Skip to main content Accessibility help
×
×
Home

Is Your ‘Double-Blind’ Design Truly Double-Blind?

  • Alison Oxtoby (a1), Angela Jones (a2) and Michael Robinson (a3)
Extract

Before a drug trial, researchers reasonably plan that participants will remain ignorant of which drug each patient is taking, reflected in the use of allegedly identical preparations. However, only rarely is this plan subjected to systematic scrutiny after the event, and our point of view is that this is unsatisfactory.

Copyright
Corresponding author
Correspondence
Footnotes
Hide All

A full bibliography is available on-request.

Footnotes
References
Hide All
Baastrup, P. C., Poulsen, J. C., Schou, M., et al (1970) Prophylactic lithium: double blind discontinuation in manic-depressive and recurrent-depressive disorders. Lancet, ii, 326330.
Brownell, K. D. & Stunkard, A. J. (1982) The double-blind in danger. Untoward consequences of informed consent. American Journal of Psychiatry, 139, 14871489.
Byington, R. P., Curb, J. D. & Matron, M. E. (1985) Assessment of double-blindness at the conclusion of the β-blocker heart attack trial. Journal of the American Medical Association, 253, 17331736.
Coppen, A., Noguera, R., Bailey, J., et al (1971) Prophylactic lithium in affective disorders. Lancet, ii, 275279.
Dickson, W. E. & Kendell, R. E. (1986) Does maintenance lithium therapy prevent recurrences of mania under ordinary clinical conditions? Psychological Medicine, 16, 521530.
Hill, L. E., Nunn, A. J. & Fox, W. (1976) Matching quality of agents employed in “double-blind” controlled clinical trials. Lancet, i, 352356.
Howard, J., Whittemore, A., Hoover, J. J., et al (1982) The aspirin myocardial infarction study research group. How blind was the patient blind in AMIS? Clinical Pharmacology and Therapeutics, 32, 543553.
Letemendia, F. J. J. & Harris, A. D. (1959) The influence of side-effects on the reporting of symptoms. Psychopharmacologia, 1, 3947.
Leyburn, P. (1967) A critical look at antidepressant drug trials. Lancet, ii, 11351138.
Marini, J. L., Sheard, M. H., Bridges, C. I., et al (1976) An evaluation of the double-blind design in a study comparing lithium carbonate with placebo. Acta Psychiatrica Scandinavica, 53, 343354.
Mawson, D., Marks, I. M. & Ramm, L. (1982) Clomipramine and exposure for chronic obsessive-compulsive rituals. British Journal of Psychiatry, 140, 1118.
Prien, R. F., Klett, C. J. & Caffey, E. M. Jr (1973) Lithium carbonate and imipramine in prevention of affective episodes. Archives of General Psychiatry, 29, 420425.
Prien, R. F., Kupfer, D. J., Mansky, P. A., et al (1984) Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Archives of General Psychiatry, 41, 10961104.
Rickels, K., Lipman, R. S., Fisher, S., et al (1969) Is a double-blind clinical trial really double-blind? Psychopharmacologia (Berlin), 16, 329336.
Robinson, M. L. (1985) MRC trial of treatment of mild hypertension (letter). British Medical Journal, 291, 347.
Sussex Clinical Trials Group (1985) Separate and combined anxiolytic and antidepressant treatment of mixed anxiety/depression. Acta Psychiatrica Scandinavica, 72, 8188.
Zifferblatt, S. M. & Wilbur, C. S. (1978) A psychological perspective for double-blind trials. Clinical Pharmacology and Therapeutics, 23, 110.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Is Your ‘Double-Blind’ Design Truly Double-Blind?

  • Alison Oxtoby (a1), Angela Jones (a2) and Michael Robinson (a3)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *