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  • Cited by 111
  • Cited by
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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Nagaratnam, Nages Nagaratnam, Kujan and Cheuk, Gary 2018. Geriatric Diseases. p. 629.
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    Janelidze, Marina Mikeladze, Nina Bochorishvili, Nazibrola Dzagnidze, Ann Kapianidze, Mariam Mikava, Nino Khatiashvili, Irene Mirvelashvili, Ekaterina Shiukashvili, Nino Lynch, John and Nadareishvili, Zurab 2018. Mild Cognitive Impairment in Republic of Georgia. Gerontology and Geriatric Medicine, Vol. 4, Issue. , p. 233372141877140.
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    Falck, Ryan S. Landry, Glenn J. Best, John R. Davis, Jennifer C. Chiu, Bryan K. and Liu-Ambrose, Teresa 2017. Cross-Sectional Relationships of Physical Activity and Sedentary Behavior With Cognitive Function in Older Adults With Probable Mild Cognitive Impairment. Physical Therapy, Vol. 97, Issue. 10, p. 975.
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    Allan, Charlotte L. Behrman, Sophie Ebmeier, Klaus P. and Valkanova, Vyara 2017. Diagnosing early cognitive decline—When, how and for whom?. Maturitas, Vol. 96, Issue. , p. 103.
    Mirzaei, Maryam Sepahvand, Elham Sahaf, Robab Mirzaei, Samaneh and Pakdel, Ahmad 2017. The Prevalence of Cognitive Impairment in Elderly Nursing Home Residents. Journal of Sabzevar University of Medical Sciences, Vol. 23, Issue. 6, p. 896.
    Er, Füsun Iscen, Pınar Sahin, Sevki Çinar, Nilgun Karsidag, Sibel and Goularas, Dionysis 2017. Distinguishing age-related cognitive decline from dementias: A study based on machine learning algorithms. Journal of Clinical Neuroscience, Vol. 42, Issue. , p. 186.
    Farina, Elisabetta Baglio, Francesca Pomati, Simone D'Amico, Alessandra Campini, Isabella C. Di Tella, Sonia Belloni, Giulia and Pozzo, Thierry 2017. The Mirror Neurons Network in Aging, Mild Cognitive Impairment, and Alzheimer Disease: A functional MRI Study. Frontiers in Aging Neuroscience, Vol. 9, Issue. ,
    Nagaratnam, Nages Nagaratnam, Kujan and Cheuk, Gary 2017. Geriatric Diseases. p. 1.
    Caldas, Érica Carvalho Rezende, Lays Aragão Oliveira, Karoline da Silva Pinheiro, Hudson Azevedo Melo, Gislane Ferreira de and Vilaça, Karla Helena Coelho 2017. Muscle strength, lower extremity functional performance and body composition in elderly women with mild cognitive impairment. Fisioterapia em Movimento, Vol. 30, Issue. 4, p. 753.
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    Booker, Anke Jacob, Louis EC Rapp, Michael Bohlken, Jens and Kostev, Karel 2016. Risk factors for dementia diagnosis in German primary care practices. International Psychogeriatrics, Vol. 28, Issue. 07, p. 1059.
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    Goh, Victor H.-H. and Hart, William G. 2015. Endocrine factors, memory and perceptual capacities and aging in Asian men. The Aging Male, Vol. 18, Issue. 2, p. 77.
    Katz, Marcelo E. Olguín, Jesica M. Terraza, Paula and Mangone, Carlos A. 2015. Cambios en la alerta social respecto a los trastornos cognitivos en los últimos 20 años. Influencia de los medios de comunicación. Neurología Argentina, Vol. 7, Issue. 2, p. 76.
    ten Brinke, Lisanne F Bolandzadeh, Niousha Nagamatsu, Lindsay S Hsu, Chun Liang Davis, Jennifer C Miran-Khan, Karim and Liu-Ambrose, Teresa 2015. Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial. British Journal of Sports Medicine, Vol. 49, Issue. 4, p. 248.
    Pocnet, Cornelia Antonietti, Jean-Philippe Donati, Alessia Popp, Julius Rossier, Jérôme and von Gunten, Armin 2015. Behavioral and psychological symptoms and cognitive decline in patients with amnestic MCI and mild AD: a two-year follow-up study. International Psychogeriatrics, Vol. 27, Issue. 08, p. 1379.
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Mild cognitive impairment: prevalence and incidence according to different diagnostic criteria: Results of the Leipzig Longitudinal Study of the Aged (LEILA75+)

  • Anja Busse (a1), Jeannette Bischkopf (a1), Steffi G. Riedel-Heller (a1) and Matthias C. Angermeyer (a1)
Abstract
Background

Although mild cognitive impairment is associated with an increased risk of developing dementia, there has been little work on its incidence and prevalence.

 Aims

To report age-specific prevalence, incidence and predictive validities for four diagnostic concepts of mild cognitive impairment.

 Method

A community sample of 1045 dementia-free individuals aged 75 years and over was examined by neuropsychological testing in a three-wave longitudinal study.

 Results

Prevalence rates ranged from 3% to 20%, depending on the concept applied. The annual incidence rates applying different case definitions varied from 8 to 77 per 1000 person-years. Rates of conversion to dementia over 2.6 years ranged from 23% to 47%.

 Conclusions

Mild cognitive impairment is frequent in older people. Prevalence, incidence and predictive validities are highly dependent on the diagnostic criteria applied.
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Copyright
COPYRIGHT: © 2003 The Royal College of Psychiatrists 
Corresponding author
Anja Busse, Department of Psychiatry, University of Leipzig, Johannisallee 20, D-04317 Leipzig, Germany. Tel: +49 341 9724530; fax: +49341 9724 539; e-mail: krausem@medizin.uni-leipzig.de
Footnotes
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Declaration of interest

The study was supported by the Interdisciplinary Centre for Clinical Research, University of Leipzig (JZKF, $1KS9504, Project C7_79934700).

Footnotes
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  • Cited by 111
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Nagaratnam, Nages Nagaratnam, Kujan and Cheuk, Gary 2018. Geriatric Diseases. p. 629.
    De Asis, Sarah J. 2018. Psychiatric Disorders Late in Life. p. 11.
    Liu-Ambrose, Teresa 2018. The Palgrave Handbook of Ageing and Physical Activity Promotion. p. 693.
    Janelidze, Marina Mikeladze, Nina Bochorishvili, Nazibrola Dzagnidze, Ann Kapianidze, Mariam Mikava, Nino Khatiashvili, Irene Mirvelashvili, Ekaterina Shiukashvili, Nino Lynch, John and Nadareishvili, Zurab 2018. Mild Cognitive Impairment in Republic of Georgia. Gerontology and Geriatric Medicine, Vol. 4, Issue. , p. 233372141877140.
    Kontaxopoulou, Dionysia Beratis, Ion N. Fragkiadaki, Stella Pavlou, Dimosthenis Yannis, George Economou, Alexandra Papanicolaou, Andrew C. and Papageorgiou, Sokratis G. 2017. Incidental and Intentional Memory: Their Relation with Attention and Executive Functions. Archives of Clinical Neuropsychology, Vol. 32, Issue. 5, p. 519.
    Falck, Ryan S. Landry, Glenn J. Best, John R. Davis, Jennifer C. Chiu, Bryan K. and Liu-Ambrose, Teresa 2017. Cross-Sectional Relationships of Physical Activity and Sedentary Behavior With Cognitive Function in Older Adults With Probable Mild Cognitive Impairment. Physical Therapy, Vol. 97, Issue. 10, p. 975.
    Mangone, Carlos A. Escalante, Natalia Gigena, Valeria de Pascale, Ana M. Olguin, Jesica Lopez Amoedo, Ines Arnaboldi, Ana Genovese, Osvaldo Dorman, Guido Alvarez Caches, Mariano Grillo, Roxana and Katz, Marcelo E. 2017. Estandarización del test de reacción cognitiva. Comprobación de su utilidad en el diagnóstico del deterioro cognitivo mínimo. Neurología Argentina, Vol. 9, Issue. 3, p. 163.
    Allan, Charlotte L. Behrman, Sophie Ebmeier, Klaus P. and Valkanova, Vyara 2017. Diagnosing early cognitive decline—When, how and for whom?. Maturitas, Vol. 96, Issue. , p. 103.
    Mirzaei, Maryam Sepahvand, Elham Sahaf, Robab Mirzaei, Samaneh and Pakdel, Ahmad 2017. The Prevalence of Cognitive Impairment in Elderly Nursing Home Residents. Journal of Sabzevar University of Medical Sciences, Vol. 23, Issue. 6, p. 896.
    Er, Füsun Iscen, Pınar Sahin, Sevki Çinar, Nilgun Karsidag, Sibel and Goularas, Dionysis 2017. Distinguishing age-related cognitive decline from dementias: A study based on machine learning algorithms. Journal of Clinical Neuroscience, Vol. 42, Issue. , p. 186.
    Farina, Elisabetta Baglio, Francesca Pomati, Simone D'Amico, Alessandra Campini, Isabella C. Di Tella, Sonia Belloni, Giulia and Pozzo, Thierry 2017. The Mirror Neurons Network in Aging, Mild Cognitive Impairment, and Alzheimer Disease: A functional MRI Study. Frontiers in Aging Neuroscience, Vol. 9, Issue. ,
    Nagaratnam, Nages Nagaratnam, Kujan and Cheuk, Gary 2017. Geriatric Diseases. p. 1.
    Caldas, Érica Carvalho Rezende, Lays Aragão Oliveira, Karoline da Silva Pinheiro, Hudson Azevedo Melo, Gislane Ferreira de and Vilaça, Karla Helena Coelho 2017. Muscle strength, lower extremity functional performance and body composition in elderly women with mild cognitive impairment. Fisioterapia em Movimento, Vol. 30, Issue. 4, p. 753.
    Porter, Kirsty Hoey, Leane Hughes, Catherine Ward, Mary and McNulty, Helene 2016. Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. Nutrients, Vol. 8, Issue. 11, p. 725.
    Booker, Anke Jacob, Louis EC Rapp, Michael Bohlken, Jens and Kostev, Karel 2016. Risk factors for dementia diagnosis in German primary care practices. International Psychogeriatrics, Vol. 28, Issue. 07, p. 1059.
    Reppou, Sofia E. Tsardoulias, Emmanouil G. Kintsakis, Athanassios M. Symeonidis, Andreas L. Mitkas, Pericles A. Psomopoulos, Fotis E. Karagiannis, George T. Zielinski, Cezary Prunet, Vincent Merlet, Jean-Pierre Iturburu, Miren and Gkiokas, Alexandros 2016. RAPP: A Robotic-Oriented Ecosystem for Delivering Smart User Empowering Applications for Older People. International Journal of Social Robotics, Vol. 8, Issue. 4, p. 539.
    Goh, Victor H.-H. and Hart, William G. 2015. Endocrine factors, memory and perceptual capacities and aging in Asian men. The Aging Male, Vol. 18, Issue. 2, p. 77.
    Katz, Marcelo E. Olguín, Jesica M. Terraza, Paula and Mangone, Carlos A. 2015. Cambios en la alerta social respecto a los trastornos cognitivos en los últimos 20 años. Influencia de los medios de comunicación. Neurología Argentina, Vol. 7, Issue. 2, p. 76.
    ten Brinke, Lisanne F Bolandzadeh, Niousha Nagamatsu, Lindsay S Hsu, Chun Liang Davis, Jennifer C Miran-Khan, Karim and Liu-Ambrose, Teresa 2015. Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial. British Journal of Sports Medicine, Vol. 49, Issue. 4, p. 248.
    Pocnet, Cornelia Antonietti, Jean-Philippe Donati, Alessia Popp, Julius Rossier, Jérôme and von Gunten, Armin 2015. Behavioral and psychological symptoms and cognitive decline in patients with amnestic MCI and mild AD: a two-year follow-up study. International Psychogeriatrics, Vol. 27, Issue. 08, p. 1379.
    Download full list
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Mild cognitive impairment: prevalence and incidence according to different diagnostic criteria: Results of the Leipzig Longitudinal Study of the Aged (LEILA75+)

  • Anja Busse (a1), Jeannette Bischkopf (a1), Steffi G. Riedel-Heller (a1) and Matthias C. Angermeyer (a1)
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