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Hippocampal volume and 2-year outcome in depression

  • Klaus-Thomas Kronmüller (a1), Johannes Pantel (a2), Sebastian Köhler (a1), Daniela Victor (a1), Frederik Giesel (a3), Vincent A. Magnotta (a4), Christoph Mundt (a1), Marco Essig (a3) and Johannes Schröder (a1)...

Summary

Although the hippocampus has been found to be smaller in people with depression, the clinical relevance of this is unclear. We investigated hippocampal volume (using high-resolution magnetic resonance imaging) and 2-year outcome in 57 patients with major depression. The left and right hippocampal volumes of patients with a depression relapse were significantly smaller than those of healthy controls. Our results support the hypothesis that the hippocampus is crucial in the outcome of depression.

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Copyright

Corresponding author

Klaus-Thomas Kronmüller, Department of Psychiatry, University of Heidelberg, Voßstraße 4, Heidelberg 69115, Germany. Email: klaus_kronmueller@med.uni-heidelberg.de

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Declaration of interest

None.

Footnotes

References

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1 Videbech, P, Ravnkilde, B. Hippocampal volume and depression. A metaanalysis of MRI studies. Am J Psychiatry 2004; 161: 1957–66.
2 Campbell, S, Marriott, M, Nahmias, C, MacQueen, GM. Lower hippocampal volume in patients suffering from depression: a meta-analysis. Am J Psychiatry 2004; 161: 598607.
3 Frodl, T, Meisenzahl, EM, Zetzsche, T, Höhne, T, Banac, S, Schorr, C, Jäger, M, Leinsinger, G, Bottlender, R, Reiser, M, Möller, HJ. Hippocampal and amygdala changes in patients with major depressive disorder and healthy controls during a 1-year follow-up. J Clin Psychiatry 2004; 65: 492–9.
4 Kronmüller, KT, Pantel, J, Götz, B, Köhler, S, Victor, D, Mundt, C, Magnotta, VA, Giesel, F, Essig, M, Schröder, J. Life events and hippocampal volume in first-episode major depression. J Affect Disord 2008; doi 10.1016/j.jad.2008.01.022.
5 Frank, E, Prien, RF, Jarrett, RB, Keller, MB, Kupfer, DJ, Lavori, PW, Rush, AJ, Weissman, MM. Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse and recurrence. Arch Gen Psychiatry 1991; 48: 851–5.
6 Keller, MB, Lavori, PW, Friedman, B, Nielsen, E, Endicott, J, McDonald-Scott, P, Andreasen, NC. The Longitudinal Interval Follow-up Evaluation. A comprehensive method for assessing outcome in prospective longitudinal studies. Arch Gen Psychiatry 1987; 44: 540–8.
7 Pantel, J, O'Leary, DS, Cretsinger, K. A new method for the in vivo volumetric measurement of the human hippocampus with high neuroanatomical accuracy. Hippocampus 2000; 10: 752–8.
8 Frodl, T, Meisenzahl, EM, Zetzsche, T. Hippocampal changes in patients with a first episode of major depression. Am J Psychiatry 2002; 159: 1112–8.

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Hippocampal volume and 2-year outcome in depression

  • Klaus-Thomas Kronmüller (a1), Johannes Pantel (a2), Sebastian Köhler (a1), Daniela Victor (a1), Frederik Giesel (a3), Vincent A. Magnotta (a4), Christoph Mundt (a1), Marco Essig (a3) and Johannes Schröder (a1)...
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