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  • Cited by 16
  • Cited by
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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Zhan, Liang Jenkins, Lisanne M. Zhang, Aifeng Conte, Giorgio Forbes, Angus Harvey, Danielle Angkustsiri, Kathleen Goodrich-Hunsaker, Naomi J. Durdle, Courtney Lee, Aaron Schumann, Cyndi Carmichael, Owen Kalish, Kristopher Leow, Alex D. and Simon, Tony J. 2018. Baseline connectome modular abnormalities in the childhood phase of a longitudinal study on individuals with chromosome 22q11.2 deletion syndrome. Human Brain Mapping, Vol. 39, Issue. 1, p. 232.
    Iwashiro, Norichika Koike, Shinsuke Satomura, Yoshihiro Suga, Motomu Nagai, Tatsuya Natsubori, Tatsunobu Tada, Mariko Gonoi, Wataru Takizawa, Ryu Kunimatsu, Akira Yamasue, Hidenori and Kasai, Kiyoto 2016. Association between impaired brain activity and volume at the sub-region of Broca's area in ultra-high risk and first-episode schizophrenia: A multi-modal neuroimaging study. Schizophrenia Research, Vol. 172, Issue. 1-3, p. 9.
    Oertel-Knöchel, Viola Knöchel, Christian Matura, Silke Stäblein, Michael Prvulovic, David Maurer, Konrad Linden, David E.J. and van de Ven, Vincent 2014. Association between symptoms of psychosis and reduced functional connectivity of auditory cortex. Schizophrenia Research, Vol. 160, Issue. 1-3, p. 35.
    Francis, Alan N. Seidman, Larry J. Jabbar, Gul A. Mesholam-Gately, Raquelle Thermenos, Heidi W. Juelich, Richard Proal, Ashley C. Shenton, Martha Kubicki, Marek Mathew, Ian Keshavan, Matcheri and DeLisi, Lynn E. 2012. Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia. Schizophrenia Research, Vol. 141, Issue. 1, p. 65.
    Bhojraj, Tejas S. Francis, Alan N. Montrose, Debra M. and Keshavan, Matcheri S. 2011. Grey matter and cognitive deficits in young relatives of schizophrenia patients. NeuroImage, Vol. 54, Issue. , p. S287.
    Diederen, Kelly M. J. De Weijer, Antoin D. Daalman, Kirstin Blom, Jan Dirk Neggers, Sebastiaan F. W. Kahn, René S. and Sommer, Iris E. C. 2010. Decreased language lateralization is characteristic of psychosis, not auditory hallucinations. Brain, Vol. 133, Issue. 12, p. 3734.
    Bhojraj, Tejas S Francis, Alan N Rajarethinam, Rajaprabhakaran Eack, Shaun Kulkarni, Shreedhar Prasad, Konasale M Montrose, Debra M Dworakowski, Diana Diwadkar, Vaibhav and Keshavan, Matcheri S 2009. Verbal fluency deficits and altered lateralization of language brain areas in individuals genetically predisposed to schizophrenia. Schizophrenia Research, Vol. 115, Issue. 2-3, p. 202.
    Andreasen, Nancy C. Calage, Chadi A. and O'Leary, Daniel S. 2008. Theory of Mind and Schizophrenia: A Positron Emission Tomography Study of Medication-Free Patients. Schizophrenia Bulletin, Vol. 34, Issue. 4, p. 708.
    Koeda, Michihiko Takahashi, Hidehiko Yahata, Noriaki Matsuura, Masato Asai, Kunihiko Okubo, Yoshiro and Tanaka, Hiroshi 2006. Language Processing and Human Voice Perception in Schizophrenia: A Functional Magnetic Resonance Imaging Study. Biological Psychiatry, Vol. 59, Issue. 10, p. 948.
    Sommer, Iris E. C. Ramsey, Nick F. Mandl, René C. W. Van Oel, Clarine J. and Kahn, René S. 2004. Language activation in monozygotic twins discordant for schizophrenia. British Journal of Psychiatry, Vol. 184, Issue. 02, p. 128.
    Ardekani, Babak A. Nierenberg, Jay Hoptman, Matthew J. Javitt, Daniel C. and Lim, Kelvin O. 2003. MRI study of white matter diffusion anisotropy in schizophrenia. NeuroReport, Vol. 14, Issue. 16, p. 2025.
    Sommer, I.E.C. Ramsey, N.F. Mandl, R.C.W. and Kahn, R.S. 2003. Language lateralization in female patients with schizophrenia: an fMRI study. Schizophrenia Research, Vol. 60, Issue. 2-3, p. 183.
    Bilder, Robert M. 2001. Schizophrenia as a neurodevelopmental disorder. Current Opinion in Psychiatry, Vol. 14, Issue. 1, p. 9.
    Sommer, I.E.C. Ramsey, N.F. and Kahn, R.S. 2001. Language lateralization in schizophrenia, an fMRI study. Schizophrenia Research, Vol. 52, Issue. 1-2, p. 57.
    Bark, Nigel 2000. Guest Editor’s Introduction. International Journal of Mental Health, Vol. 29, Issue. 3, p. 3.
    Spence, S. A. 2000. Commenting on neuroimaging. British Journal of Psychiatry, Vol. 176, Issue. 06, p. 594.
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Invited commentary on: Functional anatomy of verbal fluency in people with schizophrenia and those at genetic risk: The genetics of asymmetry and psychosis

  • T. J. Crow (a1)
Extract

Spence et al (2000, this issue) describe an original and incisive approach to the genetics of psychosis – an attempt to define brain connectivity in patients and family members closest to the genetic risk (‘obligate carriers’) by comparison with those remote from familial risk. Their findings are potentially important but I suggest an alternative interpretation: that words are simply less lateralised in those genetically predisposed to suffer from schizophrenic symptoms. This conclusion has, I believe, implications for understanding the organisation of the human brain.

