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Loci with genome-wide associations with schizophrenia in the Han Chinese population

  • Zhiqiang Li (a1), Yuqian Xiang (a2), Jianhua Chen (a3), Qiaoli Li (a4), Jiawei Shen (a3), Yun Liu (a5), Wenjin Li (a3), Qinghe Xing (a5), Qingzhong Wang (a3), Lei Wang (a5), Guoyin Feng (a6), Lin He (a1), Xinzhi Zhao (a2) and Yongyong Shi (a7)...
Abstract
Background

A large schizophrenia genome-wide association study (GWAS) and a subsequent extensive replication study of individuals of European ancestry identified eight new loci with genome-wide significance and suggested that the MIR137-mediated pathway plays a role in the predisposition for schizophrenia.

Aims

To validate the above findings in a Han Chinese population.

Method

We analysed the single nucleotide polymorphisms (SNPs) in the newly identified schizophrenia candidate loci and predicted MIR137 target genes based on our published Han Chinese populations (BIOX) GWAS data. We then analysed 18 SNPs from the candidate regions in an independent cohort that consisted of 3585 patients with schizophrenia and 5496 controls of Han Chinese ancestry.

Results

We replicated the associations of five markers (P<0.05), including three that were located in the predicted MIR137 target genes. Two loci (ITIH3/4: rs2239547, P =1.17×10–10 and CALN1: rs2944829, P=9.97×10–9) exhibited genome-wide significance in the Han Chinese population.

Conclusions

The ITIH3/4 locus has been reported to be of genome-wide significance in the European population. The successful replication of this finding in a different ethnic group provides stronger evidence for the association between schizophrenia and ITIH3/4. We detected the first genome-wide significant association of schizophrenia with CALN1, which is a predicted target of MIR137, and thus provide new evidence for the associations between MIR137 targets and schizophrenia.

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Copyright
Corresponding author
Yongyong Shi, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, People's Republic of China. Email: shiyongyong@gmail.com; Xinzhi Zhao, Children's Hospital, Fudan University, 138 Yixueyuan Road, Shanghai 200032, People's Republic of China. Email: xzzhau@fudan.edu.cn
Footnotes
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Design and conduct of the study: collection, management, analysis and interpretation of the data: the Natural Science Foundation, Ministry of Science and Technology and the Ministry of Education of China. Preparation, review or approval of the manuscript: Shanghai Municipal Science & Technology Commission, Education Commission and Education Development Foundation.

Declaration of interest

None.

Footnotes
References
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Loci with genome-wide associations with schizophrenia in the Han Chinese population

  • Zhiqiang Li (a1), Yuqian Xiang (a2), Jianhua Chen (a3), Qiaoli Li (a4), Jiawei Shen (a3), Yun Liu (a5), Wenjin Li (a3), Qinghe Xing (a5), Qingzhong Wang (a3), Lei Wang (a5), Guoyin Feng (a6), Lin He (a1), Xinzhi Zhao (a2) and Yongyong Shi (a7)...
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