Skip to main content
×
×
Home

Intellectual disability and major psychiatric disorders: A continuum of neurodevelopmental causality

  • Michael J. Owen (a1)
Summary

There is accumulating evidence for shared genetic as well as environmental risk between intellectual disability and other conditions with a neurodevelopmental basis such as autism, attention-deficit hyperactivity disorder, epilepsy and schizophrenia. These can be conceived as lying along a continuum of genetically and environmentally induced neurodevelopmental causality.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Intellectual disability and major psychiatric disorders: A continuum of neurodevelopmental causality
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Intellectual disability and major psychiatric disorders: A continuum of neurodevelopmental causality
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Intellectual disability and major psychiatric disorders: A continuum of neurodevelopmental causality
      Available formats
      ×
Copyright
References
Hide All
1 Morgan, VA, Leonard, H, Bourke, J, Jablensky, A. Intellectual disability co-occurring with schizophrenia and other psychiatric illness: population-based study. Br J Psychiatry 2008; 193: 364–72.
2 Doody, GA, Johnstone, EC, Sanderson, TL, Owens, DG, Muir, WJ. ‘Pfropfschizophrenie’ revisited. Schizophrenia in people with mild learning disability. Br J Psychiatry 1998; 173: 145–53.
3 Owen, MJ, O'Donovan, MC, Thapar, A, Craddock, N. Neurodevelopmental hypothesis of schizophrenia. Br J Psychiatry 2011; 198: 173–5.
4 Morgan, VA, Croft, ML, Valuri, GM, Zubrick, SR, Bower, C, McNeil, TF, et al. Intellectual disability and other neuropsychiatric outcomes in high-risk children of mothers with schizophrenia, bipolar disorder and unipolar major depression. Br J Psychiatry 2011; 200: 282–9.
5 Craddock, N, Owen, MJ. The Kraepelinian dichotomy – going, going … but still not gone. Br J Psychiatry 2010; 196: 92–5.
6 Pasamanick, B, Rogers, ME, Lilienfeld, AM. Pregnancy experience and the development of behavior disorder in children. Am J Psychiatry 1956; 112: 613–8.
7 Kirov, G, Pocklington, AJ, Holmans, P, Ivanov, D, Ikeda, M, Ruderfer, D, et al. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Mol Psychiatry 2011; 17: 142–53.
8 Han, SS, Williams, LA, Eggan, KC. Constructing and deconstructing stem cell models of neurological disease. Neuron 2011; 70: 626–44.
9 Gottesman, II, Gould, TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160: 636–45.
10 Walters, JT, Owen, MJ. Endophenotypes in psychiatric genetics. Mol Psychiatry 2007; 12: 886–90.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 4
Total number of PDF views: 39 *
Loading metrics...

Abstract views

Total abstract views: 121 *
Loading metrics...

* Views captured on Cambridge Core between 2nd January 2018 - 23rd May 2018. This data will be updated every 24 hours.

Intellectual disability and major psychiatric disorders: A continuum of neurodevelopmental causality

  • Michael J. Owen (a1)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *