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Impact of pre-admission depression on mortality following myocardial infarction

  • Jens Sundbøll (a1), Morten Schmidt (a1), Kasper Adelborg (a1), Lars Pedersen (a2), Hans Erik Bøtker (a3), Poul Videbech (a4) and Henrik Toft Sørensen (a2)...
Abstract
Background

The prognostic impact of previous depression on myocardial infarction survival remains poorly understood.

Aims

To examine the association between depression and all-cause mortality following myocardial infarction.

Method

Using Danish medical registries, we conducted a nationwide population-based cohort study. We included all patients with first-time myocardial infarction (1995–2014) and identified previous depression as either a depression diagnosis or use of antidepressants. We used Cox regression to compute adjusted mortality rate ratios (aMRRs) with 95% confidence intervals.

Results

We identified 170 771 patients with first-time myocardial infarction. Patients with myocardial infarction and a previous depression diagnosis had higher 19-year mortality risks (87% v. 78%). The overall aMRR was 1.11 (95% CI 1.07–1.15) increasing to 1.22 (95% CI 1.17–1.27) when including use of antidepressants in the depression definition.

Conclusions

A history of depression was associated with a moderately increased all-cause mortality following myocardial infarction.

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Copyright
Corresponding author
Jens Sundbøll, MD, Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Allé 43-45, DK-8200 Aarhus N, Denmark. Email: jens.sundboll@clin.au.dk
Footnotes
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Declaration of interest

None.

Footnotes
References
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Impact of pre-admission depression on mortality following myocardial infarction

  • Jens Sundbøll (a1), Morten Schmidt (a1), Kasper Adelborg (a1), Lars Pedersen (a2), Hans Erik Bøtker (a3), Poul Videbech (a4) and Henrik Toft Sørensen (a2)...
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