Skip to main content Accessibility help
×
Home

How Effective is the Standard Dose of Disulfiram? A Review of the Alcohol-Disulfiram Reaction in Practice

  • Colin Brewer (a1)

Summary

The current maximum recommended dose of disulfiram, 200 mg daily, is often inadequate. Of 63 patients taking disulfiram under supervision who either risked drinking alcohol or who had a medically supervised challenge with alcohol, only half produced a significant response on a dose of 200–300 mg daily. Some patients need as much as 1.5 g daily but even at high dosage significant side effects are uncommon, reversible and rarely serious.

A modification to the recommended technique for a medically supervised alcohol challenge is described, which minimises distress.

Copyright

References

Hide All
Azrin, N. H. (1976) Improvements in the community reinforcement approach to alcoholism. Behaviour Research and Therapy, 14, 339–48.
Azrin, N. H., Sisson, R. W., Meyer, S. R. & Godley, M. (1982) Alcoholism treatment by disulfiram and community reinforcement therapy. Journal of Behaviour Therapy and Experimental Psychiatry, 13 (2), 105–12.
Gerrein, J. R., Rosenberg, C. M. & Manohar, V. (1973) Disulfiram maintenance in outpatient treatment of alcoholism. Archives of General Psychiatry, 28, 798802.
Heltberg, J., Arnold, E., Kirk, L. & Hansen, T. (1976) Pharmokinetic Studies of 14C-labelled disulfiram. Nordisk Psykiatrisk Tidsskrifft, 30, 507–11.
Ludwig, A. M., Levine, J. & Stark, L. H. (1970) LSD and Alcoholism. Springfield, Illinois: Charles C. Thomas.
Paulson, S. M., Krause, S. & Iber, F. L. (1977) Development and evaluation of a compliance test for patients taking disulfiram. John Hopkins Medical Journal, 141, 119–25.
Robichaud, C., Strickler, D., Bigelow, G. & Liebson, I. (1979) Disulfiram maintenance employee alcoholism treatment: a three-phase evaluation. Behaviour Research and Therapy, 14, 618–21.
Talbot, G. D. & Gander, O. (1973) Antabuse, 1973. Maryland State Medical Journal, 22, 60–4.

How Effective is the Standard Dose of Disulfiram? A Review of the Alcohol-Disulfiram Reaction in Practice

  • Colin Brewer (a1)

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

How Effective is the Standard Dose of Disulfiram? A Review of the Alcohol-Disulfiram Reaction in Practice

  • Colin Brewer (a1)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *