Skip to main content Accessibility help

Lithium Treatment of Chronic Cluster Headaches

  • Julian Lieb (a1) and Arnold Zeff (a2)


On the basis of reports of reduced MAO activity in migraine and cluster headaches and on a report that lithium carbonate activates MAO, the authors administered lithium carbonate to two patients whose cluster headaches had brought them to the point of contemplating suicide. Both patients responded quite dramatically. Case 1 has now been virtually free of headaches for over two years and Case 2 has been in remission for over twelve months.



Hide All
Anthony, M. & Lance, J. W. (1969) Monoamine oxidase inhibition in the treatment of migraine. Archives of Neurology, 21, 263–8.
Bockar, J., Roth, R. & Heninger, G. (1974) Increased human platelet monoamine oxidase activity during lithium carbonate therapy. Life Sciences, 15, 2109–18.
Couch, J. R., Ziegler, D. K. & Hassanien, R. S. (1974) Evaluation of amitriptyline in migraine prophylaxis. Transactions of the American Neurological Association, 99, 94–8.
Couch, J. R., Ziegler, D. K. & Hassanien, R. S. (1976) Amitriptyline in the prophylaxis of migraine. Neurology, 26, 121–7.
Damasio, H. & Beck, D. (1978) Migraine, thrombocytopenia and serotonin metabolism. Lancet, i, 240–1.
Dexter, J. & Weitzman, E. D. (1970) The relationship of nocturnal headaches to sleep stage patterns. Neurology (Minneapolis), 20, 513–18.
Ekbom, K. (1977) Lithium in the treatment of chronic cluster headache. Headache, 17, 3940.
Glover, V., Sandler, M. & Grant, E. et al (1977) Transitory decrease in platelet monoamine-oxidase activity during migraine attacks. Lancet, i, 391–3.
Herberg, J. (1975) The hypothalamus and aminergic pathways in migraine. In Topics in Migraine (ed. Pearce, J.), pp. 8595. London: Heinemann.
Kudrow, L. (1977) Lithium prophylaxis for chronic cluster headache. Headache, 17, 1518.
Kupfer, D. J., Wyatt, R. J. & Greenspan, K. et al (1970) Lithium carbonate and sleep in affective illness. Archives of General Psychiatry, 23, 3540.
Mendels, J. & Chernik, D. A. (1973) The effect of lithium carbonate on the sleep of depressed patients. International Pharmacopsychiatry, 8, 184–92.
Sandler, M., Youdim, M. B. & Hanington, E. (1974) A phenylethylamine oxidising defect in migraine. Nature, 350, 335–7.
Sullivan, J. L., Dackis, C. & Stanfield, C. (1977) In vivo inhibition of platelet MAO activity by tricyclic antidepressants. American Journal of Psychiatry, 134, 188–90.

Lithium Treatment of Chronic Cluster Headaches

  • Julian Lieb (a1) and Arnold Zeff (a2)


Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.