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  • Cited by 110
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Calabrese, Edward J. and Rubio-Casillas, Alberto 2018. Biphasic effects of THC in memory and cognition. European Journal of Clinical Investigation, Vol. 48, Issue. 5, p. e12920.
    Pauselli, Luca 2018. The Complex Connection Between Cannabis and Schizophrenia. p. 183.
    Bawin, Frédérique 2018. Medisch gebruik van cannabis en zijn psychoactieve werking: een paradox?. Verslaving, Vol. 14, Issue. 1, p. 3.
    Hindocha, C. Freeman, T. P. Grabski, M. Crudgington, H. Davies, A. C. Stroud, J. B. Das, R. K. Lawn, W. Morgan, C. J. A. and Curran, H. V. 2018. The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers. Scientific Reports, Vol. 8, Issue. 1,
    Solowij, Nadia 2018. The Complex Connection Between Cannabis and Schizophrenia. p. 129.
    Deiana, Serena and Zamberletti, Erica 2018. The Complex Connection Between Cannabis and Schizophrenia. p. 309.
    Boggs, Douglas L Nguyen, Jacques D Morgenson, Daralyn Taffe, Michael A and Ranganathan, Mohini 2018. Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol. Neuropsychopharmacology, Vol. 43, Issue. 1, p. 142.
    Jikomes, Nick and Zoorob, Michael 2018. The Cannabinoid Content of Legal Cannabis in Washington State Varies Systematically Across Testing Facilities and Popular Consumer Products. Scientific Reports, Vol. 8, Issue. 1,
    Boggs, Douglas L. Surti, Toral Gupta, Aarti Gupta, Swapnil Niciu, Mark Pittman, Brian Schnakenberg Martin, Ashley M. Thurnauer, Halle Davies, Andrew D’Souza, Deepak C. and Ranganathan, Mohini 2018. The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial. Psychopharmacology,
    Hahn, Britta 2018. The Potential of Cannabidiol Treatment for Cannabis Users With Recent-Onset Psychosis. Schizophrenia Bulletin, Vol. 44, Issue. 1, p. 46.
    Cosker, E. Schwitzer, T. Ramoz, N. Ligier, F. Lalanne, L. Gorwood, P. Schwan, R. and Laprévote, V. 2018. The effect of interactions between genetics and cannabis use on neurocognition. A review. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 82, Issue. , p. 95.
    Gruber, Staci A. Sagar, Kelly A. Dahlgren, Mary K. Gonenc, Atilla Smith, Rosemary T. Lambros, Ashley M. Cabrera, Korine B. and Lukas, Scott E. 2018. The Grass Might Be Greener: Medical Marijuana Patients Exhibit Altered Brain Activity and Improved Executive Function after 3 Months of Treatment. Frontiers in Pharmacology, Vol. 8, Issue. ,
    Solowij, Nadia Broyd, Samantha J. Beale, Camilla Prick, Julie-Anne Greenwood, Lisa-marie van Hell, Hendrika Suo, Chao Galettis, Peter Pai, Nagesh Fu, Shanlin Croft, Rodney J. Martin, Jennifer H. and Yücel, Murat 2018. Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial. Cannabis and Cannabinoid Research, Vol. 3, Issue. 1, p. 21.
    Ferland, Jacqueline-Marie N. Carr, Madison R. Lee, Angela M. Hoogeland, Myrthe E. Winstanley, Catharine A. and Pattij, Tommy 2018. Examination of the effects of cannabinoid ligands on decision making in a rat gambling task. Pharmacology Biochemistry and Behavior, Vol. 170, Issue. , p. 87.
    Uhernik, A.L. Montoya, Z.T. Balkissoon, C.D. and Smith, J.P. 2018. Learning and memory is modulated by cannabidiol when administered during trace fear-conditioning. Neurobiology of Learning and Memory, Vol. 149, Issue. , p. 68.
    Ribeiro, Sidarta 2018. Plant Medicines, Healing and Psychedelic Science. p. 133.
    Vindenes, V. and Mørland, J. 2017. Handbook of Cannabis and Related Pathologies. p. 24.
    Murphy, Michelle Mills, Sierra Winstone, Joanna Leishman, Emma Wager-Miller, Jim Bradshaw, Heather and Mackie, Ken 2017. Chronic Adolescent Δ9-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment. Cannabis and Cannabinoid Research, Vol. 2, Issue. 1, p. 235.
    Englund, Amir Freeman, Tom P Murray, Robin M and McGuire, Philip 2017. Can we make cannabis safer?. The Lancet Psychiatry, Vol. 4, Issue. 8, p. 643.
    Klawitter, Jelena Sempio, Cristina Mörlein, Sophie De Bloois, Erik Klepacki, Jacek Henthorn, Thomas Leehey, Maureen A. Hoffenberg, Edward J. Knupp, Kelly Wang, George S. Hopfer, Christian Kinney, Greg Bowler, Russell Foreman, Nicholas Galinkin, Jeffrey Christians, Uwe and Klawitter, Jost 2017. An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Therapeutic Drug Monitoring, Vol. 39, Issue. 5, p. 556.
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Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study

  • Celia J. A. Morgan (a1), Gráinne Schafer (a1), Tom P. Freeman (a1) and H. Valerie Curran (a1)
Abstract
Background

The two main constituents of cannabis, cannabidiol and δ9-tetrahydrocannabinol (THC), have opposing effects both pharmacologically and behaviourally when administered in the laboratory. Street cannabis is known to contain varying levels of each cannabinoid.

 Aims

To study how the varying levels of cannabidiol and THC have an impact on the acute effects of the drug in naturalistic settings.

 Method

Cannabis users (n = 134) were tested 7 days apart on measures of memory and psychotomimetic symptoms, once while they were drug free and once while acutely intoxicated by their own chosen smoked cannabis. Using an unprecedented methodology, a sample of cannabis (as well as saliva) was collected from each user and analysed for levels of cannabinoids. On the basis of highest and lowest cannabidiol content of cannabis, two groups of individuals were directly compared.

 Results

Groups did not differ in the THC content of the cannabis they smoked. Unlike the marked impairment in prose recall of individuals who smoked cannabis low in cannabidiol, participants smoking cannabis high in cannabidiol showed no memory impairment. Cannabidiol content did not affect psychotomimetic symptoms, which were elevated in both groups when intoxicated.

 Conclusions

The antagonistic effects of cannabidiol at the CB1 receptor are probably responsible for its profile in smoked cannabis, attenuating the memory-impairing effects of THC. In terms of harm reduction, users should be made aware of the higher risk of memory impairment associated with smoking low-cannabidiol strains of cannabis like ‘skunk’ and encouraged to use strains containing higher levels of cannabidiol.
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Copyright
COPYRIGHT: © Royal College of Psychiatrists, 2010 
Corresponding author
H. Valerie Curran, Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, Gower St, London WC1E 6BT, UK. Email: v.curran@ucl.ac.uk
Footnotes
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†

See editorial, pp. 259–260, this issue.

*

This paper has been corrected in deviation from print and in accordance with a correction published in the November 2010 issue of the Journal.

This work was funded by a grant to H.V.C. and C.J.A.M. from the Medical Research Council (UK).

Declaration of interest

None.

Footnotes
References
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1 NatCen. Health Survey Findings for England 2008. National Centre for Social Research, 2009 (http://www.natcen.ac.uk/study/health-survey-for-england-2008/findings).
2 European Monitoring Centre for Drugs and Drug Addiction. Annual Report 2006: The State of the Drugs Problem in Europe. European Monitoring Centre for Drugs and Drug Addiction, 2006.
3 Moore, TH, Zammit, S, Lingford-Hughes, A, Barnes, TR, Jones, PB, Burke, M, et al. Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet 2007; 370: 319–28.
4 Gonzalez, R. Acute and non-acute effects of cannabis on brain functioning and neuropsychological performance. Neuropsychol Rev 2007; 17: 347–61.
5 Curran, HV, Brignell, C, Fletcher, S, Middleton, P, Henry, J. Cognitive and subjective dose-response effects of acute oral Delta 9-tetrahydrocannabinol (THC) in infrequent cannabis users. Psychopharmacology (Berl) 2002; 164: 61–70.
6 D'Souza, DC, Perry, E, MacDougall, L, Ammerman, Y, Cooper, T, Wu, YT, et al. The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis. Neuropsychopharmacology 2004; 29: 1558–72.
7 D'Souza, DC, Ranganathan, M, Braley, G, Gueorguieva, R, Zimolo, Z, Cooper, T, et al. Blunted psychotomimetic and amnestic effects of delta-9-tetrahydrocannabinol in frequent users of cannabis. Neuropsychopharmacology 2008; 33: 2505–16.
8 Zuardi, AW, Crippa, JA, Hallak, JE, Moreira, FA, Guimaraes, FS. Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug. Braz J Med Biol Res 2006; 39: 421–9.
9 Guimares, FS, Chiaretti, TM, Graeff, FG. Antianxiety effects of cannabidiol in the elevated plus-maze. Psychopharmacology 1990; 100: 558–9.
10 Hermann, D, Sartorius, A, Welzel, H, Walter, S, Skopp, G, Ende, G, et al. Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users. Biol Psychiatry 2007; 61: 1281–9.
11 Hardwick, S, King, LA. Home Office Cannabis Potency Study. Home Office Scientific Development Branch, 2008.
12 Morgan, CJA, Curran, HV. Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis. Br J Psychiatry 2008; 192: 306–7.
13 Pertwee, RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol 2008; 153: 199–215.
14 Solowij, N, Hall, W, Lee, N. Recreational MDMA use in Sydney: a profile of “Ecstasy” users and their experience with the drug. Br J Addict 1992; 87: 1161–72.
15 Gossop, M, Darke, S, Griffiths, P, Hando, J, Powis, B, Hall, W, et al. The Severity of Dependence Scale (SDS): psychometric properties of the SDS in English and Australian samples of heroin, cocaine and amphetamine users. Addiction 1995; 90: 607–14.
16 Wechsler, D. Wechsler Test of Adult Reading. Psychological Corporation, 2001.
17 Raine, A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull 1991; 17: 555–64.
18 Wilson, B, Cockburn, J, Baddeley, A. The Rivermead Behavioural Memory Test. Thames Valley Test Company, 1985.
19 Wilding, EL, Rugg, MD. An event-related potential study of recognition memory with and without retrieval of source. Brain 1996; 119: 889–905.
20 Mason, OJ, Morgan, CJ, Stefanovic, A, Curran, HV. The Psychotomimetic States Inventory (PSI): measuring psychotic-type experiences from ketamine and cannabis. Schizophr Res 2008; 103: 138–42.
21 Overall, JE, Gorham, DR. The Brief Psychiatric Rating Scale. Psychol Rep 1962; 10: 799–812.
22 Krystal, JH, Karper, LP, Bennett, A, D'Souza, DC, Abi-Dargham, A, Morrissey, K, et al. Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans. Psychopharmacology 1998; 135: 213–29.
23 D'Souza, DC, Perry, E, MacDougall, L, Ammerman, Y, Cooper, T, Wu, YT, et al. The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis. Neuropsychopharmacology 2004; 29: 1558–72.
24 Ilan, AB, Gevins, A, Coleman, M, Elsohly, MA, de Wit, H. Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids. Behav Pharmacol 2005; 16: 487–96.
25 Wise, LE, Thorpe, AJ, Lichtman, AH. Hippocampal CB(1) receptors mediate the memory impairing effects of delta(9)-tetrahydrocannabinol. Neuropsychopharmacology 2009; 34: 2072–80.
26 Bhattacharyya, S, Morrison, PD, Fusar-Poli, P, Martin-Santos, R, Borgwardt, S, Winton-Brown, T, et al. Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology 2009; 35: 764–74.
27 Ranganathan, M, D'Souza, DC. The acute effects of cannabinoids on memory in humans: a review. Psychopharmacology (Berl) 2006; 188: 425–44.
28 Marsicano, G, Wotjak, CT, Azad, SC, Bisogno, T, Rammes, G, Cascio, MG, et al. The endogenous cannabinoid system controls extinction of aversive memories. Nature 2002; 418: 530–4.
29 de Oliveira, AL, de Oliveira, LF, Camboim, C, Diehl, F, Genro, BP, Lanziotti, VB, et al. Amnestic effect of intrahippocampal AM251, a CB1-selective blocker, in the inhibitory avoidance, but not in the open field habituation task, in rats. Neurobiol Learn Mem 2005; 83: 119–24.
30 Watts, FN, Cooper, Z. The effects of depression on structural aspects of the recall of prose. J Abnorm Psychol 1989; 98: 150–3.
31 Horwitz, JE, McCaffrey, RJ. Effects of a third party observer and anxiety on tests of executive function. Arch Clin Neuropsychol 2008; 23: 409–17.
32 Mason, O, Morgan, CJ, Dhiman, SK, Patel, A, Parti, N, Patel, A, et al. Acute cannabis use causes increased psychotomimetic experiences in individuals prone to psychosis. Psychol Med 2009; 39: 951–6.
33 Hermann, D, Sartorius, A, Welzel, H, Walter, S, Skopp, G, Ende, G, et al. Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users. Biol Psychiatry 2007; 61: 1281–9.
34 Di Forti, M, Morgan, C, Dazzan, P, Pariante, C, Mondelli, V, Marques, TR, et al. High-potency cannabis and the risk of psychosis. Br J Psychiatry 2009; 195: 488–91.
35 Cappell, H, Kucher, E, Webster, CD. Some correlates of marihuana self-administration in man: a study of titration of intake as a function of drug potency. Psychopharmacology 1973; 29: 177–84.
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  • Cited by 110
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Calabrese, Edward J. and Rubio-Casillas, Alberto 2018. Biphasic effects of THC in memory and cognition. European Journal of Clinical Investigation, Vol. 48, Issue. 5, p. e12920.
    Pauselli, Luca 2018. The Complex Connection Between Cannabis and Schizophrenia. p. 183.
    Bawin, Frédérique 2018. Medisch gebruik van cannabis en zijn psychoactieve werking: een paradox?. Verslaving, Vol. 14, Issue. 1, p. 3.
    Hindocha, C. Freeman, T. P. Grabski, M. Crudgington, H. Davies, A. C. Stroud, J. B. Das, R. K. Lawn, W. Morgan, C. J. A. and Curran, H. V. 2018. The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers. Scientific Reports, Vol. 8, Issue. 1,
    Solowij, Nadia 2018. The Complex Connection Between Cannabis and Schizophrenia. p. 129.
    Deiana, Serena and Zamberletti, Erica 2018. The Complex Connection Between Cannabis and Schizophrenia. p. 309.
    Boggs, Douglas L Nguyen, Jacques D Morgenson, Daralyn Taffe, Michael A and Ranganathan, Mohini 2018. Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol. Neuropsychopharmacology, Vol. 43, Issue. 1, p. 142.
    Jikomes, Nick and Zoorob, Michael 2018. The Cannabinoid Content of Legal Cannabis in Washington State Varies Systematically Across Testing Facilities and Popular Consumer Products. Scientific Reports, Vol. 8, Issue. 1,
    Boggs, Douglas L. Surti, Toral Gupta, Aarti Gupta, Swapnil Niciu, Mark Pittman, Brian Schnakenberg Martin, Ashley M. Thurnauer, Halle Davies, Andrew D’Souza, Deepak C. and Ranganathan, Mohini 2018. The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial. Psychopharmacology,
    Hahn, Britta 2018. The Potential of Cannabidiol Treatment for Cannabis Users With Recent-Onset Psychosis. Schizophrenia Bulletin, Vol. 44, Issue. 1, p. 46.
    Cosker, E. Schwitzer, T. Ramoz, N. Ligier, F. Lalanne, L. Gorwood, P. Schwan, R. and Laprévote, V. 2018. The effect of interactions between genetics and cannabis use on neurocognition. A review. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 82, Issue. , p. 95.
    Gruber, Staci A. Sagar, Kelly A. Dahlgren, Mary K. Gonenc, Atilla Smith, Rosemary T. Lambros, Ashley M. Cabrera, Korine B. and Lukas, Scott E. 2018. The Grass Might Be Greener: Medical Marijuana Patients Exhibit Altered Brain Activity and Improved Executive Function after 3 Months of Treatment. Frontiers in Pharmacology, Vol. 8, Issue. ,
    Solowij, Nadia Broyd, Samantha J. Beale, Camilla Prick, Julie-Anne Greenwood, Lisa-marie van Hell, Hendrika Suo, Chao Galettis, Peter Pai, Nagesh Fu, Shanlin Croft, Rodney J. Martin, Jennifer H. and Yücel, Murat 2018. Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial. Cannabis and Cannabinoid Research, Vol. 3, Issue. 1, p. 21.
    Ferland, Jacqueline-Marie N. Carr, Madison R. Lee, Angela M. Hoogeland, Myrthe E. Winstanley, Catharine A. and Pattij, Tommy 2018. Examination of the effects of cannabinoid ligands on decision making in a rat gambling task. Pharmacology Biochemistry and Behavior, Vol. 170, Issue. , p. 87.
    Uhernik, A.L. Montoya, Z.T. Balkissoon, C.D. and Smith, J.P. 2018. Learning and memory is modulated by cannabidiol when administered during trace fear-conditioning. Neurobiology of Learning and Memory, Vol. 149, Issue. , p. 68.
    Ribeiro, Sidarta 2018. Plant Medicines, Healing and Psychedelic Science. p. 133.
    Vindenes, V. and Mørland, J. 2017. Handbook of Cannabis and Related Pathologies. p. 24.
    Murphy, Michelle Mills, Sierra Winstone, Joanna Leishman, Emma Wager-Miller, Jim Bradshaw, Heather and Mackie, Ken 2017. Chronic Adolescent Δ9-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment. Cannabis and Cannabinoid Research, Vol. 2, Issue. 1, p. 235.
    Englund, Amir Freeman, Tom P Murray, Robin M and McGuire, Philip 2017. Can we make cannabis safer?. The Lancet Psychiatry, Vol. 4, Issue. 8, p. 643.
    Klawitter, Jelena Sempio, Cristina Mörlein, Sophie De Bloois, Erik Klepacki, Jacek Henthorn, Thomas Leehey, Maureen A. Hoffenberg, Edward J. Knupp, Kelly Wang, George S. Hopfer, Christian Kinney, Greg Bowler, Russell Foreman, Nicholas Galinkin, Jeffrey Christians, Uwe and Klawitter, Jost 2017. An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Therapeutic Drug Monitoring, Vol. 39, Issue. 5, p. 556.
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Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study

  • Celia J. A. Morgan (a1), Gráinne Schafer (a1), Tom P. Freeman (a1) and H. Valerie Curran (a1)
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