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COPYRIGHT: © 2000 The Royal College of Psychiatrists 
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  • Cited by 16
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Zhan, Liang Jenkins, Lisanne M. Zhang, Aifeng Conte, Giorgio Forbes, Angus Harvey, Danielle Angkustsiri, Kathleen Goodrich-Hunsaker, Naomi J. Durdle, Courtney Lee, Aaron Schumann, Cyndi Carmichael, Owen Kalish, Kristopher Leow, Alex D. and Simon, Tony J. 2018. Baseline connectome modular abnormalities in the childhood phase of a longitudinal study on individuals with chromosome 22q11.2 deletion syndrome. Human Brain Mapping, Vol. 39, Issue. 1, p. 232.
    Iwashiro, Norichika Koike, Shinsuke Satomura, Yoshihiro Suga, Motomu Nagai, Tatsuya Natsubori, Tatsunobu Tada, Mariko Gonoi, Wataru Takizawa, Ryu Kunimatsu, Akira Yamasue, Hidenori and Kasai, Kiyoto 2016. Association between impaired brain activity and volume at the sub-region of Broca's area in ultra-high risk and first-episode schizophrenia: A multi-modal neuroimaging study. Schizophrenia Research, Vol. 172, Issue. 1-3, p. 9.
    Oertel-Knöchel, Viola Knöchel, Christian Matura, Silke Stäblein, Michael Prvulovic, David Maurer, Konrad Linden, David E.J. and van de Ven, Vincent 2014. Association between symptoms of psychosis and reduced functional connectivity of auditory cortex. Schizophrenia Research, Vol. 160, Issue. 1-3, p. 35.
    Francis, Alan N. Seidman, Larry J. Jabbar, Gul A. Mesholam-Gately, Raquelle Thermenos, Heidi W. Juelich, Richard Proal, Ashley C. Shenton, Martha Kubicki, Marek Mathew, Ian Keshavan, Matcheri and DeLisi, Lynn E. 2012. Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia. Schizophrenia Research, Vol. 141, Issue. 1, p. 65.
    Bhojraj, Tejas S. Francis, Alan N. Montrose, Debra M. and Keshavan, Matcheri S. 2011. Grey matter and cognitive deficits in young relatives of schizophrenia patients. NeuroImage, Vol. 54, Issue. , p. S287.
    Diederen, Kelly M. J. De Weijer, Antoin D. Daalman, Kirstin Blom, Jan Dirk Neggers, Sebastiaan F. W. Kahn, René S. and Sommer, Iris E. C. 2010. Decreased language lateralization is characteristic of psychosis, not auditory hallucinations. Brain, Vol. 133, Issue. 12, p. 3734.
    Bhojraj, Tejas S Francis, Alan N Rajarethinam, Rajaprabhakaran Eack, Shaun Kulkarni, Shreedhar Prasad, Konasale M Montrose, Debra M Dworakowski, Diana Diwadkar, Vaibhav and Keshavan, Matcheri S 2009. Verbal fluency deficits and altered lateralization of language brain areas in individuals genetically predisposed to schizophrenia. Schizophrenia Research, Vol. 115, Issue. 2-3, p. 202.
    Andreasen, Nancy C. Calage, Chadi A. and O'Leary, Daniel S. 2008. Theory of Mind and Schizophrenia: A Positron Emission Tomography Study of Medication-Free Patients. Schizophrenia Bulletin, Vol. 34, Issue. 4, p. 708.
    Koeda, Michihiko Takahashi, Hidehiko Yahata, Noriaki Matsuura, Masato Asai, Kunihiko Okubo, Yoshiro and Tanaka, Hiroshi 2006. Language Processing and Human Voice Perception in Schizophrenia: A Functional Magnetic Resonance Imaging Study. Biological Psychiatry, Vol. 59, Issue. 10, p. 948.
    Sommer, Iris E. C. Ramsey, Nick F. Mandl, René C. W. Van Oel, Clarine J. and Kahn, René S. 2004. Language activation in monozygotic twins discordant for schizophrenia. British Journal of Psychiatry, Vol. 184, Issue. 02, p. 128.
    Ardekani, Babak A. Nierenberg, Jay Hoptman, Matthew J. Javitt, Daniel C. and Lim, Kelvin O. 2003. MRI study of white matter diffusion anisotropy in schizophrenia. NeuroReport, Vol. 14, Issue. 16, p. 2025.
    Sommer, I.E.C. Ramsey, N.F. Mandl, R.C.W. and Kahn, R.S. 2003. Language lateralization in female patients with schizophrenia: an fMRI study. Schizophrenia Research, Vol. 60, Issue. 2-3, p. 183.
    Bilder, Robert M. 2001. Schizophrenia as a neurodevelopmental disorder. Current Opinion in Psychiatry, Vol. 14, Issue. 1, p. 9.
    Sommer, I.E.C. Ramsey, N.F. and Kahn, R.S. 2001. Language lateralization in schizophrenia, an fMRI study. Schizophrenia Research, Vol. 52, Issue. 1-2, p. 57.
    Bark, Nigel 2000. Guest Editor’s Introduction. International Journal of Mental Health, Vol. 29, Issue. 3, p. 3.
    Spence, S. A. 2000. Commenting on neuroimaging. British Journal of Psychiatry, Vol. 176, Issue. 06, p. 594.
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Invited commentary on: Functional anatomy of verbal fluency in people with schizophrenia and those at genetic risk: The genetics of asymmetry and psychosis

  • T. J. Crow (a1)
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