0.001) were found bilaterally in the ventral putamen. Regional decreases in grey matter were observed in the left hippocampal gyrus. This unbiased analysis confirmed an association between striatal abnormalities and Tourette syndrome, and the hippocampal volume alterations indicate an involvement of temporolimbic pathways of the CSTC in the syndrome.

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Copyright
Corresponding author
Jan Kassubek, MD, Department of Neurology University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany Tel: +49 731 1771206; Fax: +49 731 1771202; e-mail: jan.kassubek@uni-ulm.de
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Grey-matter abnormalities in boys with Tourette syndrome: magnetic resonance imaging study using optimised voxel-based morphometry

  • Andrea G. Ludolph (a1), Freimut D. Juengling (a2), Gerhard Libal (a3), Albert C. Ludolph (a4), Jörg M. Fegert (a5) and Jan Kassubek (a6)...
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